Aliases for SIRPB1 Gene
External Ids for SIRPB1 Gene
Previous GeneCards Identifiers for SIRPB1 Gene
The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein was found to interact with TYROBP/DAP12, a protein bearing immunoreceptor tyrosine-based activation motifs. This protein was also reported to participate in the recruitment of tyrosine kinase SYK. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]
GeneCards Summary for SIRPB1 Gene
SIRPB1 (Signal-Regulatory Protein Beta 1) is a Protein Coding gene. Diseases associated with SIRPB1 include composite lymphoma. Among its related pathways are Signaling by FGFR and Cell junction organization. An important paralog of this gene is ENSG00000260861.
Immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Participates also in the recruitment of tyrosine kinase SYK
Immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes.