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Aliases for CDKN2D Gene

Aliases for CDKN2D Gene

  • Cyclin-Dependent Kinase Inhibitor 2D (P19, Inhibits CDK4) 2 3
  • P19-INK4D 3 4
  • Cell Cycle Inhibitor, Nur77 Associating Protein 3
  • Cyclin-Dependent Kinase 4 Inhibitor D P19 3
  • Inhibitor Of Cyclin-Dependent Kinase 4d 3
  • Cyclin-Dependent Kinase 4 Inhibitor D 3
  • CDK Inhibitor P19INK4d 3
  • INK4D 3
  • P19 3

External Ids for CDKN2D Gene

Summaries for CDKN2D Gene

Entrez Gene Summary for CDKN2D Gene

  • The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to form a stable complex with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. The abundance of the transcript of this gene was found to oscillate in a cell-cycle dependent manner with the lowest expression at mid G1 and a maximal expression during S phase. The negative regulation of the cell cycle involved in this protein was shown to participate in repressing neuronal proliferation, as well as spermatogenesis. Two alternatively spliced variants of this gene, which encode an identical protein, have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for CDKN2D Gene

CDKN2D (Cyclin-Dependent Kinase Inhibitor 2D (P19, Inhibits CDK4)) is a Protein Coding gene. Diseases associated with CDKN2D include malignant melanoma, somatic and testicular germ cell tumor. Among its related pathways are ERK Signaling and GPCR Pathway. GO annotations related to this gene include protein kinase binding and cyclin-dependent protein serine/threonine kinase inhibitor activity. An important paralog of this gene is CDKN2B.

UniProtKB/Swiss-Prot for CDKN2D Gene

  • Interacts strongly with CDK4 and CDK6 and inhibits them.

Gene Wiki entry for CDKN2D Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDKN2D Gene

Genomics for CDKN2D Gene

Genomic Location for CDKN2D Gene

Start:
10,566,462 bp from pter
End:
10,569,059 bp from pter
Size:
2,598 bases
Orientation:
Minus strand

Genomic View for CDKN2D Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CDKN2D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDKN2D Gene

Regulatory Elements for CDKN2D Gene

Proteins for CDKN2D Gene

  • Protein details for CDKN2D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P55273-CDN2D_HUMAN
    Recommended name:
    Cyclin-dependent kinase 4 inhibitor D
    Protein Accession:
    P55273
    Secondary Accessions:
    • Q13102
    • Q6FGE9

    Protein attributes for CDKN2D Gene

    Size:
    166 amino acids
    Molecular mass:
    17700 Da
    Quaternary structure:
    • Interacts with CDK6.

    Three dimensional structures from OCA and Proteopedia for CDKN2D Gene

neXtProt entry for CDKN2D Gene

Proteomics data for CDKN2D Gene at MOPED

Post-translational modifications for CDKN2D Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CDKN2D Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CDKN2D Gene

Domains for CDKN2D Gene

Gene Families for CDKN2D Gene

HGNC:
  • ANKRD :Ankyrin repeat domain containing

Protein Domains for CDKN2D Gene

UniProtKB/Swiss-Prot:

CDN2D_HUMAN
Family:
  • Belongs to the CDKN2 cyclin-dependent kinase inhibitor family.:
    • P55273
Similarity:
  • Contains 4 ANK repeats.:
    • P55273
genes like me logo Genes that share domains with CDKN2D: view

Function for CDKN2D Gene

Molecular function for CDKN2D Gene

GENATLAS Biochemistry: cyclin dependent kinase 4 and 6 (CDK4/CDK6) inhibitor,p19,regulator of the cell cycle,passage through the G1 checkpoint,expressed primarily in hematopoietic tissues
UniProtKB/Swiss-Prot Function: Interacts strongly with CDK4 and CDK6 and inhibits them.

Gene Ontology (GO) - Molecular Function for CDKN2D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity IDA 8741839
GO:0005515 protein binding IPI 16189514
GO:0019901 protein kinase binding IPI 8741839
genes like me logo Genes that share ontologies with CDKN2D: view
genes like me logo Genes that share phenotypes with CDKN2D: view

miRNA for CDKN2D Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CDKN2D Gene

Localization for CDKN2D Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDKN2D Gene

Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDKN2D Gene COMPARTMENTS Subcellular localization image for CDKN2D gene
Compartment Confidence
nucleus 5
cytosol 4
extracellular 2

Gene Ontology (GO) - Cellular Components for CDKN2D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 15750620
GO:0005737 cytoplasm IDA 15750620
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with CDKN2D: view

Pathways for CDKN2D Gene

genes like me logo Genes that share pathways with CDKN2D: view

Pathways by source for CDKN2D Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for CDKN2D Gene
1 BioSystems pathway for CDKN2D Gene

Gene Ontology (GO) - Biological Process for CDKN2D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity IDA 8741839
GO:0000082 G1/S transition of mitotic cell cycle IDA 10208428
GO:0000278 mitotic cell cycle TAS --
GO:0000731 DNA synthesis involved in DNA repair IMP 15750620
GO:0007050 cell cycle arrest IDA 10208428
genes like me logo Genes that share ontologies with CDKN2D: view

Transcripts for CDKN2D Gene

mRNA/cDNA for CDKN2D Gene

Unigene Clusters for CDKN2D Gene

Cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CDKN2D Gene

No ASD Table

Relevant External Links for CDKN2D Gene

GeneLoc Exon Structure for
CDKN2D
ECgene alternative splicing isoforms for
CDKN2D

Expression for CDKN2D Gene

mRNA expression in normal human tissues for CDKN2D Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CDKN2D Gene

This gene is overexpressed in Whole Blood (13.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CDKN2D Gene

SOURCE GeneReport for Unigene cluster for CDKN2D Gene Hs.435051

genes like me logo Genes that share expressions with CDKN2D: view

Orthologs for CDKN2D Gene

This gene was present in the common ancestor of chordates.

Orthologs for CDKN2D Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDKN2D 36
  • 99.6 (n)
  • 100 (a)
CDKN2D 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CDKN2D 36
  • 85.34 (n)
  • 87.95 (a)
CDKN2D 37
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CDKN2D 36
  • 87.93 (n)
  • 90.8 (a)
mouse
(Mus musculus)
Mammalia Cdkn2d 36
  • 81.73 (n)
  • 86.75 (a)
Cdkn2d 16
Cdkn2d 37
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CDKN2D 37
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDKN2D 37
  • 59 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDKN2D 37
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdkn2d 36
  • 65.07 (n)
  • 68.49 (a)
zebrafish
(Danio rerio)
Actinopterygii cdkn2d 37
  • 56 (a)
OneToOne
LOC100333252 36
  • 64.01 (n)
  • 60.87 (a)
Species with no ortholog for CDKN2D:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CDKN2D Gene

ENSEMBL:
Gene Tree for CDKN2D (if available)
TreeFam:
Gene Tree for CDKN2D (if available)

Paralogs for CDKN2D Gene

Paralogs for CDKN2D Gene

genes like me logo Genes that share paralogs with CDKN2D: view

Variants for CDKN2D Gene

Sequence variations from dbSNP and Humsavar for CDKN2D Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs892080 -- 10,570,058(-) AAAGC(A/C)AAACA upstream-variant-2KB
rs892081 -- 10,570,008(-) GAAAC(A/C)TCATA upstream-variant-2KB
rs892082 -- 10,569,802(-) AACTA(C/T)TGTCT upstream-variant-2KB
rs1465700 -- 10,569,945(-) CTACT(C/T)GGGAG upstream-variant-2KB
rs1465701 -- 10,568,166(-) CTTCT(A/G)TGGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CDKN2D Gene

Variant ID Type Subtype PubMed ID
nsv833744 CNV Loss 17160897
nsv911042 CNV Loss 21882294
dgv3727n71 CNV Loss 21882294
nsv833745 CNV Loss 17160897
nsv911045 CNV Loss 21882294
nsv911046 CNV Loss 21882294
nsv911047 CNV Loss 21882294

Relevant External Links for CDKN2D Gene

HapMap Linkage Disequilibrium report
CDKN2D

Disorders for CDKN2D Gene

(5) Novoseek inferred disease relationships for CDKN2D Gene

Disease -log(P) Hits PubMed IDs
retinoblastoma 50.2 3
leukemia t-cell 38.7 1
cancer 26.3 3
osteosarcoma 22.1 2
tumors 16.7 4

Relevant External Links for CDKN2D

Genetic Association Database (GAD)
CDKN2D
Human Genome Epidemiology (HuGE) Navigator
CDKN2D
Tumor Gene Database (TGDB):
CDKN2D
genes like me logo Genes that share disorders with CDKN2D: view

No data available for UniProtKB/Swiss-Prot for CDKN2D Gene

Publications for CDKN2D Gene

  1. Molecular cloning, expression pattern, and chromosomal localization of human CDKN2D/INK4d, an inhibitor of cyclin D-dependent kinases. (PMID: 8575754) Okuda T. … Downing J.R. (Genomics 1995) 2 3 4 23
  2. Isolation and characterization of p19INK4d, a p16-related inhibitor specific to CDK6 and CDK4. (PMID: 8741839) Guan K.L. … Xiong Y. (Mol. Biol. Cell 1996) 3 4 23
  3. Mutation testing in melanoma families: INK4A, CDK4 and INK4D. (PMID: 10390011) Newton Bishop J.A. … Bishop D.T. (Br. J. Cancer 1999) 3 4 23
  4. Structure of human cyclin-dependent kinase inhibitor p19(INK4d): comparison to known ankyrin-repeat-containing structures and implications for the dysfunction of tumor suppressor p16(INK4a). (PMID: 9782052) Baumgartner R. … Holak T.A. (Structure 1998) 3 4 23
  5. Association of single-nucleotide polymorphisms in the cell cycle genes with breast cancer in the British population. (PMID: 18174243) Driver K.E. … Dunning A.M. (Carcinogenesis 2008) 3 23 49

Products for CDKN2D Gene

Sources for CDKN2D Gene

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