Aliases for CDKN2D Gene
External Ids for CDKN2D Gene
Previous GeneCards Identifiers for CDKN2D Gene
The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to form a stable complex with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. The abundance of the transcript of this gene was found to oscillate in a cell-cycle dependent manner with the lowest expression at mid G1 and a maximal expression during S phase. The negative regulation of the cell cycle involved in this protein was shown to participate in repressing neuronal proliferation, as well as spermatogenesis. Two alternatively spliced variants of this gene, which encode an identical protein, have been reported. [provided by RefSeq, Jul 2008]
GeneCards Summary for CDKN2D Gene
CDKN2D (Cyclin Dependent Kinase Inhibitor 2D) is a Protein Coding gene. Diseases associated with CDKN2D include Melanoma, Cutaneous Malignant 1 and Deafness, Autosomal Recessive 68. Among its related pathways are IL-10 Pathway and Cellular Senescence (REACTOME). Gene Ontology (GO) annotations related to this gene include protein kinase binding and cyclin-dependent protein serine/threonine kinase inhibitor activity. An important paralog of this gene is CDKN2C.
UniProtKB/Swiss-Prot for CDKN2D Gene
Interacts strongly with CDK4 and CDK6 and inhibits them.