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Aliases for ZNF267 Gene

Aliases for ZNF267 Gene

  • Zinc Finger Protein 267 2 3 5
  • Zinc Finger Protein HZF2 3 4
  • Zinc Finger Protein 2 3
  • Zinc Finger (C2H2) 3
  • HZF2 3

External Ids for ZNF267 Gene

Previous GeneCards Identifiers for ZNF267 Gene

  • GC16P030966
  • GC16P032222
  • GC16P031723
  • GC16P031760
  • GC16P031633
  • GC16P031792
  • GC16P029445

Summaries for ZNF267 Gene

GeneCards Summary for ZNF267 Gene

ZNF267 (Zinc Finger Protein 267) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF519.

UniProtKB/Swiss-Prot for ZNF267 Gene

  • May be involved in transcriptional regulation.

Gene Wiki entry for ZNF267 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF267 Gene

Genomics for ZNF267 Gene

Regulatory Elements for ZNF267 Gene

Enhancers for ZNF267 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF267 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF267 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF267 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF267 Gene

Chromosome:
16
Start:
31,873,758 bp from pter
End:
31,917,357 bp from pter
Size:
43,600 bases
Orientation:
Plus strand

Genomic View for ZNF267 Gene

Genes around ZNF267 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF267 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF267 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF267 Gene

Proteins for ZNF267 Gene

  • Protein details for ZNF267 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14586-ZN267_HUMAN
    Recommended name:
    Zinc finger protein 267
    Protein Accession:
    Q14586
    Secondary Accessions:
    • A0JNZ9
    • Q8NE41
    • Q9NRJ0

    Protein attributes for ZNF267 Gene

    Size:
    743 amino acids
    Molecular mass:
    87376 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF267 Gene

Proteomics data for ZNF267 Gene at MOPED

Post-translational modifications for ZNF267 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF267 Gene

No data available for DME Specific Peptides for ZNF267 Gene

Domains & Families for ZNF267 Gene

Gene Families for ZNF267 Gene

Protein Domains for ZNF267 Gene

Suggested Antigen Peptide Sequences for ZNF267 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q14586

UniProtKB/Swiss-Prot:

ZN267_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 15 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 15 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF267: view

Function for ZNF267 Gene

Molecular function for ZNF267 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
genes like me logo Genes that share phenotypes with ZNF267: view

Animal Model Products

CRISPR Products

miRNA for ZNF267 Gene

miRTarBase miRNAs that target ZNF267

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF267 Gene

Localization for ZNF267 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF267 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF267 Gene COMPARTMENTS Subcellular localization image for ZNF267 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for ZNF267 Gene

Pathways & Interactions for ZNF267 Gene

SuperPathways for ZNF267 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF267: view

Pathways by source for ZNF267 Gene

2 Reactome pathways for ZNF267 Gene

Interacting Proteins for ZNF267 Gene

Gene Ontology (GO) - Biological Process for ZNF267 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development TAS 7865130
genes like me logo Genes that share ontologies with ZNF267: view

No data available for SIGNOR curated interactions for ZNF267 Gene

Drugs & Compounds for ZNF267 Gene

No Compound Related Data Available

Transcripts for ZNF267 Gene

Unigene Clusters for ZNF267 Gene

Zinc finger protein 267:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF267 Gene

No ASD Table

Relevant External Links for ZNF267 Gene

GeneLoc Exon Structure for
ZNF267
ECgene alternative splicing isoforms for
ZNF267

Expression for ZNF267 Gene

mRNA expression in normal human tissues for ZNF267 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF267 Gene

This gene is overexpressed in Whole Blood (x4.4).

Protein differential expression in normal tissues from HIPED for ZNF267 Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF267 Gene



SOURCE GeneReport for Unigene cluster for ZNF267 Gene Hs.460645

genes like me logo Genes that share expression patterns with ZNF267: view

Protein tissue co-expression partners for ZNF267 Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for ZNF267 Gene

Orthologs for ZNF267 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF267 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia D3Ertd254e 35
  • 60.59 (n)
  • 46.99 (a)
D3Ertd254e 16
Gm19965 36
  • 26 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia ZNF267 35
  • 99.46 (n)
  • 98.92 (a)
ZNF267 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100359945 35
  • 59.36 (n)
  • 45.56 (a)
dog
(Canis familiaris)
Mammalia -- 36
  • 42 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 43 (a)
ManyToMany
-- 36
  • 47 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Cf2 37
  • 45 (a)
CG17612 37
  • 30 (a)
CG18262 37
  • 46 (a)
CG3281 37
  • 37 (a)
Kr-h1 37
  • 47 (a)
Species with no ortholog for ZNF267:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF267 Gene

ENSEMBL:
Gene Tree for ZNF267 (if available)
TreeFam:
Gene Tree for ZNF267 (if available)

Paralogs for ZNF267 Gene

Paralogs for ZNF267 Gene

(510) SIMAP similar genes for ZNF267 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for ZNF267 Gene

genes like me logo Genes that share paralogs with ZNF267: view

Variants for ZNF267 Gene

Sequence variations from dbSNP and Humsavar for ZNF267 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs7202455 - 31,915,018(+) AGAGT(A/G)TGCAT nc-transcript-variant, reference, missense
rs3850114 - 31,915,298(-) ATTTA(C/T)AGGGT nc-transcript-variant, reference, missense
rs3861268 -- 31,896,847(-) ctatg(A/G)attta intron-variant
rs3861269 -- 31,897,157(-) ttttt(G/T)ttttg intron-variant
rs3861270 -- 31,898,461(-) tgtca(G/T)tccct intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF267 Gene

Variant ID Type Subtype PubMed ID
nsv905747 CNV Gain 21882294
dgv848e1 CNV Complex 17122850
dgv849e1 CNV Complex 17122850
dgv850e1 CNV Complex 17122850
dgv851e1 CNV Complex 17122850
dgv852e1 CNV Complex 17122850
dgv853e1 CNV Complex 17122850
nsv428325 CNV Gain+Loss 18775914
nsv833196 CNV Gain 17160897
esv2640928 CNV Deletion 19546169
esv2375355 CNV Deletion 18987734
esv2666562 CNV Deletion 23128226
esv29641 CNV Loss 19812545

Variation tolerance for ZNF267 Gene

Residual Variation Intolerance Score: 18.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.46; 28.53% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ZNF267 Gene

Disorders for ZNF267 Gene

Relevant External Links for ZNF267

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF267

No disorders were found for ZNF267 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF267 Gene

Publications for ZNF267 Gene

  1. Isolation of cDNA clones for 42 different Kruppel-related zinc finger proteins expressed in the human monoblast cell line U-937. (PMID: 7865130) Abrink M. … Hellman L. (DNA Cell Biol. 1995) 2 3 4 67
  2. Characterization of the human zinc finger protein 267 promoter: essential role of nuclear factor Y. (PMID: 15814297) Hu K. … Schnabl B. (Biochim. Biophys. Acta 2005) 3 23
  3. Zinc finger protein 267 is up-regulated during the activation process of human hepatic stellate cells and functions as a negative transcriptional regulator of MMP-10. (PMID: 16054593) Schnabl B. … SchAPlmerich J. (Biochem. Biophys. Res. Commun. 2005) 3 23
  4. The protein interaction landscape of the human CMGC kinase group. (PMID: 23602568) Varjosalo M. … Gstaiger M. (Cell Rep 2013) 3
  5. Zinc finger protein 267 is up-regulated in hepatocellular carcinoma and promotes tumor cell proliferation and migration. (PMID: 21840307) Schnabl B. … Hellerbrand C. (Exp. Mol. Pathol. 2011) 3

Products for ZNF267 Gene

Sources for ZNF267 Gene

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