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Aliases for EIF1B Gene

Aliases for EIF1B Gene

  • Eukaryotic Translation Initiation Factor 1B 2 3 5
  • Protein Translation Factor SUI1 Homolog GC20 3 4
  • Translation Factor Sui1 Homolog 3
  • EIF1b 4
  • GC20 3

External Ids for EIF1B Gene

Previous GeneCards Identifiers for EIF1B Gene

  • GC03P040327
  • GC03P040351

Summaries for EIF1B Gene

GeneCards Summary for EIF1B Gene

EIF1B (Eukaryotic Translation Initiation Factor 1B) is a Protein Coding gene. Among its related pathways are RNA transport. Gene Ontology (GO) annotations related to this gene include translation initiation factor activity. An important paralog of this gene is EIF1.

UniProtKB/Swiss-Prot for EIF1B Gene

  • Probably involved in translation.

Gene Wiki entry for EIF1B Gene

Additional gene information for EIF1B Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EIF1B Gene

Genomics for EIF1B Gene

GeneHancer (GH) Regulatory Elements for EIF1B Gene

Promoters and enhancers for EIF1B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I040308 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 +0.5 455 2.9 HDGF PKNOX1 FOXA2 SMAD1 ARNT ARID4B SIN3A DMAP1 IRF4 YY1 EIF1B EIF1B-AS1 SNORA62 ENTPD3-AS1 ZNF619 RPL14 PGAM1P3
GH03I040298 Enhancer 1.5 FANTOM5 Ensembl ENCODE 11.5 -9.8 -9750 2 HDGF ATF1 ARNT POLR2B ZNF766 ARID2 FOS ATF7 KDM4B RXRA EIF1B ENTPD3-AS1 EIF1B-AS1 GC03P040264
GH03I040192 Enhancer 0.6 ENCODE 11.7 -116.8 -116837 0.2 ZNF639 PKNOX1 ATF1 SOX6 BACH1 MAFG MNT ZEB2 CHAMP1 ZNF316 EIF1B ENSG00000202517 LOC105377645 EIF1B-AS1 GC03M040043 MYRIP
GH03I040292 Enhancer 0.8 FANTOM5 4.8 -16.9 -16879 0.3 HDAC1 MEIS2 PKNOX1 ATF1 ZBTB21 ETV1 BACH1 SIN3A CEBPG MTA3 ENTPD3-AS1 ENSG00000202517 EIF1B EIF1B-AS1 GC03P040264
GH03I040229 Enhancer 0.5 FANTOM5 6 -80.1 -80145 0.4 RUNX3 SPI1 EIF1B GC03P040238 RN7SL411P EIF1B-AS1 MYRIP
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around EIF1B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the EIF1B gene promoter:

Genomic Locations for EIF1B Gene

Genomic Locations for EIF1B Gene
chr3:40,309,682-40,312,424
(GRCh38/hg38)
Size:
2,743 bases
Orientation:
Plus strand
chr3:40,351,173-40,353,915
(GRCh37/hg19)

Genomic View for EIF1B Gene

Genes around EIF1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EIF1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EIF1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EIF1B Gene

Proteins for EIF1B Gene

  • Protein details for EIF1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60739-EIF1B_HUMAN
    Recommended name:
    Eukaryotic translation initiation factor 1b
    Protein Accession:
    O60739
    Secondary Accessions:
    • Q9UQF8

    Protein attributes for EIF1B Gene

    Size:
    113 amino acids
    Molecular mass:
    12824 Da
    Quaternary structure:
    No Data Available

neXtProt entry for EIF1B Gene

Post-translational modifications for EIF1B Gene

Other Protein References for EIF1B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for EIF1B Gene

Domains & Families for EIF1B Gene

Gene Families for EIF1B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for EIF1B Gene

Suggested Antigen Peptide Sequences for EIF1B Gene

Graphical View of Domain Structure for InterPro Entry

O60739

UniProtKB/Swiss-Prot:

EIF1B_HUMAN :
  • Belongs to the SUI1 family.
Family:
  • Belongs to the SUI1 family.
genes like me logo Genes that share domains with EIF1B: view

Function for EIF1B Gene

Molecular function for EIF1B Gene

UniProtKB/Swiss-Prot Function:
Probably involved in translation.

Gene Ontology (GO) - Molecular Function for EIF1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22681889
GO:0003743 translation initiation factor activity IEA --
GO:0005515 protein binding IPI --
genes like me logo Genes that share ontologies with EIF1B: view
genes like me logo Genes that share phenotypes with EIF1B: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for EIF1B Gene

Localization for EIF1B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EIF1B gene
Compartment Confidence
nucleus 2
cytosol 2
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for EIF1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with EIF1B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for EIF1B Gene

Pathways & Interactions for EIF1B Gene

SuperPathways for EIF1B Gene

SuperPathway Contained pathways
1 RNA transport
genes like me logo Genes that share pathways with EIF1B: view

Pathways by source for EIF1B Gene

1 KEGG pathway for EIF1B Gene

Gene Ontology (GO) - Biological Process for EIF1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA --
GO:0006413 translational initiation IEA --
GO:0006446 regulation of translational initiation NAS 7904817
genes like me logo Genes that share ontologies with EIF1B: view

No data available for SIGNOR curated interactions for EIF1B Gene

Drugs & Compounds for EIF1B Gene

No Compound Related Data Available

Transcripts for EIF1B Gene

Unigene Clusters for EIF1B Gene

Eukaryotic translation initiation factor 1B:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for EIF1B Gene

No ASD Table

Relevant External Links for EIF1B Gene

GeneLoc Exon Structure for
EIF1B
ECgene alternative splicing isoforms for
EIF1B

Expression for EIF1B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for EIF1B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for EIF1B Gene

This gene is overexpressed in Heart - Left Ventricle (x4.5).

Protein differential expression in normal tissues from HIPED for EIF1B Gene

This gene is overexpressed in Peripheral blood mononuclear cells (19.5), Fetal ovary (10.6), Fetal heart (8.4), and Testis (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for EIF1B Gene



NURSA nuclear receptor signaling pathways regulating expression of EIF1B Gene:

EIF1B

SOURCE GeneReport for Unigene cluster for EIF1B Gene:

Hs.315230

Evidence on tissue expression from TISSUES for EIF1B Gene

  • Nervous system(4.8)
  • Blood(4.4)
  • Kidney(4.3)
  • Liver(4.3)
  • Pancreas(2.4)
  • Heart(2.3)
  • Muscle(2.2)
  • Bone marrow(2)
genes like me logo Genes that share expression patterns with EIF1B: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for EIF1B Gene

Orthologs for EIF1B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EIF1B Gene

Organism Taxonomy Gene Similarity Type Details
oppossum
(Monodelphis domestica)
Mammalia EIF1B 34
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia EIF1B 33 34
  • 99.71 (n)
cow
(Bos Taurus)
Mammalia EIF1B 33 34
  • 98.23 (n)
dog
(Canis familiaris)
Mammalia EIF1B 33
  • 96.46 (n)
-- 34
  • 91 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Eif1b 33
  • 92.92 (n)
mouse
(Mus musculus)
Mammalia Eif1b 33 16 34
  • 92.33 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia EIF1B 34
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves EIF1B 33 34
  • 89.09 (n)
lizard
(Anolis carolinensis)
Reptilia EIF1B 34
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia eif1b 33
  • 89.97 (n)
MGC75713 33
African clawed frog
(Xenopus laevis)
Amphibia gc20-pending-prov 33
zebrafish
(Danio rerio)
Actinopterygii EIF1B 34
  • 96 (a)
OneToOne
zgc:56676 33
  • 82.89 (n)
zgc56676 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8683 33
fruit fly
(Drosophila melanogaster)
Insecta CG17737 34
  • 68 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea eif-1 34
  • 55 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SUI1 34
  • 59 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G27130 33
  • 65.7 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.13155 33
rice
(Oryza sativa)
Liliopsida Os07g0529800 33
  • 65.15 (n)
Os.7945 33
barley
(Hordeum vulgare)
Liliopsida Hv.701 33
corn
(Zea mays)
Liliopsida Zm.355 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6142 34
  • 65 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5488 33
Species where no ortholog for EIF1B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EIF1B Gene

ENSEMBL:
Gene Tree for EIF1B (if available)
TreeFam:
Gene Tree for EIF1B (if available)

Paralogs for EIF1B Gene

Paralogs for EIF1B Gene

(3) SIMAP similar genes for EIF1B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with EIF1B: view

Variants for EIF1B Gene

Sequence variations from dbSNP and Humsavar for EIF1B Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1001009956 -- 40,308,614(+) T/C upstream_transcript_variant
rs1001519270 -- 40,312,166(+) T/C 3_prime_UTR_variant
rs1001629319 -- 40,311,308(+) C/A intron_variant
rs1002083067 -- 40,311,669(+) G/A intron_variant
rs1002086741 -- 40,310,114(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for EIF1B Gene

Variant ID Type Subtype PubMed ID
nsv834667 CNV gain 17160897

Variation tolerance for EIF1B Gene

Residual Variation Intolerance Score: 53.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.04; 0.86% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for EIF1B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
EIF1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EIF1B Gene

Disorders for EIF1B Gene

Additional Disease Information for EIF1B

No disorders were found for EIF1B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EIF1B Gene

Publications for EIF1B Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  2. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PMID: 10931946) Hu RM … Chen JL (Proceedings of the National Academy of Sciences of the United States of America 2000) 3 4 58
  3. Expressed sequence tags identify a human isolog of the suil translation initiation factor. (PMID: 7904817) Fields C … Adams MD (Biochemical and biophysical research communications 1994) 2 3 58
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C … Emili A (Nature 2015) 3 58
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58

Products for EIF1B Gene

Sources for EIF1B Gene

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