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Aliases for RGS19 Gene

Aliases for RGS19 Gene

  • Regulator Of G-Protein Signaling 19 2 3 5
  • Regulator Of G-Protein Signalling 19 2 3
  • G-Alpha-Interacting Protein 3 4
  • GAIP 3 4
  • Guanine Nucleotide Binding Protein Alpha Inhibiting Activity Polypeptide 3 Interacting Protein 3
  • G Protein Signalling Regulator 19 3
  • G Alpha Interacting Protein 3
  • RGSGAIP 3
  • GNAI3IP 4

External Ids for RGS19 Gene

Previous GeneCards Identifiers for RGS19 Gene

  • GC20M062582
  • GC20M063383
  • GC20M063430
  • GC20M062174
  • GC20M062704
  • GC20M059438

Summaries for RGS19 Gene

Entrez Gene Summary for RGS19 Gene

  • G proteins mediate a number of cellular processes. The protein encoded by this gene belongs to the RGS (regulators of G-protein signaling) family and specifically interacts with G protein, GAI3. This protein is a guanosine triphosphatase-activating protein that functions to down-regulate Galpha i/Galpha q-linked signaling. Alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for RGS19 Gene

RGS19 (Regulator Of G-Protein Signaling 19) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include GTPase activator activity and G-protein alpha-subunit binding. An important paralog of this gene is RGS18.

UniProtKB/Swiss-Prot for RGS19 Gene

  • Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, with the order G(i)a3 > G(i)a1 > G(o)a >> G(z)a/G(i)a2. Activity on G(z)-alpha is inhibited by phosphorylation and palmitoylation of the G-protein.

Gene Wiki entry for RGS19 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RGS19 Gene

Genomics for RGS19 Gene

Regulatory Elements for RGS19 Gene

Promoters for RGS19 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RGS19 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the RGS19 gene promoter:

Genomic Location for RGS19 Gene

Chromosome:
20
Start:
64,073,181 bp from pter
End:
64,080,003 bp from pter
Size:
6,823 bases
Orientation:
Minus strand

Genomic View for RGS19 Gene

Genes around RGS19 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RGS19 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RGS19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RGS19 Gene

Proteins for RGS19 Gene

  • Protein details for RGS19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49795-RGS19_HUMAN
    Recommended name:
    Regulator of G-protein signaling 19
    Protein Accession:
    P49795
    Secondary Accessions:
    • A8K216
    • E1P5G9
    • Q53XN0
    • Q8TD60

    Protein attributes for RGS19 Gene

    Size:
    217 amino acids
    Molecular mass:
    24636 Da
    Quaternary structure:
    • Interacts with GIPC PDZ domain.

    Three dimensional structures from OCA and Proteopedia for RGS19 Gene

neXtProt entry for RGS19 Gene

Proteomics data for RGS19 Gene at MOPED

Post-translational modifications for RGS19 Gene

Other Protein References for RGS19 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for RGS19 Gene

Domains & Families for RGS19 Gene

Gene Families for RGS19 Gene

Protein Domains for RGS19 Gene

Suggested Antigen Peptide Sequences for RGS19 Gene

Graphical View of Domain Structure for InterPro Entry

P49795

UniProtKB/Swiss-Prot:

RGS19_HUMAN :
  • Contains 1 RGS domain.
Domain:
  • Contains 1 RGS domain.
genes like me logo Genes that share domains with RGS19: view

Function for RGS19 Gene

Molecular function for RGS19 Gene

UniProtKB/Swiss-Prot Function:
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, with the order G(i)a3 > G(i)a1 > G(o)a >> G(z)a/G(i)a2. Activity on G(z)-alpha is inhibited by phosphorylation and palmitoylation of the G-protein.

Gene Ontology (GO) - Molecular Function for RGS19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008013 beta-catenin binding IBA --
genes like me logo Genes that share ontologies with RGS19: view
genes like me logo Genes that share phenotypes with RGS19: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RGS19 Gene

Localization for RGS19 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RGS19 Gene

Membrane; Lipid-anchor.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RGS19 Gene COMPARTMENTS Subcellular localization image for RGS19 gene
Compartment Confidence
golgi apparatus 5
cytoskeleton 3
cytosol 3
extracellular 2
nucleus 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for RGS19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005834 colocalizes_with heterotrimeric G-protein complex TAS 8524874
GO:0005881 cytoplasmic microtubule IBA --
GO:0005903 brush border IEA --
GO:0005938 cell cortex IBA --
GO:0030136 clathrin-coated vesicle IEA --
genes like me logo Genes that share ontologies with RGS19: view

Pathways & Interactions for RGS19 Gene

genes like me logo Genes that share pathways with RGS19: view

SIGNOR curated interactions for RGS19 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for RGS19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IBA --
GO:0007186 G-protein coupled receptor signaling pathway TAS 8524874
GO:0030154 cell differentiation IBA --
GO:0043547 positive regulation of GTPase activity IBA --
GO:0071407 cellular response to organic cyclic compound IBA --
genes like me logo Genes that share ontologies with RGS19: view

Drugs & Compounds for RGS19 Gene

(3) Drugs for RGS19 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for RGS19 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RGS19: view

Transcripts for RGS19 Gene

Unigene Clusters for RGS19 Gene

Regulator of G-protein signaling 19:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RGS19 Gene

No ASD Table

Relevant External Links for RGS19 Gene

GeneLoc Exon Structure for
RGS19
ECgene alternative splicing isoforms for
RGS19

Expression for RGS19 Gene

mRNA expression in normal human tissues for RGS19 Gene

mRNA differential expression in normal tissues according to GTEx for RGS19 Gene

This gene is overexpressed in Whole Blood (x24.5) and Spleen (x4.7).

Protein differential expression in normal tissues from HIPED for RGS19 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (41.8) and Monocytes (10.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RGS19 Gene



SOURCE GeneReport for Unigene cluster for RGS19 Gene Hs.422336

mRNA Expression by UniProt/SwissProt for RGS19 Gene

P49795-RGS19_HUMAN
Tissue specificity: Highest expression in lung. Placenta, liver and heart also express high levels of GAIP.
genes like me logo Genes that share expression patterns with RGS19: view

Protein tissue co-expression partners for RGS19 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for RGS19 Gene

Orthologs for RGS19 Gene

This gene was present in the common ancestor of animals.

Orthologs for RGS19 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RGS19 35
  • 88.33 (n)
  • 93.09 (a)
RGS19 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RGS19 35
  • 90.32 (n)
  • 92.63 (a)
RGS19 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rgs19 35
  • 84.27 (n)
  • 91.59 (a)
Rgs19 16
Rgs19 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RGS19 35
  • 99.6 (n)
  • 100 (a)
RGS19 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rgs19 35
  • 84.42 (n)
  • 90.65 (a)
oppossum
(Monodelphis domestica)
Mammalia RGS19 36
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves RGS19 35
  • 79.68 (n)
  • 78.11 (a)
RGS19 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RGS19 36
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rgs19 35
  • 68.54 (n)
  • 67.14 (a)
African clawed frog
(Xenopus laevis)
Amphibia rgs19-prov 35
zebrafish
(Danio rerio)
Actinopterygii rgs19 35
  • 72.97 (n)
  • 67.07 (a)
rgs19 36
  • 61 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta EG:52C10.2 37
  • 71 (a)
CG5036 36
  • 39 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rgs-1 36
  • 35 (a)
ManyToMany
rgs-2 36
  • 48 (a)
ManyToMany
Species with no ortholog for RGS19:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RGS19 Gene

ENSEMBL:
Gene Tree for RGS19 (if available)
TreeFam:
Gene Tree for RGS19 (if available)

Paralogs for RGS19 Gene

Paralogs for RGS19 Gene

(19) SIMAP similar genes for RGS19 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RGS19: view

Variants for RGS19 Gene

Sequence variations from dbSNP and Humsavar for RGS19 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs10039 -- 64,073,301(-) ATGAA(C/T)TTTAA utr-variant-3-prime
rs1128674 -- 64,073,360(-) TTAGG(A/C)CCTCA utr-variant-3-prime
rs1128682 -- 64,073,321(-) AATTT(C/T)TGTTT utr-variant-3-prime
rs4372964 -- 64,076,174(+) CTGCA(C/T)CTGGC intron-variant
rs4372965 -- 64,076,437(+) TGCCT(C/G)GGAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RGS19 Gene

Variant ID Type Subtype PubMed ID
nsv913190 CNV Loss 21882294
nsv428381 CNV Gain+Loss 18775914
nsv913270 CNV Loss 21882294
dgv4654n71 CNV Loss 21882294
nsv509785 CNV Insertion 20534489
dgv1346e1 CNV Complex 17122850
dgv1347e1 CNV Complex 17122850
dgv4658n71 CNV Loss 21882294
dgv4659n71 CNV Loss 21882294
nsv913304 CNV Loss 21882294
nsv470564 CNV Gain 18288195
dgv4661n71 CNV Loss 21882294
dgv4662n71 CNV Loss 21882294
nsv913313 CNV Loss 21882294
nsv913314 CNV Loss 21882294
esv1008416 CNV Insertion 20482838
nsv179409 CNV Insertion 16902084

Variation tolerance for RGS19 Gene

Residual Variation Intolerance Score: 28% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.61; 13.19% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RGS19 Gene

HapMap Linkage Disequilibrium report
RGS19

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RGS19 Gene

Disorders for RGS19 Gene

Relevant External Links for RGS19

Genetic Association Database (GAD)
RGS19
Human Genome Epidemiology (HuGE) Navigator
RGS19
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RGS19

No disorders were found for RGS19 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RGS19 Gene

Publications for RGS19 Gene

  1. GAIP, a protein that specifically interacts with the trimeric G protein G alpha i3, is a member of a protein family with a highly conserved core domain. (PMID: 8524874) de Vries L. … Farquhar M.G. (Proc. Natl. Acad. Sci. U.S.A. 1995) 2 3 4 23 67
  2. GIPC recruits GAIP (RGS19) to attenuate dopamine D2 receptor signaling. (PMID: 15356268) Jeanneteau F. … Sokoloff P. (Mol. Biol. Cell 2004) 3 23
  3. GIPC and GAIP form a complex with TrkA: a putative link between G protein and receptor tyrosine kinase pathways. (PMID: 11251075) Lou X. … Farquhar M.G. (Mol. Biol. Cell 2001) 3 23
  4. Erk1/2-dependent phosphorylation of Galpha-interacting protein stimulates its GTPase accelerating activity and autophagy in human colon cancer cells. (PMID: 10993892) Ogier-Denis E. … Codogno P. (J. Biol. Chem. 2000) 3 23
  5. A core-promoter region functions bi-directionally for human opioid- receptor-like gene ORL1 and its 5'-adjacent gene GAIP. (PMID: 11090272) Ito E. … Palmer P.P. (J. Mol. Biol. 2000) 3 23

Products for RGS19 Gene

Sources for RGS19 Gene

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