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Aliases for UBE4B Gene

Aliases for UBE4B Gene

  • Ubiquitination Factor E4B 2 3 5
  • Ubiquitination Factor E4B (Homologous To Yeast UFD2) 2 3
  • Ubiquitination Factor E4B (UFD2 Homolog, Yeast) 2 3
  • Homozygously Deleted In Neuroblastoma 1 3 4
  • Ubiquitin Fusion Degradation Protein 2 3 4
  • HDNB1 3 4
  • UFD2 3 4
  • Homozygously Deleted In Neuroblastoma-1 3
  • Ubiquitin-Fusion Degradation Protein 2 3
  • UFD2A-III/UBE4B-III Splice Isoform 3
  • Homologous To Yeast UFD2 3
  • EC 6.3.2.- 4
  • KIAA0684 4
  • UBOX3 3
  • UFD2A 3
  • E4 3

External Ids for UBE4B Gene

Previous GeneCards Identifiers for UBE4B Gene

  • GC01P010054
  • GC01P009937
  • GC01P009702
  • GC01P009803
  • GC01P009802
  • GC01P010027
  • GC01P010092
  • GC01P009247

Summaries for UBE4B Gene

Entrez Gene Summary for UBE4B Gene

  • The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes an additional conjugation factor, E4, which is involved in multiubiquitin chain assembly. This gene is also the strongest candidate in the neuroblastoma tumor suppressor genes. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for UBE4B Gene

UBE4B (Ubiquitination Factor E4B) is a Protein Coding gene. Diseases associated with UBE4B include neuroblastoma and wallerian degeneration. Among its related pathways are Antigen processing- Ubiquitination and Proteasome degradation and Protein processing in endoplasmic reticulum. GO annotations related to this gene include enzyme binding and ubiquitin-protein transferase activity. An important paralog of this gene is UBE4A.

UniProtKB/Swiss-Prot for UBE4B Gene

  • Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase.

Gene Wiki entry for UBE4B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBE4B Gene

Genomics for UBE4B Gene

Regulatory Elements for UBE4B Gene

Promoters for UBE4B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around UBE4B on UCSC Golden Path with GeneCards custom track

Genomic Location for UBE4B Gene

Chromosome:
1
Start:
10,032,832 bp from pter
End:
10,181,239 bp from pter
Size:
148,408 bases
Orientation:
Plus strand

Genomic View for UBE4B Gene

Genes around UBE4B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBE4B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBE4B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBE4B Gene

Proteins for UBE4B Gene

  • Protein details for UBE4B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95155-UBE4B_HUMAN
    Recommended name:
    Ubiquitin conjugation factor E4 B
    Protein Accession:
    O95155
    Secondary Accessions:
    • A8K8S9
    • G0ZJH6
    • O75169
    • O95338
    • Q5SZ12
    • Q5SZ16
    • Q96QD4
    • Q9BYI7

    Protein attributes for UBE4B Gene

    Size:
    1302 amino acids
    Molecular mass:
    146185 Da
    Quaternary structure:
    • Interacts with VCP.
    SequenceCaution:
    • Sequence=BAA31659.3; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for UBE4B Gene

    Alternative splice isoforms for UBE4B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UBE4B Gene

Proteomics data for UBE4B Gene at MOPED

Post-translational modifications for UBE4B Gene

  • Proteolytically cleaved by caspases during apoptosis. Cleaved efficiently at Asp-123 by caspase-6 and granzyme B. Cleaved with approximately 10-fold less efficiency at Asp-109 by caspase-3 and caspase-7.
  • Ubiquitination at Lys 610, Lys 801, Lys 951, Lys 964, Lys 989, Lys 1106, and Lys 1189
  • Modification sites at PhosphoSitePlus

Other Protein References for UBE4B Gene

Antibody Products

No data available for DME Specific Peptides for UBE4B Gene

Domains & Families for UBE4B Gene

Gene Families for UBE4B Gene

Protein Domains for UBE4B Gene

Suggested Antigen Peptide Sequences for UBE4B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95155

UniProtKB/Swiss-Prot:

UBE4B_HUMAN :
  • The U-box domain is required for the ubiquitin protein ligase activity.
  • Belongs to the ubiquitin conjugation factor E4 family.
Domain:
  • The U-box domain is required for the ubiquitin protein ligase activity.
  • Contains 1 U-box domain.
Family:
  • Belongs to the ubiquitin conjugation factor E4 family.
genes like me logo Genes that share domains with UBE4B: view

Function for UBE4B Gene

Molecular function for UBE4B Gene

GENATLAS Biochemistry:
ubiquitination factor E4B (homologous to yeast UFD2),cDNA sequence,expressed in brain,required in 4A,related to Drosophila NOSA
UniProtKB/Swiss-Prot Function:
Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase.

Enzyme Numbers (IUBMB) for UBE4B Gene

Gene Ontology (GO) - Molecular Function for UBE4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
GO:0016874 ligase activity IEA --
GO:0051117 ATPase binding IEA --
genes like me logo Genes that share ontologies with UBE4B: view
genes like me logo Genes that share phenotypes with UBE4B: view

Animal Models for UBE4B Gene

MGI Knock Outs for UBE4B:

Animal Model Products

CRISPR Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for UBE4B Gene

Localization for UBE4B Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBE4B Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UBE4B Gene COMPARTMENTS Subcellular localization image for UBE4B gene
Compartment Confidence
nucleus 4
cytosol 2
cytoskeleton 1
endoplasmic reticulum 1

No data available for Gene Ontology (GO) - Cellular Components for UBE4B Gene

Pathways & Interactions for UBE4B Gene

genes like me logo Genes that share pathways with UBE4B: view

Pathways by source for UBE4B Gene

UniProtKB/Swiss-Prot O95155-UBE4B_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for UBE4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003222 ventricular trabecula myocardium morphogenesis IEA --
GO:0006511 ubiquitin-dependent protein catabolic process IEA --
GO:0008626 granzyme-mediated apoptotic signaling pathway IDA 11802788
GO:0016567 protein ubiquitination IEA --
GO:0034976 response to endoplasmic reticulum stress IEA --
genes like me logo Genes that share ontologies with UBE4B: view

No data available for SIGNOR curated interactions for UBE4B Gene

Drugs & Compounds for UBE4B Gene

(3) Drugs for UBE4B Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0
Diphosphate Experimental Pharma 0

(1) Additional Compounds for UBE4B Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
genes like me logo Genes that share compounds with UBE4B: view

Transcripts for UBE4B Gene

Unigene Clusters for UBE4B Gene

Ubiquitination factor E4B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UBE4B Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19a · 19b ^ 20a ·
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8: -
SP9:
SP10:
SP11:
SP12: -

ExUns: 20b ^ 21 ^ 22a · 22b · 22c ^ 23 ^ 24a · 24b ^ 25a · 25b ^ 26 ^ 27a · 27b
SP1:
SP2:
SP3: -
SP4:
SP5:
SP6: -
SP7: -
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for UBE4B Gene

GeneLoc Exon Structure for
UBE4B
ECgene alternative splicing isoforms for
UBE4B

Expression for UBE4B Gene

mRNA expression in normal human tissues for UBE4B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for UBE4B Gene

This gene is overexpressed in Lymph node (7.7) and Peripheral blood mononuclear cells (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for UBE4B Gene



SOURCE GeneReport for Unigene cluster for UBE4B Gene Hs.593974

mRNA Expression by UniProt/SwissProt for UBE4B Gene

O95155-UBE4B_HUMAN
Tissue specificity: Highest expression in ovary, testis, heart and skeletal muscle. Expression is low in colon, thymus and peripheral blood leukocytes. Almost undetectable in lung and spleen.
genes like me logo Genes that share expression patterns with UBE4B: view

Protein tissue co-expression partners for UBE4B Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for UBE4B Gene

Orthologs for UBE4B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UBE4B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia UBE4B 35
  • 90.52 (n)
  • 96.31 (a)
UBE4B 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UBE4B 35
  • 91.6 (n)
  • 96.7 (a)
UBE4B 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ube4b 35
  • 89.64 (n)
  • 97.52 (a)
Ube4b 16
Ube4b 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia UBE4B 35
  • 99.74 (n)
  • 99.77 (a)
UBE4B 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ube4b 35
  • 89.56 (n)
  • 97.43 (a)
oppossum
(Monodelphis domestica)
Mammalia UBE4B 36
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 83 (a)
OneToMany
-- 36
  • 94 (a)
OneToMany
-- 36
  • 97 (a)
OneToMany
-- 36
  • 90 (a)
OneToMany
chicken
(Gallus gallus)
Aves UBE4B 35
  • 79.82 (n)
  • 88.85 (a)
UBE4B 36
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UBE4B 36
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.16539 35
ube4b 35
  • 76.2 (n)
  • 86.34 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.3889 35
zebrafish
(Danio rerio)
Actinopterygii ube4b 35
  • 73.66 (n)
  • 81.25 (a)
ube4b 36
  • 72 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG9934 37
  • 41 (a)
CG9934 35
  • 50.49 (n)
  • 42.94 (a)
CG9934 36
  • 32 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007870 35
  • 51.31 (n)
  • 44.3 (a)
worm
(Caenorhabditis elegans)
Secernentea T05H10.5a 37
  • 29 (a)
T05H10.5b 37
  • 29 (a)
ufd-2 35
  • 44.84 (n)
  • 32.91 (a)
ufd-2 36
  • 28 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR096C 35
  • 44.02 (n)
  • 31.78 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F05269g 35
  • 43.41 (n)
  • 30.58 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UFD2 35
  • 45.03 (n)
  • 33.28 (a)
UFD2 36
  • 25 (a)
OneToMany
UFD2 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G15400 35
  • 44.9 (n)
  • 33.94 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5759 35
bread mold
(Neurospora crassa)
Ascomycetes NCU03357 35
  • 44.08 (n)
  • 33.46 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ufd2 35
  • 43.71 (n)
  • 33.96 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 54 (a)
OneToMany
CSA.4101 36
  • 62 (a)
OneToMany
Species with no ortholog for UBE4B:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UBE4B Gene

ENSEMBL:
Gene Tree for UBE4B (if available)
TreeFam:
Gene Tree for UBE4B (if available)

Paralogs for UBE4B Gene

Paralogs for UBE4B Gene

genes like me logo Genes that share paralogs with UBE4B: view

Variants for UBE4B Gene

Sequence variations from dbSNP and Humsavar for UBE4B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs17034499 - 10,130,715(+) TCCAG(A/G)TTAAA nc-transcript-variant, reference, missense
rs15191 -- 10,179,520(+) CGGAC(A/C)CCTTC nc-transcript-variant, reference, missense
rs1074461 -- 10,143,387(-) GCCTC(A/G)CTCTA intron-variant
rs1046277 -- 10,180,036(+) GCTGC(C/T)GTTCA nc-transcript-variant, utr-variant-3-prime
rs1801442 -- 10,171,204(+) AGTGC(C/G/T)GTGAC nc-transcript-variant, downstream-variant-500B, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for UBE4B Gene

Variant ID Type Subtype PubMed ID
nsv527217 CNV Gain 19592680
dgv12e199 CNV Deletion 23128226
nsv522629 CNV Gain 19592680
esv2668231 CNV Deletion 23128226
nsv525216 CNV Gain 19592680
esv2562286 CNV Deletion 19546169
dgv17e1 CNV Complex 17122850

Variation tolerance for UBE4B Gene

Residual Variation Intolerance Score: 7.01% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.48; 71.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UBE4B Gene

HapMap Linkage Disequilibrium report
UBE4B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBE4B Gene

Disorders for UBE4B Gene

MalaCards: The human disease database

(2) MalaCards diseases for UBE4B Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
neuroblastoma
  • neuroblastoma 1
wallerian degeneration
  • wallerian degeneration of the pyramidal tract
- elite association - COSMIC cancer census association via MalaCards
Search UBE4B in MalaCards View complete list of genes associated with diseases

Relevant External Links for UBE4B

Genetic Association Database (GAD)
UBE4B
Human Genome Epidemiology (HuGE) Navigator
UBE4B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UBE4B
genes like me logo Genes that share disorders with UBE4B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for UBE4B Gene

Publications for UBE4B Gene

  1. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9734811) Ishikawa K. … Ohara O. (DNA Res. 1998) 2 3 4 67
  2. Molecular clearance of ataxin-3 is regulated by a mammalian E4. (PMID: 14749733) Matsumoto M. … Nakayama K.I. (EMBO J. 2004) 3 23
  3. The human homologue of the yeast polyubiquitination factor Ufd2p is cleaved by caspase 6 and granzyme B during apoptosis. (PMID: 11802788) Mahoney J.A. … Rosen A. (Biochem. J. 2002) 3 23
  4. A novel ubiquitination factor, E4, is involved in multiubiquitin chain assembly. (PMID: 10089879) Koegl M. … Jentsch S. (Cell 1999) 2 3
  5. Substrate trapping proteomics reveals targets of the I^TrCP2/FBXW11 ubiquitin ligase. (PMID: 25332235) Kim T.Y. … Major M.B. (Mol. Cell. Biol. 2015) 3

Products for UBE4B Gene

Sources for UBE4B Gene

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