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Aliases for CDKN1A Gene

Aliases for CDKN1A Gene

  • Cyclin-Dependent Kinase Inhibitor 1A 2 3
  • Cyclin-Dependent Kinase Inhibitor 1A (P21, Cip1) 2 3 5
  • CDK-Interacting Protein 1 3 4
  • CDKN1 3 4
  • CAP20 3 4
  • MDA-6 3 4
  • CIP1 3 4
  • SDI1 3 4
  • WAF1 3 4
  • P21 3 4
  • Melanoma Differentiation Associated Protein 6 3
  • Melanoma Differentiation-Associated Protein 6 4
  • Wild-Type P53-Activated Fragment 1 3
  • CDK-Interaction Protein 1 3
  • DNA Synthesis Inhibitor 3
  • P21CIP1 3
  • MDA6 4
  • PIC1 4

External Ids for CDKN1A Gene

Previous HGNC Symbols for CDKN1A Gene

  • CDKN1

Previous GeneCards Identifiers for CDKN1A Gene

  • GC06P036648
  • GC06P036693
  • GC06P036754
  • GC06P036645
  • GC06P036364
  • GC06P036649
  • GC06P036761
  • GC06P037308
  • GC06P036956
  • GC06P036998

Summaries for CDKN1A Gene

Entrez Gene Summary for CDKN1A Gene

  • This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-cyclin-dependent kinase2 or -cyclin-dependent kinase4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen, a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of cyclin-dependent kinase2, and may be instrumental in the execution of apoptosis following caspase activation. Mice that lack this gene have the ability to regenerate damaged or missing tissue. Multiple alternatively spliced variants have been found for this gene. [provided by RefSeq, Sep 2015]

GeneCards Summary for CDKN1A Gene

CDKN1A (Cyclin-Dependent Kinase Inhibitor 1A) is a Protein Coding gene. Diseases associated with CDKN1A include hypervitaminosis a and cervical cancer, somatic. Among its related pathways are Gene Expression and Signaling by GPCR. GO annotations related to this gene include ubiquitin protein ligase binding and cyclin binding. An important paralog of this gene is CDKN1B.

UniProtKB/Swiss-Prot for CDKN1A Gene

  • May be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex.

Gene Wiki entry for CDKN1A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDKN1A Gene

Genomics for CDKN1A Gene

Regulatory Elements for CDKN1A Gene

Promoters for CDKN1A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CDKN1A on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the CDKN1A gene promoter:

Genomic Location for CDKN1A Gene

Chromosome:
6
Start:
36,676,460 bp from pter
End:
36,687,339 bp from pter
Size:
10,880 bases
Orientation:
Plus strand

Genomic View for CDKN1A Gene

Genes around CDKN1A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDKN1A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDKN1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDKN1A Gene

Proteins for CDKN1A Gene

  • Protein details for CDKN1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P38936-CDN1A_HUMAN
    Recommended name:
    Cyclin-dependent kinase inhibitor 1
    Protein Accession:
    P38936
    Secondary Accessions:
    • Q14010
    • Q6FI05
    • Q9BUT4

    Protein attributes for CDKN1A Gene

    Size:
    164 amino acids
    Molecular mass:
    18119 Da
    Quaternary structure:
    • Interacts with HDAC1; the interaction is prevented by competitive binding of C10orf90/FATS to HDAC1 facilitating acetylation and protein stabilization of CDKN1A/p21 (By similarity). Interacts with MKRN1. Interacts with PSMA3. Interacts with PCNA. Component of the ternary complex, cyclin D-CDK4-CDKN1A. Interacts (via its N-terminal domain) with CDK4; the interaction promotes the assembly of the cyclin D-CDK4 complex, its nuclear translocation and promotes the cyclin D-dependent enzyme activity of CDK4. Binding to CDK2 leads to CDK2/cyclin E inactivation at the G1-S phase DNA damage checkpoint, thereby arresting cells at the G1-S transition during DNA repair. Interacts with PIM1. Interacts with STK11 and NUAK1.
    SequenceCaution:
    • Sequence=AAB59559.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAB59560.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CDKN1A Gene

neXtProt entry for CDKN1A Gene

Proteomics data for CDKN1A Gene at MOPED

Post-translational modifications for CDKN1A Gene

  • Acetylation leads to protein stability. Acetylated in vitro on Lys-141, Lys-154, Lys-161 and Lys-163. Deacetylation by HDAC1 is prevented by competitive binding of C10orf90/FATS to HDAC1 (By similarity).
  • Phosphorylation of Thr-145 by Akt or of Ser-146 by PKC impairs binding to PCNA. Phosphorylation at Ser-114 by GSK3-beta enhances ubiquitination by the DCX(DTL) complex. Phosphorylation of Thr-145 by PIM2 enhances CDKN1A stability and inhibits cell proliferation. Phosphorylation of Thr-145 by PIM1 results in the relocation of CDKN1A to the cytoplasm and enhanced CDKN1A protein stability. UV radiation-induced phosphorylation at Thr-80 by LKB1 and at Ser-146 by NUAK1 leads to its degradation.
  • Ubiquitinated by MKRN1; leading to polyubiquitination and 26S proteasome-dependent degradation. Ubiquitinated by the DCX(DTL) complex, also named CRL4(CDT2) complex, leading to its degradation during S phase or following UV irradiation. Ubiquitination by the DCX(DTL) complex is essential to control replication licensing and is PCNA-dependent: interacts with PCNA via its PIP-box, while the presence of the containing the K+4 motif in the PIP box, recruit the DCX(DTL) complex, leading to its degradation. Ubiquitination at Ser-2 leads to degradation by the proteasome pathway. Ubiquitinated by RNF114; leading to proteasomal degradation.
  • Ubiquitination at Lys 75
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for CDKN1A (p21/CIP1/CDKN1A)
  • Cell Signaling Technology (CST) Antibodies for CDKN1A (p21Cip1)
  • Cloud-Clone Corp. Antibodies for CDKN1A

No data available for DME Specific Peptides for CDKN1A Gene

Domains & Families for CDKN1A Gene

Protein Domains for CDKN1A Gene

Suggested Antigen Peptide Sequences for CDKN1A Gene

Graphical View of Domain Structure for InterPro Entry

P38936

UniProtKB/Swiss-Prot:

CDN1A_HUMAN :
  • The PIP-box K+4 motif mediates both the interaction with PCNA and the recuitment of the DCX(DTL) complex: while the PIP-box interacts with PCNA, the presence of the K+4 submotif, recruits the DCX(DTL) complex, leading to its ubiquitination.
  • Belongs to the CDI family.
Domain:
  • The PIP-box K+4 motif mediates both the interaction with PCNA and the recuitment of the DCX(DTL) complex: while the PIP-box interacts with PCNA, the presence of the K+4 submotif, recruits the DCX(DTL) complex, leading to its ubiquitination.
  • The C-terminal is required for nuclear localization of the cyclin D-CDK4 complex.
Family:
  • Belongs to the CDI family.
genes like me logo Genes that share domains with CDKN1A: view

No data available for Gene Families for CDKN1A Gene

Function for CDKN1A Gene

Molecular function for CDKN1A Gene

GENATLAS Biochemistry:
wild type p53-activated fragment 1,p21,regulator of cell cycle,cyclin dependent kinases 2 and 4 (CDK2/CDK4) inhibitor protein,involved in cell cycle exit in megacaryocyte,inhibiting cycle progression by interacting with G1 cyclin/CDK complexes and PCNA,this inhibitory activity antagonizing apoptosis being located in cell nucleus while,apoptosis activity located in cytoplasm,cleaved by caspase 3 in the earlier stage of apoptosis,mutated in breast carcinoma,deleted in some papillary thyroid carcinoma,hybridizing with WI-7311,WI-10190,inhibited by AMPHL in early stage of muscle differentiation program,controlling differentiation of skeletal muscle and alveoli in the lung in parallel with P21 and myogenin,also functioning as a suppressor of malignant skin tumor formation and as a determinant of keratinocyte stem-cell potential
UniProtKB/Swiss-Prot Function:
May be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex.
UniProtKB/Swiss-Prot Induction:
Activated by p53/TP53, mezerein (antileukemic compound) and IFNB1. Repressed by HDAC1.

Gene Ontology (GO) - Molecular Function for CDKN1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with CDKN1A: view
genes like me logo Genes that share phenotypes with CDKN1A: view

Human Phenotype Ontology for CDKN1A Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for CDKN1A Gene

MGI Knock Outs for CDKN1A:

Animal Model Products

miRNA for CDKN1A Gene

miRTarBase miRNAs that target CDKN1A

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CDKN1A Gene

Localization for CDKN1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDKN1A Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDKN1A Gene COMPARTMENTS Subcellular localization image for CDKN1A gene
Compartment Confidence
cytosol 5
nucleus 5
cytoskeleton 2
extracellular 2
mitochondrion 2
plasma membrane 2
endoplasmic reticulum 1

No data available for Gene Ontology (GO) - Cellular Components for CDKN1A Gene

Pathways & Interactions for CDKN1A Gene

SuperPathways for CDKN1A Gene

Superpath Contained pathways
1 Interleukin-3, 5 and GM-CSF signaling
2 CDK-mediated phosphorylation and removal of Cdc6
.78
3 PI3K events in ERBB4 signaling
4 Glioma
.51
.43
5 Cyclins and Cell Cycle Regulation
.32
genes like me logo Genes that share pathways with CDKN1A: view

SIGNOR curated interactions for CDKN1A Gene

Gene Ontology (GO) - Biological Process for CDKN1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity TAS 8242751
GO:0000082 G1/S transition of mitotic cell cycle TAS --
GO:0000086 G2/M transition of mitotic cell cycle IMP 17553787
GO:0000278 mitotic cell cycle TAS --
GO:0006974 cellular response to DNA damage stimulus IMP 20160708
genes like me logo Genes that share ontologies with CDKN1A: view

Drugs & Compounds for CDKN1A Gene

(63) Drugs for CDKN1A Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(84) Additional Compounds for CDKN1A Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CDKN1A: view

Transcripts for CDKN1A Gene

Unigene Clusters for CDKN1A Gene

Cyclin-dependent kinase inhibitor 1A (p21, Cip1):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CDKN1A Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d · 4e · 4f ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c · 10d
SP1: - - - - - - - - -
SP2: - - - - - -
SP3: - - - - -
SP4: - - -
SP5: - -
SP6: - - - - - - - - - - -
SP7: - - - -
SP8: -
SP9:

Relevant External Links for CDKN1A Gene

GeneLoc Exon Structure for
CDKN1A
ECgene alternative splicing isoforms for
CDKN1A

Expression for CDKN1A Gene

mRNA expression in normal human tissues for CDKN1A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CDKN1A Gene

This gene is overexpressed in Bone (60.7) and Platelet (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CDKN1A Gene



SOURCE GeneReport for Unigene cluster for CDKN1A Gene Hs.370771

mRNA Expression by UniProt/SwissProt for CDKN1A Gene

P38936-CDN1A_HUMAN
Tissue specificity: Expressed in all adult tissues, with 5-fold lower levels observed in the brain.
genes like me logo Genes that share expression patterns with CDKN1A: view

Protein tissue co-expression partners for CDKN1A Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for CDKN1A Gene

Orthologs for CDKN1A Gene

This gene was present in the common ancestor of chordates.

Orthologs for CDKN1A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDKN1A 36
  • 83 (a)
OneToOne
CDKN1A 35
  • 99.8 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia CDKN1A 35
  • 82.4 (n)
  • 81.99 (a)
CDKN1A 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CDKN1A 36
  • 83 (a)
OneToOne
CDKN1A 35
  • 83.33 (n)
  • 82.93 (a)
mouse
(Mus musculus)
Mammalia Cdkn1a 16
Cdkn1a 36
  • 77 (a)
OneToOne
Cdkn1a 35
  • 76.52 (n)
  • 79.25 (a)
oppossum
(Monodelphis domestica)
Mammalia CDKN1A 36
  • 66 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdkn1a 35
  • 76.54 (n)
  • 76.54 (a)
chicken
(Gallus gallus)
Aves CIP1 36
  • 39 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDKN1A 36
  • 40 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii cdkn1a 36
  • 30 (a)
OneToOne
Species with no ortholog for CDKN1A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CDKN1A Gene

ENSEMBL:
Gene Tree for CDKN1A (if available)
TreeFam:
Gene Tree for CDKN1A (if available)

Paralogs for CDKN1A Gene

Paralogs for CDKN1A Gene

(3) SIMAP similar genes for CDKN1A Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CDKN1A: view

Variants for CDKN1A Gene

Sequence variations from dbSNP and Humsavar for CDKN1A Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1801270 - 36,684,194(+) CTGAG(A/C/T)CGCGA reference, missense
VAR_014875 -
rs4986866 - 36,684,112(+) AGAAC(A/C/T)GGCTG reference, missense
rs4986867 - 36,684,290(+) GACTT(A/C/T)GCCTG reference, missense
rs1136646 -- 36,687,282(+) ctccc(A/C)caatg utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CDKN1A Gene

Variant ID Type Subtype PubMed ID
nsv885807 CNV Loss 21882294

Variation tolerance for CDKN1A Gene

Residual Variation Intolerance Score: 73.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.84; 73.94% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDKN1A Gene

HapMap Linkage Disequilibrium report
CDKN1A
Human Gene Mutation Database (HGMD)
CDKN1A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDKN1A Gene

Disorders for CDKN1A Gene

MalaCards: The human disease database

(54) MalaCards diseases for CDKN1A Gene - From: Orphanet, DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CDKN1A

Genetic Association Database (GAD)
CDKN1A
Human Genome Epidemiology (HuGE) Navigator
CDKN1A
Tumor Gene Database (TGDB):
CDKN1A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CDKN1A
genes like me logo Genes that share disorders with CDKN1A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CDKN1A Gene

Publications for CDKN1A Gene

  1. The melanoma differentiation-associated gene mda-6, which encodes the cyclin-dependent kinase inhibitor p21, is differentially expressed during growth, differentiation and progression in human melanoma cells. (PMID: 7753561) Jiang H. … Fisher P.B. (Oncogene 1995) 3 4 23 67
  2. Feedback between p21 and reactive oxygen production is necessary for cell senescence. (PMID: 20160708) Passos J.F. … von Zglinicki T. (Mol. Syst. Biol. 2010) 3 23
  3. The SANT domain of p400 ATPase represses acetyltransferase activity and coactivator function of TIP60 in basal p21 gene expression. (PMID: 20351180) Park J.H. … Roeder R.G. (Mol. Cell. Biol. 2010) 3 23
  4. ID1 enhances docetaxel cytotoxicity in prostate cancer cells through inhibition of p21. (PMID: 20388787) Geng H. … Qian D.Z. (Cancer Res. 2010) 3 23
  5. Opposing actions of the progesterone metabolites, 5alpha-dihydroprogesterone (5alphaP) and 3alpha-dihydroprogesterone (3alphaHP) on mitosis, apoptosis, and expression of Bcl-2, Bax and p21 in human breast cell lines. (PMID: 19931389) Wiebe J.P. … Cialacu V. (J. Steroid Biochem. Mol. Biol. 2010) 3 23

Products for CDKN1A Gene

Sources for CDKN1A Gene

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