Aliases for ABCC4 Gene
External Ids for ABCC4 Gene
Previous GeneCards Identifiers for ABCC4 Gene
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This family member plays a role in cellular detoxification as a pump for its substrate, organic anions. It may also function in prostaglandin-mediated cAMP signaling in ciliogenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2014]
GeneCards Summary for ABCC4 Gene
ABCC4 (ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 4) is a Protein Coding gene. Diseases associated with ABCC4 include lung cancer. Among its related pathways are Hemostasis and Hemostasis. GO annotations related to this gene include ATPase activity, coupled to transmembrane movement of substances and 15-hydroxyprostaglandin dehydrogenase (NAD+) activity. An important paralog of this gene is ABCC5.
UniProtKB/Swiss-Prot for ABCC4 Gene
May be an organic anion pump relevant to cellular detoxification