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Aliases for ABCC4 Gene

Aliases for ABCC4 Gene

  • ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 4 2 3
  • MRP4 3 4 6
  • Canalicular Multispecific Organic Anion Transporter (ABC Superfamily) 2 3
  • Multi-Specific Organic Anion Transporter B 3 4
  • Multidrug Resistance-Associated Protein 4 2 3
  • MRP/CMOAT-Related ABC Transporter 3 4
  • MOAT-B 3 4
  • MOATB 3 6
  • BA464I2.1 (ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 4) 3
  • ATP-Binding Cassette Sub-Family C Member 4 4
  • Multispecific Organic Anion Transporter B 2
  • BA464I2.1 (ATP-Binding Cassette 2
  • Sub-Family C (CFTR/MRP) 2
  • Member 4) 2

External Ids for ABCC4 Gene

Summaries for ABCC4 Gene

Entrez Gene Summary for ABCC4 Gene

  • The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This family member plays a role in cellular detoxification as a pump for its substrate, organic anions. It may also function in prostaglandin-mediated cAMP signaling in ciliogenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2014]

GeneCards Summary for ABCC4 Gene

ABCC4 (ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 4) is a Protein Coding gene. Diseases associated with ABCC4 include lung cancer. Among its related pathways are Hemostasis and Hemostasis. GO annotations related to this gene include ATPase activity, coupled to transmembrane movement of substances and 15-hydroxyprostaglandin dehydrogenase (NAD+) activity. An important paralog of this gene is ABCC5.

UniProtKB/Swiss-Prot for ABCC4 Gene

  • May be an organic anion pump relevant to cellular detoxification

Gene Wiki entry for ABCC4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ABCC4 Gene

Genomics for ABCC4 Gene

Genomic Location for ABCC4 Gene

Start:
95,019,829 bp from pter
End:
95,301,441 bp from pter
Size:
281,613 bases
Orientation:
Minus strand

Genomic View for ABCC4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ABCC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ABCC4 Gene

Regulatory Elements for ABCC4 Gene

Proteins for ABCC4 Gene

  • Protein details for ABCC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15439-MRP4_HUMAN
    Recommended name:
    Multidrug resistance-associated protein 4
    Protein Accession:
    O15439
    Secondary Accessions:
    • A9Z1Z7
    • B7Z3Q7
    • Q8IVZ4
    • Q8IZN6
    • Q8NEW8
    • Q9Y6J2

    Protein attributes for ABCC4 Gene

    Size:
    1325 amino acids
    Molecular mass:
    149527 Da
    Quaternary structure:
    • Interacts (via PDZ-binding motif) with SNX27 (via PDZ domain).

    Alternative splice isoforms for ABCC4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ABCC4 Gene

Proteomics data for ABCC4 Gene at MOPED

Post-translational modifications for ABCC4 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys702, Lys1265, Lys1271, and Lys1289
  • Glycosylation at Asn651, Asn690, Asn746, Asn754, Asn792, Asn1176, and Asn1309

Other Protein References for ABCC4 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ABCC4 Gene

Domains for ABCC4 Gene

Gene Families for ABCC4 Gene

HGNC:
  • ABCC :ATP binding cassette transporters / subfamily C
IUPHAR :

Protein Domains for ABCC4 Gene

UniProtKB/Swiss-Prot:

MRP4_HUMAN
Domain:
  • Contains 2 ABC transmembrane type-1 domains.:
    • O15439
  • Contains 2 ABC transporter domains.:
    • O15439
Family:
  • Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.:
    • O15439
genes like me logo Genes that share domains with ABCC4: view

Function for ABCC4 Gene

Molecular function for ABCC4 Gene

GENATLAS Biochemistry: ATP binding cassette superfamily,subfamily C (CFTR/MRP),member 4
UniProtKB/Swiss-Prot Function: May be an organic anion pump relevant to cellular detoxification

Gene Ontology (GO) - Molecular Function for ABCC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
GO:0016404 15-hydroxyprostaglandin dehydrogenase (NAD+) activity NAS 7557451
GO:0016887 ATPase activity --
GO:0042626 ATPase activity, coupled to transmembrane movement of substances IEA --
genes like me logo Genes that share ontologies with ABCC4: view
genes like me logo Genes that share phenotypes with ABCC4: view

Animal Models for ABCC4 Gene

MGI Knock Outs for ABCC4:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for ABCC4 Gene

Localization for ABCC4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ABCC4 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ABCC4 Gene COMPARTMENTS Subcellular localization image for ABCC4 gene
Compartment Confidence
plasma membrane 5
cytosol 1
endoplasmic reticulum 1
extracellular 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ABCC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IDA 15297306
GO:0016021 integral component of membrane IEA --
GO:0016323 basolateral plasma membrane IDA 24130369
GO:0031088 platelet dense granule membrane TAS --
genes like me logo Genes that share ontologies with ABCC4: view

Pathways for ABCC4 Gene

genes like me logo Genes that share pathways with ABCC4: view

Gene Ontology (GO) - Biological Process for ABCC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002576 platelet degranulation TAS --
GO:0006200 obsolete ATP catabolic process --
GO:0006810 transport --
GO:0007596 blood coagulation TAS --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with ABCC4: view

Compounds for ABCC4 Gene

(39) Drugbank Compounds for ABCC4 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Adefovir Dipivoxil
  • Adefovir
142340-99-6 transporter substrate
Alprostadil
745-65-3 transporter substrate
Atorvastatin
134523-00-5 transporter substrate
Cefazolin
  • Cefazolin sodium
25953-19-9 transporter substrate
Celecoxib
169590-42-5 transporter inhibitor

(48) Novoseek inferred chemical compound relationships for ABCC4 Gene

Compound -log(P) Hits PubMed IDs
mk 571 85.1 2
adefovir 83 21
probenecid 75.9 3
sulfinpyrazone 74.3 1
nucleoside monophosphate 69.1 3

(9) PharmGKB related drug/compound annotations for ABCC4 Gene

genes like me logo Genes that share compounds with ABCC4: view

Transcripts for ABCC4 Gene

Unigene Clusters for ABCC4 Gene

ATP-binding cassette, sub-family C (CFTR/MRP), member 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ABCC4 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25a ·
SP1: - - - -
SP2: - - - - -
SP3: - -
SP4:
SP5: -
SP6: -
SP7:
SP8:
SP9:

ExUns: 25b ^ 26a · 26b ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35a · 35b
SP1: -
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7: - - -
SP8:
SP9:

Relevant External Links for ABCC4 Gene

GeneLoc Exon Structure for
ABCC4
ECgene alternative splicing isoforms for
ABCC4

Expression for ABCC4 Gene

mRNA expression in normal human tissues for ABCC4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ABCC4 Gene

This gene is overexpressed in Bladder (5.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ABCC4 Gene

SOURCE GeneReport for Unigene cluster for ABCC4 Gene Hs.508423

mRNA Expression by UniProt/SwissProt for ABCC4 Gene

O15439-MRP4_HUMAN
Tissue specificity: Widely expressed, with particularly high levels in prostate, but is barely detectable in liver
genes like me logo Genes that share expressions with ABCC4: view

Orthologs for ABCC4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ABCC4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ABCC4 36
  • 99.4 (n)
  • 99.62 (a)
ABCC4 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ABCC4 37
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ABCC4 36
  • 86.94 (n)
  • 89.43 (a)
ABCC4 37
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Abcc4 36
  • 81.61 (n)
  • 87.09 (a)
Abcc4 16
Abcc4 37
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ABCC4 37
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ABCC4 37
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Abcc4 36
  • 81.74 (n)
  • 86.87 (a)
chicken
(Gallus gallus)
Aves ABCC4 36
  • 74.9 (n)
  • 78.4 (a)
ABCC4 37
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 32 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia abcc4 36
  • 70.63 (n)
  • 73.54 (a)
zebrafish
(Danio rerio)
Actinopterygii abcc4 36
  • 65.9 (n)
  • 70.25 (a)
abcc4 37
  • 69 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006427 36
  • 51.2 (n)
  • 48.72 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG31792 37
  • 41 (a)
OneToMany
CG4562 36
  • 51.88 (n)
  • 47.87 (a)
CG7627 37
  • 42 (a)
OneToMany
Mrp4 37
  • 42 (a)
OneToMany
Sur 38
  • 43 (a)
CG9270 38
  • 46 (a)
CG10505 38
  • 39 (a)
CG7806 38
  • 31 (a)
CG5789 38
  • 42 (a)
CG4562 38
  • 43 (a)
CG11898 38
  • 35 (a)
CG7627 38
  • 44 (a)
BEST:CK01227 38
  • 42 (a)
CG11897 38
  • 39 (a)
worm
(Caenorhabditis elegans)
Secernentea mrp-2 37
  • 30 (a)
OneToMany
mrp-4 37
  • 30 (a)
OneToMany
mrp-6 36
  • 49.22 (n)
  • 39.98 (a)
mrp-7 37
  • 29 (a)
OneToMany
mrp-6 38
  • 35 (a)
C18C4.2 38
  • 24 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 39
YCF1 37
  • 32 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons MRP3 36
  • 45.62 (n)
  • 35.33 (a)
rice
(Oryza sativa)
Liliopsida Os.33212 36
Os01g0173900 36
  • 44.54 (n)
  • 34.92 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 32 (a)
ManyToMany
Species with no ortholog for ABCC4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ABCC4 Gene

ENSEMBL:
Gene Tree for ABCC4 (if available)
TreeFam:
Gene Tree for ABCC4 (if available)

Paralogs for ABCC4 Gene

Paralogs for ABCC4 Gene

genes like me logo Genes that share paralogs with ABCC4: view

Variants for ABCC4 Gene

Sequence variations from dbSNP and Humsavar for ABCC4 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs3770 -- 95,019,983(+) CTATC(A/G)TTTTA utr-variant-3-prime
rs870004 -- 95,265,809(+) CTTCC(A/G)TACAG intron-variant
rs871051 -- 95,297,956(+) aTGAT(G/T)ATTAT intron-variant
rs871052 -- 95,298,486(-) ccact(C/T)tggac intron-variant
rs871175 -- 95,266,711(-) CCCCA(C/T)TTACT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ABCC4 Gene

Variant ID Type Subtype PubMed ID
nsv7246 OTHER Inversion 18451855
nsv832688 CNV Gain 17160897
nsv525194 CNV Loss 19592680
esv2530045 CNV Insertion 19546169
esv1580429 CNV Insertion 17803354
nsv832689 CNV Loss 17160897
esv2666461 CNV Deletion 23128226
nsv900925 CNV Gain 21882294
esv2672928 CNV Deletion 23128226
esv2747844 CNV Deletion 23290073
esv2393854 CNV Deletion 18987734
esv2903 CNV Deletion 18987735
nsv522179 CNV Loss 19592680
esv2666266 CNV Deletion 23128226
dgv1781n71 CNV Gain 21882294
nsv900928 CNV Gain 21882294
nsv456078 CNV Gain 19166990
nsv471169 CNV Gain 18288195
nsv517610 CNV Gain+Loss 19592680
nsv456080 CNV Gain 19166990

Relevant External Links for ABCC4 Gene

HapMap Linkage Disequilibrium report
ABCC4
Human Gene Mutation Database (HGMD)
ABCC4

Disorders for ABCC4 Gene

(1) MalaCards Diseases for ABCC4 Gene

Search for ABCC4 Gene in MalaCards »

(2) University of Copenhagen DISEASES for ABCC4 Gene

(11) Novoseek inferred disease relationships for ABCC4 Gene

Disease -log(P) Hits PubMed IDs
cholestasis 64.9 3
breast cancer 39.2 10
cancer 26.9 3
small cell lung cancer 25.1 2
ovarian carcinoma 16.5 1

Relevant External Links for ABCC4

Genetic Association Database (GAD)
ABCC4
Human Genome Epidemiology (HuGE) Navigator
ABCC4
genes like me logo Genes that share disorders with ABCC4: view

No data available for UniProtKB/Swiss-Prot for ABCC4 Gene

Publications for ABCC4 Gene

  1. Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines. (PMID: 9270026) Kool M. … Borst P. (Cancer Res. 1997) 3 4 23
  2. Expression of MRP4 confers resistance to ganciclovir and compromises bystander cell killing. (PMID: 12105214) Adachi M. … Schuetz J. (J. Biol. Chem. 2002) 3 4 23
  3. Association between ABCC2 gene haplotypes and tenofovir-induced proximal tubulopathy. (PMID: 17083032) Izzedine H. … Deray A.G. (J. Infect. Dis. 2006) 3 23 49
  4. Isolation of MOAT-B, a widely expressed multidrug resistance- associated protein/canalicular multispecific organic anion transporter-related transporter. (PMID: 9661885) Lee K. … Kruh G.D. (Cancer Res. 1998) 2 3 4
  5. The human multidrug resistance protein 4 (MRP4, ABCC4): functional analysis of a highly polymorphic gene. (PMID: 18364470) Abla N. … Kroetz D.L. (J. Pharmacol. Exp. Ther. 2008) 3 23 25

Products for ABCC4 Gene

Sources for ABCC4 Gene

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