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Aliases for CDK9 Gene

Aliases for CDK9 Gene

  • Cyclin-Dependent Kinase 9 2 3
  • CDC2L4 3 4 6
  • Tat-Associated Kinase Complex Catalytic Subunit 3 4
  • Cell Division Cycle 2-Like Protein Kinase 4 3 4
  • Cell Division Protein Kinase 9 3 4
  • C-2k 3 4
  • TAK 3 4
  • Cyclin-Dependent Kinase 9 (CDC2-Related Kinase) 2
  • Serine/Threonine Protein Kinase PITALRE 3
  • Serine/Threonine-Protein Kinase PITALRE 4
  • CDC2-Related Kinase 3
  • EC 2.7.11.22 4
  • EC 2.7.11.23 4
  • EC 2.7.11 63
  • PITALRE 3
  • CTK1 3

External Ids for CDK9 Gene

Previous HGNC Symbols for CDK9 Gene

  • CDC2L4

Previous GeneCards Identifiers for CDK9 Gene

  • GC09P121663
  • GC09P122194
  • GC09P124002
  • GC09P125925
  • GC09P125926
  • GC09P127627
  • GC09P129588
  • GC09P130547

Summaries for CDK9 Gene

Entrez Gene Summary for CDK9 Gene

  • The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and known as important cell cycle regulators. This kinase was found to be a component of the multiprotein complex TAK/P-TEFb, which is an elongation factor for RNA polymerase II-directed transcription and functions by phosphorylating the C-terminal domain of the largest subunit of RNA polymerase II. This protein forms a complex with and is regulated by its regulatory subunit cyclin T or cyclin K. HIV-1 Tat protein was found to interact with this protein and cyclin T, which suggested a possible involvement of this protein in AIDS. [provided by RefSeq, Jul 2008]

GeneCards Summary for CDK9 Gene

CDK9 (Cyclin-Dependent Kinase 9) is a Protein Coding gene. Diseases associated with CDK9 include hiv-1. Among its related pathways are Signaling by GPCR and Disease. GO annotations related to this gene include chromatin binding and transcription regulatory region DNA binding. An important paralog of this gene is CDK12.

UniProtKB/Swiss-Prot for CDK9 Gene

  • Protein kinase involved in the regulation of transcription. Member of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, also called positive transcription elongation factor b (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A, SUPT5H and RDBP. This complex is inactive when in the 7SK snRNP complex form. Phosphorylates EP300, MYOD1, RPB1/POLR2A and AR, and the negative elongation factors DSIF and NELF. Regulates cytokine inducible transcription networks by facilitating promoter recognition of target transcription factors (e.g. TNF-inducible RELA/p65 activation and IL-6-inducible STAT3 signaling). Promotes RNA synthesis in genetic programs for cell growth, differentiation and viral pathogenesis. P-TEFb is also involved in cotranscriptional histone modification, mRNA processing and mRNA export. Modulates a complex network of chromatin modifications including histone H2B monoubiquitination (H2Bub1), H3 lysine 4 trimethylation (H3K4me3) and H3K36me3; integrates phosphorylation during transcription with chromatin modifications to control co-transcriptional histone mRNA processing. The CDK9/cyclin-K complex has also a kinase activity towards CTD of RNAP II and can substitute for CDK9/cyclin-T P-TEFb in vitro. Replication stress response protein; the CDK9/cyclin-K complex is required for genome integrity maintenance, by promoting cell cycle recovery from replication arrest and limiting single-stranded DNA amount in response to replication stress, thus reducing the breakdown of stalled replication forks and avoiding DNA damage. In addition, probable function in DNA repair of isoform 2 via interaction with KU70/XRCC6. Promotes cardiac myocyte enlargement. RPB1/POLR2A phosphorylation on Ser-2 in CTD activates transcription. AR phosphorylation modulates AR transcription factor promoter selectivity and cell growth. DSIF and NELF phosphorylation promotes transcription by inhibiting their negative effect. The phosphorylation of MYOD1 enhances its transcriptional activity and thus promotes muscle differentiation.

Tocris Summary for CDK9 Gene

  • Cdks (cyclin-dependent kinases) are heteromeric serine/threonine kinases that control progression through the cell cycle in concert with their regulatory subunits, the cyclins. Although there are 12 different cdk genes, only 5 have been shown to directly drive the cell cycle (Cdk1, -2, -3, -4, and -6). Following extracellular mitogenic stimuli, cyclin D gene expression is upregulated. Cdk4 forms a complex with cyclin D and phosphorylates Rb protein, leading to liberation of the transcription factor E2F. E2F induces transcription of genes including cyclins A and E, DNA polymerase and thymidine kinase. Cdk4-cyclin E complexes form and initiate G1/S transition. Subsequently, Cdk1-cyclin B complexes form and induce G2/M phase transition. Cdk1-cyclin B activation induces the breakdown of the nuclear envelope and the initiation of mitosis. Cdks are constitutively expressed and are regulated by several kinases and phosphastases, including Wee1, CDK-activating kinase and Cdc25 phosphatase. In addition, cyclin expression is induced by molecular signals at specific points of the cell cycle, leading to activation of Cdks. Tight control of Cdks is essential as misregulation can induce unscheduled proliferation, and genomic and chromosomal instability. Cdk4 has been shown to be mutated in some types of cancer, whilst a chromosomal rearrangement can lead to Cdk6 overexpression in lymphoma, leukemia and melanoma. Cdks are currently under investigation as potential targets for antineoplastic therapy, but as Cdks are essential for driving each cell cycle phase, therapeutic strategies that block Cdk activity are unlikely to selectively target tumor cells.

Gene Wiki entry for CDK9 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDK9 Gene

Genomics for CDK9 Gene

Regulatory Elements for CDK9 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CDK9 Gene

Start:
127,785,679 bp from pter
End:
127,790,787 bp from pter
Size:
5,109 bases
Orientation:
Plus strand

Genomic View for CDK9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CDK9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDK9 Gene

Proteins for CDK9 Gene

  • Protein details for CDK9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P50750-CDK9_HUMAN
    Recommended name:
    Cyclin-dependent kinase 9
    Protein Accession:
    P50750
    Secondary Accessions:
    • Q5JU24
    • Q5JU25
    • Q5U006
    • Q96TF1

    Protein attributes for CDK9 Gene

    Size:
    372 amino acids
    Molecular mass:
    42778 Da
    Quaternary structure:
    • Component of the super elongation complex (SEC), at least composed of EAF1, EAF2, CDK9, MLLT3/AF9, AFF (AFF1 or AFF4), the P-TEFb complex and ELL (ELL, ELL2 or ELL3). Associates with CCNT1/cyclin-T1, CCNT2/cyclin-T2 (isoform A and isoform B) or CCNK/cyclin-K to form active P-TEFb. P-TEFb forms a complex with AFF4/AF5Q31 and is part of the super elongation complex (SEC). Component of a complex which is composed of at least 5 members: HTATSF1/Tat-SF1, P-TEFb complex, RNA pol II, SUPT5H, and NCL/nucleolin. Associates with UBR5 and forms a transcription regulatory complex composed of CDK9, RNAP II, UBR5 and TFIIS/TCEA1 that can stimulate target gene transcription (e.g. gamma fibrinogen/FGG) by recruiting their promoters. Component of the 7SK snRNP inactive complex which is composed of at least 8 members: P-TEFb (composed of CDK9 and CCNT1/cyclin-T1), HEXIM1, HEXIM2, LARP7, BCDIN3, SART3 proteins and 7SK and U6 snRNAs. This inactive 7SK snRNP complex can also interact with NCOR1 and HDAC3, probably to regulate CDK9 acetylation. Release of P-TEFb from P-TEFb/7SK snRNP complex requires both PP2B to transduce calcium Ca(2+) signaling in response to stimuli (e.g. UV or hexamethylene bisacetamide (HMBA)), and PPP1CA to dephosphorylate Thr-186. This released P-TEFb remains inactive in the pre-initiation complex with BRD4 until new Thr-186 phosphorylation occurs after the synthesis of a short RNA. Interacts with BRD4, probably to target chromatin binding. Interacts with the acidic/proline-rich region of HIV-1 and HIV-2 Tat via T-loop region, and is thus required for HIV to hijack host transcription machinery during its replication through cooperative binding to viral TAR RNA. Interacts with activated nuclear STAT3 and RELA/p65. Binds to AR and MYOD1. Forms a complex composed of CDK9, CCNT1/cyclin-T1, EP300 and GATA4 that stimulates hypertrophy in cardiomyocytes. The large PER complex involved in the repression of transcriptional termination is composed of at least PER2, CDK9, DDX5, DHX9, NCBP1 and POLR2A. Isoform 3 binds to KU70/XRCC6. Interacts with herpes simplex virus 1 protein ICP22; this interaction inhibits the positive transcription elongation factor b (P-TEFb).
    Miscellaneous:
    • CDK9 inhibition contributes to the anticancer activity of most CDK inhibitors under clinical investigation (PubMed:18423896 and PubMed:21779453). As a retroviruses target during the hijack of host transcription (e.g. HIV), CDK9 inhibitors might become specific antiretroviral agents (PubMed:18423896). May be a target for cardiac hypertrophy future treatments (PubMed:19757441 and PubMed:18423896). May also be a target in anti-inflammatory therapy in innate immunity and systemic inflammation (PubMed:18728388).
    SequenceCaution:
    • Sequence=CAI39767.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CDK9 Gene

    Alternative splice isoforms for CDK9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDK9 Gene

Proteomics data for CDK9 Gene at MOPED

Selected DME Specific Peptides for CDK9 Gene

Post-translational modifications for CDK9 Gene

  • Autophosphorylation at Thr-186, Ser-347, Thr-350, Ser-353, Thr-354 and Ser-357 triggers kinase activity by promoting cyclin and substrate binding (e.g. HIV TAT) upon conformational changes. Thr-186 phosphorylation requires the calcium Ca(2+) signaling pathway, including CaMK1D and calmodulin. This inhibition is relieved by Thr-29 dephosphorylation. However, phosphorylation at Thr-29 is inhibitory within the HIV transcription initiation complex. Phosphorylation at Ser-175 inhibits kinase activity. Can be phosphorylated on either Thr-362 or Thr-363 but not on both simultaneously (PubMed:18566585).
  • Dephosphorylation of Thr-186 by PPM1A and PPM1B blocks CDK9 activity and may lead to CDK9 proteasomal degradation. However, PPP1CA-mediated Thr-186 dephosphorylation is required to release P-TEFb from its inactive P-TEFb/7SK snRNP complex. Dephosphorylation of C-terminus Thr and Ser residues by protein phosphatase-1 (PP1) triggers CDK9 activity, contributing to the activation of HIV-1 transcription
  • N6-acetylation of Lys-44 by CBP/p300 promotes kinase activity, whereas acetylation of both Lys-44 and Lys-48 mediated by PCAF/KAT2B and GCN5/KAT2A reduces kinase activity. The acetylated form associates with PML bodies in the nuclear matrix and with the transcriptionally silent HIV-1 genome; deacetylated upon transcription stimulation.
  • Polyubiquitinated and thus activated by UBR5. This ubiquitination is promoted by TFIIS/TCEA1 and favors Ser-2 phosphorylation of RPB1/POLR2A CTD.
  • Ubiquitination at Lys3, Lys35, Lys68, Lys164, Lys178, Lys294, and Lys345
  • Modification sites at PhosphoSitePlus

Other Protein References for CDK9 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CDK9 (CDK9)

Domains for CDK9 Gene

Gene Families for CDK9 Gene

HGNC:
  • CDK :Cyclin-dependent kinases
IUPHAR :

Suggested Antigen Peptide Sequences for CDK9 Gene

Graphical View of Domain Structure for InterPro Entry

P50750

UniProtKB/Swiss-Prot:

CDK9_HUMAN :
  • P50750
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
genes like me logo Genes that share domains with CDK9: view

Function for CDK9 Gene

Molecular function for CDK9 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot CatalyticActivity: ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate
UniProtKB/Swiss-Prot EnzymeRegulation: Inhibited by CDKI-71, CR8, GPC-286199, AG-024322, flavopiridol (alvocidib), RBG-286147, anilinopyrimidine 32, arylazopyrazole 31b, indirubin 3-monoxime, meriolin 3,P276-00, olomoucine II, pyrazolotriazine, meriolin, variolin, thiazolyl-pyrimidine, thiazolyl-pyrimidine, indirubin-30-monoxime, ZK 304709, AG-012986, AT7519, R547, RGB-286638, imidazole pyrimidine, EXEL-3700, EXEL-8647, 5,6-dichloro-1-b-ribofur-anosyl-benzimidazole (DRB), P276-00, roscovitine (seliciclib, CYC202) and SNS-032 (BMS-387032). Activation by Thr-186 phosphorylation is calcium Ca(2+) signaling pathway-dependent; actively inactivated by dephosphorylation mediated by PPP1CA, PPM1A and PPM1B. Reversibly repressed by acetylation at Lys-44 and Lys-48.
UniProtKB/Swiss-Prot Function: Protein kinase involved in the regulation of transcription. Member of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, also called positive transcription elongation factor b (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A, SUPT5H and RDBP. This complex is inactive when in the 7SK snRNP complex form. Phosphorylates EP300, MYOD1, RPB1/POLR2A and AR, and the negative elongation factors DSIF and NELF. Regulates cytokine inducible transcription networks by facilitating promoter recognition of target transcription factors (e.g. TNF-inducible RELA/p65 activation and IL-6-inducible STAT3 signaling). Promotes RNA synthesis in genetic programs for cell growth, differentiation and viral pathogenesis. P-TEFb is also involved in cotranscriptional histone modification, mRNA processing and mRNA export. Modulates a complex network of chromatin modifications including histone H2B monoubiquitination (H2Bub1), H3 lysine 4 trimethylation (H3K4me3) and H3K36me3; integrates phosphorylation during transcription with chromatin modifications to control co-transcriptional histone mRNA processing. The CDK9/cyclin-K complex has also a kinase activity towards CTD of RNAP II and can substitute for CDK9/cyclin-T P-TEFb in vitro. Replication stress response protein; the CDK9/cyclin-K complex is required for genome integrity maintenance, by promoting cell cycle recovery from replication arrest and limiting single-stranded DNA amount in response to replication stress, thus reducing the breakdown of stalled replication forks and avoiding DNA damage. In addition, probable function in DNA repair of isoform 2 via interaction with KU70/XRCC6. Promotes cardiac myocyte enlargement. RPB1/POLR2A phosphorylation on Ser-2 in CTD activates transcription. AR phosphorylation modulates AR transcription factor promoter selectivity and cell growth. DSIF and NELF phosphorylation promotes transcription by inhibiting their negative effect. The phosphorylation of MYOD1 enhances its transcriptional activity and thus promotes muscle differentiation.
UniProtKB/Swiss-Prot Induction: By replication stress, in chromatin. Probably degraded by the proteasome upon Thr-186 dephosphorylation

Enzyme Numbers (IUBMB) for CDK9 Gene

Gene Ontology (GO) - Molecular Function for CDK9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IDA 16109376
GO:0003682 chromatin binding IEA --
GO:0004672 protein kinase activity TAS 8170997
GO:0004693 cyclin-dependent protein serine/threonine kinase activity IEA --
GO:0004713 protein tyrosine kinase activity --
genes like me logo Genes that share ontologies with CDK9: view
genes like me logo Genes that share phenotypes with CDK9: view

Animal Model Products

CRISPR Products

miRNA for CDK9 Gene

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for CDK9 Gene

Localization for CDK9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDK9 Gene

Nucleus. Cytoplasm. Nucleus, PML body. Note=Accumulates on chromatin in response to replication stress. Complexed with CCNT1 in nuclear speckles, but uncomplexed form in the cytoplasm. The translocation from nucleus to cytoplasm is XPO1/CRM1-dependent. Associates with PML body when acetylated.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDK9 Gene COMPARTMENTS Subcellular localization image for CDK9 gene
Compartment Confidence
nucleus 5
cytosol 1

Gene Ontology (GO) - Cellular Components for CDK9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
GO:0008023 transcription elongation factor complex IDA 22195968
GO:0008024 positive transcription elongation factor complex b IDA 15905409
genes like me logo Genes that share ontologies with CDK9: view

Pathways for CDK9 Gene

SuperPathways for CDK9 Gene

Superpath Contained pathways
1 Loss of Function of SMAD2/3 in Cancer
2 Formation of RNA Pol II elongation complex
3 HIV Life Cycle
4 Gene Expression
5 Signaling by GPCR
genes like me logo Genes that share pathways with CDK9: view

Pathways by source for CDK9 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for CDK9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair IEA --
GO:0006282 regulation of DNA repair IDA 20493174
GO:0006351 transcription, DNA-templated TAS --
GO:0006366 transcription from RNA polymerase II promoter TAS --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
genes like me logo Genes that share ontologies with CDK9: view

Compounds for CDK9 Gene

Compound Products

(20) ApexBio Compounds for CDK9 Gene

Compound Action Cas Number
AT7519 novel small molecule effective as a multi-cyclin-dependent kinase inhibitor [844442-38-2]
AZD-5438 Potent CDK1/2/9 inhibitor [602306-29-6]
BMS265246 potent and selective Cdk1/Cdk2 inhibitor [582315-72-8]
BS-181 HCl small molecule inhibitor which is highly selective for Cdk7 activity [1397219-81-6]
Deferasirox rationally-designed oral iron chelator. [201530-41-8]
Dinaciclib (SCH727965) CDK inhibitor [779353-01-4]
Flavopiridol hydrochloride pan-cdk inhibitor. [131740-09-5]
LEE011 orally available CDK inhibitor. [1211441-98-3]
LY2835219 orally available CDK inhibitor, targets the CDK4 and CDK6 [1231930-82-7]
Nu 6027 potent inhibitor of cellular ATR activity [220036-08-8]
Palbociclib (PD0332991) Isethionate Highly selective CDK4/6 inhibitor [827022-33-3]
PD 0332991 (Palbociclib) HCl Highly selective CDK4/6 inhibitor [827022-33-3]
PHA-793887 novel pan-Cdk inhibitor [718630-59-2]
PHA-848125 potent, ATP-competitive Cdk2/cyclin A inhibitor. [802539-81-7]
Purvalanol B cyclin-dependent kinase inhibitor. [212844-54-7]
R547 novel, selective inhibitor of cell cycle and transcriptional CDK. [741713-40-6]
Roscovitine (Seliciclib,CYC202) potent and selective inhibitor of cyclin-dependent kinases [186692-46-6]
SB1317 novel pyrimidine-based multi-kinase inhibitor that inhibits CDKs 1, 2, 7 and 9 together with JAK2 and FLT3 [937270-47-8]
SCH900776 S-isomer potent, selective and orally bioavailable inhibitor of checkpoint kinase Chk1 [891494-64-7]
SNS-032 (BMS-387032) Potent and selective CDK inhibitor [345627-80-7]

(5) Tocris Compounds for CDK9 Gene

Compound Action Cas Number
Flavopiridol hydrochloride Cyclin-dependent kinase inhibitor [131740-09-5]
PD 0332991 isethionate Potent, selective Cdk4/6 inhibitor; brain penetrant [827022-33-3]
Purvalanol B Cyclin-dependent kinase inhibitor [212844-54-7]
Ro 3306 Cyclin-dependent kinase (cdk) 1 inhibitor [872573-93-8]
Senexin A Cyclin-dependent kinase 8 (cdk8) inhibitor

(2) HMDB Compounds for CDK9 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0

(1) Drugbank Compounds for CDK9 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Flavopiridol
  • Alvocidib
131740-09-5 target

(11) Novoseek inferred chemical compound relationships for CDK9 Gene

Compound -log(P) Hits PubMed IDs
flavopiridol 88.5 18
5,6-dichloro-1-beta-d-ribofuranosylbenzimidazole 81.3 7
roscovitine 77.8 8
hmba 72.5 2
threonine 24.6 5
genes like me logo Genes that share compounds with CDK9: view

Transcripts for CDK9 Gene

Unigene Clusters for CDK9 Gene

Cyclin-dependent kinase 9:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CDK9

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDK9 Gene

No ASD Table

Relevant External Links for CDK9 Gene

GeneLoc Exon Structure for
CDK9
ECgene alternative splicing isoforms for
CDK9

Expression for CDK9 Gene

mRNA expression in normal human tissues for CDK9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CDK9 Gene

SOURCE GeneReport for Unigene cluster for CDK9 Gene Hs.150423

mRNA Expression by UniProt/SwissProt for CDK9 Gene

P50750-CDK9_HUMAN
Tissue specificity: Ubiquitous
genes like me logo Genes that share expressions with CDK9: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for CDK9 Gene

Orthologs for CDK9 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CDK9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDK9 35
  • 99.46 (n)
  • 100 (a)
CDK9 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CDK9 35
  • 93.64 (n)
  • 98.66 (a)
CDK9 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CDK9 35
  • 92.03 (n)
  • 98.39 (a)
CDK9 36
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdk9 35
  • 89.25 (n)
  • 98.66 (a)
Cdk9 16
Cdk9 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CDK9 36
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDK9 36
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdk9 35
  • 89.7 (n)
  • 98.66 (a)
chicken
(Gallus gallus)
Aves CDK9 35
  • 82.97 (n)
  • 93.01 (a)
CDK9 36
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDK9 36
  • 90 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia cdk9-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia cdk9 35
  • 79.03 (n)
  • 90.59 (a)
zebrafish
(Danio rerio)
Actinopterygii cdk9 35
  • 79.42 (n)
  • 90.57 (a)
cdk9 36
  • 85 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008541 35
  • 70.58 (n)
  • 74.3 (a)
fruit fly
(Drosophila melanogaster)
Insecta Cdk9 35
  • 68.25 (n)
  • 74.02 (a)
Cdk9 36
  • 67 (a)
OneToOne
Cdk9 37
  • 73 (a)
worm
(Caenorhabditis elegans)
Secernentea cdk-9 35
  • 55.15 (n)
  • 57.02 (a)
cdk-9 36
  • 42 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CTK1 36
  • 23 (a)
OneToMany
SGV1 38
rice
(Oryza sativa)
Liliopsida Os.14473 35
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cdk9 35
  • 49.53 (n)
  • 45.74 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2443 36
  • 74 (a)
OneToOne
Species with no ortholog for CDK9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CDK9 Gene

ENSEMBL:
Gene Tree for CDK9 (if available)
TreeFam:
Gene Tree for CDK9 (if available)

Paralogs for CDK9 Gene

Paralogs for CDK9 Gene

genes like me logo Genes that share paralogs with CDK9: view

Variants for CDK9 Gene

Sequence variations from dbSNP and Humsavar for CDK9 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs8083 -- 127,789,900(+) GCGTG(A/C/G)GGACA utr-variant-3-prime
rs10460 -- 127,788,632(+) CAGGG(C/T)AACAC reference, synonymous-codon
rs1056472 -- 127,789,769(+) TCCCA(A/G)AGGGT utr-variant-3-prime
rs1056473 -- 127,789,818(+) TTTTT(C/T)TAAGA utr-variant-3-prime
rs2297214 -- 127,788,874(+) GTCTC(A/G)GTTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CDK9 Gene

Variant ID Type Subtype PubMed ID
nsv893859 CNV Loss 21882294
nsv893860 CNV Gain 21882294
nsv893865 CNV Loss 21882294
nsv893867 CNV Loss 21882294
nsv893868 CNV Loss 21882294
dgv8287n71 CNV Loss 21882294
nsv471323 CNV Loss 18288195
nsv466573 CNV Loss 19166990
nsv825094 CNV Gain 20364138
dgv8288n71 CNV Loss 21882294
nsv466575 CNV Loss 19166990
nsv893874 CNV Loss 21882294
nsv825095 CNV Gain 20364138
nsv466576 CNV Loss 19166990

Relevant External Links for CDK9 Gene

HapMap Linkage Disequilibrium report
CDK9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDK9 Gene

Disorders for CDK9 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for CDK9 Gene including...

Search for CDK9 Gene in MalaCards »

UniProtKB/Swiss-Prot

CDK9_HUMAN
  • Note=Chronic activation of CDK9 causes cardiac myocyte enlargement leading to cardiac hypertrophy, and confers predisposition to heart failure.

(13) Novoseek inferred disease relationships for CDK9 Gene

Disease -log(P) Hits PubMed IDs
immunodeficiency 68.1 28
equine infectious anemia 60 1
cardiac hypertrophy 51.1 4
retinoblastoma 44.8 6
promyelocytic leukemia 18.3 1
genes like me logo Genes that share disorders with CDK9: view

Publications for CDK9 Gene

  1. PITALRE, a nuclear CDC2-related protein kinase that phosphorylates the retinoblastoma protein in vitro. (PMID: 8170997) Grana X. … Giordano A. (Proc. Natl. Acad. Sci. U.S.A. 1994) 2 3 4 23
  2. TAK, an HIV Tat-associated kinase, is a member of the cyclin-dependent family of protein kinases and is induced by activation of peripheral blood lymphocytes and differentiation of promonocytic cell lines. (PMID: 9356449) Yang X. … Herrmann C.H. (Proc. Natl. Acad. Sci. U.S.A. 1997) 2 3 23
  3. Identification of multiple cyclin subunits of human P-TEFb. (PMID: 9499409) Peng J.-M. … Price D.H. (Genes Dev. 1998) 3 4 23
  4. Genomic organization and characterization of promoter function of the human CDK9 gene. (PMID: 10903437) Liu H. … Rice A.P. (Gene 2000) 3 4 23
  5. CDK9 autophosphorylation regulates high-affinity binding of the human immunodeficiency virus type 1 tat-P-TEFb complex to TAR RNA. (PMID: 10958691) Garber M.E. … Jones K.A. (Mol. Cell. Biol. 2000) 3 4 23

Products for CDK9 Gene

  • Addgene plasmids for CDK9

Sources for CDK9 Gene

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