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Aliases for CDK9 Gene

Aliases for CDK9 Gene

  • Cyclin-Dependent Kinase 9 2 3 5
  • Tat-Associated Kinase Complex Catalytic Subunit 3 4
  • Cell Division Cycle 2-Like Protein Kinase 4 3 4
  • Cell Division Protein Kinase 9 3 4
  • CDC2L4 3 4
  • C-2k 3 4
  • TAK 3 4
  • Cyclin-Dependent Kinase 9 (CDC2-Related Kinase) 2
  • Serine/Threonine Protein Kinase PITALRE 3
  • Serine/Threonine-Protein Kinase PITALRE 4
  • CDC2-Related Kinase 3
  • EC 2.7.11.22 4
  • EC 2.7.11.23 4
  • EC 2.7.11 63
  • PITALRE 3
  • CTK1 3

External Ids for CDK9 Gene

Previous HGNC Symbols for CDK9 Gene

  • CDC2L4

Previous GeneCards Identifiers for CDK9 Gene

  • GC09P121663
  • GC09P122194
  • GC09P124002
  • GC09P125925
  • GC09P125926
  • GC09P127627
  • GC09P129588
  • GC09P130547
  • GC09P127787
  • GC09P127789

Summaries for CDK9 Gene

Entrez Gene Summary for CDK9 Gene

  • The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and known as important cell cycle regulators. This kinase was found to be a component of the multiprotein complex TAK/P-TEFb, which is an elongation factor for RNA polymerase II-directed transcription and functions by phosphorylating the C-terminal domain of the largest subunit of RNA polymerase II. This protein forms a complex with and is regulated by its regulatory subunit cyclin T or cyclin K. HIV-1 Tat protein was found to interact with this protein and cyclin T, which suggested a possible involvement of this protein in AIDS. [provided by RefSeq, Jul 2008]

GeneCards Summary for CDK9 Gene

CDK9 (Cyclin-Dependent Kinase 9) is a Protein Coding gene. Diseases associated with CDK9 include hiv-1 and ipex syndrome. Among its related pathways are Transcriptional misregulation in cancer and DNA Damage. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CDK12.

UniProtKB/Swiss-Prot for CDK9 Gene

  • Protein kinase involved in the regulation of transcription. Member of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, also called positive transcription elongation factor b (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A, SUPT5H and RDBP. This complex is inactive when in the 7SK snRNP complex form. Phosphorylates EP300, MYOD1, RPB1/POLR2A and AR, and the negative elongation factors DSIF and NELF. Regulates cytokine inducible transcription networks by facilitating promoter recognition of target transcription factors (e.g. TNF-inducible RELA/p65 activation and IL-6-inducible STAT3 signaling). Promotes RNA synthesis in genetic programs for cell growth, differentiation and viral pathogenesis. P-TEFb is also involved in cotranscriptional histone modification, mRNA processing and mRNA export. Modulates a complex network of chromatin modifications including histone H2B monoubiquitination (H2Bub1), H3 lysine 4 trimethylation (H3K4me3) and H3K36me3; integrates phosphorylation during transcription with chromatin modifications to control co-transcriptional histone mRNA processing. The CDK9/cyclin-K complex has also a kinase activity towards CTD of RNAP II and can substitute for CDK9/cyclin-T P-TEFb in vitro. Replication stress response protein; the CDK9/cyclin-K complex is required for genome integrity maintenance, by promoting cell cycle recovery from replication arrest and limiting single-stranded DNA amount in response to replication stress, thus reducing the breakdown of stalled replication forks and avoiding DNA damage. In addition, probable function in DNA repair of isoform 2 via interaction with KU70/XRCC6. Promotes cardiac myocyte enlargement. RPB1/POLR2A phosphorylation on Ser-2 in CTD activates transcription. AR phosphorylation modulates AR transcription factor promoter selectivity and cell growth. DSIF and NELF phosphorylation promotes transcription by inhibiting their negative effect. The phosphorylation of MYOD1 enhances its transcriptional activity and thus promotes muscle differentiation.

Tocris Summary for CDK9 Gene

  • Cdks (cyclin-dependent kinases) are heteromeric serine/threonine kinases that control progression through the cell cycle in concert with their regulatory subunits, the cyclins. Although there are 12 different cdk genes, only 5 have been shown to directly drive the cell cycle.

Gene Wiki entry for CDK9 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDK9 Gene

Genomics for CDK9 Gene

Regulatory Elements for CDK9 Gene

Enhancers for CDK9 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CDK9 on UCSC Golden Path with GeneCards custom track

Promoters for CDK9 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CDK9 on UCSC Golden Path with GeneCards custom track

Genomic Location for CDK9 Gene

Chromosome:
9
Start:
127,785,679 bp from pter
End:
127,790,787 bp from pter
Size:
5,109 bases
Orientation:
Plus strand

Genomic View for CDK9 Gene

Genes around CDK9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDK9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDK9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDK9 Gene

Proteins for CDK9 Gene

  • Protein details for CDK9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P50750-CDK9_HUMAN
    Recommended name:
    Cyclin-dependent kinase 9
    Protein Accession:
    P50750
    Secondary Accessions:
    • Q5JU24
    • Q5JU25
    • Q5U006
    • Q96TF1

    Protein attributes for CDK9 Gene

    Size:
    372 amino acids
    Molecular mass:
    42778 Da
    Quaternary structure:
    • Component of the super elongation complex (SEC), at least composed of EAF1, EAF2, CDK9, MLLT3/AF9, AFF (AFF1 or AFF4), the P-TEFb complex and ELL (ELL, ELL2 or ELL3). Associates with CCNT1/cyclin-T1, CCNT2/cyclin-T2 (isoform A and isoform B) or CCNK/cyclin-K to form active P-TEFb. P-TEFb forms a complex with AFF4/AF5Q31 and is part of the super elongation complex (SEC). Component of a complex which is composed of at least 5 members: HTATSF1/Tat-SF1, P-TEFb complex, RNA pol II, SUPT5H, and NCL/nucleolin. Associates with UBR5 and forms a transcription regulatory complex composed of CDK9, RNAP II, UBR5 and TFIIS/TCEA1 that can stimulate target gene transcription (e.g. gamma fibrinogen/FGG) by recruiting their promoters. Component of the 7SK snRNP inactive complex which is composed of at least 8 members: P-TEFb (composed of CDK9 and CCNT1/cyclin-T1), HEXIM1, HEXIM2, LARP7, BCDIN3, SART3 proteins and 7SK and U6 snRNAs. This inactive 7SK snRNP complex can also interact with NCOR1 and HDAC3, probably to regulate CDK9 acetylation. Release of P-TEFb from P-TEFb/7SK snRNP complex requires both PP2B to transduce calcium Ca(2+) signaling in response to stimuli (e.g. UV or hexamethylene bisacetamide (HMBA)), and PPP1CA to dephosphorylate Thr-186. This released P-TEFb remains inactive in the pre-initiation complex with BRD4 until new Thr-186 phosphorylation occurs after the synthesis of a short RNA. Interacts with BRD4, probably to target chromatin binding. Interacts with the acidic/proline-rich region of HIV-1 and HIV-2 Tat via T-loop region, and is thus required for HIV to hijack host transcription machinery during its replication through cooperative binding to viral TAR RNA. Interacts with activated nuclear STAT3 and RELA/p65. Binds to AR and MYOD1. Forms a complex composed of CDK9, CCNT1/cyclin-T1, EP300 and GATA4 that stimulates hypertrophy in cardiomyocytes. The large PER complex involved in the repression of transcriptional termination is composed of at least PER2, CDK9, DDX5, DHX9, NCBP1 and POLR2A. Isoform 3 binds to KU70/XRCC6. Interacts with herpes simplex virus 1 protein ICP22; this interaction inhibits the positive transcription elongation factor b (P-TEFb).
    Miscellaneous:
    • CDK9 inhibition contributes to the anticancer activity of most CDK inhibitors under clinical investigation (PubMed:18423896 and PubMed:21779453). As a retroviruses target during the hijack of host transcription (e.g. HIV), CDK9 inhibitors might become specific antiretroviral agents (PubMed:18423896). May be a target for cardiac hypertrophy future treatments (PubMed:19757441 and PubMed:18423896). May also be a target in anti-inflammatory therapy in innate immunity and systemic inflammation (PubMed:18728388).
    SequenceCaution:
    • Sequence=CAI39767.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CDK9 Gene

    Alternative splice isoforms for CDK9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDK9 Gene

Proteomics data for CDK9 Gene at MOPED

Selected DME Specific Peptides for CDK9 Gene

Post-translational modifications for CDK9 Gene

  • Autophosphorylation at Thr-186, Ser-347, Thr-350, Ser-353, Thr-354 and Ser-357 triggers kinase activity by promoting cyclin and substrate binding (e.g. HIV TAT) upon conformational changes. Thr-186 phosphorylation requires the calcium Ca(2+) signaling pathway, including CaMK1D and calmodulin. This inhibition is relieved by Thr-29 dephosphorylation. However, phosphorylation at Thr-29 is inhibitory within the HIV transcription initiation complex. Phosphorylation at Ser-175 inhibits kinase activity. Can be phosphorylated on either Thr-362 or Thr-363 but not on both simultaneously (PubMed:18566585).
  • Dephosphorylation of Thr-186 by PPM1A and PPM1B blocks CDK9 activity and may lead to CDK9 proteasomal degradation. However, PPP1CA-mediated Thr-186 dephosphorylation is required to release P-TEFb from its inactive P-TEFb/7SK snRNP complex. Dephosphorylation of C-terminus Thr and Ser residues by protein phosphatase-1 (PP1) triggers CDK9 activity, contributing to the activation of HIV-1 transcription.
  • N6-acetylation of Lys-44 by CBP/p300 promotes kinase activity, whereas acetylation of both Lys-44 and Lys-48 mediated by PCAF/KAT2B and GCN5/KAT2A reduces kinase activity. The acetylated form associates with PML bodies in the nuclear matrix and with the transcriptionally silent HIV-1 genome; deacetylated upon transcription stimulation.
  • Polyubiquitinated and thus activated by UBR5. This ubiquitination is promoted by TFIIS/TCEA1 and favors Ser-2 phosphorylation of RPB1/POLR2A CTD.
  • Ubiquitination at Lys 3, Lys 35, Lys 68, Lys 164, Lys 178, and Lys 294
  • Modification sites at PhosphoSitePlus

Other Protein References for CDK9 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CDK9 (CDK9)

Domains & Families for CDK9 Gene

Gene Families for CDK9 Gene

Suggested Antigen Peptide Sequences for CDK9 Gene

Graphical View of Domain Structure for InterPro Entry

P50750

UniProtKB/Swiss-Prot:

CDK9_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
genes like me logo Genes that share domains with CDK9: view

Function for CDK9 Gene

Molecular function for CDK9 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by CDKI-71, CR8, GPC-286199, AG-024322, flavopiridol (alvocidib), RBG-286147, anilinopyrimidine 32, arylazopyrazole 31b, indirubin 3-monoxime, meriolin 3,P276-00, olomoucine II, pyrazolotriazine, meriolin, variolin, thiazolyl-pyrimidine, thiazolyl-pyrimidine, indirubin-30-monoxime, ZK 304709, AG-012986, AT7519, R547, RGB-286638, imidazole pyrimidine, EXEL-3700, EXEL-8647, 5,6-dichloro-1-b-ribofur-anosyl-benzimidazole (DRB), P276-00, roscovitine (seliciclib, CYC202) and SNS-032 (BMS-387032). Activation by Thr-186 phosphorylation is calcium Ca(2+) signaling pathway-dependent; actively inactivated by dephosphorylation mediated by PPP1CA, PPM1A and PPM1B. Reversibly repressed by acetylation at Lys-44 and Lys-48.
UniProtKB/Swiss-Prot Function:
Protein kinase involved in the regulation of transcription. Member of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, also called positive transcription elongation factor b (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A, SUPT5H and RDBP. This complex is inactive when in the 7SK snRNP complex form. Phosphorylates EP300, MYOD1, RPB1/POLR2A and AR, and the negative elongation factors DSIF and NELF. Regulates cytokine inducible transcription networks by facilitating promoter recognition of target transcription factors (e.g. TNF-inducible RELA/p65 activation and IL-6-inducible STAT3 signaling). Promotes RNA synthesis in genetic programs for cell growth, differentiation and viral pathogenesis. P-TEFb is also involved in cotranscriptional histone modification, mRNA processing and mRNA export. Modulates a complex network of chromatin modifications including histone H2B monoubiquitination (H2Bub1), H3 lysine 4 trimethylation (H3K4me3) and H3K36me3; integrates phosphorylation during transcription with chromatin modifications to control co-transcriptional histone mRNA processing. The CDK9/cyclin-K complex has also a kinase activity towards CTD of RNAP II and can substitute for CDK9/cyclin-T P-TEFb in vitro. Replication stress response protein; the CDK9/cyclin-K complex is required for genome integrity maintenance, by promoting cell cycle recovery from replication arrest and limiting single-stranded DNA amount in response to replication stress, thus reducing the breakdown of stalled replication forks and avoiding DNA damage. In addition, probable function in DNA repair of isoform 2 via interaction with KU70/XRCC6. Promotes cardiac myocyte enlargement. RPB1/POLR2A phosphorylation on Ser-2 in CTD activates transcription. AR phosphorylation modulates AR transcription factor promoter selectivity and cell growth. DSIF and NELF phosphorylation promotes transcription by inhibiting their negative effect. The phosphorylation of MYOD1 enhances its transcriptional activity and thus promotes muscle differentiation.
UniProtKB/Swiss-Prot Induction:
By replication stress, in chromatin. Probably degraded by the proteasome upon Thr-186 dephosphorylation.

Enzyme Numbers (IUBMB) for CDK9 Gene

Gene Ontology (GO) - Molecular Function for CDK9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001223 transcription coactivator binding IPI 12037672
GO:0003677 DNA binding IDA 16109376
GO:0016301 kinase activity TAS --
GO:0017069 snRNA binding IEA --
genes like me logo Genes that share ontologies with CDK9: view
genes like me logo Genes that share phenotypes with CDK9: view

Animal Models for CDK9 Gene

MGI Knock Outs for CDK9:
  • Cdk9 tm1.1(KOMP)Vlcg

Animal Model Products

  • Taconic Biosciences Mouse Models for CDK9

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CDK9 Gene

Localization for CDK9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDK9 Gene

Nucleus. Cytoplasm. Nucleus, PML body. Note=Accumulates on chromatin in response to replication stress. Complexed with CCNT1 in nuclear speckles, but uncomplexed form in the cytoplasm. The translocation from nucleus to cytoplasm is XPO1/CRM1-dependent. Associates with PML body when acetylated.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDK9 Gene COMPARTMENTS Subcellular localization image for CDK9 gene
Compartment Confidence
nucleus 5
cytosol 1

Gene Ontology (GO) - Cellular Components for CDK9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0008023 transcription elongation factor complex IDA 22195968
GO:0016605 PML body IDA 18250157
genes like me logo Genes that share ontologies with CDK9: view

Pathways & Interactions for CDK9 Gene

genes like me logo Genes that share pathways with CDK9: view

Pathways by source for CDK9 Gene

SIGNOR curated interactions for CDK9 Gene

Activates:
Inactivates:
Is activated by:
Other effect:

Gene Ontology (GO) - Biological Process for CDK9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair IEA --
GO:0006282 regulation of DNA repair IDA 20493174
GO:0006366 transcription from RNA polymerase II promoter TAS --
GO:0006368 transcription elongation from RNA polymerase II promoter TAS --
GO:0006468 protein phosphorylation IEA,IDA 16109376
genes like me logo Genes that share ontologies with CDK9: view

Drugs & Compounds for CDK9 Gene

(23) Drugs for CDK9 Gene - From: DrugBank, ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Flavopiridol Experimental, Investigational Pharma inhibitor, Target Kinase Inhibitors 59
Olomoucine Experimental Pharma Cyclin-dependent kinase inhibitor 0
Purvalanol A Experimental Pharma Cyclin-dependent kinase inhibitor 0
SCH727965 Pharma Inhibition, inhibitor, Biomarker CDK inhibitor, CDK2 Inhibitors, Kinase Inhibitors 0

(6) Additional Compounds for CDK9 Gene - From: HMDB, Tocris, and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
10Z-Hymenialdisine
82005-12-7

(5) Tocris Compounds for CDK9 Gene

Compound Action Cas Number
10Z-Hymenialdisine Pan kinase inhibitor; potently inhibits MEK1 82005-12-7
Kenpaullone Potent cyclin-dependent kinase inhibitor. Also inhibits GSK-3 142273-20-9
Olomoucine Cyclin-dependent kinase inhibitor 101622-51-9
Purvalanol A Cyclin-dependent kinase inhibitor 212844-53-6
Purvalanol B Cyclin-dependent kinase inhibitor 212844-54-7

(5) ApexBio Compounds for CDK9 Gene

Compound Action Cas Number
AZD-5438 Potent CDK1/2/9 inhibitor 602306-29-6
Dinaciclib (SCH727965) Potent CDK inhibitor 779353-01-4
LDC000067 1073485-20-7
P276-00 CDK-1/CDK4/CDK9 inhibitor 920113-03-7
SNS-032 (BMS-387032) CDK inhibitor 345627-80-7
genes like me logo Genes that share compounds with CDK9: view

Drug Products

Transcripts for CDK9 Gene

Unigene Clusters for CDK9 Gene

Cyclin-dependent kinase 9:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CDK9 Gene

No ASD Table

Relevant External Links for CDK9 Gene

GeneLoc Exon Structure for
CDK9
ECgene alternative splicing isoforms for
CDK9

Expression for CDK9 Gene

mRNA expression in normal human tissues for CDK9 Gene

Protein differential expression in normal tissues from HIPED for CDK9 Gene

This gene is overexpressed in Breast (24.9) and Lung (15.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CDK9 Gene



SOURCE GeneReport for Unigene cluster for CDK9 Gene Hs.150423

mRNA Expression by UniProt/SwissProt for CDK9 Gene

P50750-CDK9_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with CDK9: view

Protein tissue co-expression partners for CDK9 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for CDK9 Gene

Orthologs for CDK9 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CDK9 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CDK9 35
  • 93.64 (n)
  • 98.66 (a)
CDK9 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CDK9 35
  • 92.03 (n)
  • 98.39 (a)
CDK9 36
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdk9 35
  • 89.25 (n)
  • 98.66 (a)
Cdk9 16
Cdk9 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CDK9 35
  • 99.46 (n)
  • 100 (a)
CDK9 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdk9 35
  • 89.7 (n)
  • 98.66 (a)
oppossum
(Monodelphis domestica)
Mammalia CDK9 36
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDK9 36
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves CDK9 35
  • 82.97 (n)
  • 93.01 (a)
CDK9 36
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDK9 36
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdk9 35
  • 79.03 (n)
  • 90.59 (a)
African clawed frog
(Xenopus laevis)
Amphibia cdk9-prov 35
zebrafish
(Danio rerio)
Actinopterygii cdk9 35
  • 79.42 (n)
  • 90.57 (a)
cdk9 36
  • 85 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Cdk9 37
  • 73 (a)
Cdk9 35
  • 68.25 (n)
  • 74.02 (a)
Cdk9 36
  • 67 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008541 35
  • 70.58 (n)
  • 74.3 (a)
worm
(Caenorhabditis elegans)
Secernentea cdk-9 35
  • 55.15 (n)
  • 57.02 (a)
cdk-9 36
  • 42 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CTK1 36
  • 23 (a)
OneToMany
SGV1 38
rice
(Oryza sativa)
Liliopsida Os.14473 35
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cdk9 35
  • 49.53 (n)
  • 45.74 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2443 36
  • 74 (a)
OneToOne
Species with no ortholog for CDK9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CDK9 Gene

ENSEMBL:
Gene Tree for CDK9 (if available)
TreeFam:
Gene Tree for CDK9 (if available)

Paralogs for CDK9 Gene

Paralogs for CDK9 Gene

genes like me logo Genes that share paralogs with CDK9: view

Variants for CDK9 Gene

Sequence variations from dbSNP and Humsavar for CDK9 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
VAR_013456 -
rs55640715 - 127,787,520(+) CAGTT(A/C)CCCAT reference, missense
rs1056472 -- 127,789,769(+) TCCCA(A/G)AGGGT utr-variant-3-prime
rs1056473 -- 127,789,818(+) TTTTT(C/T)TAAGA utr-variant-3-prime
rs113604114 -- 127,789,984(+) CTTCA(A/G)CAGGA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CDK9 Gene

Variant ID Type Subtype PubMed ID
nsv893859 CNV Loss 21882294
nsv893860 CNV Gain 21882294
nsv893865 CNV Loss 21882294
nsv893867 CNV Loss 21882294
nsv893868 CNV Loss 21882294
dgv8287n71 CNV Loss 21882294
nsv471323 CNV Loss 18288195
nsv466573 CNV Loss 19166990
nsv825094 CNV Gain 20364138
dgv8288n71 CNV Loss 21882294
nsv466575 CNV Loss 19166990
nsv893874 CNV Loss 21882294
nsv825095 CNV Gain 20364138
nsv466576 CNV Loss 19166990

Variation tolerance for CDK9 Gene

Residual Variation Intolerance Score: 10.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.33; 7.33% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDK9 Gene

HapMap Linkage Disequilibrium report
CDK9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDK9 Gene

Disorders for CDK9 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CDK9 Gene - From: Novoseek and GeneCards

Disorder Aliases PubMed IDs
hiv-1
  • aids, slow progression to
ipex syndrome
  • immunodeficiency
- elite association - COSMIC cancer census association via MalaCards
Search CDK9 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

CDK9_HUMAN
  • Note=Chronic activation of CDK9 causes cardiac myocyte enlargement leading to cardiac hypertrophy, and confers predisposition to heart failure.

Relevant External Links for CDK9

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CDK9
genes like me logo Genes that share disorders with CDK9: view

No data available for Genatlas for CDK9 Gene

Publications for CDK9 Gene

  1. PITALRE, a nuclear CDC2-related protein kinase that phosphorylates the retinoblastoma protein in vitro. (PMID: 8170997) Grana X. … Giordano A. (Proc. Natl. Acad. Sci. U.S.A. 1994) 2 3 4 23 67
  2. TAK, an HIV Tat-associated kinase, is a member of the cyclin-dependent family of protein kinases and is induced by activation of peripheral blood lymphocytes and differentiation of promonocytic cell lines. (PMID: 9356449) Yang X. … Herrmann C.H. (Proc. Natl. Acad. Sci. U.S.A. 1997) 2 3 23
  3. Selective control of gene expression by CDK9 in human cells. (PMID: 19780058) Garriga J. … GraA+a X. (J. Cell. Physiol. 2010) 3 23
  4. Cyclin-dependent kinase-9 is a component of the p300/GATA4 complex required for phenylephrine-induced hypertrophy in cardiomyocytes. (PMID: 20081228) Sunagawa Y. … Hasegawa K. (J. Biol. Chem. 2010) 3 23
  5. Induction of monocyte chemoattractant protein-1 (MCP-1/CCL2) gene expression by human immunodeficiency virus-1 Tat in human astrocytes is CDK9 dependent. (PMID: 20370601) Khiati A. … Horellou P. (J. Neurovirol. 2010) 3 23

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