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Aliases for KCNMB2 Gene

Aliases for KCNMB2 Gene

  • Potassium Calcium-Activated Channel Subfamily M Regulatory Beta Subunit 2 2 3
  • Potassium Channel Subfamily M Regulatory Beta Subunit 2 2 3 5
  • Potassium Large Conductance Calcium-Activated Channel, Subfamily M, Beta Member 2 2 3
  • Charybdotoxin Receptor Subunit Beta-2 3 4
  • Big Potassium Channel Beta Subunit 2 2 3
  • MaxiK Channel Beta-Subunit 2 2 3
  • BK Channel Beta Subunit 2 2 3
  • BK Channel Subunit Beta-2 3 4
  • K(VCA)Beta-2 3 4
  • Slo-Beta-2 3 4
  • Hbeta2 3 4
  • Large Conductance Calcium-Activated Potassium Channel Beta 2 Subunit 3
  • Calcium-Activated Potassium Channel, Subfamily M Subunit Beta-2 4
  • Large-Conductance Ca2+-Activated K+ Channel Beta2 Subunit 3
  • Maxi K Channel Subunit Beta-2 4
  • MaxiK Channel Beta 2 Subunit 3
  • HCG1646471 3
  • BKbeta2 4
  • Hbeta3 4

External Ids for KCNMB2 Gene

Previous GeneCards Identifiers for KCNMB2 Gene

  • GC03M181111
  • GC03U900023
  • GC03P179656
  • GC03P179575
  • GC03P179736
  • GC03P177990
  • GC03P175660
  • GC03P178420

Summaries for KCNMB2 Gene

Entrez Gene Summary for KCNMB2 Gene

  • MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which decreases the activation time of MaxiK alpha subunit currents. Alternative splicing results in multiple transcript variants of this gene. Additional variants are discussed in the literature, but their full length nature has not been described. [provided by RefSeq, Jul 2013]

GeneCards Summary for KCNMB2 Gene

KCNMB2 (Potassium Calcium-Activated Channel Subfamily M Regulatory Beta Subunit 2) is a Protein Coding gene. Among its related pathways are Transmission across Chemical Synapses and Potassium Channels. GO annotations related to this gene include potassium channel regulator activity and ion channel inhibitor activity. An important paralog of this gene is KCNMB4.

UniProtKB/Swiss-Prot for KCNMB2 Gene

  • Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Acts as a negative regulator that confers rapid and complete inactivation of KCNMA1 channel complex. May participate in KCNMA1 inactivation in chromaffin cells of the adrenal gland or in hippocampal CA1 neurons.

Tocris Summary for KCNMB2 Gene

  • Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The alpha-subunits contain a single pore-forming region and combine to form tetramers.

Gene Wiki entry for KCNMB2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNMB2 Gene

Genomics for KCNMB2 Gene

Regulatory Elements for KCNMB2 Gene

Enhancers for KCNMB2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around KCNMB2 on UCSC Golden Path with GeneCards custom track

Genomic Location for KCNMB2 Gene

Chromosome:
3
Start:
178,272,932 bp from pter
End:
178,844,429 bp from pter
Size:
571,498 bases
Orientation:
Plus strand

Genomic View for KCNMB2 Gene

Genes around KCNMB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KCNMB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KCNMB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCNMB2 Gene

Proteins for KCNMB2 Gene

  • Protein details for KCNMB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y691-KCMB2_HUMAN
    Recommended name:
    Calcium-activated potassium channel subunit beta-2
    Protein Accession:
    Q9Y691

    Protein attributes for KCNMB2 Gene

    Size:
    235 amino acids
    Molecular mass:
    27130 Da
    Quaternary structure:
    • Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB2 per KCNMA1 tetramer.

    Three dimensional structures from OCA and Proteopedia for KCNMB2 Gene

neXtProt entry for KCNMB2 Gene

Proteomics data for KCNMB2 Gene at MOPED

Post-translational modifications for KCNMB2 Gene

Antibody Products

No data available for DME Specific Peptides for KCNMB2 Gene

Domains & Families for KCNMB2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y691

UniProtKB/Swiss-Prot:

KCMB2_HUMAN :
  • The ball and chain domain mediates the inactivation of KCNMA1. It occludes the conduction pathway of KCNMA1 channels, and comprises the pore-blocking ball domain (residues 1-17) and the chain domain (residues 20-45) linking it to the transmembrane segment. The ball domain is made up of a flexible N-terminus anchored at a well ordered loop-helix motif. The chain domain consists of a 4-turn helix with an unfolded linker at its C-terminus.
  • Belongs to the KCNMB (TC 8.A.14.1) family. KCNMB2 subfamily.
Domain:
  • The ball and chain domain mediates the inactivation of KCNMA1. It occludes the conduction pathway of KCNMA1 channels, and comprises the pore-blocking ball domain (residues 1-17) and the chain domain (residues 20-45) linking it to the transmembrane segment. The ball domain is made up of a flexible N-terminus anchored at a well ordered loop-helix motif. The chain domain consists of a 4-turn helix with an unfolded linker at its C-terminus.
Family:
  • Belongs to the KCNMB (TC 8.A.14.1) family. KCNMB2 subfamily.
genes like me logo Genes that share domains with KCNMB2: view

Function for KCNMB2 Gene

Molecular function for KCNMB2 Gene

UniProtKB/Swiss-Prot Function:
Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Acts as a negative regulator that confers rapid and complete inactivation of KCNMA1 channel complex. May participate in KCNMA1 inactivation in chromaffin cells of the adrenal gland or in hippocampal CA1 neurons.
genes like me logo Genes that share phenotypes with KCNMB2: view

Animal Models for KCNMB2 Gene

MGI Knock Outs for KCNMB2:

Animal Model Products

miRNA for KCNMB2 Gene

miRTarBase miRNAs that target KCNMB2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KCNMB2 Gene

Localization for KCNMB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNMB2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KCNMB2 Gene COMPARTMENTS Subcellular localization image for KCNMB2 gene
Compartment Confidence
plasma membrane 5
cytosol 1
endoplasmic reticulum 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for KCNMB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0008076 voltage-gated potassium channel complex IDA 10692449
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with KCNMB2: view

Pathways & Interactions for KCNMB2 Gene

genes like me logo Genes that share pathways with KCNMB2: view

Interacting Proteins for KCNMB2 Gene

Gene Ontology (GO) - Biological Process for KCNMB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001508 action potential IDA 10692449
GO:0005513 detection of calcium ion IDA 10692449
GO:0006813 potassium ion transport IEA,IDA 10692449
GO:0019229 regulation of vasoconstriction TAS 10692449
genes like me logo Genes that share ontologies with KCNMB2: view

No data available for SIGNOR curated interactions for KCNMB2 Gene

Drugs & Compounds for KCNMB2 Gene

(5) Drugs for KCNMB2 Gene - From: DrugBank, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Miconazole Approved, Investigational Pharma Antagonist, Pore Blocker, Target, inhibitor 3525
Procaine Approved, Investigational Pharma Channel blocker, Target, binder 43
(2r,3r,4s,5r)-2-Acetamido-3,4-Dihydroxy-5-Hydroxymethyl-Piperidinium Experimental Pharma Target 0
calcium Nutra 0
Flupirtine maleate Pharma KV7 channel activator 0

(4) Additional Compounds for KCNMB2 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
L-364,373
103342-82-1
NS 1643
448895-37-2
NS 5806
426834-69-7
PD 118057
313674-97-4

(5) Tocris Compounds for KCNMB2 Gene

Compound Action Cas Number
Flupirtine maleate KV7 channel activator 75507-68-5
L-364,373 KV7.1 channel activator, activates IKs 103342-82-1
NS 1643 KV11.1 (hERG) channel activator; antiarrhythmic 448895-37-2
NS 5806 KV4.3 channel activator 426834-69-7
PD 118057 Selective KV11.1 (hERG) channel activator 313674-97-4
genes like me logo Genes that share compounds with KCNMB2: view

Transcripts for KCNMB2 Gene

Unigene Clusters for KCNMB2 Gene

Potassium large conductance calcium-activated channel, subfamily M, beta member 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KCNMB2 Gene

No ASD Table

Relevant External Links for KCNMB2 Gene

GeneLoc Exon Structure for
KCNMB2
ECgene alternative splicing isoforms for
KCNMB2

Expression for KCNMB2 Gene

mRNA expression in normal human tissues for KCNMB2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KCNMB2 Gene

This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (x5.1) and Brain - Hippocampus (x4.6).

SOURCE GeneReport for Unigene cluster for KCNMB2 Gene Hs.478368

mRNA Expression by UniProt/SwissProt for KCNMB2 Gene

Q9Y691-KCMB2_HUMAN
Tissue specificity: Expressed in kidney, heart and brain. Highly expressed in ovary. Expressed at low level in other tissues.
genes like me logo Genes that share expression patterns with KCNMB2: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for KCNMB2 Gene

Orthologs for KCNMB2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KCNMB2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KCNMB2 35
  • 93.76 (n)
  • 99.57 (a)
KCNMB3 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KCNMB2 35
  • 89.22 (n)
  • 96.6 (a)
KCNMB2 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kcnmb2 35
  • 88.65 (n)
  • 95.32 (a)
Kcnmb2 16
Kcnmb2 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia KCNMB2 35
  • 99.57 (n)
  • 100 (a)
KCNMB2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kcnmb2 35
  • 88.23 (n)
  • 95.74 (a)
oppossum
(Monodelphis domestica)
Mammalia KCNMB2 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KCNMB2 36
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves KCNMB2 35
  • 81.56 (n)
  • 92.77 (a)
KCNMB2 36
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KCNMB2 36
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kcnmb2 35
  • 79.86 (n)
  • 87.23 (a)
Str.13335 35
zebrafish
(Danio rerio)
Actinopterygii LOC796753 35
  • 59.26 (n)
  • 54.27 (a)
CR855338.1 36
  • 54 (a)
ManyToMany
kcnmb2 36
  • 47 (a)
ManyToMany
Species with no ortholog for KCNMB2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KCNMB2 Gene

ENSEMBL:
Gene Tree for KCNMB2 (if available)
TreeFam:
Gene Tree for KCNMB2 (if available)

Paralogs for KCNMB2 Gene

Paralogs for KCNMB2 Gene

genes like me logo Genes that share paralogs with KCNMB2: view

Variants for KCNMB2 Gene

Structural Variations from Database of Genomic Variants (DGV) for KCNMB2 Gene

Variant ID Type Subtype PubMed ID
nsv524447 CNV Gain 19592680
esv5751 CNV Gain 19470904
nsv515673 CNV Loss 19592680
esv2666875 CNV Deletion 23128226
esv2726249 CNV Deletion 23290073
esv1239393 CNV Insertion 17803354
esv1312525 CNV Deletion 17803354
esv2726250 CNV Deletion 23290073
esv1105229 CNV Deletion 17803354
nsv237839 CNV Loss 16902084
esv2726253 CNV Deletion 23290073
esv1084850 CNV Deletion 17803354
nsv513094 CNV Loss 21212237
esv2536068 CNV Deletion 19546169
nsv820302 CNV Gain 19587683
esv2299103 CNV Deletion 18987734
esv2726254 CNV Deletion 23290073
esv5860 CNV Loss 19470904
nsv236354 CNV Loss 16902084
esv1066766 CNV Deletion 17803354
nsv820700 CNV Deletion 20802225
esv24242 CNV Gain 19812545
nsv822350 CNV Gain 20364138

Variation tolerance for KCNMB2 Gene

Residual Variation Intolerance Score: 38.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.48; 10.51% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Relevant External Links for KCNMB2 Gene

Disorders for KCNMB2 Gene

Relevant External Links for KCNMB2

Genetic Association Database (GAD)
KCNMB2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KCNMB2

No disorders were found for KCNMB2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KCNMB2 Gene

Publications for KCNMB2 Gene

  1. Molecular basis of fast inactivation in voltage and Ca2+-activated K+ channels: a transmembrane beta-subunit homolog. (PMID: 10097176) Wallner M. … Toro L. (Proc. Natl. Acad. Sci. U.S.A. 1999) 2 3 4 67
  2. Effects of cytochrome P-450 inhibitors on ionic currents in isolated rat type I carotid body cells. (PMID: 8760033) Hatton C.J. … Peers C. (Am. J. Physiol. 1996) 25 26
  3. High affinity inhibition of Ca(2+)-dependent K+ channels by cytochrome P-450 inhibitors. (PMID: 1376313) Alvarez J. … Garcia-Sancho J. (J. Biol. Chem. 1992) 25 26
  4. Two distinct effects of PIP2 underlie auxiliary subunit-dependent modulation of Slo1 BK channels. (PMID: 25825171) Tian Y. … Hoshi T. (J. Gen. Physiol. 2015) 3
  5. IFN-I^-mediated reduction of large-conductance, Ca2+-activated, voltage-dependent K+ (BK) channel activity in airway epithelial cells leads to mucociliary dysfunction. (PMID: 24414257) Manzanares D. … Salathe M. (Am. J. Physiol. Lung Cell Mol. Physiol. 2014) 3

Products for KCNMB2 Gene

Sources for KCNMB2 Gene

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