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Aliases for CDK8 Gene

Aliases for CDK8 Gene

  • Cyclin-Dependent Kinase 8 2 3
  • Mediator Of RNA Polymerase II Transcription Subunit CDK8 3 4
  • Cell Division Protein Kinase 8 3 4
  • Mediator Complex Subunit CDK8 3 4
  • Protein Kinase K35 3 4
  • CDK8 Protein Kinase 3
  • EC 2.7.11.22 4
  • EC 2.7.11.23 4
  • EC 2.7.11 63
  • K35 3

External Ids for CDK8 Gene

Previous GeneCards Identifiers for CDK8 Gene

  • GC13P024808
  • GC13P020808
  • GC13P025758
  • GC13P024626
  • GC13P025726
  • GC13P026828
  • GC13P007646

Summaries for CDK8 Gene

Entrez Gene Summary for CDK8 Gene

  • The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase and its regulatory subunit cyclin C are components of the RNA polymerase II holoenzyme complex, which phosphorylates the carboxy-terminal domain (CTD) of the largest subunit of RNA polymerase II. This kinase has also been shown to regulate transcription by targeting the CDK7/cyclin H subunits of the general transcription initiation factor IIH (TFIIH), thus providing a link between the 'Mediator-like' protein complexes and the basal transcription machinery. [provided by RefSeq, Jul 2008]

GeneCards Summary for CDK8 Gene

CDK8 (Cyclin-Dependent Kinase 8) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Disease. GO annotations related to this gene include protein kinase activity and RNA polymerase II carboxy-terminal domain kinase activity. An important paralog of this gene is CDK19.

UniProtKB/Swiss-Prot for CDK8 Gene

  • Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex. Phosphorylates CCNH leading to down-regulation of the TFIIH complex and transcriptional repression. Recruited through interaction with MAML1 to hyperphosphorylate the intracellular domain of NOTCH, leading to its degradation.

Gene Wiki entry for CDK8 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDK8 Gene

Genomics for CDK8 Gene

Regulatory Elements for CDK8 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CDK8 Gene

Start:
26,254,125 bp from pter
End:
26,405,238 bp from pter
Size:
151,114 bases
Orientation:
Plus strand

Genomic View for CDK8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CDK8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDK8 Gene

Proteins for CDK8 Gene

  • Protein details for CDK8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49336-CDK8_HUMAN
    Recommended name:
    Cyclin-dependent kinase 8
    Protein Accession:
    P49336
    Secondary Accessions:
    • Q5VUF3
    • Q6ISB5

    Protein attributes for CDK8 Gene

    Size:
    464 amino acids
    Molecular mass:
    53284 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. The cylin/CDK pair formed by CCNC/CDK8 also associates with the large subunit of RNA polymerase II. Interacts with CTNNB1, GLI3 and MAML1.

    Three dimensional structures from OCA and Proteopedia for CDK8 Gene

    Alternative splice isoforms for CDK8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDK8 Gene

Proteomics data for CDK8 Gene at MOPED

Selected DME Specific Peptides for CDK8 Gene

Post-translational modifications for CDK8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CDK8 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CDK8 (CDK8)

Domains for CDK8 Gene

Gene Families for CDK8 Gene

HGNC:
  • CDK :Cyclin-dependent kinases
IUPHAR :

Suggested Antigen Peptide Sequences for CDK8 Gene

Graphical View of Domain Structure for InterPro Entry

P49336

UniProtKB/Swiss-Prot:

CDK8_HUMAN :
  • P49336
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
genes like me logo Genes that share domains with CDK8: view

Function for CDK8 Gene

Molecular function for CDK8 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot CatalyticActivity: ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.
UniProtKB/Swiss-Prot Function: Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex. Phosphorylates CCNH leading to down-regulation of the TFIIH complex and transcriptional repression. Recruited through interaction with MAML1 to hyperphosphorylate the intracellular domain of NOTCH, leading to its degradation.

Enzyme Numbers (IUBMB) for CDK8 Gene

Gene Ontology (GO) - Molecular Function for CDK8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity TAS 7568034
GO:0004693 cyclin-dependent protein serine/threonine kinase activity IEA --
GO:0004713 protein tyrosine kinase activity --
GO:0005515 protein binding IPI 15546612
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with CDK8: view
genes like me logo Genes that share phenotypes with CDK8: view

Animal Model Products

CRISPR Products

miRNA for CDK8 Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CDK8

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for CDK8 Gene

Localization for CDK8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDK8 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDK8 Gene COMPARTMENTS Subcellular localization image for CDK8 gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CDK8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 16109376
GO:0005654 nucleoplasm TAS --
GO:0016592 mediator complex IDA 14638676
genes like me logo Genes that share ontologies with CDK8: view

Pathways for CDK8 Gene

SuperPathways for CDK8 Gene

Superpath Contained pathways
1 Loss of Function of SMAD2/3 in Cancer
2 Signaling by NOTCH1 PEST Domain Mutants in Cancer
3 Fatty acid, triacylglycerol, and ketone body metabolism
4 Metabolism
5 Gene Expression
genes like me logo Genes that share pathways with CDK8: view

Pathways by source for CDK8 Gene

1 Sino Biological pathway for CDK8 Gene
1 Cell Signaling Technology pathway for CDK8 Gene
1 BioSystems pathway for CDK8 Gene
1 GeneGo (Thomson Reuters) pathway for CDK8 Gene
1 R&D Systems pathway for CDK8 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for CDK8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated TAS --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0006468 protein phosphorylation IEA --
GO:0007179 transforming growth factor beta receptor signaling pathway TAS --
GO:0007219 Notch signaling pathway TAS --
genes like me logo Genes that share ontologies with CDK8: view

Compounds for CDK8 Gene

(3) HMDB Compounds for CDK8 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Magnesium
  • Magnesium
7439-95-4

(1) Drugbank Compounds for CDK8 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Flavopiridol
  • Alvocidib
131740-09-5 target

(1) Novoseek inferred chemical compound relationships for CDK8 Gene

Compound -log(P) Hits PubMed IDs
threonine 16.4 2
genes like me logo Genes that share compounds with CDK8: view

Transcripts for CDK8 Gene

Unigene Clusters for CDK8 Gene

Cyclin-dependent kinase 8:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CDK8

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDK8 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c
SP1:
SP2:
SP3: -

Relevant External Links for CDK8 Gene

GeneLoc Exon Structure for
CDK8
ECgene alternative splicing isoforms for
CDK8

Expression for CDK8 Gene

mRNA expression in normal human tissues for CDK8 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CDK8 Gene

SOURCE GeneReport for Unigene cluster for CDK8 Gene Hs.382306

genes like me logo Genes that share expressions with CDK8: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CDK8 Gene

Orthologs for CDK8 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CDK8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDK8 35
  • 99.71 (n)
  • 100 (a)
CDK8 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CDK8 35
  • 95.99 (n)
  • 99.5 (a)
CDK8 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CDK8 35
  • 97.05 (n)
  • 99.78 (a)
CDK8 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdk8 35
  • 93.97 (n)
  • 98.92 (a)
Cdk8 16
Cdk8 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CDK8 36
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDK8 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdk8 35
  • 93.68 (n)
  • 99.35 (a)
chicken
(Gallus gallus)
Aves CDK8 35
  • 91.72 (n)
  • 98.06 (a)
CDK8 36
  • 98 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDK8 36
  • 100 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdk8 35
  • 85.99 (n)
  • 97.41 (a)
MGC76204 35
zebrafish
(Danio rerio)
Actinopterygii cdk8 35
  • 79.96 (n)
  • 95.69 (a)
cdk8 36
  • 96 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009936 35
  • 71.04 (n)
  • 87.7 (a)
fruit fly
(Drosophila melanogaster)
Insecta Cdk8 35
  • 69.58 (n)
  • 85.25 (a)
Cdk8 36
  • 73 (a)
OneToMany
Cdk8 37
  • 84 (a)
worm
(Caenorhabditis elegans)
Secernentea cdk-8 35
  • 62.99 (n)
  • 63.36 (a)
cdk-8 36
  • 44 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SSN3 36
  • 28 (a)
OneToMany
SSN3 38
rice
(Oryza sativa)
Liliopsida Os.2989 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.10765 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 81 (a)
OneToMany
Species with no ortholog for CDK8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CDK8 Gene

ENSEMBL:
Gene Tree for CDK8 (if available)
TreeFam:
Gene Tree for CDK8 (if available)

Paralogs for CDK8 Gene

Paralogs for CDK8 Gene

Pseudogenes.org Pseudogenes for CDK8 Gene

genes like me logo Genes that share paralogs with CDK8: view

Variants for CDK8 Gene

Sequence variations from dbSNP and Humsavar for CDK8 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs478752 -- 26,310,125(-) tagat(G/T)gtggt intron-variant
rs543474 -- 26,268,752(-) AATAG(A/G)GAAAT intron-variant
rs559665 -- 26,293,006(+) TAGAA(A/C)GTATT intron-variant
rs566365 -- 26,309,944(-) acccc(A/G)tctct intron-variant
rs570541 -- 26,257,923(-) CTCTC(A/T)CACAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CDK8 Gene

Variant ID Type Subtype PubMed ID
esv268548 CNV Insertion 20981092

Relevant External Links for CDK8 Gene

HapMap Linkage Disequilibrium report
CDK8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDK8 Gene

Disorders for CDK8 Gene

(1) Novoseek inferred disease relationships for CDK8 Gene

Disease -log(P) Hits PubMed IDs
tumors 0 7

Relevant External Links for CDK8

Genetic Association Database (GAD)
CDK8
Human Genome Epidemiology (HuGE) Navigator
CDK8
genes like me logo Genes that share disorders with CDK8: view

No data available for UniProtKB/Swiss-Prot for CDK8 Gene

Publications for CDK8 Gene

  1. Identification of human cyclin-dependent kinase 8, a putative protein kinase partner for cyclin C. (PMID: 7568034) Tassan J.-P. … Nigg E.A. (Proc. Natl. Acad. Sci. U.S.A. 1995) 2 3 4 23
  2. Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover. (PMID: 15546612) Fryer C.J. … Jones K.A. (Mol. Cell 2004) 3 4 23
  3. Three RNA polymerase II carboxyl-terminal domain kinases display distinct substrate preferences. (PMID: 11278802) Ramanathan Y. … Pe'ery T. (J. Biol. Chem. 2001) 3 23
  4. Ras induces mediator complex exchange on C/EBP beta. (PMID: 14759369) Mo X. … Leutz A. (Mol. Cell 2004) 3 23
  5. Three cyclin-dependent kinases preferentially phosphorylate different parts of the C-terminal domain of the large subunit of RNA polymerase II. (PMID: 15009212) Pinhero R. … Yankulov K. (Eur. J. Biochem. 2004) 3 23

Products for CDK8 Gene

  • Addgene plasmids for CDK8

Sources for CDK8 Gene

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