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Aliases for AP3S2 Gene

Aliases for AP3S2 Gene

  • Adaptor-Related Protein Complex 3, Sigma 2 Subunit 2 3
  • Adaptor-Related Protein Complex 3 Subunit Sigma-2 3 4
  • AP-3 Complex Subunit Sigma-3B 3 4
  • Sigma-Adaptin 3b 3 4
  • Sigma-3B-Adaptin 3 4
  • Clathrin-Associated/Assembly/Adaptor Protein, Small 4, 22-KD 3
  • Adapter-Related Protein Complex 3 Subunit Sigma-2 3
  • AP-3 Complex Subunit Sigma-2 3
  • Adaptor Complex Sigma3B 3
  • Sigma3B-Adaptin 4
  • Sigma3b 3
  • AP3S3 3

External Ids for AP3S2 Gene

Summaries for AP3S2 Gene

GeneCards Summary for AP3S2 Gene

AP3S2 (Adaptor-Related Protein Complex 3, Sigma 2 Subunit) is a Protein Coding gene. Among its related pathways are Lysosome. GO annotations related to this gene include protein transporter activity. An important paralog of this gene is AP3S1.

UniProtKB/Swiss-Prot for AP3S2 Gene

  • Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals

Gene Wiki entry for AP3S2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AP3S2 Gene

Genomics for AP3S2 Gene

Genomic Location for AP3S2 Gene

Start:
89,830,599 bp from pter
End:
89,894,638 bp from pter
Size:
64,040 bases
Orientation:
Minus strand

Genomic View for AP3S2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AP3S2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AP3S2 Gene

Regulatory Elements for AP3S2 Gene

Proteins for AP3S2 Gene

  • Protein details for AP3S2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P59780-AP3S2_HUMAN
    Recommended name:
    AP-3 complex subunit sigma-2
    Protein Accession:
    P59780
    Secondary Accessions:
    • B2R677
    • B4DGQ3
    • O09077
    • O09149
    • Q53H83
    • Q99589

    Protein attributes for AP3S2 Gene

    Size:
    193 amino acids
    Molecular mass:
    22017 Da
    Quaternary structure:
    • Adaptor protein complex 3 (AP-3) is a heterotetramer composed of two large adaptins (delta-type subunit AP3D1 and beta-type subunit AP3B1 or AP3B2), a medium adaptin (mu-type subunit AP3M1 or AP3M2) and a small adaptin (sigma-type subunit APS1 or AP3S2). Interacts with AGAP1. AP-3 associates with the BLOC-1 complex (By similarity).

    Alternative splice isoforms for AP3S2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AP3S2 Gene

Proteomics data for AP3S2 Gene at MOPED

Post-translational modifications for AP3S2 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys166

No data available for DME Specific Peptides for AP3S2 Gene

Domains for AP3S2 Gene

UniProtKB/Swiss-Prot:

AP3S2_HUMAN
Family:
  • Belongs to the adaptor complexes small subunit family.:
    • P59780
genes like me logo Genes that share domains with AP3S2: view

No data available for Gene Families for AP3S2 Gene

Function for AP3S2 Gene

Molecular function for AP3S2 Gene

UniProtKB/Swiss-Prot Function: Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals

Gene Ontology (GO) - Molecular Function for AP3S2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008565 protein transporter activity IEA --
genes like me logo Genes that share ontologies with AP3S2: view

Phenotypes for AP3S2 Gene

GenomeRNAi human phenotypes for AP3S2:
genes like me logo Genes that share phenotypes with AP3S2: view

miRNA for AP3S2 Gene

miRTarBase miRNAs that target AP3S2

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for AP3S2 Gene

Localization for AP3S2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AP3S2 Gene

Golgi apparatus. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AP3S2 Gene COMPARTMENTS Subcellular localization image for AP3S2 gene
Compartment Confidence
golgi apparatus 5
cytosol 3
mitochondrion 2
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for AP3S2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane --
GO:0030117 membrane coat --
GO:0030123 AP-3 adaptor complex IDA 9118953
GO:0030659 cytoplasmic vesicle membrane IEA --
genes like me logo Genes that share ontologies with AP3S2: view

Pathways for AP3S2 Gene

SuperPathways for AP3S2 Gene

Superpath Contained pathways
1 Lysosome
genes like me logo Genes that share pathways with AP3S2: view

Pathways by source for AP3S2 Gene

1 KEGG pathway for AP3S2 Gene

Gene Ontology (GO) - Biological Process for AP3S2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport --
GO:0006886 intracellular protein transport IEA --
GO:0008089 anterograde axon cargo transport ISS --
GO:0015031 protein transport --
GO:0016192 vesicle-mediated transport --
genes like me logo Genes that share ontologies with AP3S2: view

Transcripts for AP3S2 Gene

Unigene Clusters for AP3S2 Gene

Adaptor-related protein complex 3, sigma 2 subunit:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AP3S2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c · 13d · 13e · 13f
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - - -
SP4: - - - - - - - -
SP5: - -
SP6: - - - -
SP7: - - -
SP8: -
SP9:

Relevant External Links for AP3S2 Gene

GeneLoc Exon Structure for
AP3S2
ECgene alternative splicing isoforms for
AP3S2

Expression for AP3S2 Gene

mRNA expression in normal human tissues for AP3S2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for AP3S2 Gene

SOURCE GeneReport for Unigene cluster for AP3S2 Gene Hs.632161

mRNA Expression by UniProt/SwissProt for AP3S2 Gene

P59780-AP3S2_HUMAN
Tissue specificity: Present in all adult tissues examined.
genes like me logo Genes that share expressions with AP3S2: view

Orthologs for AP3S2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for AP3S2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AP3S2 36
  • 99.31 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia AP3S2 36
  • 93.44 (n)
  • 99.48 (a)
AP3S2 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AP3S2 36
  • 93.78 (n)
  • 100 (a)
AP3S2 37
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ap3s2 36
  • 91.02 (n)
  • 100 (a)
Ap3s2 16
Ap3s2 37
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia AP3S2 37
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ap3s2 36
  • 93.44 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves AP3S2 37
  • 70 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.4289 36
tropical clawed frog
(Silurana tropicalis)
Amphibia ap3s2 36
  • 77.72 (n)
  • 86.01 (a)
Str.1103 36
zebrafish
(Danio rerio)
Actinopterygii ap3s2 36
  • 77.95 (n)
  • 91.15 (a)
ap3s2 37
  • 91 (a)
OneToOne
Dr.18325 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007522 36
  • 70.02 (n)
  • 76.72 (a)
fruit fly
(Drosophila melanogaster)
Insecta or 36
  • 70.15 (n)
  • 78.57 (a)
or 37
  • 75 (a)
OneToOne
or 38
  • 78 (a)
worm
(Caenorhabditis elegans)
Secernentea aps-3 36
  • 66.49 (n)
  • 75.27 (a)
aps-3 37
  • 73 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes APS3 37
  • 36 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G50860 36
  • 55.69 (n)
  • 50 (a)
rice
(Oryza sativa)
Liliopsida Os03g0228400 36
  • 52.87 (n)
  • 50.96 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9680 37
  • 76 (a)
OneToOne
Species with no ortholog for AP3S2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for AP3S2 Gene

ENSEMBL:
Gene Tree for AP3S2 (if available)
TreeFam:
Gene Tree for AP3S2 (if available)

Paralogs for AP3S2 Gene

Paralogs for AP3S2 Gene

genes like me logo Genes that share paralogs with AP3S2: view

Variants for AP3S2 Gene

Structural Variations from Database of Genomic Variants (DGV) for AP3S2 Gene

Variant ID Type Subtype PubMed ID
nsv1661 CNV Insertion 18451855
esv2667255 CNV Deletion 23128226
esv1678655 CNV Deletion 17803354
esv2750010 CNV Deletion 23290073

Relevant External Links for AP3S2 Gene

HapMap Linkage Disequilibrium report
AP3S2

No data available for Sequence variations from dbSNP and Humsavar for AP3S2 Gene

Disorders for AP3S2 Gene

Relevant External Links for AP3S2

Genetic Association Database (GAD)
AP3S2
Human Genome Epidemiology (HuGE) Navigator
AP3S2
genes like me logo Genes that share disorders with AP3S2: view

No data available for UniProtKB/Swiss-Prot for AP3S2 Gene

Publications for AP3S2 Gene

  1. AP-3: an adaptor-like protein complex with ubiquitous expression. (PMID: 9118953) Dell'Angelica E.C. … Bonifacino J.S. (EMBO J. 1997) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci. (PMID: 21874001) Kooner J.S. … Chambers J.C. (Nat. Genet. 2011) 3 49
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. Genomewide linkage and peakwide association analyses of carotid plaque in Caribbean Hispanics. (PMID: 20966410) Dong C. … Sacco R.L. (Stroke 2010) 3 49

Products for AP3S2 Gene

Sources for AP3S2 Gene

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