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Aliases for MSLN Gene

Aliases for MSLN Gene

  • Mesothelin 2 3 5
  • Pre-Pro-Megakaryocyte-Potentiating Factor 3 4
  • CAK1 Antigen 3 4
  • MPF 3 4
  • Soluble MPF Mesothelin Related Protein 3
  • Megakaryocyte Potentiating Factor 3
  • SMRP 3

External Ids for MSLN Gene

Previous GeneCards Identifiers for MSLN Gene

  • GC16P000829
  • GC16P000750
  • GC16P000751
  • GC16P000811
  • GC16P000732
  • GC16P000810
  • GC16P000697
  • GC16P000702
  • GC16P000724
  • GC16P000774
  • GC16P000791
  • GC16P000839

Summaries for MSLN Gene

Entrez Gene Summary for MSLN Gene

  • This gene encodes a preproprotein that is proteolytically processed to generate two protein products, megakaryocyte potentiating factor and mesothelin. Megakaryocyte potentiating factor functions as a cytokine that can stimulate colony formation of bone marrow megakaryocytes. Mesothelin is a glycosylphosphatidylinositol-anchored cell-surface protein that may function as a cell adhesion protein. This protein is overexpressed in epithelial mesotheliomas, ovarian cancers and in specific squamous cell carcinomas. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]

GeneCards Summary for MSLN Gene

MSLN (Mesothelin) is a Protein Coding gene. Diseases associated with MSLN include Ovarian Cancer and Malignant Pleural Mesothelioma. Among its related pathways are Adhesion. An important paralog of this gene is MSLNL.

UniProtKB/Swiss-Prot for MSLN Gene

  • Membrane-anchored forms may play a role in cellular adhesion.

  • Megakaryocyte-potentiating factor (MPF) potentiates megakaryocyte colony formation in vitro.

Gene Wiki entry for MSLN Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MSLN Gene

Genomics for MSLN Gene

Regulatory Elements for MSLN Gene

Enhancers for MSLN Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MSLN on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the MSLN gene promoter:

Genomic Location for MSLN Gene

643,262 bp from pter
768,865 bp from pter
125,604 bases
Plus strand

Genomic View for MSLN Gene

Genes around MSLN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MSLN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MSLN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MSLN Gene

Proteins for MSLN Gene

  • Protein details for MSLN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • D3DU65
    • Q14859
    • Q4VQD5
    • Q96GR6
    • Q96KJ5
    • Q9BR17
    • Q9BTR2
    • Q9UCB2
    • Q9UK57

    Protein attributes for MSLN Gene

    630 amino acids
    Molecular mass:
    68986 Da
    Quaternary structure:
    • Interacts with MUC16.

    Three dimensional structures from OCA and Proteopedia for MSLN Gene

    Alternative splice isoforms for MSLN Gene


neXtProt entry for MSLN Gene

Proteomics data for MSLN Gene at MOPED

Post-translational modifications for MSLN Gene

  • Both MPF and the cleaved form of mesothelin are N-glycosylated.
  • Proteolytically cleaved by a furin-like convertase to generate megakaryocyte-potentiating factor (MPF), and the cleaved form of mesothelin.
  • Glycosylation at Asn 57, Asn 388, Asn 496, and Asn 523
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for MSLN Gene

Domains & Families for MSLN Gene

Protein Domains for MSLN Gene


Suggested Antigen Peptide Sequences for MSLN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the mesothelin family.
  • Belongs to the mesothelin family.
genes like me logo Genes that share domains with MSLN: view

No data available for Gene Families for MSLN Gene

Function for MSLN Gene

Molecular function for MSLN Gene

GENATLAS Biochemistry:
Mesothelin,megakaryocyte potentiating factor. Expressed by mesothelial,detectable in sera from patients with ovarian carcinoma. Putatively involved in cell adhesion
UniProtKB/Swiss-Prot Function:
Membrane-anchored forms may play a role in cellular adhesion.
UniProtKB/Swiss-Prot Function:
Megakaryocyte-potentiating factor (MPF) potentiates megakaryocyte colony formation in vitro.
genes like me logo Genes that share phenotypes with MSLN: view

Animal Models for MSLN Gene

MGI Knock Outs for MSLN:

Animal Model Products

miRNA for MSLN Gene

miRTarBase miRNAs that target MSLN

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MSLN Gene

Localization for MSLN Gene

Subcellular locations from UniProtKB/Swiss-Prot for MSLN Gene

Cell membrane; Lipid-anchor, GPI-anchor. Golgi apparatus.
Megakaryocyte-potentiating factor: Secreted.
Isoform 3: Secreted.

Subcellular locations from

Jensen Localization Image for MSLN Gene COMPARTMENTS Subcellular localization image for MSLN gene
Compartment Confidence
extracellular 5
golgi apparatus 5
plasma membrane 5
cytoskeleton 1
endoplasmic reticulum 1
lysosome 1
nucleus 1
vacuole 1

Gene Ontology (GO) - Cellular Components for MSLN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0009986 cell surface IBA --
GO:0016020 membrane NAS 8552591
genes like me logo Genes that share ontologies with MSLN: view

Pathways & Interactions for MSLN Gene

SuperPathways for MSLN Gene

Superpath Contained pathways
1 Adhesion
genes like me logo Genes that share pathways with MSLN: view

Pathways by source for MSLN Gene

1 Cell Signaling Technology pathway for MSLN Gene

Gene Ontology (GO) - Biological Process for MSLN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007160 cell-matrix adhesion IBA --
genes like me logo Genes that share ontologies with MSLN: view

No data available for SIGNOR curated interactions for MSLN Gene

Drugs & Compounds for MSLN Gene

(4) Drugs for MSLN Gene - From: DGIdb and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
SS1(DSFV)-PE38 Pharma 0

(4) Additional Compounds for MSLN Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MSLN: view

Transcripts for MSLN Gene

Unigene Clusters for MSLN Gene

Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MSLN Gene

No ASD Table

Relevant External Links for MSLN Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MSLN Gene

mRNA expression in normal human tissues for MSLN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MSLN Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x16.4), Lung (x12.1), and Fallopian Tube (x5.2).

Protein differential expression in normal tissues from HIPED for MSLN Gene

This gene is overexpressed in Amniocyte (20.6), Cervix (15.8), Testis (15.1), and Ovary (14.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MSLN Gene

SOURCE GeneReport for Unigene cluster for MSLN Gene Hs.408488

mRNA Expression by UniProt/SwissProt for MSLN Gene

Tissue specificity: Expressed in lung. Expressed at low levels in heart, placenta and kidney. Expressed in mesothelial cells. Highly expressed in mesotheliomas, ovarian cancers, and some squamous cell carcinomas (at protein level).
genes like me logo Genes that share expression patterns with MSLN: view

Primer Products

No data available for Protein tissue co-expression partners for MSLN Gene

Orthologs for MSLN Gene

This gene was present in the common ancestor of chordates.

Orthologs for MSLN Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MSLN 35
  • 74.46 (n)
  • 63.74 (a)
  • 56 (a)
(Canis familiaris)
Mammalia MSLN 35
  • 76.78 (n)
  • 66.76 (a)
  • 69 (a)
(Mus musculus)
Mammalia Msln 35
  • 70.96 (n)
  • 58.91 (a)
Msln 16
Msln 36
  • 57 (a)
(Pan troglodytes)
Mammalia MSLN 35
  • 97.26 (n)
  • 95.56 (a)
  • 97 (a)
(Rattus norvegicus)
Mammalia Msln 35
  • 71.23 (n)
  • 58.91 (a)
(Monodelphis domestica)
Mammalia MSLN 36
  • 21 (a)
(Gallus gallus)
Aves MSLN 35
  • 48.6 (n)
  • 39.63 (a)
  • 34 (a)
(Anolis carolinensis)
Reptilia MSLN 36
  • 37 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101733400 35
  • 40.69 (n)
  • 29.2 (a)
(Danio rerio)
Actinopterygii MSLN (1 of 2) 36
  • 6 (a)
MSLN (2 of 2) 36
  • 22 (a)
Species with no ortholog for MSLN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MSLN Gene

Gene Tree for MSLN (if available)
Gene Tree for MSLN (if available)

Paralogs for MSLN Gene

Paralogs for MSLN Gene

genes like me logo Genes that share paralogs with MSLN: view

Variants for MSLN Gene

Sequence variations from dbSNP and Humsavar for MSLN Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs9927389 - 764,058(+) GTGTG(C/T)GGAGG reference, missense
rs17850474 - 766,089(+) GGCCC(A/C/G)CGAGA reference, missense
VAR_028383 -
rs35935235 - 766,977(-) CGGAC(C/T)CGTTC reference, missense
rs8062940 -- 765,202(+) TCGGC(C/T)GAAGT reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for MSLN Gene

Variant ID Type Subtype PubMed ID
esv2422427 CNV Duplication 17116639
nsv526903 CNV Loss 19592680
dgv2475n71 CNV Loss 21882294
nsv471063 CNV Loss 18288195
dgv2485n71 CNV Loss 21882294
nsv9321 CNV Gain+Loss 18304495
nsv904796 CNV Loss 21882294
nsv904797 CNV Loss 21882294
nsv457311 CNV Loss 19166990
nsv1702 CNV Insertion 18451855
dgv2498n71 CNV Loss 21882294
dgv2499n71 CNV Loss 21882294
dgv2500n71 CNV Loss 21882294
nsv457312 CNV Loss 19166990
nsv517488 CNV Loss 19592680
esv27245 CNV Gain+Loss 19812545

Variation tolerance for MSLN Gene

Residual Variation Intolerance Score: 99.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.39; 71.07% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for MSLN Gene

Disorders for MSLN Gene

MalaCards: The human disease database

(14) MalaCards diseases for MSLN Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
ovarian cancer
  • malignant ovarian tumor
malignant pleural mesothelioma
  • malignant mesothelioma of pleura
pancreatic cancer
  • pancreatic carcinoma, somatic
mesothelioma, somatic
  • malignant mesothelioma
triple-receptor negative breast cancer
- elite association - COSMIC cancer census association via MalaCards
Search MSLN in MalaCards View complete list of genes associated with diseases


  • Note=Antibodies against MSLN are detected in patients with mesothelioma and ovarian cancer. {ECO:0000269 PubMed:15897581}.

Relevant External Links for MSLN

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with MSLN: view

No data available for Genatlas for MSLN Gene

Publications for MSLN Gene

  1. Molecular cloning of mesothelin, a differentiation antigen present on mesothelium, mesotheliomas, and ovarian cancers. (PMID: 8552591) Chang K. … Pastan I. (Proc. Natl. Acad. Sci. U.S.A. 1996) 2 3 4 23 67
  2. Mesothelin gene expression and promoter methylation/hypomethylation in gynecological tumors. (PMID: 20349783) Obulhasim G. … Hino O. (Eur. J. Gynaecol. Oncol. 2010) 3 23
  3. A binding domain on mesothelin for CA125/MUC16. (PMID: 19075018) Kaneko O. … Ho M. (J. Biol. Chem. 2009) 3 23
  4. High mesothelin correlates with chemoresistance and poor survival in epithelial ovarian carcinoma. (PMID: 19293794) Cheng W.F. … Chen C.A. (Br. J. Cancer 2009) 3 23
  5. Mesothelin inhibits paclitaxel-induced apoptosis through the PI3K pathway. (PMID: 19747165) Chang M.C. … Cheng W.F. (Biochem. J. 2009) 3 23

Products for MSLN Gene

Sources for MSLN Gene