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Aliases for STX6 Gene

Aliases for STX6 Gene

  • Syntaxin 6 2 3 5
  • Syntaxin-6 3

External Ids for STX6 Gene

Previous GeneCards Identifiers for STX6 Gene

  • GC01M178439
  • GC01M176341
  • GC01M177433
  • GC01M178152
  • GC01M178177
  • GC01M177644
  • GC01M179179
  • GC01M179208
  • GC01M180941
  • GC01M152173
  • GC01M180972

Summaries for STX6 Gene

GeneCards Summary for STX6 Gene

STX6 (Syntaxin 6) is a Protein Coding gene. Among its related pathways are Intra-Golgi traffic and Vesicle-mediated transport. GO annotations related to this gene include syntaxin binding and SNAP receptor activity. An important paralog of this gene is STX10.

UniProtKB/Swiss-Prot for STX6 Gene

  • Involved in intracellular vesicle trafficking.

Gene Wiki entry for STX6 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STX6 Gene

Genomics for STX6 Gene

Regulatory Elements for STX6 Gene

Enhancers for STX6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G181086 2.1 FANTOM5 Ensembl ENCODE dbSUPER 3.2 -69.4 -69442 11.6 MLX CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 IER5 MR1 ACBD6 KIAA1614 LHX4 STX6 GC01M181092 GC01M181116
GH01G181139 2 FANTOM5 Ensembl ENCODE dbSUPER 3.1 -118.1 -118079 4.0 HDGF PKNOX1 FOXA2 ARID4B SIN3A DMAP1 ZNF2 SLC30A9 ZNF143 FOS IER5 STX6 MR1 GC01M181116 LINC01732
GH01G181132 2.1 FANTOM5 Ensembl ENCODE dbSUPER 1.7 -111.8 -111795 4.4 DMAP1 YBX1 ZNF548 ZNF263 SP3 TBX21 ZFP41 MEF2D ZNF585B GLIS1 LHX4 IER5 ACBD6 KIAA1614 MR1 STX6 GC01M181116 LINC01732
GH01G181159 1.6 FANTOM5 Ensembl ENCODE 1.6 -137.5 -137473 3.2 HDGF PKNOX1 ARNT FOS ZNF548 MCM5 JUNB REST TBX21 MEF2D IER5 MR1 ACBD6 KIAA1614 STX6 LINC01732 GC01M181116
GH01G181020 1.1 ENCODE 0.7 +0.6 625 3.1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B YY1 ZNF766 ZNF143 ACBD6 LHX4 KIAA1614 STX6 ENSG00000243155
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around STX6 on UCSC Golden Path with GeneCards custom track

Promoters for STX6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000016603 721 2001 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B YY1 ZNF766 ZNF143

Genomic Location for STX6 Gene

Chromosome:
1
Start:
180,949,690 bp from pter
End:
181,023,121 bp from pter
Size:
73,432 bases
Orientation:
Minus strand

Genomic View for STX6 Gene

Genes around STX6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STX6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STX6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STX6 Gene

Proteins for STX6 Gene

  • Protein details for STX6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43752-STX6_HUMAN
    Recommended name:
    Syntaxin-6
    Protein Accession:
    O43752
    Secondary Accessions:
    • B2R652
    • B4DR17
    • Q5VY08
    • Q6FH83

    Protein attributes for STX6 Gene

    Size:
    255 amino acids
    Molecular mass:
    29176 Da
    Quaternary structure:
    • Binds EEA1. Interacts with VPS45A. Interacts with MARCH2 and MARCH3 (By similarity). Interacts with GOPC. Identified in a complex containing STX6, STX12, VAMP4 and VTI1A.

    Three dimensional structures from OCA and Proteopedia for STX6 Gene

    Alternative splice isoforms for STX6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STX6 Gene

Post-translational modifications for STX6 Gene

  • Ubiquitination at isoforms=77 and Lys139
  • Modification sites at PhosphoSitePlus

Other Protein References for STX6 Gene

No data available for DME Specific Peptides for STX6 Gene

Domains & Families for STX6 Gene

Gene Families for STX6 Gene

Protein Domains for STX6 Gene

Suggested Antigen Peptide Sequences for STX6 Gene

Graphical View of Domain Structure for InterPro Entry

O43752

UniProtKB/Swiss-Prot:

STX6_HUMAN :
  • Belongs to the syntaxin family.
Family:
  • Belongs to the syntaxin family.
genes like me logo Genes that share domains with STX6: view

Function for STX6 Gene

Molecular function for STX6 Gene

UniProtKB/Swiss-Prot Function:
Involved in intracellular vesicle trafficking.

Gene Ontology (GO) - Molecular Function for STX6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005484 SNAP receptor activity IBA --
GO:0005515 protein binding IPI 11384996
GO:0019905 syntaxin binding IPI 16154903
genes like me logo Genes that share ontologies with STX6: view
genes like me logo Genes that share phenotypes with STX6: view

Animal Model Products

CRISPR Products

miRNA for STX6 Gene

miRTarBase miRNAs that target STX6

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for STX6
  • Applied Biological Materials Clones for STX6

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for STX6 Gene

Localization for STX6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STX6 Gene

Golgi apparatus membrane; Single-pass type IV membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STX6 gene
Compartment Confidence
plasma membrane 5
nucleus 5
cytosol 5
golgi apparatus 5
endosome 5
cytoskeleton 2
lysosome 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for STX6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005654 nucleoplasm IDA --
GO:0005769 early endosome IDA 10506127
GO:0005794 Golgi apparatus IEA,IDA 19224922
GO:0005802 trans-Golgi network IDA 16154903
genes like me logo Genes that share ontologies with STX6: view

Pathways & Interactions for STX6 Gene

genes like me logo Genes that share pathways with STX6: view

Gene Ontology (GO) - Biological Process for STX6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006886 intracellular protein transport IBA --
GO:0006906 vesicle fusion IPI 10506127
GO:0007032 endosome organization IEA --
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with STX6: view

No data available for SIGNOR curated interactions for STX6 Gene

Drugs & Compounds for STX6 Gene

(3) Drugs for STX6 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for STX6 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with STX6: view

Transcripts for STX6 Gene

Unigene Clusters for STX6 Gene

Syntaxin 6:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for STX6
  • Applied Biological Materials Clones for STX6

Alternative Splicing Database (ASD) splice patterns (SP) for STX6 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11
SP1: - -
SP2: -
SP3:
SP4: - - - -
SP5:

Relevant External Links for STX6 Gene

GeneLoc Exon Structure for
STX6
ECgene alternative splicing isoforms for
STX6

Expression for STX6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for STX6 Gene

Protein differential expression in normal tissues from HIPED for STX6 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (32.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for STX6 Gene



Protein tissue co-expression partners for STX6 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of STX6 Gene:

STX6

SOURCE GeneReport for Unigene cluster for STX6 Gene:

Hs.518417

Evidence on tissue expression from TISSUES for STX6 Gene

  • Nervous system(4.8)
  • Muscle(4.2)
genes like me logo Genes that share expression patterns with STX6: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for STX6 Gene

Orthologs for STX6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for STX6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STX6 34 35
  • 99.87 (n)
dog
(Canis familiaris)
Mammalia -- 35
  • 93 (a)
OneToMany
STX6 34
  • 92.61 (n)
-- 35
  • 74 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia STX6 35
  • 93 (a)
OneToOne
cow
(Bos Taurus)
Mammalia STX6 34 35
  • 92.61 (n)
mouse
(Mus musculus)
Mammalia Stx6 34 16 35
  • 91.07 (n)
rat
(Rattus norvegicus)
Mammalia Stx6 34
  • 90.52 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia STX6 35
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves STX6 34 35
  • 82.14 (n)
lizard
(Anolis carolinensis)
Reptilia STX6 35
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia stx6 34
  • 73 (n)
Str.15502 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.2793 34
zebrafish
(Danio rerio)
Actinopterygii stx6 34 35
  • 70.31 (n)
Dr.11734 34
fruit fly
(Drosophila melanogaster)
Insecta Syx6 34 35
  • 57.65 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006251 34
  • 54.61 (n)
worm
(Caenorhabditis elegans)
Secernentea syx-6 35
  • 36 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons SYP61 34
  • 45.48 (n)
rice
(Oryza sativa)
Liliopsida Os01g0963300 34
  • 48.55 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7279 35
  • 48 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU01199 34
  • 45.8 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes tlg1 34
  • 42.18 (n)
Species where no ortholog for STX6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STX6 Gene

ENSEMBL:
Gene Tree for STX6 (if available)
TreeFam:
Gene Tree for STX6 (if available)

Paralogs for STX6 Gene

Paralogs for STX6 Gene

(1) SIMAP similar genes for STX6 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with STX6: view

Variants for STX6 Gene

Sequence variations from dbSNP and Humsavar for STX6 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000038024 -- 181,009,882(+) GAATA(C/G)TATTC intron-variant
rs1000083084 -- 180,963,614(+) GTCAC(C/T)TTCCA intron-variant
rs1000088599 -- 181,010,077(+) TGGGG(A/G)AAGGA intron-variant
rs1000099315 -- 180,963,823(+) TCGCT(C/T)TGACC intron-variant
rs1000144255 -- 180,967,146(+) GCTGA(A/G)GGGTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STX6 Gene

Variant ID Type Subtype PubMed ID
esv2719940 CNV deletion 23290073
esv2719951 CNV deletion 23290073
esv2719962 CNV deletion 23290073
esv3359336 CNV duplication 20981092
esv3890804 CNV gain 25118596
nsv1122427 CNV deletion 24896259

Variation tolerance for STX6 Gene

Residual Variation Intolerance Score: 55.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.72; 15.37% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for STX6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
STX6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STX6 Gene

Disorders for STX6 Gene

Relevant External Links for STX6

Genetic Association Database (GAD)
STX6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
STX6

No disorders were found for STX6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STX6 Gene

Publications for STX6 Gene

  1. Co-expression of several human syntaxin genes in neutrophils and differentiating HL-60 cells: variant isoforms and detection of syntaxin 1. (PMID: 10080545) Martin-Martin B. … Mollinedo F. (J. Leukoc. Biol. 1999) 2 3 4 64
  2. Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy. (PMID: 21685912) HAPglinger G.U. … Schellenberg G.D. (Nat. Genet. 2011) 3 46 64
  3. Syntaxin 6 and CAL mediate the degradation of the cystic fibrosis transmembrane conductance regulator. (PMID: 20130090) Cheng J. … Guggino W.B. (Mol. Biol. Cell 2010) 3 22 64
  4. Dual roles of the mammalian GARP complex in tethering and SNARE complex assembly at the trans-golgi network. (PMID: 19620288) PAcrez-Victoria F.J. … Bonifacino J.S. (Mol. Cell. Biol. 2009) 3 22 64
  5. Syntaxin 6, a regulator of the protein trafficking machinery and a target of the p53 family, is required for cell adhesion and survival. (PMID: 18779328) Zhang Y. … Chen X. (J. Biol. Chem. 2008) 3 22 64

Products for STX6 Gene

  • Addgene plasmids for STX6

Sources for STX6 Gene

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