Aliases for PLIN3 Gene
External Ids for PLIN3 Gene
Previous HGNC Symbols for PLIN3 Gene
Previous GeneCards Identifiers for PLIN3 Gene
Mannose 6-phophate receptors (MPRs) deliver lysosomal hydrolase from the Golgi to endosomes and then return to the Golgi complex. The protein encoded by this gene interacts with the cytoplasmic domains of both cation-independent and cation-dependent MPRs, and is required for endosome-to-Golgi transport. This protein also binds directly to the GTPase RAB9 (RAB9A), a member of the RAS oncogene family. The interaction with RAB9 has been shown to increase the affinity of this protein for its cargo. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2009]
GeneCards Summary for PLIN3 Gene
PLIN3 (Perilipin 3) is a Protein Coding gene. Among its related pathways are Cholesterol and Sphingolipids transport / Distribution to the intracellular membrane compartments (normal and CF) and Vesicle-mediated transport. An important paralog of this gene is PLIN2.
UniProtKB/Swiss-Prot for PLIN3 Gene
Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network.