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Aliases for TRIB1 Gene

Aliases for TRIB1 Gene

  • Tribbles Pseudokinase 1 2 3 5
  • G-Protein-Coupled Receptor-Induced Gene 2 Protein 3 4
  • GIG-2 3 4
  • SKIP1 3 4
  • TRB-1 3 4
  • TRB1 3 4
  • C8FW 3 4
  • GIG2 3 4
  • Phosphoprotein Regulated By Mitogenic Pathways 3
  • G-Protein-Coupled Receptor-Induced Protein 2 3
  • G-Protein-Coupled Receptor Induced Protein 3
  • Tribbles Homolog 1 (Drosophila) 2
  • Tribbles-Like Protein 1 3
  • Tribbles Homolog 1 3

External Ids for TRIB1 Gene

Previous GeneCards Identifiers for TRIB1 Gene

  • GC08P126400
  • GC08P126511
  • GC08P121766
  • GC08P126442

Summaries for TRIB1 Gene

GeneCards Summary for TRIB1 Gene

TRIB1 (Tribbles Pseudokinase 1) is a Protein Coding gene. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and transcription factor binding. An important paralog of this gene is TRIB2.

UniProtKB/Swiss-Prot for TRIB1 Gene

  • Adapter protein involved in protein degradation by interacting with RFWD2/COP1 ubiquitin ligase (PubMed:27041596). The RFWD2-binding motif is masked by autoinhibitory interactions with the protein kinase domain (PubMed:26455797). Serves to alter RFWD2 substrate specificity by directing the activity of RFWD2 toward CEBPA (PubMed:27041596). Binds selectively the recognition sequence of CEBPA (PubMed:26455797). Regulates myeloid cell differentiation by altering the expression of CEBPA in a RFWD2-dependent manner (By similarity). Controls macrophage, eosinophil and neutrophil differentiation via the COP1-binding domain (By similarity). Interacts with MAPK kinases and regulates activation of MAP kinases, but has no kinase activity (PubMed:15299019, PubMed:26455797).

Gene Wiki entry for TRIB1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIB1 Gene

Genomics for TRIB1 Gene

Regulatory Elements for TRIB1 Gene

Enhancers for TRIB1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08G125428 1.8 FANTOM5 ENCODE dbSUPER 40.1 +2.3 2302 8.3 MLX CREB3L1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC TRIB1 NSMCE2 WASHC5 GC08P125444
GH08G125524 1.6 FANTOM5 Ensembl ENCODE 31.8 +97.0 96958 4.8 PKNOX1 FOXA2 MLX ARID4B YY1 SLC30A9 ZNF766 FOS DEK REST TRIB1 NSMCE2 WASHC5 GC08P125497 LOC105375746
GH08G125232 1.8 FANTOM5 Ensembl ENCODE dbSUPER 27.6 -197.8 -197757 1.5 FOXA2 ARID4B SIN3A BRCA1 FOS KAT8 SREBF1 MIER3 MAFF RCOR2 TRIB1 LINC00964 ENSG00000253106 RNF139-AS1 WASHC5 NSMCE2 RN7SL329P
GH08G125270 2 FANTOM5 Ensembl ENCODE dbSUPER 23.9 -157.7 -157721 4.3 PKNOX1 ARNT FEZF1 CBX5 FOS ZNF263 JUNB TBX21 ZNF592 ZNF585B TRIB1 ENSG00000254431 TRMT12 ENSG00000253106 RNF139-AS1 WASHC5-AS1 NSMCE2 WASHC5 RN7SL329P
GH08G125340 1.5 FANTOM5 Ensembl ENCODE 29.9 -88.0 -87995 2.9 HDAC1 ELF3 HDGF FOXA2 SIN3A EGR1 FOS RELB IKZF2 CEBPB TRIB1 NSMCE2 WASHC5 ENSG00000254431 RN7SL329P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TRIB1 on UCSC Golden Path with GeneCards custom track

Promoters for TRIB1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000230315 879 4001 MLX CREB3L1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 MEF2D

Genomic Location for TRIB1 Gene

Chromosome:
8
Start:
125,430,321 bp from pter
End:
125,438,405 bp from pter
Size:
8,085 bases
Orientation:
Plus strand

Genomic View for TRIB1 Gene

Genes around TRIB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIB1 Gene

Proteins for TRIB1 Gene

  • Protein details for TRIB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96RU8-TRIB1_HUMAN
    Recommended name:
    Tribbles homolog 1
    Protein Accession:
    Q96RU8
    Secondary Accessions:
    • B4DMM6
    • C5HU08
    • O15180
    • Q9H2Y8

    Protein attributes for TRIB1 Gene

    Size:
    372 amino acids
    Molecular mass:
    41009 Da
    Quaternary structure:
    • Monomer (PubMed:26455797). Interacts (via protein kinase domain) with CEBPA (PubMed:20410507, PubMed:26455797). Interacts with RFWD2 (PubMed:20410507, PubMed:27041596).

    Three dimensional structures from OCA and Proteopedia for TRIB1 Gene

    Alternative splice isoforms for TRIB1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRIB1 Gene

Post-translational modifications for TRIB1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TRIB1 Gene

Antibody Products

  • Abcam antibodies for TRIB1
  • Santa Cruz Biotechnology (SCBT) Antibodies for TRIB1

No data available for DME Specific Peptides for TRIB1 Gene

Domains & Families for TRIB1 Gene

Gene Families for TRIB1 Gene

Protein Domains for TRIB1 Gene

Suggested Antigen Peptide Sequences for TRIB1 Gene

Graphical View of Domain Structure for InterPro Entry

Q96RU8

UniProtKB/Swiss-Prot:

TRIB1_HUMAN :
  • The protein kinase active site is incompatible with ATP binding and is inactive (PubMed:26455797).
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Tribbles subfamily.
Domain:
  • The protein kinase active site is incompatible with ATP binding and is inactive (PubMed:26455797).
  • The C-terminus (351-372) is required for interaction with COP1 (PubMed:27041596).
  • The COP1-binding motif (355-360) is required for regulation activity (By similarity).
Family:
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Tribbles subfamily.
genes like me logo Genes that share domains with TRIB1: view

Function for TRIB1 Gene

Molecular function for TRIB1 Gene

UniProtKB/Swiss-Prot Function:
Adapter protein involved in protein degradation by interacting with RFWD2/COP1 ubiquitin ligase (PubMed:27041596). The RFWD2-binding motif is masked by autoinhibitory interactions with the protein kinase domain (PubMed:26455797). Serves to alter RFWD2 substrate specificity by directing the activity of RFWD2 toward CEBPA (PubMed:27041596). Binds selectively the recognition sequence of CEBPA (PubMed:26455797). Regulates myeloid cell differentiation by altering the expression of CEBPA in a RFWD2-dependent manner (By similarity). Controls macrophage, eosinophil and neutrophil differentiation via the COP1-binding domain (By similarity). Interacts with MAPK kinases and regulates activation of MAP kinases, but has no kinase activity (PubMed:15299019, PubMed:26455797).

Gene Ontology (GO) - Molecular Function for TRIB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 NOT protein kinase activity TAS 20410507
GO:0004860 protein kinase inhibitor activity IMP 15299019
GO:0005515 protein binding IPI 25852190
GO:0005524 NOT ATP binding IEA,TAS 20410507
GO:0008134 transcription factor binding IPI 17724128
genes like me logo Genes that share ontologies with TRIB1: view
genes like me logo Genes that share phenotypes with TRIB1: view

Animal Models for TRIB1 Gene

MGI Knock Outs for TRIB1:

Animal Model Products

  • Taconic Biosciences Mouse Models for TRIB1

miRNA for TRIB1 Gene

miRTarBase miRNAs that target TRIB1

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TRIB1 Gene

Localization for TRIB1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRIB1 gene
Compartment Confidence
nucleus 5
mitochondrion 3
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TRIB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 17452330
GO:0005737 cytoplasm IDA 17452330
genes like me logo Genes that share ontologies with TRIB1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TRIB1 Gene

Pathways & Interactions for TRIB1 Gene

SuperPathways for TRIB1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TRIB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 NOT protein phosphorylation TAS,IEA 20410507
GO:0006469 negative regulation of protein kinase activity IMP 15299019
GO:0007254 JNK cascade IMP 17452330
GO:0014912 negative regulation of smooth muscle cell migration IMP 17452330
GO:0031665 negative regulation of lipopolysaccharide-mediated signaling pathway IMP 17452330
genes like me logo Genes that share ontologies with TRIB1: view

No data available for Pathways by source and SIGNOR curated interactions for TRIB1 Gene

Transcripts for TRIB1 Gene

Unigene Clusters for TRIB1 Gene

Tribbles homolog 1 (Drosophila):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRIB1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c
SP1: - - -
SP2: - -
SP3:
SP4:

Relevant External Links for TRIB1 Gene

GeneLoc Exon Structure for
TRIB1
ECgene alternative splicing isoforms for
TRIB1

Expression for TRIB1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRIB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TRIB1 Gene

This gene is overexpressed in Whole Blood (x6.5), Thyroid (x4.5), and Liver (x4.2).

Protein differential expression in normal tissues from HIPED for TRIB1 Gene

This gene is overexpressed in Pancreas (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TRIB1 Gene



Protein tissue co-expression partners for TRIB1 Gene

NURSA nuclear receptor signaling pathways regulating expression of TRIB1 Gene:

TRIB1

SOURCE GeneReport for Unigene cluster for TRIB1 Gene:

Hs.444947

mRNA Expression by UniProt/SwissProt for TRIB1 Gene:

Q96RU8-TRIB1_HUMAN
Tissue specificity: Expressed in most human tissues with the highest levels in skeletal muscle, thyroid gland, pancreas, peripheral blood leukocytes, and bone marrow.

Evidence on tissue expression from TISSUES for TRIB1 Gene

  • Kidney(4.3)
  • Nervous system(4.3)
  • Lymph node(4.2)
  • Bone marrow(2.6)
  • Liver(2.5)
  • Lung(2.3)
  • Blood(2)
genes like me logo Genes that share expression patterns with TRIB1: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for TRIB1 Gene

Orthologs for TRIB1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TRIB1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRIB1 34 35
  • 99.28 (n)
dog
(Canis familiaris)
Mammalia TRIB1 34 35
  • 93.64 (n)
cow
(Bos Taurus)
Mammalia TRIB1 34 35
  • 92.11 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TRIB1 35
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trib1 34
  • 88.8 (n)
mouse
(Mus musculus)
Mammalia Trib1 34 16 35
  • 88.35 (n)
oppossum
(Monodelphis domestica)
Mammalia TRIB1 35
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves TRIB1 35
  • 85 (a)
OneToOne
LOC428386 34
  • 80.9 (n)
lizard
(Anolis carolinensis)
Reptilia TRIB1 35
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia trib1 34
  • 73.17 (n)
zebrafish
(Danio rerio)
Actinopterygii trib1 35
  • 51 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta trbl 35
  • 25 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea nipi-3 35
  • 12 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8356 35
  • 35 (a)
OneToMany
Species where no ortholog for TRIB1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRIB1 Gene

ENSEMBL:
Gene Tree for TRIB1 (if available)
TreeFam:
Gene Tree for TRIB1 (if available)

Paralogs for TRIB1 Gene

Paralogs for TRIB1 Gene

genes like me logo Genes that share paralogs with TRIB1: view

Variants for TRIB1 Gene

Sequence variations from dbSNP and Humsavar for TRIB1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
VAR_042370 A lung large cell carcinoma sample
rs1000292679 -- 125,431,794(+) AGACT(A/G)GAACA intron-variant, upstream-variant-2KB
rs1000830202 -- 125,431,454(+) AATGG(A/G)GGCGC intron-variant, upstream-variant-2KB
rs1000882327 -- 125,431,710(+) ACCCG(A/G)GCTCA intron-variant, upstream-variant-2KB
rs1001007333 -- 125,437,394(+) CTCCC(A/G)AGAGC nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TRIB1 Gene

Variant ID Type Subtype PubMed ID
esv1002169 CNV loss 20482838
esv2737545 CNV deletion 23290073
esv3572980 CNV loss 25503493
esv3572981 CNV loss 25503493
esv3618720 CNV gain 21293372
nsv509276 CNV insertion 20534489

Variation tolerance for TRIB1 Gene

Residual Variation Intolerance Score: 34.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.81; 47.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRIB1 Gene

Human Gene Mutation Database (HGMD)
TRIB1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRIB1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIB1 Gene

Disorders for TRIB1 Gene

Relevant External Links for TRIB1

Genetic Association Database (GAD)
TRIB1
Human Genome Epidemiology (HuGE) Navigator
TRIB1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRIB1

No disorders were found for TRIB1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRIB1 Gene

Publications for TRIB1 Gene

  1. Characterization of a phosphoprotein whose mRNA is regulated by the mitogenic pathways in dog thyroid cells. (PMID: 9342215) Wilkin F. … Maenhaut C. (Eur. J. Biochem. 1997) 2 3 4 64
  2. Structural basis for substrate selectivity of the E3 ligase COP1. (PMID: 27041596) Uljon S. … Blacklow S.C. (Structure 2016) 3 4 64
  3. Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. (PMID: 22479202) Dastani Z. … Kathiresan S. (PLoS Genet. 2012) 3 46 64
  4. A bivariate genome-wide approach to metabolic syndrome: STAMPEED consortium. (PMID: 21386085) Kraja A.T. … Borecki I.B. (Diabetes 2011) 3 46 64
  5. Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. (PMID: 22001757) Chambers J.C. … Kooner J.S. (Nat. Genet. 2011) 3 46 64

Products for TRIB1 Gene

Sources for TRIB1 Gene

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