Aliases for TRIB1 Gene
External Ids for TRIB1 Gene
Previous GeneCards Identifiers for TRIB1 Gene
GeneCards Summary for TRIB1 Gene
TRIB1 (Tribbles Pseudokinase 1) is a Protein Coding gene. Diseases associated with TRIB1 include Megakaryocytic Leukemia. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and transcription factor binding. An important paralog of this gene is TRIB2.
UniProtKB/Swiss-Prot for TRIB1 Gene
Adapter protein involved in protein degradation by interacting with RFWD2/COP1 ubiquitin ligase (PubMed:27041596). The RFWD2-binding motif is masked by autoinhibitory interactions with the protein kinase domain (PubMed:26455797). Serves to alter RFWD2 substrate specificity by directing the activity of RFWD2 toward CEBPA (PubMed:27041596). Binds selectively the recognition sequence of CEBPA (PubMed:26455797). Regulates myeloid cell differentiation by altering the expression of CEBPA in a RFWD2-dependent manner (By similarity). Controls macrophage, eosinophil and neutrophil differentiation via the COP1-binding domain (By similarity). Interacts with MAPK kinases and regulates activation of MAP kinases, but has no kinase activity (PubMed:15299019, PubMed:26455797).