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Aliases for TRIB1 Gene

Aliases for TRIB1 Gene

  • Tribbles Pseudokinase 1 2 3 5
  • G-Protein-Coupled Receptor-Induced Gene 2 Protein 3 4
  • GIG-2 3 4
  • SKIP1 3 4
  • TRB-1 3 4
  • TRB1 3 4
  • C8FW 3 4
  • GIG2 3 4
  • Phosphoprotein Regulated By Mitogenic Pathways 3
  • G-Protein-Coupled Receptor-Induced Protein 2 3
  • G-Protein-Coupled Receptor Induced Protein 3
  • Tribbles Homolog 1 (Drosophila) 2
  • Tribbles-Like Protein 1 3

External Ids for TRIB1 Gene

Previous GeneCards Identifiers for TRIB1 Gene

  • GC08P126400
  • GC08P126511
  • GC08P121766
  • GC08P126442

Summaries for TRIB1 Gene

GeneCards Summary for TRIB1 Gene

TRIB1 (Tribbles Pseudokinase 1) is a Protein Coding gene. Diseases associated with TRIB1 include megakaryocytic leukemia. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and transcription factor binding. An important paralog of this gene is TRIB2.

UniProtKB/Swiss-Prot for TRIB1 Gene

  • Interacts with MAPK kinases and regulates activation of MAP kinases. May not display kinase activity.

Gene Wiki entry for TRIB1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIB1 Gene

Genomics for TRIB1 Gene

Regulatory Elements for TRIB1 Gene

Promoters for TRIB1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TRIB1 on UCSC Golden Path with GeneCards custom track

Genomic Location for TRIB1 Gene

Chromosome:
8
Start:
125,430,321 bp from pter
End:
125,438,405 bp from pter
Size:
8,085 bases
Orientation:
Plus strand

Genomic View for TRIB1 Gene

Genes around TRIB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIB1 Gene

Proteins for TRIB1 Gene

  • Protein details for TRIB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96RU8-TRIB1_HUMAN
    Recommended name:
    Tribbles homolog 1
    Protein Accession:
    Q96RU8
    Secondary Accessions:
    • B4DMM6
    • C5HU08
    • O15180
    • Q9H2Y8

    Protein attributes for TRIB1 Gene

    Size:
    372 amino acids
    Molecular mass:
    41009 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for TRIB1 Gene

    Alternative splice isoforms for TRIB1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRIB1 Gene

Proteomics data for TRIB1 Gene at MOPED

Post-translational modifications for TRIB1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TRIB1 Gene

Antibody Products

No data available for DME Specific Peptides for TRIB1 Gene

Domains & Families for TRIB1 Gene

Gene Families for TRIB1 Gene

Protein Domains for TRIB1 Gene

Suggested Antigen Peptide Sequences for TRIB1 Gene

Graphical View of Domain Structure for InterPro Entry

Q96RU8

UniProtKB/Swiss-Prot:

TRIB1_HUMAN :
  • The protein kinase domain is predicted to be catalytically inactive.
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Tribbles subfamily.
Domain:
  • The protein kinase domain is predicted to be catalytically inactive.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Tribbles subfamily.
genes like me logo Genes that share domains with TRIB1: view

Function for TRIB1 Gene

Molecular function for TRIB1 Gene

UniProtKB/Swiss-Prot Function:
Interacts with MAPK kinases and regulates activation of MAP kinases. May not display kinase activity.

Gene Ontology (GO) - Molecular Function for TRIB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 NOT protein kinase activity TAS 20410507
GO:0005515 protein binding IPI 25852190
GO:0031434 mitogen-activated protein kinase kinase binding IDA 15299019
genes like me logo Genes that share ontologies with TRIB1: view
genes like me logo Genes that share phenotypes with TRIB1: view

Animal Models for TRIB1 Gene

MGI Knock Outs for TRIB1:

Animal Model Products

  • Taconic Biosciences Mouse Models for TRIB1

miRNA for TRIB1 Gene

miRTarBase miRNAs that target TRIB1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TRIB1 Gene

Localization for TRIB1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRIB1 Gene COMPARTMENTS Subcellular localization image for TRIB1 gene
Compartment Confidence
nucleus 5
mitochondrion 3
extracellular 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TRIB1 Gene

Pathways & Interactions for TRIB1 Gene

SuperPathways for TRIB1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TRIB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 NOT protein phosphorylation IEA,TAS 20410507
GO:0007254 JNK cascade IMP 17452330
GO:0031665 negative regulation of lipopolysaccharide-mediated signaling pathway IMP 17452330
GO:0032496 response to lipopolysaccharide ISS 17724128
GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity ISS 17724128
genes like me logo Genes that share ontologies with TRIB1: view

No data available for Pathways by source and SIGNOR curated interactions for TRIB1 Gene

Drugs & Compounds for TRIB1 Gene

No Compound Related Data Available

Transcripts for TRIB1 Gene

Unigene Clusters for TRIB1 Gene

Tribbles homolog 1 (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRIB1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c
SP1: - - -
SP2: - -
SP3:
SP4:

Relevant External Links for TRIB1 Gene

GeneLoc Exon Structure for
TRIB1
ECgene alternative splicing isoforms for
TRIB1

Expression for TRIB1 Gene

mRNA expression in normal human tissues for TRIB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TRIB1 Gene

This gene is overexpressed in Whole Blood (x6.5), Thyroid (x4.5), and Liver (x4.2).

Protein differential expression in normal tissues from HIPED for TRIB1 Gene

This gene is overexpressed in Pancreas (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TRIB1 Gene



SOURCE GeneReport for Unigene cluster for TRIB1 Gene Hs.444947

mRNA Expression by UniProt/SwissProt for TRIB1 Gene

Q96RU8-TRIB1_HUMAN
Tissue specificity: Expressed in most human tissues with the highest levels in skeletal muscle, thyroid gland, pancreas, peripheral blood leukocytes, and bone marrow.
genes like me logo Genes that share expression patterns with TRIB1: view

Protein tissue co-expression partners for TRIB1 Gene

Primer Products

In Situ Assay Products

Orthologs for TRIB1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TRIB1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TRIB1 35
  • 92.11 (n)
  • 96.77 (a)
TRIB1 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRIB1 35
  • 93.64 (n)
  • 96.77 (a)
TRIB1 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trib1 35
  • 88.35 (n)
  • 93.82 (a)
Trib1 16
Trib1 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TRIB1 35
  • 99.28 (n)
  • 99.46 (a)
TRIB1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trib1 35
  • 88.8 (n)
  • 93.55 (a)
oppossum
(Monodelphis domestica)
Mammalia TRIB1 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRIB1 36
  • 92 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC428386 35
  • 80.9 (n)
  • 91.3 (a)
TRIB1 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TRIB1 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia trib1 35
  • 73.17 (n)
  • 75.53 (a)
zebrafish
(Danio rerio)
Actinopterygii trib1 36
  • 51 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta trbl 36
  • 25 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea nipi-3 36
  • 12 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8356 36
  • 35 (a)
OneToMany
Species with no ortholog for TRIB1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRIB1 Gene

ENSEMBL:
Gene Tree for TRIB1 (if available)
TreeFam:
Gene Tree for TRIB1 (if available)

Paralogs for TRIB1 Gene

Paralogs for TRIB1 Gene

genes like me logo Genes that share paralogs with TRIB1: view

Variants for TRIB1 Gene

Sequence variations from dbSNP and Humsavar for TRIB1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs56285697 - 125,433,475(+) CGAAG(C/G)CGGAA nc-transcript-variant, reference, missense
rs34349706 - 125,433,600(+) CTCCA(C/T)GGAGG nc-transcript-variant, reference, missense
rs56056430 - 125,436,151(+) CGGAC(A/G)TTTGG nc-transcript-variant, reference, missense
rs55953723 - 125,436,244(+) TTCGG(C/G/T)GTGGA nc-transcript-variant, reference, missense
rs35454769 - 125,436,431(+) TCCAG(A/C)GTACC nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for TRIB1 Gene

Variant ID Type Subtype PubMed ID
nsv509276 CNV Insertion 20534489
esv2737545 CNV Deletion 23290073
esv1002169 CNV Loss 20482838

Variation tolerance for TRIB1 Gene

Residual Variation Intolerance Score: 34.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.81; 47.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRIB1 Gene

HapMap Linkage Disequilibrium report
TRIB1
Human Gene Mutation Database (HGMD)
TRIB1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIB1 Gene

Disorders for TRIB1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TRIB1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
megakaryocytic leukemia
  • acute megakaryoblastic leukaemia, fab m7
- elite association - COSMIC cancer census association via MalaCards
Search TRIB1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TRIB1

Genetic Association Database (GAD)
TRIB1
Human Genome Epidemiology (HuGE) Navigator
TRIB1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRIB1
genes like me logo Genes that share disorders with TRIB1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TRIB1 Gene

Publications for TRIB1 Gene

  1. Characterization of a phosphoprotein whose mRNA is regulated by the mitogenic pathways in dog thyroid cells. (PMID: 9342215) Wilkin F. … Maenhaut C. (Eur. J. Biochem. 1997) 2 3 4 67
  2. Tribbles-1 and -2 are tumour suppressors, down-regulated in human acute myeloid leukaemia. (PMID: 20005259) Gilby D.C. … Kiss-Toth E. (Immunol. Lett. 2010) 3 23
  3. Tribbles: novel regulators of cell function; evolutionary aspects. (PMID: 16715410) Hegedus Z. … Kiss-Toth E. (Cell. Mol. Life Sci. 2006) 2 3
  4. Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy. (PMID: 25852190) So J. … Colwill K. (Sci Signal 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for TRIB1 Gene

Sources for TRIB1 Gene

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