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Aliases for TRIB1 Gene

Aliases for TRIB1 Gene

  • Tribbles Pseudokinase 1 2 3
  • SKIP1 3 4 6
  • C8FW 3 4 6
  • TRB1 3 4 6
  • G-Protein-Coupled Receptor-Induced Gene 2 Protein 3 4
  • GIG-2 3 4
  • TRB-1 3 4
  • GIG2 3 4
  • Phosphoprotein Regulated By Mitogenic Pathways 3
  • G-Protein-Coupled Receptor-Induced Protein 2 3
  • G-Protein-Coupled Receptor Induced Protein 3
  • Tribbles Homolog 1 (Drosophila) 2
  • Tribbles-Like Protein 1 3
  • Tribbles Homolog 1 3

External Ids for TRIB1 Gene

Previous GeneCards Identifiers for TRIB1 Gene

  • GC08P126400
  • GC08P126511
  • GC08P121766
  • GC08P126442

Summaries for TRIB1 Gene

GeneCards Summary for TRIB1 Gene

TRIB1 (Tribbles Pseudokinase 1) is a Protein Coding gene. Diseases associated with TRIB1 include ischemic heart disease and megakaryocytic leukemia. GO annotations related to this gene include transcription factor binding and ubiquitin protein ligase binding. An important paralog of this gene is NUAK1.

UniProtKB/Swiss-Prot for TRIB1 Gene

  • Interacts with MAPK kinases and regulates activation of MAP kinases. May not display kinase activity.

Gene Wiki entry for TRIB1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIB1 Gene

Genomics for TRIB1 Gene

Regulatory Elements for TRIB1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TRIB1 Gene

125,430,321 bp from pter
125,438,405 bp from pter
8,085 bases
Plus strand

Genomic View for TRIB1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRIB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIB1 Gene

Proteins for TRIB1 Gene

  • Protein details for TRIB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tribbles homolog 1
    Protein Accession:
    Secondary Accessions:
    • B4DMM6
    • C5HU08
    • O15180
    • Q9H2Y8

    Protein attributes for TRIB1 Gene

    372 amino acids
    Molecular mass:
    41009 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TRIB1 Gene


neXtProt entry for TRIB1 Gene

Proteomics data for TRIB1 Gene at MOPED

Post-translational modifications for TRIB1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TRIB1 Gene

No data available for DME Specific Peptides for TRIB1 Gene

Domains for TRIB1 Gene

Gene Families for TRIB1 Gene

Protein Domains for TRIB1 Gene

Suggested Antigen Peptide Sequences for TRIB1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q96RU8
  • The protein kinase domain is predicted to be catalytically inactive
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Tribbles subfamily.
genes like me logo Genes that share domains with TRIB1: view

Function for TRIB1 Gene

Molecular function for TRIB1 Gene

UniProtKB/Swiss-Prot Function: Interacts with MAPK kinases and regulates activation of MAP kinases. May not display kinase activity.

Gene Ontology (GO) - Molecular Function for TRIB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 NOT protein kinase activity TAS 20410507
GO:0004860 protein kinase inhibitor activity IMP 15299019
GO:0005524 NOT ATP binding TAS 20410507
GO:0008134 transcription factor binding IPI 17724128
GO:0016772 transferase activity, transferring phosphorus-containing groups --
genes like me logo Genes that share ontologies with TRIB1: view
genes like me logo Genes that share phenotypes with TRIB1: view

Animal Models for TRIB1 Gene

MGI Knock Outs for TRIB1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRIB1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for TRIB1 Gene

Localization for TRIB1 Gene

Subcellular locations from

Jensen Localization Image for TRIB1 Gene COMPARTMENTS Subcellular localization image for TRIB1 gene
Compartment Confidence
nucleus 4
mitochondrion 3
peroxisome 1

Gene Ontology (GO) - Cellular Components for TRIB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 17452330
GO:0005737 cytoplasm IDA 17452330
genes like me logo Genes that share ontologies with TRIB1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TRIB1 Gene

Pathways for TRIB1 Gene

SuperPathways for TRIB1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TRIB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 NOT protein phosphorylation TAS 20410507
GO:0006469 negative regulation of protein kinase activity IMP 15299019
GO:0007254 JNK cascade IMP 17452330
GO:0014912 negative regulation of smooth muscle cell migration IMP 17452330
GO:0031665 negative regulation of lipopolysaccharide-mediated signaling pathway IMP 17452330
genes like me logo Genes that share ontologies with TRIB1: view

No data available for Pathways by source for TRIB1 Gene

Transcripts for TRIB1 Gene

Unigene Clusters for TRIB1 Gene

Tribbles homolog 1 (Drosophila):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRIB1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRIB1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c
SP1: - - -
SP2: - -

Relevant External Links for TRIB1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TRIB1 Gene

mRNA expression in normal human tissues for TRIB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TRIB1 Gene

This gene is overexpressed in Whole Blood (6.5), Thyroid (4.5), and Liver (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TRIB1 Gene

SOURCE GeneReport for Unigene cluster for TRIB1 Gene Hs.444947

mRNA Expression by UniProt/SwissProt for TRIB1 Gene

Tissue specificity: Expressed in most human tissues with the highest levels in skeletal muscle, thyroid gland, pancreas, peripheral blood leukocytes, and bone marrow.
genes like me logo Genes that share expressions with TRIB1: view

In Situ Assay Products

Orthologs for TRIB1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TRIB1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TRIB1 35
  • 99.28 (n)
  • 99.46 (a)
TRIB1 36
  • 99 (a)
(Bos Taurus)
Mammalia TRIB1 35
  • 92.11 (n)
  • 96.77 (a)
TRIB1 36
  • 97 (a)
(Canis familiaris)
Mammalia TRIB1 35
  • 93.64 (n)
  • 96.77 (a)
TRIB1 36
  • 97 (a)
(Mus musculus)
Mammalia Trib1 35
  • 88.35 (n)
  • 93.82 (a)
Trib1 16
Trib1 36
  • 94 (a)
(Monodelphis domestica)
Mammalia TRIB1 36
  • 88 (a)
(Ornithorhynchus anatinus)
Mammalia TRIB1 36
  • 92 (a)
(Rattus norvegicus)
Mammalia Trib1 35
  • 88.8 (n)
  • 93.55 (a)
(Gallus gallus)
Aves LOC428386 35
  • 80.9 (n)
  • 91.3 (a)
TRIB1 36
  • 85 (a)
(Anolis carolinensis)
Reptilia TRIB1 36
  • 79 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia trib1 35
  • 73.17 (n)
  • 75.53 (a)
(Danio rerio)
Actinopterygii trib1 36
  • 51 (a)
fruit fly
(Drosophila melanogaster)
Insecta trbl 36
  • 25 (a)
(Caenorhabditis elegans)
Secernentea nipi-3 36
  • 12 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8356 36
  • 35 (a)
Species with no ortholog for TRIB1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRIB1 Gene

Gene Tree for TRIB1 (if available)
Gene Tree for TRIB1 (if available)

Paralogs for TRIB1 Gene

Paralogs for TRIB1 Gene

genes like me logo Genes that share paralogs with TRIB1: view

Variants for TRIB1 Gene

Sequence variations from dbSNP and Humsavar for TRIB1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs2235108 -- 125,436,547(-) TACCA(C/T)GCCAA utr-variant-3-prime, nc-transcript-variant
rs2235109 -- 125,433,302(-) GAAGG(A/C/G/T)GGGCC intron-variant
rs2235110 -- 125,433,295(-) GGCCC(A/G)TTTAG intron-variant
rs2235111 -- 125,433,114(-) AAGCT(C/G)TAGAC intron-variant, upstream-variant-2KB
rs2280826 -- 125,430,692(-) CCGGG(A/G)GGCGG upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for TRIB1 Gene

Variant ID Type Subtype PubMed ID
nsv509276 CNV Insertion 20534489
esv2737545 CNV Deletion 23290073
esv1002169 CNV Loss 20482838

Relevant External Links for TRIB1 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIB1 Gene

Disorders for TRIB1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for TRIB1 Gene including...

Search for TRIB1 Gene in MalaCards »

Relevant External Links for TRIB1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with TRIB1: view

No data available for UniProtKB/Swiss-Prot for TRIB1 Gene

Publications for TRIB1 Gene

  1. Characterization of a phosphoprotein whose mRNA is regulated by the mitogenic pathways in dog thyroid cells. (PMID: 9342215) Wilkin F. … Maenhaut C. (Eur. J. Biochem. 1997) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Human tribbles, a protein family controlling mitogen-activated protein kinase cascades. (PMID: 15299019) Kiss-Toth E. … Dower S.K. (J. Biol. Chem. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Newly identified loci that influence lipid concentrations and risk of coronary artery disease. (PMID: 18193043) Willer C.J. … Abecasis G.R. (Nat. Genet. 2008) 3 48

Products for TRIB1 Gene

Sources for TRIB1 Gene

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