Aliases for GDF11 Gene
External Ids for GDF11 Gene
Previous GeneCards Identifiers for GDF11 Gene
The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in mice and Xenopus suggest that this protein is involved in mesodermal formation and neurogenesis during embryonic development. [provided by RefSeq, Jul 2008]
GeneCards Summary for GDF11 Gene
GDF11 (Growth Differentiation Factor 11) is a Protein Coding gene. Diseases associated with GDF11 include currarino syndrome. GO annotations related to this gene include cytokine activity and transforming growth factor beta receptor binding. An important paralog of this gene is INHBB.
UniProtKB/Swiss-Prot for GDF11 Gene
Secreted signal that acts globally to specify positional identity along the anterior/posterior axis during development. Play critical roles in patterning both mesodermal and neural tissues and in establishing the skeletal pattern