Aliases for CDK7 Gene
Aliases for CDK7 Gene
- Cyclin Dependent Kinase 7 2 3 5
- Cyclin-Dependent Kinase 7 (MO15 Homolog, Xenopus Laevis, Cdk-Activating Kinase) 2 3
- TFIIH Basal Transcription Factor Complex Kinase Subunit 3 4
- Cell Division Protein Kinase 7 3 4
- CDK-Activating Kinase 1 3 4
- 39 KDa Protein Kinase 3 4
- EC 2.7.11.22 4 56
- CDKN7 3 4
- STK1 3 4
- CAK1 3 4
- MO15 3 4
- CAK 3 4
- Cyclin-Dependent Kinase 7 (Homolog Of Xenopus MO15 Cdk-Activating Kinase) 2
- Homolog Of Xenopus MO15 Cdk-Activating Kinase 3
External Ids for CDK7 Gene
- HGNC: 1778
- Entrez Gene: 1022
- Ensembl: ENSG00000134058
- OMIM: 601955
- UniProtKB: P50613
Previous GeneCards Identifiers for CDK7 Gene
- GC05P068682
- GC05P070096
- GC05P068501
- GC05P068546
- GC05P068566
- GC05P068530
- GC05P065486
Summaries for CDK7 Gene
-
The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This protein forms a trimeric complex with cyclin H and MAT1, which functions as a Cdk-activating kinase (CAK). It is an essential component of the transcription factor TFIIH, that is involved in transcription initiation and DNA repair. This protein is thought to serve as a direct link between the regulation of transcription and the cell cycle. [provided by RefSeq, Jul 2008]
GeneCards Summary for CDK7 Gene
CDK7 (Cyclin Dependent Kinase 7) is a Protein Coding gene. Diseases associated with CDK7 include Breast Cancer and Hemophagocytic Lymphohistiocytosis, Familial, 3. Among its related pathways are RNA Polymerase II Transcription Initiation And Promoter Clearance and Formation of HIV elongation complex in the absence of HIV Tat. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CDK20.
UniProtKB/Swiss-Prot for CDK7 Gene
-
Serine/threonine kinase involved in cell cycle control and in RNA polymerase II-mediated RNA transcription. Cyclin-dependent kinases (CDKs) are activated by the binding to a cyclin and mediate the progression through the cell cycle. Each different complex controls a specific transition between 2 subsequent phases in the cell cycle. Required for both activation and complex formation of CDK1/cyclin-B during G2-M transition, and for activation of CDK2/cyclins during G1-S transition (but not complex formation). CDK7 is the catalytic subunit of the CDK-activating kinase (CAK) complex. Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation, thus regulating cell cycle progression. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Phosphorylation of POLR2A in complex with DNA promotes transcription initiation by triggering dissociation from DNA. Its expression and activity are constant throughout the cell cycle. Upon DNA damage, triggers p53/TP53 activation by phosphorylation, but is inactivated in turn by p53/TP53; this feedback loop may lead to an arrest of the cell cycle and of the transcription, helping in cell recovery, or to apoptosis. Required for DNA-bound peptides-mediated transcription and cellular growth inhibition.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDK7 Gene
Genomics for CDK7 Gene
GeneHancer (GH) Regulatory Elements for CDK7 Gene
Regulatory Element Products
Genomic Locations for CDK7 Gene
- chr5:69,234,795-69,277,430
- (GRCh38/hg38)
- Size:
- 42,636 bases
- Orientation:
- Plus strand
- chr5:68,530,622-68,573,257
- (GRCh37/hg19)
Genomic View for CDK7 Gene
- Cytogenetic band:
-
- 5q13.2 by Ensembl
- 5q13.2 by Entrez Gene
- 5q13.2 by HGNC


RefSeq DNA sequence for CDK7 Gene
Proteins for CDK7 Gene
-
Protein details for CDK7 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P50613-CDK7_HUMAN
- Recommended name:
- Cyclin-dependent kinase 7
- Protein Accession:
- P50613
- Q9BS60
- Q9UE19
Protein attributes for CDK7 Gene
- Size:
- 346 amino acids
- Molecular mass:
- 39038 Da
- Quaternary structure:
-
- Associates primarily with cyclin-H (CCNH) and MAT1 to form the CAK complex. CAK can further associate with the core-TFIIH to form the TFIIH basal transcription factor; this complex is sensitive to UV light. The CAK complex binds to p53/TP53 in response to DNA damage. Interacts with CDK2, SF1/NR5A1, PUF60 and PRKCI.
Protein Expression for CDK7 Gene
Selected DME Specific Peptides for CDK7 Gene
- P50613:
-
- ILHRDLK
- LREIKLL
- LADFGLA
- LGTPTEE
- TRWYRAPE
Post-translational modifications for CDK7 Gene
- Phosphorylation of Ser-164 during mitosis inactivates the enzyme. Phosphorylation of Thr-170 is required for activity. Phosphorylated at Ser-164 and Thr-170 by CDK2.
Other Protein References for CDK7 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Cell Signaling Technology (CST) Antibodies for CDK7 (CDK7)
-
Custom Antibody ServicesOriGene Antibodies for CDK7
- Novus Biologicals Antibodies for CDK7
-
Abcam antibodies for CDK7
- Invitrogen Antibodies for CDK7
- GeneTex CDK7 antibody for CDK7
-
Santa Cruz Biotechnology (SCBT) Antibodies for CDK7
Protein Products
-
OriGene Purified Proteins for CDK7
- Search Origene for MassSpec and Protein Over-expression Lysates for CDK7
- Origene Custom Protein Services for CDK7
- GeneTex Proteins for CDK7
-
ProSci Proteins for CDK7
-
Abcam proteins for CDK7
Assay Products
Domains & Families for CDK7 Gene
Gene Families for CDK7 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Enzymes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for CDK7 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for CDK7 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P50613UniProtKB/Swiss-Prot:
CDK7_HUMAN :- Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
- Family:
-
- Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Function for CDK7 Gene
Molecular function for CDK7 Gene
- GENATLAS Biochemistry:
- CDK-activating kinase 1,homolog of Xenopus p40-M015,gene or pseudogene,expressed in a breast cancer line,forming aternary complex with CCNH and MNAT1 (see symbols),associating in the multisubunit complex TFIIH (GTF2H),putatively involved in cell cycle control,transcription DNA repair
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + a protein = ADP + a phosphoprotein.
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Inactivated by phosphorylation. Repressed by roscovitine (seliciclib, CYC202), R547 (Ro-4584820) and SNS-032 (BMS-387032). The association of p53/TP53 to the CAK complex in response to DNA damage reduces kinase activity toward CDK2 and RNA polymerase II repetitive C-terminal domain (CTD), thus stopping cell cycle progression. The inactivation by roscovitine promotes caspase-mediated apoptosis in leukemic cells.
- UniProtKB/Swiss-Prot Function:
- Serine/threonine kinase involved in cell cycle control and in RNA polymerase II-mediated RNA transcription. Cyclin-dependent kinases (CDKs) are activated by the binding to a cyclin and mediate the progression through the cell cycle. Each different complex controls a specific transition between 2 subsequent phases in the cell cycle. Required for both activation and complex formation of CDK1/cyclin-B during G2-M transition, and for activation of CDK2/cyclins during G1-S transition (but not complex formation). CDK7 is the catalytic subunit of the CDK-activating kinase (CAK) complex. Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation, thus regulating cell cycle progression. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Phosphorylation of POLR2A in complex with DNA promotes transcription initiation by triggering dissociation from DNA. Its expression and activity are constant throughout the cell cycle. Upon DNA damage, triggers p53/TP53 activation by phosphorylation, but is inactivated in turn by p53/TP53; this feedback loop may lead to an arrest of the cell cycle and of the transcription, helping in cell recovery, or to apoptosis. Required for DNA-bound peptides-mediated transcription and cellular growth inhibition.
- UniProtKB/Swiss-Prot Induction:
- Repressed by DNA-bound peptides.
Enzyme Numbers (IUBMB) for CDK7 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000166 | nucleotide binding | IEA | -- |
GO:0003713 | transcription coactivator activity | NAS | 15572661 |
GO:0004672 | protein kinase activity | TAS,IEA | 7533895 |
GO:0004674 | protein serine/threonine kinase activity | TAS | -- |
GO:0004693 | cyclin-dependent protein serine/threonine kinase activity | IBA,TAS | -- |
Phenotypes for CDK7 Gene
- MGI mutant phenotypes for CDK7:
-
inferred from 2 alleles
- mortality/aging
- cellular phenotype
- growth/size/body region phenotype
- digestive/alimentary phenotype
- endocrine/exocrine gland phenotype
- integument phenotype
- embryo phenotype
- hematopoietic system phenotype
- skeleton phenotype
- pigmentation phenotype
- renal/urinary system phenotype
- adipose tissue phenotype
- GenomeRNAi human phenotypes for CDK7:
-
- Increased vaccinia virus (VACV) infection
- shRNA abundance <= 50%
- Decreased viability ratio
- Decreased viability after Maraba virus infection
- Decreased viability
- Decreased substrate adherent cell growth
- Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance
- Decreased shRNA abundance
- Increased cell death HMECs cells
- Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435)
- Increased viability with MLN4924 (a NAE inhibitor)
- Decreased human cytomegalovirus (HCMV) strain AD169 replication
- Increased cell viability after pRB stimulation
- Increased viability with TRAIL
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for CDK7 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CDK7 gene
- Search ViGene Biosciences for CDK7
CRISPR Products
-
OriGene CRISPR knockouts for CDK7
- genomics-online: gRNA clones - Search results for 112 available CDK7 gene related products
- Overview of 112 available CDK7 gene related products
- Applied Biological Materials CRISPR for CDK7
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CDK7
- GenScript: Design CRISPR guide RNA sequences for CDK7
miRNA for CDK7 Gene
- miRTarBase miRNAs that target CDK7
miRNA Products
- Search ViGene Biosciences for CDK7
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CDK7
- Browse OriGene Inhibitory RNA Products For CDK7
- genomics-online: shRNA clones - Search results for 112 available CDK7 gene related products
- Overview of 112 available CDK7 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for CDK7 gene
Clone Products
- Sino Biological Human cDNA Clone for CDK7
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for CDK7
- Applied Biological Materials Clones for CDK7
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for CDK7 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for CDK7 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CDK7 gene
No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CDK7 Gene
Localization for CDK7 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CDK7 Gene
- Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Note=Colocalizes with PRKCI in the cytoplasm and nucleus. Translocates from the nucleus to cytoplasm and perinuclear region in response to DNA-bound peptides.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IDA | 16109376 |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0005675 | holo TFIIH complex | IDA | 9852112 |
GO:0005737 | cytoplasm | IBA | -- |
GO:0019907 | cyclin-dependent protein kinase activating kinase holoenzyme complex | IMP | 23393140 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for CDK7 Gene
Pathways & Interactions for CDK7 Gene
Pathways by source for CDK7 Gene
1 GeneTex pathway for CDK7 Gene
1 Cell Signaling Technology pathway for CDK7 Gene
6 BioSystems pathways for CDK7 Gene
3 KEGG pathways for CDK7 Gene
2 GeneGo (Thomson Reuters) pathways for CDK7 Gene
5 Qiagen pathways for CDK7 Gene
Interacting Proteins for CDK7 Gene
SIGNOR curated interactions for CDK7 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000079 | regulation of cyclin-dependent protein serine/threonine kinase activity | TAS | 7533895 |
GO:0000082 | G1/S transition of mitotic cell cycle | TAS | -- |
GO:0000086 | G2/M transition of mitotic cell cycle | TAS | -- |
GO:0006281 | DNA repair | IEA | -- |
GO:0006283 | transcription-coupled nucleotide-excision repair | TAS | -- |
Drugs & Compounds for CDK7 Gene
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Alvocidib | Experimental, Investigational | Pharma | Target, inhibitor | Pan-cdk inhibitor, Kinase Inhibitors | 60 | |
Phosphonothreonine | Experimental | Pharma | Target | 0 | ||
ATP | Investigational | Nutra | Agonist | 0 | ||
AT7519 | Investigational | Pharma | Multi-CDK inhibitor | 0 | ||
PHA-793887 | Investigational | Pharma | Pan-Cdk inhibitor | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
ADP |
|
Full agonist, Agonist | 58-64-0 |
|
(14) ApexBio Compounds for CDK7 Gene
Compound | Action | Cas Number |
---|---|---|
AT7519 | Multi-CDK inhibitor | 844442-38-2 |
BS-181 | CDK7 inhibitor,highly selective | 1092443-52-1 |
BS-181 HCl | CDK7 inhibitor,highly selective | 1397219-81-6 |
CDK7-IN-1 | 1604810-84-5 | |
Flavopiridol hydrochloride | 131740-09-5 | |
JNJ-7706621 | Potent CDK/Aurora kinase inhibitor | 443797-96-4 |
LDC000067 | 1073485-20-7 | |
PHA-793887 | Pan-Cdk inhibitor | 718630-59-2 |
PHA-848125 | CDK inhibitor,potent and ATP-competitive | 802539-81-7 |
Roscovitine (Seliciclib,CYC202) | CDK inhibitor,potent and selective | 186692-46-6 |
SNS-032 (BMS-387032) | CDK inhibitor | 345627-80-7 |
THZ1 | Covalent CDK7 inhibitor,potent and selective | |
THZ1 Hydrochloride | CDK7 inhibitor | |
THZ2 | CDK7 inhibitor | 1604810-84-5 |
Transcripts for CDK7 Gene
mRNA/cDNA for CDK7 Gene
- (10) REFSEQ mRNAs :
- (9) Additional mRNA sequences :
- (207) Selected AceView cDNA sequences:
- (15) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for CDK7 Gene
CRISPR Products
-
OriGene CRISPR knockouts for CDK7
- genomics-online: gRNA clones - Search results for 112 available CDK7 gene related products
- Overview of 112 available CDK7 gene related products
- Applied Biological Materials CRISPR for CDK7
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CDK7
- GenScript: Design CRISPR guide RNA sequences for CDK7
miRNA Products
- Search ViGene Biosciences for CDK7
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CDK7
- Browse OriGene Inhibitory RNA Products For CDK7
- genomics-online: shRNA clones - Search results for 112 available CDK7 gene related products
- Overview of 112 available CDK7 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for CDK7 gene
Clone Products
- Sino Biological Human cDNA Clone for CDK7
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for CDK7
- Applied Biological Materials Clones for CDK7
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | |||||||||||||||||||||||||||||||
SP2: | - | ||||||||||||||||||||||||||||||
SP3: | - | ||||||||||||||||||||||||||||||
SP4: | - |
Expression for CDK7 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CDK7 Gene
NURSA nuclear receptor signaling pathways regulating expression of CDK7 Gene:
CDK7SOURCE GeneReport for Unigene cluster for CDK7 Gene:
Hs.184298mRNA Expression by UniProt/SwissProt for CDK7 Gene:
P50613-CDK7_HUMANEvidence on tissue expression from TISSUES for CDK7 Gene
- Liver(4.3)
- Lung(4.2)
- Nervous system(2.8)
Primer Products
-
OriGene qPCR primer pairs and template standards for CDK7
-
OriGene qPCR primer pairs for CDK7
- genomics-online: primer clones - Search results for 112 available CDK7 gene related products
- Overview of 112 available CDK7 gene related products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CDK7 Gene
Orthologs for CDK7 Gene
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | CDK7 33 34 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | CDK7 34 |
|
OneToOne | |
cow (Bos Taurus) |
Mammalia | CDK7 33 34 |
|
||
dog (Canis familiaris) |
Mammalia | CDK7 33 34 |
|
||
platypus (Ornithorhynchus anatinus) |
Mammalia | CDK7 34 |
|
OneToOne | |
mouse (Mus musculus) |
Mammalia | Cdk7 33 16 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | Cdk7 33 |
|
||
chicken (Gallus gallus) |
Aves | CDK7 33 34 |
|
||
lizard (Anolis carolinensis) |
Reptilia | CDK7 34 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | cdk7 33 |
|
||
Str.10484 33 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.1768 33 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | cdk7 33 34 |
|
||
fruit fly (Drosophila melanogaster) |
Insecta | Cdk7 35 33 34 |
|
||
CG6800 35 |
|
|
|||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP002646 33 |
|
||
worm (Caenorhabditis elegans) |
Secernentea | cdk-7 33 34 |
|
||
H01G02.2 35 |
|
|
|||
baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | KIN28 33 34 36 |
|
||
K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0E14785g 33 |
|
||
A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_ADL283W 33 |
|
||
thale cress (Arabidopsis thaliana) |
eudicotyledons | CAK4 33 |
|
||
rice (Oryza sativa) |
Liliopsida | Os.2689 33 |
|
||
fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | mcs6 33 |
|
||
bread mold (Neurospora crassa) |
Ascomycetes | NCU03659 33 |
|
||
sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.961 33 |
|
- Species where no ortholog for CDK7 was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for CDK7 Gene
(98) SIMAP similar genes for CDK7 Gene using alignment to 10 proteins:
- CDK1
- CDK18
- CSNK2A2
- CDC2
- CDK3
- DKFZp686L20222
- DYRK4
- DYRK1A
- CDK16
- CDKL2
- CDK11B
- CDK5
- CDK11A
- CDK2
- CDK4
- MAPK7
- CDKL5
- CDC2L1
- CDK6
- CDK20
- CDK14
- TAOK3
- CDK12
- NLK
- CDK15
- AURKB
- PCTK3
- CDC2L2
- CDKL3
- MOK
- TXK
- STK11
- TLK2
- STK4
- GRK6
- CDK17
- AURKC
- CDK10
- CDKL4
- CDKL1
- MAPK3
- ULK3
- PCTK1
- NEK8
- MAPK15
- DAPK3
- CAMKK2
- MAPK14
- STK25
- CSNK2A3
- MAK
- NEK9
- MARK2
- MAP3K15
- ICK
- GRK5
- CDK13
- CCRK
- MAPK9
- BRSK2
- MAPK4
- RPS6KA4
- PRPF4B
- PRKACA
- GSK3A
- DKFZp686D0638
- MAPK8
- MAPK10
- RPS6KA1
- DKFZp686O0215
- MAPK11
- MAP4K1
- FLT1
- CHEK1
- MAPK13
- GSK3B
- STK36
- CDK9
- MARK4
- MAPK6
- HIPK1
- PRKCH
- PLK4
- OBSCN
- MAPK1
- AKT2
- BRAF
- CDK19
- MAPK12
- RPS6KA2
- PRKCZ
- DKFZp434M058
- CDK8
- PAK1
- MAST4
- MAP3K3
- DYRK2
- PRKCG
Pseudogenes.org Pseudogenes for CDK7 Gene
Variants for CDK7 Gene
SNP ID | Clin | Chr 05 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000026517 | -- | 69,271,306(+) | A/G | intron_variant | |
rs1000309175 | -- | 69,270,255(+) | G/A | intron_variant | |
rs1000319513 | -- | 69,245,107(+) | A/T | intron_variant | |
rs1000352636 | -- | 69,263,110(+) | AAAAAAAA/AAAAAAAAA | intron_variant | |
rs1000361272 | -- | 69,249,887(+) | C/T | intron_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv5694n100 | CNV | gain | 25217958 |
nsv821643 | CNV | loss | 15273396 |
Additional Variant Information for CDK7 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CDK7
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDK7 Gene
Disorders for CDK7 Gene
Disorder | Aliases | PubMed IDs |
---|---|---|
breast cancer |
|
|
hemophagocytic lymphohistiocytosis, familial, 3 |
|
|
Additional Disease Information for CDK7
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for CDK7 Gene
Publications for CDK7 Gene
- A novel cyclin associates with MO15/CDK7 to form the CDK-activating kinase. (PMID: 8069918) Fisher RP … Morgan DO (Cell 1994) 2 3 4 22 58
- Combined genetic effect of CDK7 and ESR1 polymorphisms on breast cancer. (PMID: 19941161) Jeon S … Kang D (Breast cancer research and treatment 2010) 3 22 44 58
- TFIIH-associated Cdk7 kinase functions in phosphorylation of C-terminal domain Ser7 residues, promoter-proximal pausing, and termination by RNA polymerase II. (PMID: 19667075) Glover-Cutter K … Bentley DL (Molecular and cellular biology 2009) 3 4 22 58
- Phosphorylation of steroidogenic factor 1 is mediated by cyclin-dependent kinase 7. (PMID: 17901130) Lewis AE … Bakke M (Molecular endocrinology (Baltimore, Md.) 2008) 3 4 22 58
- Requirements for Cdk7 in the assembly of Cdk1/cyclin B and activation of Cdk2 revealed by chemical genetics in human cells. (PMID: 17386261) Larochelle S … Fisher RP (Molecular cell 2007) 3 4 22 58
Products for CDK7 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
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- Custom Antibody ServicesOriGene Antibodies for CDK7
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for CDK7
- Search Origene for MassSpec and Protein Over-expression Lysates for CDK7
- Origene Custom Protein Services for CDK7
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CDK7
- Browse OriGene Inhibitory RNA Products For CDK7
- OriGene qPCR primer pairs and template standards for CDK7
- OriGene qPCR primer pairs for CDK7
- OriGene CRISPR knockouts for CDK7
- OriGene ORF clones in human for CDK7
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CDK7
- GenScript: Next-day shipping of latest version cDNA ORF clones for CDK7 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for CDK7
- GenScript Custom Assay Services for CDK7
- GenScript Custom overexpressing Cell Line Services for CDK7
- GenScript: Design CRISPR guide RNA sequences for CDK7
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for CDK7
- Cell Signaling Technology (CST) Antibodies for CDK7 (CDK7)
- Search for Antibodies & Assays
- Sino Biological Human cDNA Clone for CDK7
- Browse Sino Biological Cell Lysates
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- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for CDK7
- Novus Biologicals lysates and proteins for CDK7
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for CDK7
- Abcam proteins for CDK7
- Find your target
- Browse Primary Antibodies
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- Browse Antibodies at Cloud-Clone Corp.
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- Browse Assay Kits at Cloud-Clone Corp.
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for CDK7
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- ApexBio compounds for CDK7
- Addgene plasmids for CDK7
- antibodies-online: Search results for 210 available CDK7 Antibodies ranked by validation data
- Compare Top CDK7 Antibodies
- antibodies-online: Search results for 31 available CDK7 Elisa Kits ranked by validation data
- Compare Top CDK7 Elisa Kits
- antibodies-online: Search results for 16 available CDK7 Proteins ranked by validation data
- Compare Top CDK7 Proteins
- GeneTex CDK7 antibody for CDK7
- GeneTex Proteins for CDK7
- ViGene Biosciences adenoviral particle packaged cDNA for CDK7 gene
- ViGene Biosciences lentiviral particle packaged cDNA for CDK7 gene
- ViGene Biosciences ready-to-package AAV shRNAs for CDK7 gene
- Search ViGene Biosciences for CDK7
- Santa Cruz Biotechnology (SCBT) Antibodies for CDK7
- Search Santa Cruz Biotechnology (SCBT) for CDK7 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CDK7
- Search for CDK7 Antibodies at ProSci
- Custom Antibody Services
- ProSci Proteins for CDK7
- genomics-online: cdna clones - Search results for 112 available CDK7 gene related products
- Overview of 112 available CDK7 gene related products
- orf clones - Search results for 112 available CDK7 gene related products
- Overview of 112 available CDK7 gene related products
- genomics-online: gRNA clones - Search results for 112 available CDK7 gene related products
- Overview of 112 available CDK7 gene related products
- genomics-online: primer clones - Search results for 112 available CDK7 gene related products
- Overview of 112 available CDK7 gene related products
- genomics-online: shRNA clones - Search results for 112 available CDK7 gene related products
- Overview of 112 available CDK7 gene related products
Sources for CDK7 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew