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Aliases for CDK7 Gene

Aliases for CDK7 Gene

  • Cyclin-Dependent Kinase 7 2 3
  • CAK1 3 4 6
  • STK1 3 4 6
  • Cyclin-Dependent Kinase 7 (MO15 Homolog, Xenopus Laevis, Cdk-Activating Kinase) 2 3
  • TFIIH Basal Transcription Factor Complex Kinase Subunit 3 4
  • Serine/Threonine-Protein Kinase 1 3 4
  • Cell Division Protein Kinase 7 3 4
  • CDK-Activating Kinase 1 3 4
  • 39 KDa Protein Kinase 3 4
  • EC 2.7.11.22 4 64
  • P39 Mo15 3 4
  • CDKN7 3 4
  • MO15 3 4
  • CAK 3 4
  • Cyclin-Dependent Kinase 7 (Homolog Of Xenopus MO15 Cdk-Activating Kinase) 2
  • Homolog Of Xenopus MO15 Cdk-Activating Kinase 3
  • Serine/Threonine Protein Kinase MO15 3
  • Serine/Threonine Protein Kinase 1 3
  • Serine/Threonine Kinase Stk1 3
  • Kinase Subunit Of CAK 3
  • Protein Kinase 3
  • EC 2.7.11.24 64
  • EC 2.7.11.23 4
  • EC 2.7.11 64
  • P39MO15 3
  • HCAK 3

External Ids for CDK7 Gene

Summaries for CDK7 Gene

Entrez Gene Summary for CDK7 Gene

  • The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This protein forms a trimeric complex with cyclin H and MAT1, which functions as a Cdk-activating kinase (CAK). It is an essential component of the transcription factor TFIIH, that is involved in transcription initiation and DNA repair. This protein is thought to serve as a direct link between the regulation of transcription and the cell cycle. [provided by RefSeq, Jul 2008]

GeneCards Summary for CDK7 Gene

CDK7 (Cyclin-Dependent Kinase 7) is a Protein Coding gene. Diseases associated with CDK7 include trichothiodystrophy. Among its related pathways are Disease and Cell Cycle, Mitotic. GO annotations related to this gene include transcription coactivator activity and protein C-terminus binding. An important paralog of this gene is CDKL3.

UniProtKB/Swiss-Prot for CDK7 Gene

  • Serine/threonine kinase involved in cell cycle control and in RNA polymerase II-mediated RNA transcription. Cyclin-dependent kinases (CDKs) are activated by the binding to a cyclin and mediate the progression through the cell cycle. Each different complex controls a specific transition between 2 subsequent phases in the cell cycle. Required for both activation and complex formation of CDK1/cyclin-B during G2-M transition, and for activation of CDK2/cyclins during G1-S transition (but not complex formation). CDK7 is the catalytic subunit of the CDK-activating kinase (CAK) complex. Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation, thus regulating cell cycle progression. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Phosphorylation of POLR2A in complex with DNA promotes transcription initiation by triggering dissociation from DNA. Its expression and activity are constant throughout the cell cycle. Upon DNA damage, triggers p53/TP53 activation by phosphorylation, but is inactivated in turn by p53/TP53; this feedback loop may lead to an arrest of the cell cycle and of the transcription, helping in cell recovery, or to apoptosis. Required for DNA-bound peptides-mediated transcription and cellular growth inhibition.

Gene Wiki entry for CDK7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDK7 Gene

Genomics for CDK7 Gene

Genomic Location for CDK7 Gene

Start:
69,234,795 bp from pter
End:
69,277,430 bp from pter
Size:
42,636 bases
Orientation:
Plus strand

Genomic View for CDK7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CDK7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDK7 Gene

Regulatory Elements for CDK7 Gene

Proteins for CDK7 Gene

  • Protein details for CDK7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P50613-CDK7_HUMAN
    Recommended name:
    Cyclin-dependent kinase 7
    Protein Accession:
    P50613
    Secondary Accessions:
    • Q9BS60
    • Q9UE19

    Protein attributes for CDK7 Gene

    Size:
    346 amino acids
    Molecular mass:
    39038 Da
    Quaternary structure:
    • Associates primarily with cyclin-H (CCNH) and MAT1 to form the CAK complex. CAK can further associate with the core-TFIIH to form the TFIIH basal transcription factor; this complex is sensitive to UV light. The CAK complex binds to p53/TP53 in response to DNA damage. Interacts with CDK2, SF1/NR5A1, PUF60 and PRKCI.

    Three dimensional structures from OCA and Proteopedia for CDK7 Gene

neXtProt entry for CDK7 Gene

Proteomics data for CDK7 Gene at MOPED

Selected DME Specific Peptides for CDK7 Gene

Post-translational modifications for CDK7 Gene

  • Phosphorylation of Ser-164 during mitosis inactivates the enzyme. Phosphorylation of Thr-170 is required for activity. Phosphorylated at Ser-164 and Thr-170 by CDK2.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CDK7 Gene

Domains for CDK7 Gene

Gene Families for CDK7 Gene

HGNC:
  • CDK :Cyclin-dependent kinases
  • TFIIH :General transcription factor IIH complex subunits
IUPHAR :

UniProtKB/Swiss-Prot:

CDK7_HUMAN
Domain:
  • Contains 1 protein kinase domain.:
    • P50613
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.:
    • P50613
genes like me logo Genes that share domains with CDK7: view

Function for CDK7 Gene

Molecular function for CDK7 Gene

GENATLAS Biochemistry: CDK-activating kinase 1,homolog of Xenopus p40-M015,gene or pseudogene,expressed in a breast cancer line,forming aternary complex with CCNH and MNAT1 (see symbols),associating in the multisubunit complex TFIIH (GTF2H),putatively involved in cell cycle control,transcription DNA repair
UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot CatalyticActivity: ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate
UniProtKB/Swiss-Prot EnzymeRegulation: Inactivated by phosphorylation. Repressed by roscovitine (seliciclib, CYC202), R547 (Ro-4584820) and SNS-032 (BMS-387032). The association of p53/TP53 to the CAK complex in response to DNA damage reduces kinase activity toward CDK2 and RNA polymerase II repetitive C-terminal domain (CTD), thus stopping cell cycle progression. The inactivation by roscovitine promotes caspase-mediated apoptosis in leukemic cells.
UniProtKB/Swiss-Prot Function: Serine/threonine kinase involved in cell cycle control and in RNA polymerase II-mediated RNA transcription. Cyclin-dependent kinases (CDKs) are activated by the binding to a cyclin and mediate the progression through the cell cycle. Each different complex controls a specific transition between 2 subsequent phases in the cell cycle. Required for both activation and complex formation of CDK1/cyclin-B during G2-M transition, and for activation of CDK2/cyclins during G1-S transition (but not complex formation). CDK7 is the catalytic subunit of the CDK-activating kinase (CAK) complex. Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation, thus regulating cell cycle progression. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Phosphorylation of POLR2A in complex with DNA promotes transcription initiation by triggering dissociation from DNA. Its expression and activity are constant throughout the cell cycle. Upon DNA damage, triggers p53/TP53 activation by phosphorylation, but is inactivated in turn by p53/TP53; this feedback loop may lead to an arrest of the cell cycle and of the transcription, helping in cell recovery, or to apoptosis. Required for DNA-bound peptides-mediated transcription and cellular growth inhibition.
UniProtKB/Swiss-Prot Induction: Repressed by DNA-bound peptides.

Enzyme Numbers (IUBMB) for CDK7 Gene

Gene Ontology (GO) - Molecular Function for CDK7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity NAS 15572661
GO:0004672 protein kinase activity TAS 7533895
GO:0004674 protein serine/threonine kinase activity --
GO:0004693 cyclin-dependent protein serine/threonine kinase activity IEA --
GO:0004713 protein tyrosine kinase activity --
genes like me logo Genes that share ontologies with CDK7: view
genes like me logo Genes that share phenotypes with CDK7: view

miRNA for CDK7 Gene

miRTarBase miRNAs that target CDK7

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for CDK7 Gene

Localization for CDK7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDK7 Gene

Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Note=Colocalizes with PRKCI in the cytoplasm and nucleus. Translocates from the nucleus to cytoplasm and perinuclear region in response to DNA-bound peptides.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDK7 Gene COMPARTMENTS Subcellular localization image for CDK7 gene
Compartment Confidence
nucleus 5
mitochondrion 4
cytosol 3
peroxisome 1

Gene Ontology (GO) - Cellular Components for CDK7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005675 holo TFIIH complex IDA 9852112
GO:0005737 cytoplasm IDA --
GO:0005739 mitochondrion IDA --
genes like me logo Genes that share ontologies with CDK7: view

Pathways for CDK7 Gene

SuperPathways for CDK7 Gene

Superpath Contained pathways
1 Formation of RNA Pol II elongation complex
2 DNA Repair
3 Global Genomic NER (GG-NER)
4 RNA Polymerase I Promoter Opening
5 HIV Life Cycle
genes like me logo Genes that share pathways with CDK7: view

Gene Ontology (GO) - Biological Process for CDK7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity TAS 7533895
GO:0000082 G1/S transition of mitotic cell cycle TAS --
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0000278 mitotic cell cycle TAS --
GO:0000718 nucleotide-excision repair, DNA damage removal TAS --
genes like me logo Genes that share ontologies with CDK7: view

Compounds for CDK7 Gene

(20) ApexBio Compounds for CDK7 Gene

Compound Action Cas Number
AT7519 novel small molecule effective as a multi-cyclin-dependent kinase inhibitor [844442-38-2]
AZD-5438 Potent CDK1/2/9 inhibitor [602306-29-6]
BMS265246 potent and selective Cdk1/Cdk2 inhibitor [582315-72-8]
BS-181 HCl small molecule inhibitor which is highly selective for Cdk7 activity [1397219-81-6]
Deferasirox rationally-designed oral iron chelator. [201530-41-8]
Dinaciclib (SCH727965) CDK inhibitor [779353-01-4]
Flavopiridol hydrochloride pan-cdk inhibitor. [131740-09-5]
LEE011 orally available CDK inhibitor. [1211441-98-3]
LY2835219 orally available CDK inhibitor, targets the CDK4 and CDK6 [1231930-82-7]
Nu 6027 potent inhibitor of cellular ATR activity [220036-08-8]
Palbociclib (PD0332991) Isethionate Highly selective CDK4/6 inhibitor [827022-33-3]
PD 0332991 (Palbociclib) HCl Highly selective CDK4/6 inhibitor [827022-33-3]
PHA-793887 novel pan-Cdk inhibitor [718630-59-2]
PHA-848125 potent, ATP-competitive Cdk2/cyclin A inhibitor. [802539-81-7]
Purvalanol B cyclin-dependent kinase inhibitor. [212844-54-7]
R547 novel, selective inhibitor of cell cycle and transcriptional CDK. [741713-40-6]
Roscovitine (Seliciclib,CYC202) potent and selective inhibitor of cyclin-dependent kinases [186692-46-6]
SB1317 novel pyrimidine-based multi-kinase inhibitor that inhibits CDKs 1, 2, 7 and 9 together with JAK2 and FLT3 [937270-47-8]
SCH900776 S-isomer potent, selective and orally bioavailable inhibitor of checkpoint kinase Chk1 [891494-64-7]
SNS-032 (BMS-387032) Potent and selective CDK inhibitor [345627-80-7]

(2) HMDB Compounds for CDK7 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0

(2) Drugbank Compounds for CDK7 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Flavopiridol
  • Alvocidib
131740-09-5 target
Phosphonothreonine
target

(12) Novoseek inferred chemical compound relationships for CDK7 Gene

Compound -log(P) Hits PubMed IDs
roscovitine 77.8 10
threonine 56.7 15
5,6-dichloro-1-beta-d-ribofuranosylbenzimidazole 50.5 1
atp 28.5 5
serine 28.4 4
genes like me logo Genes that share compounds with CDK7: view

Transcripts for CDK7 Gene

Unigene Clusters for CDK7 Gene

Cyclin-dependent kinase 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CDK7 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b
SP1:
SP2: -
SP3: -
SP4: -

Relevant External Links for CDK7 Gene

GeneLoc Exon Structure for
CDK7
ECgene alternative splicing isoforms for
CDK7

Expression for CDK7 Gene

mRNA expression in normal human tissues for CDK7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CDK7 Gene

SOURCE GeneReport for Unigene cluster for CDK7 Gene Hs.184298

mRNA Expression by UniProt/SwissProt for CDK7 Gene

P50613-CDK7_HUMAN
Tissue specificity: Ubiquitous
genes like me logo Genes that share expressions with CDK7: view

Orthologs for CDK7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CDK7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDK7 36
  • 99.52 (n)
  • 100 (a)
CDK7 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CDK7 36
  • 93.35 (n)
  • 96.82 (a)
CDK7 37
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CDK7 36
  • 92.2 (n)
  • 94.51 (a)
CDK7 37
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdk7 36
  • 87.67 (n)
  • 95.09 (a)
Cdk7 16
Cdk7 37
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CDK7 37
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDK7 37
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdk7 36
  • 85.55 (n)
  • 90.46 (a)
chicken
(Gallus gallus)
Aves CDK7 36
  • 79.59 (n)
  • 88.34 (a)
CDK7 37
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDK7 37
  • 88 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.1768 36
tropical clawed frog
(Silurana tropicalis)
Amphibia cdk7 36
  • 75.17 (n)
  • 86.67 (a)
Str.10484 36
zebrafish
(Danio rerio)
Actinopterygii cdk7 36
  • 74.4 (n)
  • 85.8 (a)
cdk7 37
  • 86 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002646 36
  • 56.73 (n)
  • 67.84 (a)
fruit fly
(Drosophila melanogaster)
Insecta Cdk7 36
  • 61.11 (n)
  • 67.54 (a)
Cdk7 37
  • 66 (a)
OneToOne
Cdk7 38
  • 66 (a)
CG6800 38
  • 38 (a)
worm
(Caenorhabditis elegans)
Secernentea cdk-7 36
  • 59.27 (n)
  • 60.93 (a)
cdk-7 37
  • 59 (a)
OneToOne
H01G02.2 38
  • 40 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL283W 36
  • 50.44 (n)
  • 47.33 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KIN28 36
  • 54.51 (n)
  • 49.31 (a)
KIN28 37
  • 47 (a)
OneToMany
KIN28 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E14785g 36
  • 54.14 (n)
  • 48.04 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons CAK4 36
  • 58.04 (n)
  • 56.63 (a)
rice
(Oryza sativa)
Liliopsida Os.2689 36
bread mold
(Neurospora crassa)
Ascomycetes NCU03659 36
  • 48.28 (n)
  • 43.85 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes mcs6 36
  • 55.33 (n)
  • 54 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.961 36
Species with no ortholog for CDK7:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CDK7 Gene

ENSEMBL:
Gene Tree for CDK7 (if available)
TreeFam:
Gene Tree for CDK7 (if available)

Paralogs for CDK7 Gene

Paralogs for CDK7 Gene

Pseudogenes.org Pseudogenes for CDK7 Gene

genes like me logo Genes that share paralogs with CDK7: view

Variants for CDK7 Gene

Sequence variations from dbSNP and Humsavar for CDK7 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs1137380 -- 69,277,333(+) AGAGT(A/C/G)CAAAA utr-variant-3-prime
rs1137381 -- 69,277,335(+) AGTGC(A/C)AAAGT utr-variant-3-prime
rs1203197 -- 69,240,261(+) ttttt(C/T)ttctt intron-variant
rs2054974 -- 69,254,048(+) tgagc(C/T)gagat intron-variant
rs2054975 -- 69,254,804(+) TTCTA(C/T)CCCGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CDK7 Gene

Variant ID Type Subtype PubMed ID
nsv821643 CNV Loss 15273396

Relevant External Links for CDK7 Gene

HapMap Linkage Disequilibrium report
CDK7

Disorders for CDK7 Gene

(1) MalaCards Diseases for CDK7 Gene

Search for CDK7 Gene in MalaCards »

(12) Novoseek inferred disease relationships for CDK7 Gene

Disease -log(P) Hits PubMed IDs
xeroderma pigmentosum 50.9 1
cancer 13.2 4
glioma 11.6 2
shock 0 2
breast cancer 0 6

Relevant External Links for CDK7

Genetic Association Database (GAD)
CDK7
Human Genome Epidemiology (HuGE) Navigator
CDK7
genes like me logo Genes that share disorders with CDK7: view

No data available for UniProtKB/Swiss-Prot for CDK7 Gene

Publications for CDK7 Gene

  1. A novel cyclin associates with MO15/CDK7 to form the CDK-activating kinase. (PMID: 8069918) Fisher R.P. … Morgan D.O. (Cell 1994) 2 3 4 23
  2. Cell cycle analysis of the activity, subcellular localization, and subunit composition of human CAK (CDK-activating kinase). (PMID: 7929589) Tassan J.-P. … Nigg E.A. (J. Cell Biol. 1994) 3 4 23
  3. Cloning, expression and subcellular localization of the human homolog of p40MO15 catalytic subunit of cdk-activating kinase. (PMID: 7936635) Darbon J.-M. … Blanchard J.-M. (Oncogene 1994) 3 4 23
  4. Two novel human serine/threonine kinases with homologies to the cell cycle regulating Xenopus MO15, and NIMA kinases: cloning and characterization of their expression pattern. (PMID: 8208544) Levedakou E.N. … Liu E.T. (Oncogene 1994) 3 4 23
  5. p53 is phosphorylated by CDK7-cyclin H in a p36MAT1-dependent manner. (PMID: 9372954) Ko L.J. … Pan Z.-Q. (Mol. Cell. Biol. 1997) 3 4 23

Products for CDK7 Gene

  • Addgene plasmids for CDK7

Sources for CDK7 Gene

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