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CDK7 Gene(Protein Coding)

Cyclin Dependent Kinase 7

GCID:
GC05P069242
GIFtS:
54
Genes Participants
UDN Logo

Aliases for CDK7 Gene

Aliases for CDK7 Gene

  • Cyclin Dependent Kinase 7 2 3 5
  • Cyclin-Dependent Kinase 7 (MO15 Homolog, Xenopus Laevis, Cdk-Activating Kinase) 2 3
  • TFIIH Basal Transcription Factor Complex Kinase Subunit 3 4
  • Cell Division Protein Kinase 7 3 4
  • CDK-Activating Kinase 1 3 4
  • 39 KDa Protein Kinase 3 4
  • EC 2.7.11.22 4 56
  • CDKN7 3 4
  • STK1 3 4
  • CAK1 3 4
  • MO15 3 4
  • CAK 3 4
  • Cyclin-Dependent Kinase 7 (Homolog Of Xenopus MO15 Cdk-Activating Kinase) 2
  • Homolog Of Xenopus MO15 Cdk-Activating Kinase 3
  • Serine/Threonine Protein Kinase MO15 3
  • Serine/Threonine Protein Kinase 1 3
  • Serine/Threonine-Protein Kinase 1 4
  • Serine/Threonine Kinase Stk1 3
  • Cyclin-Dependent Kinase 7 3
  • Kinase Subunit Of CAK 3
  • EC 2.7.11.24 56
  • EC 2.7.11.23 4
  • EC 2.7.11 56
  • P39 Mo15 4
  • P39MO15 3
  • HCAK 3

External Ids for CDK7 Gene

Previous GeneCards Identifiers for CDK7 Gene

  • GC05P068682
  • GC05P070096
  • GC05P068501
  • GC05P068546
  • GC05P068566
  • GC05P068530
  • GC05P065486

Summaries for CDK7 Gene

Entrez Gene Summary for CDK7 Gene

  • The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This protein forms a trimeric complex with cyclin H and MAT1, which functions as a Cdk-activating kinase (CAK). It is an essential component of the transcription factor TFIIH, that is involved in transcription initiation and DNA repair. This protein is thought to serve as a direct link between the regulation of transcription and the cell cycle. [provided by RefSeq, Jul 2008]

GeneCards Summary for CDK7 Gene

CDK7 (Cyclin Dependent Kinase 7) is a Protein Coding gene. Diseases associated with CDK7 include Breast Cancer and Hemophagocytic Lymphohistiocytosis, Familial, 3. Among its related pathways are RNA Polymerase II Transcription Initiation And Promoter Clearance and Formation of HIV elongation complex in the absence of HIV Tat. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CDK20.

UniProtKB/Swiss-Prot for CDK7 Gene

  • Serine/threonine kinase involved in cell cycle control and in RNA polymerase II-mediated RNA transcription. Cyclin-dependent kinases (CDKs) are activated by the binding to a cyclin and mediate the progression through the cell cycle. Each different complex controls a specific transition between 2 subsequent phases in the cell cycle. Required for both activation and complex formation of CDK1/cyclin-B during G2-M transition, and for activation of CDK2/cyclins during G1-S transition (but not complex formation). CDK7 is the catalytic subunit of the CDK-activating kinase (CAK) complex. Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation, thus regulating cell cycle progression. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Phosphorylation of POLR2A in complex with DNA promotes transcription initiation by triggering dissociation from DNA. Its expression and activity are constant throughout the cell cycle. Upon DNA damage, triggers p53/TP53 activation by phosphorylation, but is inactivated in turn by p53/TP53; this feedback loop may lead to an arrest of the cell cycle and of the transcription, helping in cell recovery, or to apoptosis. Required for DNA-bound peptides-mediated transcription and cellular growth inhibition.

Gene Wiki entry for CDK7 Gene

Additional gene information for CDK7 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDK7 Gene

Genomics for CDK7 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for CDK7 Gene

Promoters and enhancers for CDK7 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH05I069233 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 565 +0.1 121 2.2 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 POLR2B CDK7 CCDC125 SLC30A5 GTF2H2C ENSG00000198237 ENSG00000254701 CENPH CCNB1 SNORA50D SMN2
GH05I069188 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 13.1 -45.1 -45070 2.4 PKNOX1 ARNT ARID4B NEUROD1 SIN3A FEZF1 DMAP1 YY1 SLC30A9 POLR2B CENPH ENSG00000280187 PIR38105 PIR48224 PIR41528 PIR42195 CCDC125 CDK7 CCNB1 SNORA50D
GH05I069489 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 9.8 +258.6 258597 8.8 PKNOX1 FOXA2 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 SP3 NFYC OCLN ENSG00000198237 ENSG00000254701 MARVELD2 RNU6-724P SLC30A5 SMA4 CDK7 GUSBP3 ENSG00000179978
GH05I069275 Enhancer 0.8 ENCODE 26 +42.2 42192 2.1 ELF3 SOX13 FOXA2 SAP130 ARID4B ZNF384 CEBPG RARA ETS1 TEAD3 CDK7 CCDC125 RAD17 CCNB1 GC05P069259 GC05P069260 CFL1P5
GH05I069330 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 9.9 +97.7 97719 3.4 HDGF SMAD1 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 IRF4 CCDC125 CHCHD2P2 GC05P069334 ENSG00000198237 ENSG00000254701 GTF2H2C SLC30A5 SMA4 AK6 CDK7
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CDK7 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CDK7 gene promoter:

Genomic Locations for CDK7 Gene

Genomic Locations for CDK7 Gene
chr5:69,234,795-69,277,430
(GRCh38/hg38)
Size:
42,636 bases
Orientation:
Plus strand
chr5:68,530,622-68,573,257
(GRCh37/hg19)

Genomic View for CDK7 Gene

Genes around CDK7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDK7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDK7 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CDK7 Gene

Proteins for CDK7 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for CDK7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P50613-CDK7_HUMAN
    Recommended name:
    Cyclin-dependent kinase 7
    Protein Accession:
    P50613
    Secondary Accessions:
    • Q9BS60
    • Q9UE19

    Protein attributes for CDK7 Gene

    Size:
    346 amino acids
    Molecular mass:
    39038 Da
    Quaternary structure:
    • Associates primarily with cyclin-H (CCNH) and MAT1 to form the CAK complex. CAK can further associate with the core-TFIIH to form the TFIIH basal transcription factor; this complex is sensitive to UV light. The CAK complex binds to p53/TP53 in response to DNA damage. Interacts with CDK2, SF1/NR5A1, PUF60 and PRKCI.

    Three dimensional structures from OCA and Proteopedia for CDK7 Gene

neXtProt entry for CDK7 Gene

Protein Expression for CDK7 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for CDK7 Gene

P50613:
  • ILHRDLK
  • LREIKLL
  • LADFGLA
  • LGTPTEE
  • TRWYRAPE

Post-translational modifications for CDK7 Gene

  • Phosphorylation of Ser-164 during mitosis inactivates the enzyme. Phosphorylation of Thr-170 is required for activity. Phosphorylated at Ser-164 and Thr-170 by CDK2.

Other Protein References for CDK7 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for CDK7 Gene

Gene Families for CDK7 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for CDK7 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CDK7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P50613

UniProtKB/Swiss-Prot:

CDK7_HUMAN :
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
genes like me logo Genes that share domains with CDK7: view

Function for CDK7 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for CDK7 Gene

GENATLAS Biochemistry:
CDK-activating kinase 1,homolog of Xenopus p40-M015,gene or pseudogene,expressed in a breast cancer line,forming aternary complex with CCNH and MNAT1 (see symbols),associating in the multisubunit complex TFIIH (GTF2H),putatively involved in cell cycle control,transcription DNA repair
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inactivated by phosphorylation. Repressed by roscovitine (seliciclib, CYC202), R547 (Ro-4584820) and SNS-032 (BMS-387032). The association of p53/TP53 to the CAK complex in response to DNA damage reduces kinase activity toward CDK2 and RNA polymerase II repetitive C-terminal domain (CTD), thus stopping cell cycle progression. The inactivation by roscovitine promotes caspase-mediated apoptosis in leukemic cells.
UniProtKB/Swiss-Prot Function:
Serine/threonine kinase involved in cell cycle control and in RNA polymerase II-mediated RNA transcription. Cyclin-dependent kinases (CDKs) are activated by the binding to a cyclin and mediate the progression through the cell cycle. Each different complex controls a specific transition between 2 subsequent phases in the cell cycle. Required for both activation and complex formation of CDK1/cyclin-B during G2-M transition, and for activation of CDK2/cyclins during G1-S transition (but not complex formation). CDK7 is the catalytic subunit of the CDK-activating kinase (CAK) complex. Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation, thus regulating cell cycle progression. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Phosphorylation of POLR2A in complex with DNA promotes transcription initiation by triggering dissociation from DNA. Its expression and activity are constant throughout the cell cycle. Upon DNA damage, triggers p53/TP53 activation by phosphorylation, but is inactivated in turn by p53/TP53; this feedback loop may lead to an arrest of the cell cycle and of the transcription, helping in cell recovery, or to apoptosis. Required for DNA-bound peptides-mediated transcription and cellular growth inhibition.
UniProtKB/Swiss-Prot Induction:
Repressed by DNA-bound peptides.

Enzyme Numbers (IUBMB) for CDK7 Gene

Gene Ontology (GO) - Molecular Function for CDK7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003713 transcription coactivator activity NAS 15572661
GO:0004672 protein kinase activity TAS,IEA 7533895
GO:0004674 protein serine/threonine kinase activity TAS --
GO:0004693 cyclin-dependent protein serine/threonine kinase activity IBA,TAS --
genes like me logo Genes that share ontologies with CDK7: view
genes like me logo Genes that share phenotypes with CDK7: view

miRNA for CDK7 Gene

miRTarBase miRNAs that target CDK7

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CDK7 Gene

Localization for CDK7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDK7 Gene

Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Note=Colocalizes with PRKCI in the cytoplasm and nucleus. Translocates from the nucleus to cytoplasm and perinuclear region in response to DNA-bound peptides.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDK7 gene
Compartment Confidence
nucleus 5
cytosol 4
mitochondrion 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for CDK7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 16109376
GO:0005654 nucleoplasm TAS --
GO:0005675 holo TFIIH complex IDA 9852112
GO:0005737 cytoplasm IBA --
GO:0019907 cyclin-dependent protein kinase activating kinase holoenzyme complex IMP 23393140
genes like me logo Genes that share ontologies with CDK7: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CDK7 Gene

Pathways & Interactions for CDK7 Gene

SuperPathways for CDK7 Gene

PathCards logo More details on SuperPathways for CDK7
SuperPathway Contained pathways
1 Formation of HIV elongation complex in the absence of HIV Tat
RNA Polymerase II Pre-transcription Events
.84
Transcription of the HIV genome
.84
Formation of HIV elongation complex in the absence of HIV Tat
.81
Formation of RNA Pol II elongation complex
.81
RNA Polymerase II Transcription Elongation
.81
Formation of HIV-1 elongation complex containing HIV-1 Tat
.78
HIV Transcription Elongation
.78
Tat-mediated elongation of the HIV-1 transcript
.78
TP53 Regulates Transcription of DNA Repair Genes
.70
RNA Polymerase II Transcription
.56
2 RNA Polymerase II Transcription Initiation And Promoter Clearance
HIV Transcription Initiation
.71
RNA Polymerase II HIV Promoter Escape
.71
RNA Polymerase II Promoter Escape
.71
RNA Polymerase II Transcription Initiation
.71
RNA Polymerase II Transcription Initiation And Promoter Clearance
.71
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
.71
Basal transcription factors
.59
Eukaryotic Transcription Initiation
.53
Transcription Ligand-Dependent Transcription of Retinoid-Target genes
.32
3 Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Dual incision in TC-NER
.90
Gap-filling DNA repair synthesis and ligation in TC-NER
.90
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
.84
Global Genome Nucleotide Excision Repair (GG-NER)
.76
Nucleotide Excision Repair
.76
Formation of TC-NER Pre-Incision Complex
.68
Formation of Incision Complex in GG-NER
.51
4 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
NoRC negatively regulates rRNA expression
.83
RNA Polymerase I Chain Elongation
.83
RNA Polymerase I Transcription
.81
Negative epigenetic regulation of rRNA expression
.81
RNA Polymerase I Promoter Clearance
.81
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
.75
Epigenetic regulation of gene expression
.73
5 HIV Life Cycle
HIV Life Cycle
.92
Late Phase of HIV Life Cycle
.92
HIV Infection
.65
Infectious disease
.61
Disease
.45
genes like me logo Genes that share pathways with CDK7: view

SIGNOR curated interactions for CDK7 Gene

Activates:
Inactivates:
Is activated by:
Other effect:

Gene Ontology (GO) - Biological Process for CDK7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity TAS 7533895
GO:0000082 G1/S transition of mitotic cell cycle TAS --
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0006281 DNA repair IEA --
GO:0006283 transcription-coupled nucleotide-excision repair TAS --
genes like me logo Genes that share ontologies with CDK7: view

Drugs & Compounds for CDK7 Gene

Products:

  1. Drug

(32) Drugs for CDK7 Gene - From: DrugBank, ApexBio, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Alvocidib Experimental, Investigational Pharma Target, inhibitor Pan-cdk inhibitor, Kinase Inhibitors 60
Phosphonothreonine Experimental Pharma Target 0
ATP Investigational Nutra Agonist 0
AT7519 Investigational Pharma Multi-CDK inhibitor 0
PHA-793887 Investigational Pharma Pan-Cdk inhibitor 0

(3) Additional Compounds for CDK7 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
 Full agonist, Agonist 58-64-0

(14) ApexBio Compounds for CDK7 Gene

Compound Action Cas Number
AT7519 Multi-CDK inhibitor 844442-38-2
BS-181 CDK7 inhibitor,highly selective 1092443-52-1
BS-181 HCl CDK7 inhibitor,highly selective 1397219-81-6
CDK7-IN-1 1604810-84-5
Flavopiridol hydrochloride 131740-09-5
JNJ-7706621 Potent CDK/Aurora kinase inhibitor 443797-96-4
LDC000067 1073485-20-7
PHA-793887 Pan-Cdk inhibitor 718630-59-2
PHA-848125 CDK inhibitor,potent and ATP-competitive 802539-81-7
Roscovitine (Seliciclib,CYC202) CDK inhibitor,potent and selective 186692-46-6
SNS-032 (BMS-387032) CDK inhibitor 345627-80-7
THZ1 Covalent CDK7 inhibitor,potent and selective
THZ1 Hydrochloride CDK7 inhibitor
THZ2 CDK7 inhibitor 1604810-84-5
genes like me logo Genes that share compounds with CDK7: view

Drug Products

Transcripts for CDK7 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for CDK7 Gene

(10) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(207) Selected AceView cDNA sequences:
(15) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CDK7 Gene

Cyclin-dependent kinase 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CDK7 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b
SP1:
SP2: -
SP3: -
SP4: -

Relevant External Links for CDK7 Gene

GeneLoc Exon Structure for
CDK7
ECgene alternative splicing isoforms for
CDK7

Expression for CDK7 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CDK7 Gene

mRNA expression in normal human tissues for CDK7 Gene
mRNA expression by BioGPS for CDK7 GenemRNA expression by GTEx for CDK7 Gene

Protein differential expression in normal tissues from HIPED for CDK7 Gene

This gene is overexpressed in Breast (48.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CDK7 Gene



Protein tissue co-expression partners for CDK7 Gene

NURSA nuclear receptor signaling pathways regulating expression of CDK7 Gene:

CDK7

SOURCE GeneReport for Unigene cluster for CDK7 Gene:

Hs.184298

mRNA Expression by UniProt/SwissProt for CDK7 Gene:

P50613-CDK7_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for CDK7 Gene

  • Liver(4.3)
  • Lung(4.2)
  • Nervous system(2.8)
genes like me logo Genes that share expression patterns with CDK7: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CDK7 Gene

Orthologs for CDK7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CDK7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia CDK7 33 34
  • 99.52 (n)
oppossum
(Monodelphis domestica)
 Mammalia CDK7 34
  • 96 (a)
 OneToOne
cow
(Bos Taurus)
 Mammalia CDK7 33 34
  • 93.35 (n)
dog
(Canis familiaris)
 Mammalia CDK7 33 34
  • 92.2 (n)
platypus
(Ornithorhynchus anatinus)
 Mammalia CDK7 34
  • 90 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Cdk7 33 16 34
  • 87.67 (n)
rat
(Rattus norvegicus)
 Mammalia Cdk7 33
  • 85.55 (n)
chicken
(Gallus gallus)
 Aves CDK7 33 34
  • 79.59 (n)
lizard
(Anolis carolinensis)
 Reptilia CDK7 34
  • 88 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia cdk7 33
  • 75.17 (n)
Str.10484 33
African clawed frog
(Xenopus laevis)
 Amphibia Xl.1768 33
zebrafish
(Danio rerio)
 Actinopterygii cdk7 33 34
  • 74.4 (n)
fruit fly
(Drosophila melanogaster)
 Insecta Cdk7 35 33 34
  • 61.11 (n)
CG6800 35
  • 38 (a)
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP002646 33
  • 56.73 (n)
worm
(Caenorhabditis elegans)
 Secernentea cdk-7 33 34
  • 59.27 (n)
H01G02.2 35
  • 40 (a)
baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes KIN28 33 34 36
  • 54.51 (n)
K. lactis yeast
(Kluyveromyces lactis)
 Saccharomycetes KLLA0E14785g 33
  • 54.14 (n)
A. gosspyii yeast
(Ashbya gossypii)
 Saccharomycetes AGOS_ADL283W 33
  • 50.44 (n)
thale cress
(Arabidopsis thaliana)
 eudicotyledons CAK4 33
  • 58.04 (n)
rice
(Oryza sativa)
 Liliopsida Os.2689 33
fission yeast
(Schizosaccharomyces pombe)
 Schizosaccharomycetes mcs6 33
  • 55.33 (n)
bread mold
(Neurospora crassa)
 Ascomycetes NCU03659 33
  • 48.28 (n)
sea squirt
(Ciona intestinalis)
 Ascidiacea Cin.961 33
Species where no ortholog for CDK7 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CDK7 Gene

ENSEMBL:
Gene Tree for CDK7 (if available)
TreeFam:
Gene Tree for CDK7 (if available)

Paralogs for CDK7 Gene

Paralogs for CDK7 Gene

(98) SIMAP similar genes for CDK7 Gene using alignment to 10 proteins:

Pseudogenes.org Pseudogenes for CDK7 Gene

genes like me logo Genes that share paralogs with CDK7: view

Variants for CDK7 Gene

Sequence variations from dbSNP and Humsavar for CDK7 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000026517 -- 69,271,306(+) A/G intron_variant
rs1000309175 -- 69,270,255(+) G/A intron_variant
rs1000319513 -- 69,245,107(+) A/T intron_variant
rs1000352636 -- 69,263,110(+) AAAAAAAA/AAAAAAAAA intron_variant
rs1000361272 -- 69,249,887(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CDK7 Gene

Variant ID Type Subtype PubMed ID
dgv5694n100 CNV gain 25217958
nsv821643 CNV loss 15273396

Variation tolerance for CDK7 Gene

Residual Variation Intolerance Score: 32.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.07; 37.97% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CDK7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDK7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDK7 Gene

Disorders for CDK7 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CDK7 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
breast cancer
  • breast cancer, familial
hemophagocytic lymphohistiocytosis, familial, 3
  • fhl3
- elite association - COSMIC cancer census association via MalaCards
Search CDK7 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CDK7

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CDK7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CDK7 Gene

Publications for CDK7 Gene

  1. A novel cyclin associates with MO15/CDK7 to form the CDK-activating kinase. (PMID: 8069918) Fisher RP … Morgan DO (Cell 1994) 2 3 4 22 58
  2. Combined genetic effect of CDK7 and ESR1 polymorphisms on breast cancer. (PMID: 19941161) Jeon S … Kang D (Breast cancer research and treatment 2010) 3 22 44 58
  3. TFIIH-associated Cdk7 kinase functions in phosphorylation of C-terminal domain Ser7 residues, promoter-proximal pausing, and termination by RNA polymerase II. (PMID: 19667075) Glover-Cutter K … Bentley DL (Molecular and cellular biology 2009) 3 4 22 58
  4. Phosphorylation of steroidogenic factor 1 is mediated by cyclin-dependent kinase 7. (PMID: 17901130) Lewis AE … Bakke M (Molecular endocrinology (Baltimore, Md.) 2008) 3 4 22 58
  5. Requirements for Cdk7 in the assembly of Cdk1/cyclin B and activation of Cdk2 revealed by chemical genetics in human cells. (PMID: 17386261) Larochelle S … Fisher RP (Molecular cell 2007) 3 4 22 58

Products for CDK7 Gene

  • Addgene plasmids for CDK7

Sources for CDK7 Gene

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