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Aliases for CDK7 Gene

Aliases for CDK7 Gene

  • Cyclin-Dependent Kinase 7 2 3
  • Cyclin-Dependent Kinase 7 (MO15 Homolog, Xenopus Laevis, Cdk-Activating Kinase) 2 3
  • TFIIH Basal Transcription Factor Complex Kinase Subunit 3 4
  • Serine/Threonine-Protein Kinase 1 3 4
  • Cell Division Protein Kinase 7 3 4
  • CDK-Activating Kinase 1 3 4
  • 39 KDa Protein Kinase 3 4
  • EC 2.7.11.22 4 63
  • P39 Mo15 3 4
  • CDKN7 3 4
  • CAK1 3 4
  • MO15 3 4
  • STK1 3 4
  • CAK 3 4
  • Cyclin-Dependent Kinase 7 (Homolog Of Xenopus MO15 Cdk-Activating Kinase) 2
  • Homolog Of Xenopus MO15 Cdk-Activating Kinase 3
  • Serine/Threonine Protein Kinase MO15 3
  • Serine/Threonine Protein Kinase 1 3
  • Serine/Threonine Kinase Stk1 3
  • Kinase Subunit Of CAK 3
  • Protein Kinase 3
  • EC 2.7.11.24 63
  • EC 2.7.11.23 4
  • EC 2.7.11 63
  • P39MO15 3
  • HCAK 3

External Ids for CDK7 Gene

Previous GeneCards Identifiers for CDK7 Gene

  • GC05P068682
  • GC05P070096
  • GC05P068501
  • GC05P068546
  • GC05P068566
  • GC05P068530
  • GC05P065486

Summaries for CDK7 Gene

Entrez Gene Summary for CDK7 Gene

  • The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This protein forms a trimeric complex with cyclin H and MAT1, which functions as a Cdk-activating kinase (CAK). It is an essential component of the transcription factor TFIIH, that is involved in transcription initiation and DNA repair. This protein is thought to serve as a direct link between the regulation of transcription and the cell cycle. [provided by RefSeq, Jul 2008]

GeneCards Summary for CDK7 Gene

CDK7 (Cyclin-Dependent Kinase 7) is a Protein Coding gene. Diseases associated with CDK7 include xeroderma pigmentosum, variant type and breast cancer. Among its related pathways are Infectious disease and Regulation of PLK1 Activity at G2/M Transition. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CDKL3.

UniProtKB/Swiss-Prot for CDK7 Gene

  • Serine/threonine kinase involved in cell cycle control and in RNA polymerase II-mediated RNA transcription. Cyclin-dependent kinases (CDKs) are activated by the binding to a cyclin and mediate the progression through the cell cycle. Each different complex controls a specific transition between 2 subsequent phases in the cell cycle. Required for both activation and complex formation of CDK1/cyclin-B during G2-M transition, and for activation of CDK2/cyclins during G1-S transition (but not complex formation). CDK7 is the catalytic subunit of the CDK-activating kinase (CAK) complex. Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation, thus regulating cell cycle progression. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Phosphorylation of POLR2A in complex with DNA promotes transcription initiation by triggering dissociation from DNA. Its expression and activity are constant throughout the cell cycle. Upon DNA damage, triggers p53/TP53 activation by phosphorylation, but is inactivated in turn by p53/TP53; this feedback loop may lead to an arrest of the cell cycle and of the transcription, helping in cell recovery, or to apoptosis. Required for DNA-bound peptides-mediated transcription and cellular growth inhibition.

Gene Wiki entry for CDK7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDK7 Gene

Genomics for CDK7 Gene

Regulatory Elements for CDK7 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CDK7 Gene

Chromosome:
5
Start:
69,234,795 bp from pter
End:
69,277,430 bp from pter
Size:
42,636 bases
Orientation:
Plus strand

Genomic View for CDK7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CDK7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDK7 Gene

Proteins for CDK7 Gene

  • Protein details for CDK7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P50613-CDK7_HUMAN
    Recommended name:
    Cyclin-dependent kinase 7
    Protein Accession:
    P50613
    Secondary Accessions:
    • Q9BS60
    • Q9UE19

    Protein attributes for CDK7 Gene

    Size:
    346 amino acids
    Molecular mass:
    39038 Da
    Quaternary structure:
    • Associates primarily with cyclin-H (CCNH) and MAT1 to form the CAK complex. CAK can further associate with the core-TFIIH to form the TFIIH basal transcription factor; this complex is sensitive to UV light. The CAK complex binds to p53/TP53 in response to DNA damage. Interacts with CDK2, SF1/NR5A1, PUF60 and PRKCI.

    Three dimensional structures from OCA and Proteopedia for CDK7 Gene

neXtProt entry for CDK7 Gene

Proteomics data for CDK7 Gene at MOPED

Selected DME Specific Peptides for CDK7 Gene

Post-translational modifications for CDK7 Gene

  • Phosphorylation of Ser-164 during mitosis inactivates the enzyme. Phosphorylation of Thr-170 is required for activity. Phosphorylated at Ser-164 and Thr-170 by CDK2.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CDK7 (CDK7)

Domains & Families for CDK7 Gene

Gene Families for CDK7 Gene

Suggested Antigen Peptide Sequences for CDK7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P50613

UniProtKB/Swiss-Prot:

CDK7_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
genes like me logo Genes that share domains with CDK7: view

Function for CDK7 Gene

Molecular function for CDK7 Gene

GENATLAS Biochemistry:
CDK-activating kinase 1,homolog of Xenopus p40-M015,gene or pseudogene,expressed in a breast cancer line,forming aternary complex with CCNH and MNAT1 (see symbols),associating in the multisubunit complex TFIIH (GTF2H),putatively involved in cell cycle control,transcription DNA repair
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate
UniProtKB/Swiss-Prot EnzymeRegulation:
Inactivated by phosphorylation. Repressed by roscovitine (seliciclib, CYC202), R547 (Ro-4584820) and SNS-032 (BMS-387032). The association of p53/TP53 to the CAK complex in response to DNA damage reduces kinase activity toward CDK2 and RNA polymerase II repetitive C-terminal domain (CTD), thus stopping cell cycle progression. The inactivation by roscovitine promotes caspase-mediated apoptosis in leukemic cells.
UniProtKB/Swiss-Prot Function:
Serine/threonine kinase involved in cell cycle control and in RNA polymerase II-mediated RNA transcription. Cyclin-dependent kinases (CDKs) are activated by the binding to a cyclin and mediate the progression through the cell cycle. Each different complex controls a specific transition between 2 subsequent phases in the cell cycle. Required for both activation and complex formation of CDK1/cyclin-B during G2-M transition, and for activation of CDK2/cyclins during G1-S transition (but not complex formation). CDK7 is the catalytic subunit of the CDK-activating kinase (CAK) complex. Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation, thus regulating cell cycle progression. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Phosphorylation of POLR2A in complex with DNA promotes transcription initiation by triggering dissociation from DNA. Its expression and activity are constant throughout the cell cycle. Upon DNA damage, triggers p53/TP53 activation by phosphorylation, but is inactivated in turn by p53/TP53; this feedback loop may lead to an arrest of the cell cycle and of the transcription, helping in cell recovery, or to apoptosis. Required for DNA-bound peptides-mediated transcription and cellular growth inhibition.
UniProtKB/Swiss-Prot Induction:
Repressed by DNA-bound peptides.

Enzyme Numbers (IUBMB) for CDK7 Gene

Gene Ontology (GO) - Molecular Function for CDK7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity NAS 15572661
GO:0004672 protein kinase activity TAS 7533895
GO:0004693 cyclin-dependent protein serine/threonine kinase activity IEA --
GO:0005515 protein binding IPI 23397142
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with CDK7: view
genes like me logo Genes that share phenotypes with CDK7: view

Animal Model Products

miRNA for CDK7 Gene

miRTarBase miRNAs that target CDK7

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for CDK7 Gene

Localization for CDK7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDK7 Gene

Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Note=Colocalizes with PRKCI in the cytoplasm and nucleus. Translocates from the nucleus to cytoplasm and perinuclear region in response to DNA-bound peptides.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDK7 Gene COMPARTMENTS Subcellular localization image for CDK7 gene
Compartment Confidence
nucleus 5
mitochondrion 4
cytosol 2

Gene Ontology (GO) - Cellular Components for CDK7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 16109376
GO:0005654 nucleoplasm TAS --
GO:0005675 holo TFIIH complex IDA 9852112
GO:0005737 cytoplasm IDA --
GO:0005739 mitochondrion IDA --
genes like me logo Genes that share ontologies with CDK7: view

Pathways & Interactions for CDK7 Gene

SuperPathways for CDK7 Gene

Superpath Contained pathways
1 RNA Polymerase II Transcription Initiation And Promoter Clearance
2 Formation of the HIV-1 Early Elongation Complex
3 RNA Polymerase I Transcription
4 Transcription-Coupled Nucleotide Excision Repair (TC-NER)
5 Infectious disease
.53
genes like me logo Genes that share pathways with CDK7: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

SIGNOR curated interactions for CDK7 Gene

Activates:
Inactivates:
Is activated by:
Other effect:

Gene Ontology (GO) - Biological Process for CDK7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity TAS 7533895
GO:0000082 G1/S transition of mitotic cell cycle TAS --
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0000278 mitotic cell cycle TAS --
GO:0000718 nucleotide-excision repair, DNA damage removal --
genes like me logo Genes that share ontologies with CDK7: view

Drugs & Compounds for CDK7 Gene

(23) Drugs for CDK7 Gene - From: NovoSeek, HMDB, DGIdb, DrugBank, and ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Isoproterenol Approved Pharma Full agonist, Agonist 15
Nitric Oxide Approved Pharma 540
Progesterone Approved Pharma Inhibition, Pore Blocker Endogenous progesterone receptor agonist 473
Flavopiridol Experimental, Investigational Pharma inhibitor, Target Kinase Inhibitors 60

(3) Additional Compounds for CDK7 Gene - From: HMDB and NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Antagonist, Gating inhibitor 58-64-0
5,6-dichloro-1-beta-d-ribofuranosylbenzimidazole
retinoic acid
302-79-4
genes like me logo Genes that share compounds with CDK7: view

Transcripts for CDK7 Gene

Unigene Clusters for CDK7 Gene

Cyclin-dependent kinase 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CDK7 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b
SP1:
SP2: -
SP3: -
SP4: -

Relevant External Links for CDK7 Gene

GeneLoc Exon Structure for
CDK7
ECgene alternative splicing isoforms for
CDK7

Expression for CDK7 Gene

mRNA expression in normal human tissues for CDK7 Gene

Protein differential expression in normal tissues from HIPED for CDK7 Gene

This gene is overexpressed in Breast (48.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CDK7 Gene



SOURCE GeneReport for Unigene cluster for CDK7 Gene Hs.184298

mRNA Expression by UniProt/SwissProt for CDK7 Gene

P50613-CDK7_HUMAN
Tissue specificity: Ubiquitous
genes like me logo Genes that share expression patterns with CDK7: view

Protein tissue co-expression partners for CDK7 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for CDK7 Gene

Orthologs for CDK7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CDK7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CDK7 35
  • 93.35 (n)
  • 96.82 (a)
CDK7 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CDK7 35
  • 92.2 (n)
  • 94.51 (a)
CDK7 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdk7 35
  • 87.67 (n)
  • 95.09 (a)
Cdk7 16
Cdk7 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CDK7 35
  • 99.52 (n)
  • 100 (a)
CDK7 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdk7 35
  • 85.55 (n)
  • 90.46 (a)
oppossum
(Monodelphis domestica)
Mammalia CDK7 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDK7 36
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves CDK7 35
  • 79.59 (n)
  • 88.34 (a)
CDK7 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDK7 36
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdk7 35
  • 75.17 (n)
  • 86.67 (a)
Str.10484 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.1768 35
zebrafish
(Danio rerio)
Actinopterygii cdk7 35
  • 74.4 (n)
  • 85.8 (a)
cdk7 36
  • 86 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Cdk7 37
  • 66 (a)
CG6800 37
  • 38 (a)
Cdk7 35
  • 61.11 (n)
  • 67.54 (a)
Cdk7 36
  • 66 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002646 35
  • 56.73 (n)
  • 67.84 (a)
worm
(Caenorhabditis elegans)
Secernentea H01G02.2 37
  • 40 (a)
cdk-7 35
  • 59.27 (n)
  • 60.93 (a)
cdk-7 36
  • 59 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL283W 35
  • 50.44 (n)
  • 47.33 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E14785g 35
  • 54.14 (n)
  • 48.04 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KIN28 35
  • 54.51 (n)
  • 49.31 (a)
KIN28 36
  • 47 (a)
OneToMany
KIN28 38
thale cress
(Arabidopsis thaliana)
eudicotyledons CAK4 35
  • 58.04 (n)
  • 56.63 (a)
rice
(Oryza sativa)
Liliopsida Os.2689 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.961 35
bread mold
(Neurospora crassa)
Ascomycetes NCU03659 35
  • 48.28 (n)
  • 43.85 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes mcs6 35
  • 55.33 (n)
  • 54 (a)
Species with no ortholog for CDK7:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CDK7 Gene

ENSEMBL:
Gene Tree for CDK7 (if available)
TreeFam:
Gene Tree for CDK7 (if available)

Paralogs for CDK7 Gene

Paralogs for CDK7 Gene

Pseudogenes.org Pseudogenes for CDK7 Gene

genes like me logo Genes that share paralogs with CDK7: view

Variants for CDK7 Gene

Sequence variations from dbSNP and Humsavar for CDK7 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
VAR_023118 -
VAR_023119 -

Structural Variations from Database of Genomic Variants (DGV) for CDK7 Gene

Variant ID Type Subtype PubMed ID
nsv821643 CNV Loss 15273396

Variation tolerance for CDK7 Gene

Residual Variation Intolerance Score: 32.39% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.07; 37.97% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDK7 Gene

HapMap Linkage Disequilibrium report
CDK7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDK7 Gene

Disorders for CDK7 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CDK7 Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
xeroderma pigmentosum, variant type
  • de sanctis-cacchione syndrome
breast cancer
  • breast cancer, invasive ductal
- elite association
Search CDK7 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CDK7

Genetic Association Database (GAD)
CDK7
Human Genome Epidemiology (HuGE) Navigator
CDK7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CDK7
genes like me logo Genes that share disorders with CDK7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CDK7 Gene

Publications for CDK7 Gene

  1. A novel cyclin associates with MO15/CDK7 to form the CDK-activating kinase. (PMID: 8069918) Fisher R.P. … Morgan D.O. (Cell 1994) 2 23 67
  2. RNA polymerase II C-terminal heptarepeat domain Ser-7 phosphorylation is established in a mediator-dependent fashion. (PMID: 19901026) Boeing S. … Meisterernst M. (J. Biol. Chem. 2010) 23 67
  3. R-roscovitine (Seliciclib) affects CLL cells more strongly than combinations of fludarabine or cladribine with cyclophosphamide: Inhibition of CDK7 sensitizes leukemic cells to caspase-dependent apoptosis. (PMID: 19911397) Rogalinska M. … Wesierska-Gadek J. (J. Cell. Biochem. 2010) 23 67
  4. 8-Amino-adenosine inhibits multiple mechanisms of transcription. (PMID: 20053765) Frey J.A. … Gandhi V. (Mol. Cancer Ther. 2010) 23 67
  5. Cdc25 phosphatases are required for timely assembly of CDK1-cyclin B at the G2/M transition. (PMID: 20360007) Timofeev O. … Hoffmann I. (J. Biol. Chem. 2010) 23 67

Products for CDK7 Gene

  • Addgene plasmids for CDK7

Sources for CDK7 Gene

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