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Aliases for PRG4 Gene

Aliases for PRG4 Gene

  • Proteoglycan 4 2 3
  • Lubricin 2 3 4
  • Articular Superficial Zone Protein 2 3
  • Megakaryocyte Stimulating Factor 2 3
  • Superficial Zone Proteoglycan 3 4
  • MSF 3 4
  • SZP 3 4
  • Proteoglycan 4, (Megakaryocyte Stimulating Factor, Articular Superficial Zone Protein, Camptodactyly, Arthropathy, Coxa Vara, Pericarditis Syndrome) 2
  • Jacobs Camptodactyly-Arthropathy-Pericarditis Syndrome 2
  • BG174L6.2 (MSF: Megakaryocyte Stimulating Factor ) 2
  • Megakaryocyte-Stimulating Factor 4
  • Pericarditis Syndrome 2
  • Hemangiopoietin) 6
  • Hemangiopoietin 3
  • Camptodactyly 2
  • Arthropathy 2
  • Coxa Vara 2
  • JCAP 3
  • HAPO 3
  • CACP 3

External Ids for PRG4 Gene

Previous Symbols for PRG4 Gene

  • CACP

Summaries for PRG4 Gene

Entrez Gene Summary for PRG4 Gene

  • The protein encoded by this gene is a large proteoglycan that is synthesized by chondrocytes located at the surface of articular cartilage and by some synovial lining cells. This protein contains both chondroitin sulfate and keratan sulfate glycosaminoglycans. It functions as a boundary lubricant at the cartilage surface and contributes to the elastic absorption and energy dissipation of synovial fluid. Mutations in this gene result in camptodactyly-arthropathy-coxa vara-pericarditis syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

GeneCards Summary for PRG4 Gene

PRG4 (Proteoglycan 4) is a Protein Coding gene. Diseases associated with PRG4 include camptodactyly-arthropathy-coxa vara-pericarditis syndrome and pericarditis. Among its related pathways are ERK Signaling and ERK Signaling. GO annotations related to this gene include scavenger receptor activity and polysaccharide binding. An important paralog of this gene is ENSG00000273171.

UniProtKB/Swiss-Prot for PRG4 Gene

  • Plays a role in boundary lubrication within articulating joints. Prevents protein deposition onto cartilage from synovial fluid by controlling adhesion-dependent synovial growth and inhibiting the adhesion of synovial cells to the cartilage surface

  • Isoform F plays a role as a growth factor acting on the primitive cells of both hematopoietic and endothelial cell lineages

Gene Wiki entry for PRG4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRG4 Gene

Genomics for PRG4 Gene

Genomic Location for PRG4 Gene

Start:
186,296,273 bp from pter
End:
186,314,562 bp from pter
Size:
18,290 bases
Orientation:
Plus strand

Genomic View for PRG4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PRG4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRG4 Gene

Regulatory Elements for PRG4 Gene

Proteins for PRG4 Gene

  • Protein details for PRG4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92954-PRG4_HUMAN
    Recommended name:
    Proteoglycan 4
    Protein Accession:
    Q92954
    Secondary Accessions:
    • Q6DNC4
    • Q6DNC5
    • Q6ZMZ5
    • Q9BX49

    Protein attributes for PRG4 Gene

    Size:
    1404 amino acids
    Molecular mass:
    151077 Da
    Quaternary structure:
    • Homodimer; disulfide-linked.
    Miscellaneous:
    • Different forms varying in molecular weight have been observed. Such forms are possibly due to different levels of glycosylation and protein cleavage (By similarity).

    Alternative splice isoforms for PRG4 Gene

neXtProt entry for PRG4 Gene

Proteomics data for PRG4 Gene at MOPED

Post-translational modifications for PRG4 Gene

  • N-glycosylated (PubMed:16335952).
  • O-glycosylated; contains glycosaminoglycan chondroitin sulfate and keratan sulfate. O-glycosylated with sialylated oligosaccharides which are predominantly represented by the monosialylated core type I structure, NeuNAcalpha2-3Galbeta1-3GalNAc, with smaller amounts of disialylated O-glycans (PubMed:25187573).
  • The disulfide bond between Cys-1146 and Cys-1403 is essential for protein cleavage.
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn206 and Asn1159

No data available for DME Specific Peptides for PRG4 Gene

Domains for PRG4 Gene

UniProtKB/Swiss-Prot:

PRG4_HUMAN
Domain:
  • Contains 2 SMB (somatomedin-B) domains.:
    • Q92954
Similarity:
  • Contains 2 hemopexin repeats.:
    • Q92954
genes like me logo Genes that share domains with PRG4: view

No data available for Gene Families for PRG4 Gene

Function for PRG4 Gene

Molecular function for PRG4 Gene

UniProtKB/Swiss-Prot Function: Plays a role in boundary lubrication within articulating joints. Prevents protein deposition onto cartilage from synovial fluid by controlling adhesion-dependent synovial growth and inhibiting the adhesion of synovial cells to the cartilage surface
UniProtKB/Swiss-Prot Function: Isoform F plays a role as a growth factor acting on the primitive cells of both hematopoietic and endothelial cell lineages

Gene Ontology (GO) - Molecular Function for PRG4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005044 scavenger receptor activity IEA --
GO:0030247 polysaccharide binding IEA --
genes like me logo Genes that share ontologies with PRG4: view
genes like me logo Genes that share phenotypes with PRG4: view

Animal Models for PRG4 Gene

MGI Knock Outs for PRG4:

miRNA for PRG4 Gene

miRTarBase miRNAs that target PRG4

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for PRG4 Gene

Localization for PRG4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRG4 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRG4 Gene COMPARTMENTS Subcellular localization image for PRG4 gene
Compartment Confidence
extracellular 5
cytosol 1
endoplasmic reticulum 1
golgi apparatus 1
nucleus 1

Gene Ontology (GO) - Cellular Components for PRG4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA --
genes like me logo Genes that share ontologies with PRG4: view

Pathways for PRG4 Gene

genes like me logo Genes that share pathways with PRG4: view

Pathways by source for PRG4 Gene

Gene Ontology (GO) - Biological Process for PRG4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006898 receptor-mediated endocytosis IEA --
GO:0006955 immune response IEA --
GO:0008283 cell proliferation TAS 10545950
GO:0042127 regulation of cell proliferation IEA --
GO:0045409 negative regulation of interleukin-6 biosynthetic process IEA --
genes like me logo Genes that share ontologies with PRG4: view

Compounds for PRG4 Gene

(6) Novoseek inferred chemical compound relationships for PRG4 Gene

Compound -log(P) Hits PubMed IDs
hyaluronic acid 61.6 15
keratan sulfate 53.5 1
alginate 30.8 2
latex 29.2 2
hydroxyapatite 22.6 2
genes like me logo Genes that share compounds with PRG4: view

Transcripts for PRG4 Gene

Unigene Clusters for PRG4 Gene

Proteoglycan 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PRG4 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1:
SP2:
SP3: -
SP4: - -

Relevant External Links for PRG4 Gene

GeneLoc Exon Structure for
PRG4
ECgene alternative splicing isoforms for
PRG4

Expression for PRG4 Gene

mRNA expression in normal human tissues for PRG4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PRG4 Gene

This gene is overexpressed in Liver (14.2), Adipose - Visceral (Omentum) (8.5), Heart - Atrial Appendage (5.0), and Adipose - Subcutaneous (4.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PRG4 Gene

SOURCE GeneReport for Unigene cluster for PRG4 Gene Hs.647723

mRNA Expression by UniProt/SwissProt for PRG4 Gene

Q92954-PRG4_HUMAN
Tissue specificity: Highly expressed in synovial tissue, cartilage and liver and weakly in heart and lung. Isoform B is expressed in kidney, lung, liver, heart and brain. Isoform C and isoform D are widely expressed.
genes like me logo Genes that share expressions with PRG4: view

Orthologs for PRG4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PRG4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRG4 36
  • 96.8 (n)
  • 95.68 (a)
cow
(Bos Taurus)
Mammalia PRG4 36
  • 81.51 (n)
  • 74.19 (a)
PRG4 37
  • 68 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PRG4 37
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Prg4 16
Prg4 37
  • 68 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PRG4 37
  • 50 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PRG4 37
  • 40 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prg4 36
  • 79.21 (n)
  • 76.01 (a)
chicken
(Gallus gallus)
Aves PRG4 37
  • 34 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PRG4 37
  • 29 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii prg4a 37
  • 33 (a)
OneToMany
prg4b 37
  • 32 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 20 (a)
OneToMany
Species with no ortholog for PRG4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PRG4 Gene

ENSEMBL:
Gene Tree for PRG4 (if available)
TreeFam:
Gene Tree for PRG4 (if available)

Paralogs for PRG4 Gene

Paralogs for PRG4 Gene

Selected SIMAP similar genes for PRG4 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with PRG4: view

Variants for PRG4 Gene

Sequence variations from dbSNP and Humsavar for PRG4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1293987 -- 186,296,816(+) AGAGC(A/T)GTTTT intron-variant
rs1293988 -- 186,297,161(+) CTTGT(A/G)TAAAG intron-variant
rs1293989 -- 186,297,968(+) TAACA(A/C)TATGA intron-variant
rs1293990 -- 186,301,107(-) ATGCA(C/G)AGGCC intron-variant
rs1293991 -- 186,303,927(+) AGAAC(C/T)AGTAT intron-variant

Relevant External Links for PRG4 Gene

HapMap Linkage Disequilibrium report
PRG4
Human Gene Mutation Database (HGMD)
PRG4

No data available for Structural Variations from Database of Genomic Variants (DGV) for PRG4 Gene

Disorders for PRG4 Gene

(1) OMIM Diseases for PRG4 Gene (604283)

UniProtKB/Swiss-Prot

PRG4_HUMAN
  • Camptodactyly-arthropathy-coxa vara-pericarditis syndrome (CACP) [MIM:208250]: An autosomal recessive disorder characterized by the association of congenital or early-onset camptodactyly and non-inflammatory arthropathy with synovial hyperplasia. Individuals with CACP have normal appearing joints at birth but with advancing age develop joint failure, non-inflammatory synoviocyte hyperplasia and subintimal fibrosis of the synovial capsule. Some patients also manifest progressive coxa vara deformity and/or non-inflammatory pericardial or pleural effusions. {ECO:0000269 PubMed:10545950}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(5) University of Copenhagen DISEASES for PRG4 Gene

(6) Novoseek inferred disease relationships for PRG4 Gene

Disease -log(P) Hits PubMed IDs
cacp syndrome 96 8
osteoarthritis 62.6 4
synovitis 42 1
rheumatoid arthritis 28 3
inflammation 0 2

Relevant External Links for PRG4

Genetic Association Database (GAD)
PRG4
Human Genome Epidemiology (HuGE) Navigator
PRG4
genes like me logo Genes that share disorders with PRG4: view

Publications for PRG4 Gene

  1. Articular cartilage superficial zone protein (SZP) is homologous to megakaryocyte stimulating factor precursor and is a multifunctional proteoglycan with potential growth-promoting, cytoprotective, and lubricating properties in cartilage metabolism. (PMID: 9920774) Flannery C.R. … Caterson B. (Biochem. Biophys. Res. Commun. 1999) 2 3 4 23
  2. CACP, encoding a secreted proteoglycan, is mutated in camptodactyly- arthropathy-coxa vara-pericarditis syndrome. (PMID: 10545950) Marcelino J. … Warman M.L. (Nat. Genet. 1999) 2 3 4 23
  3. Lubricin is a product of megakaryocyte stimulating factor gene expression by human synovial fibroblasts. (PMID: 10743795) Jay G.D. … Cha C.-J. (J. Rheumatol. 2000) 3 4 23
  4. Isolation, characterization and mapping of the mouse and human PRG4 (proteoglycan 4) genes. (PMID: 11124536) Ikegawa S. … Nakamura Y. (Cytogenet. Cell Genet. 2000) 3 4 23
  5. Homology of lubricin and superficial zone protein (SZP): products of megakaryocyte stimulating factor (MSF) gene expression by human synovial fibroblasts and articular chondrocytes localized to chromosome 1q25. (PMID: 11518279) Jay G.D. … Cha C.J. (J. Orthop. Res. 2001) 3 23

Products for PRG4 Gene

Sources for PRG4 Gene

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