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Aliases for CALCRL Gene

Aliases for CALCRL Gene

  • Calcitonin Receptor-Like 2 3
  • CGRPR 3 4 6
  • Calcitonin Receptor-Like Receptor 3 4
  • CGRP Type 1 Receptor 3 4
  • CRLR 3 6
  • Calcitonin Gene-Related Peptide Type 1 Receptor 3

External Ids for CALCRL Gene

Previous GeneCards Identifiers for CALCRL Gene

  • GC02M186419
  • GC02M186892
  • GC02M188171
  • GC02M188412
  • GC02M188035
  • GC02M187918
  • GC02M180067

Summaries for CALCRL Gene

GeneCards Summary for CALCRL Gene

CALCRL (Calcitonin Receptor-Like) is a Protein Coding gene. Diseases associated with CALCRL include pulpitis and primary angle-closure glaucoma. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and calcitonin receptor activity. An important paralog of this gene is VIPR2.

UniProtKB/Swiss-Prot for CALCRL Gene

  • Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP3 (By similarity). Receptor for adrenomedullin together with RAMP2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

Tocris Summary for CALCRL Gene

  • Calcitonin and related receptors are a family of G-protein-coupled receptors that comprises of eight subtypes; CT, AMY1, AMY2, AMY3, CALCR, CGRP, AM1 and AM2. The receptors have a wide biological distribution; high concentrations are found in the brain, lung, liver, heart and spleen with lower expression levels present in the testes, gastrointestinal tract and thyroid. The main function of CT receptors is to inhibit bone reabsorption and enhance calcium excretion by the kidneys. AMY receptors are heterodimers of the CT receptor and receptor activating modifying proteins (RAMP) 1-3, which have been implicated in type II diabetes pathology. The CALCRL receptor alone is non-functioning, but forms heterodimers with RAMPs to form the CGRP (CALCRL with RAMP1), AM1 (CALCRL with RAMP2) and AM2 (CALCRL with RAMP3) receptors. Their main function is inducing vasodilation, which causes hypotension.

Gene Wiki entry for CALCRL Gene

No data available for Entrez Gene Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CALCRL Gene

Genomics for CALCRL Gene

Regulatory Elements for CALCRL Gene

Genomic Location for CALCRL Gene

187,341,963 bp from pter
187,448,460 bp from pter
106,498 bases
Minus strand

Genomic View for CALCRL Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CALCRL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CALCRL Gene

Proteins for CALCRL Gene

  • Protein details for CALCRL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Calcitonin gene-related peptide type 1 receptor
    Protein Accession:
    Secondary Accessions:
    • A8K6G5
    • A8KAD3
    • Q53S02
    • Q53TS5

    Protein attributes for CALCRL Gene

    461 amino acids
    Molecular mass:
    52929 Da
    Quaternary structure:
    • Heterodimer of CALCRL and RAMP3 (By similarity). Heterodimer of CALCRL and RAMP1 or CALCRL and RAMP2.
    • Sequence=BAF84319.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CALCRL Gene

neXtProt entry for CALCRL Gene

Proteomics data for CALCRL Gene at MOPED

Post-translational modifications for CALCRL Gene

  • Glycosylation at Asn66, Asn118, and Asn123
  • Modification sites at PhosphoSitePlus

Other Protein References for CALCRL Gene

Antibody Products

No data available for DME Specific Peptides for CALCRL Gene

Domains for CALCRL Gene

Gene Families for CALCRL Gene

  • CALCR :GPCR / Class B : Calcitonin receptors

Suggested Antigen Peptide Sequences for CALCRL Gene

Graphical View of Domain Structure for InterPro Entry



  • Q16602
  • Belongs to the G-protein coupled receptor 2 family.
genes like me logo Genes that share domains with CALCRL: view

Function for CALCRL Gene

Molecular function for CALCRL Gene

UniProtKB/Swiss-Prot Function:
Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP3 (By similarity). Receptor for adrenomedullin together with RAMP2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

Gene Ontology (GO) - Molecular Function for CALCRL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001605 adrenomedullin receptor activity IDA 22102369
GO:0001635 calcitonin gene-related peptide receptor activity IEA --
GO:0004888 transmembrane signaling receptor activity --
GO:0004930 G-protein coupled receptor activity TAS 7818539
GO:0004948 calcitonin receptor activity IEA --
genes like me logo Genes that share ontologies with CALCRL: view
genes like me logo Genes that share phenotypes with CALCRL: view

Animal Models for CALCRL Gene

MGI Knock Outs for CALCRL:

Animal Model Products

CRISPR Products

miRNA for CALCRL Gene

miRTarBase miRNAs that target CALCRL

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CALCRL

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CALCRL Gene

Localization for CALCRL Gene

Subcellular locations from UniProtKB/Swiss-Prot for CALCRL Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for CALCRL Gene COMPARTMENTS Subcellular localization image for CALCRL gene
Compartment Confidence
endoplasmic reticulum 5
endosome 5
lysosome 5
plasma membrane 5
vacuole 5
extracellular 2

Gene Ontology (GO) - Cellular Components for CALCRL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005764 lysosome IDA 10882736
GO:0005768 endosome IDA 10882736
GO:0005783 endoplasmic reticulum IDA 10882736
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 7818539
genes like me logo Genes that share ontologies with CALCRL: view

Pathways for CALCRL Gene

genes like me logo Genes that share pathways with CALCRL: view

Pathways by source for CALCRL Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • G Protein Coupled Receptors 384HT in human,mouse,rat
    • cAMP / Ca2+ Signaling PathwayFinder in human,mouse,rat

Gene Ontology (GO) - Biological Process for CALCRL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IDA 20596610
GO:0006171 cAMP biosynthetic process IDA 20074556
GO:0006816 calcium ion transport IDA 10882736
GO:0006937 regulation of muscle contraction IEA --
GO:0007166 cell surface receptor signaling pathway --
genes like me logo Genes that share ontologies with CALCRL: view

Compounds for CALCRL Gene

(5) Tocris Compounds for CALCRL Gene

Compound Action Cas Number
AC 187 Potent and selective amylin receptor antagonist [151804-77-2]
alpha-CGRP (human) CGRP receptor agonist [90954-53-3]
BIBN 4096 Potent and selective CGRP receptor antagonist [204697-65-4]
CGRP (rat) Potent vasodilator [83651-90-5]
CGRP 8-37 (rat) CGRP1 receptor antagonist [129121-73-9]

(8) Novoseek inferred chemical compound relationships for CALCRL Gene

Compound -log(P) Hits PubMed IDs
bibn 4096 bs 90.9 4
cyclic amp 30.5 1
glibenclamide 28.7 1
adenylate 27 3
tunicamycin 19.2 2
genes like me logo Genes that share compounds with CALCRL: view

Transcripts for CALCRL Gene

Unigene Clusters for CALCRL Gene

Calcitonin receptor-like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CALCRL

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CALCRL Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1: - - - -
SP2: - - -
SP3: - - - - - - - -
SP4: -
SP5: - - - - -
SP6: - - - - - - -
SP7: - -
SP8: - - - - - -
SP9: - -
SP11: - - - -

Relevant External Links for CALCRL Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CALCRL Gene

mRNA expression in normal human tissues for CALCRL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CALCRL Gene

This gene is overexpressed in Lung (6.1) and Adipose - Visceral (Omentum) (4.4).

Protein differential expression in normal tissues for CALCRL Gene

This gene is overexpressed in Lung (38.1) and Spinal cord (18.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CALCRL Gene

SOURCE GeneReport for Unigene cluster for CALCRL Gene Hs.470882

mRNA Expression by UniProt/SwissProt for CALCRL Gene

Tissue specificity: Predominantly expressed in the lung and heart
genes like me logo Genes that share expressions with CALCRL: view

Expression partners for CALCRL Gene

In Situ Assay Products

Orthologs for CALCRL Gene

This gene was present in the common ancestor of animals.

Orthologs for CALCRL Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CALCRL 35
  • 90.53 (n)
  • 92.41 (a)
  • 91 (a)
(Canis familiaris)
Mammalia CALCRL 35
  • 90.09 (n)
  • 93.71 (a)
  • 94 (a)
(Mus musculus)
Mammalia Calcrl 35
  • 85.36 (n)
  • 90.22 (a)
Calcrl 16
Calcrl 36
  • 89 (a)
(Pan troglodytes)
Mammalia CALCRL 35
  • 99.86 (n)
  • 100 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Calcrl 35
  • 86.23 (n)
  • 90.87 (a)
(Monodelphis domestica)
Mammalia CALCRL 36
  • 85 (a)
(Ornithorhynchus anatinus)
Mammalia CALCRL 36
  • 68 (a)
(Gallus gallus)
Aves CALCRL 35
  • 77.2 (n)
  • 83.3 (a)
  • 81 (a)
(Anolis carolinensis)
Reptilia CALCRL 36
  • 73 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia calcrl 35
  • 74.55 (n)
  • 84.09 (a)
Str.12334 35
African clawed frog
(Xenopus laevis)
Amphibia calcrl-prov 35
(Danio rerio)
Actinopterygii calcrla 35
  • 69.32 (n)
  • 73.67 (a)
calcrla 36
  • 70 (a)
calcrlb 36
  • 63 (a)
fruit fly
(Drosophila melanogaster)
Insecta EG:BACR25B3.3 37
  • 28 (a)
Dh31-R1 35
  • 50.28 (n)
  • 43.79 (a)
Dh31-R1 36
  • 34 (a)
hec 36
  • 27 (a)
Pdfr 36
  • 19 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta GPRCAL1 35
  • 49.32 (n)
  • 44.8 (a)
(Caenorhabditis elegans)
Secernentea pdfr-1 36
  • 21 (a)
Species with no ortholog for CALCRL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CALCRL Gene

Gene Tree for CALCRL (if available)
Gene Tree for CALCRL (if available)

Paralogs for CALCRL Gene

Selected SIMAP similar genes for CALCRL Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CALCRL: view

Variants for CALCRL Gene

Sequence variations from dbSNP and Humsavar for CALCRL Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs696092 -- 187,345,487(-) CAATC(C/T)TACTT utr-variant-3-prime
rs696573 -- 187,364,608(+) AATAG(A/C)CTGTG intron-variant
rs696574 -- 187,363,789(+) CATAA(C/T)TAATA intron-variant
rs698574 -- 187,397,603(+) AGTGC(A/G)TAGTT intron-variant
rs698575 -- 187,395,678(+) TTGAA(C/G)AACAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CALCRL Gene

Variant ID Type Subtype PubMed ID
nsv834487 CNV Gain 17160897
esv2249015 CNV Deletion 18987734
esv3033 CNV Deletion 18987735
esv2721246 CNV Deletion 23290073
esv992040 CNV Deletion 20482838
esv1045156 CNV Deletion 17803354
esv6916 CNV Loss 19470904
dgv4393n71 CNV Loss 21882294
nsv875560 CNV Loss 21882294
dgv4394n71 CNV Loss 21882294
nsv517687 CNV Loss 19592680
dgv4395n71 CNV Loss 21882294
dgv4396n71 CNV Loss 21882294
nsv834488 CNV Gain+Loss 17160897
esv1009899 CNV Deletion 20482838
nsv459989 CNV Loss 19166990

Relevant External Links for CALCRL Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CALCRL Gene

Disorders for CALCRL Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for CALCRL Gene in MalaCards »

(2) Diseases for CALCRL Gene including...

(2) University of Copenhagen DISEASES for CALCRL Gene

(13) Novoseek inferred disease relationships for CALCRL Gene

Disease -log(P) Hits PubMed IDs
pheochromocytoma 46.5 3
migraine 39.5 3
glioblastoma 17.1 1
glioma 9.82 7
pancreatic cancer 9.09 4

Relevant External Links for CALCRL

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with CALCRL: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for CALCRL Gene

Publications for CALCRL Gene

  1. Association study of calcitonin-receptor-like receptor gene in essential hypertension. (PMID: 15797661) Sano M. … Kokubun S. (Am. J. Hypertens. 2005) 3 23 48
  2. Lack of linkage and association of adrenomedullin and its receptor genes in French Caucasian rheumatoid arthritis trio families. (PMID: 19210874) Michou L. … LiotAc F. (Clin. Exp. Rheumatol. 2008) 3 23 48
  3. Investigation of the association between CALCRL polymorphisms and primary angle closure glaucoma. (PMID: 19898635) Cao D. … Mao Z. (Mol. Vis. 2009) 3 23 48
  4. A human orphan calcitonin receptor-like structure. (PMID: 7818539) Fluehmann B. … Born W. (Biochem. Biophys. Res. Commun. 1995) 2 3 4
  5. A cDNA encoding the calcitonin gene-related peptide type 1 receptor. (PMID: 8626685) Aiyar N. … Li Y. (J. Biol. Chem. 1996) 2 3 4

Products for CALCRL Gene

Sources for CALCRL Gene

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