Aliases for CALCRL Gene
External Ids for CALCRL Gene
Previous GeneCards Identifiers for CALCRL Gene
GeneCards Summary for CALCRL Gene
CALCRL (Calcitonin Receptor Like Receptor) is a Protein Coding gene. Diseases associated with CALCRL include migraine with or without aura 1 and gastroesophageal junction adenocarcinoma. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and protein transporter activity. An important paralog of this gene is MGC57346-CRHR1.
UniProtKB/Swiss-Prot for CALCRL Gene
Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP3 (By similarity). Receptor for adrenomedullin together with RAMP2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
Calcitonin and related receptors are a family of G-protein-coupled receptors that comprises of eight subtypes; CT, AMY1, AMY2, AMY3, CALCR, CGRP, AM1 and AM2. The main function of CT receptors is to inhibit bone reabsorption and enhance calcium excretion by the kidneys.