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Aliases for DHRS2 Gene

Aliases for DHRS2 Gene

  • Dehydrogenase/Reductase (SDR Family) Member 2 2 3 5
  • Short Chain Dehydrogenase/Reductase Family 25C Member 1 3 4
  • Dicarbonyl Reductase HEP27 3 4
  • Protein D 3 4
  • SDR25C1 3 4
  • Short Chain Dehydrogenase/Reductase Family 25C, Member 1 3
  • Short-Chain Alcohol Dehydrogenase Family Member 3
  • Short Chain Dehydrogenase/Reductase Family 25C 2
  • Dehydrogenase/Reductase Member 2 3
  • EC 1.1.1.184 63
  • EC 1.1.1.- 4
  • Member 1 2
  • HEP27 3

External Ids for DHRS2 Gene

Previous GeneCards Identifiers for DHRS2 Gene

  • GC14P021478
  • GC14P017892
  • GC14P022089
  • GC14P022095
  • GC14P023175
  • GC14P024099
  • GC14P004222
  • GC14P023638
  • GC14P023641

Summaries for DHRS2 Gene

GeneCards Summary for DHRS2 Gene

DHRS2 (Dehydrogenase/Reductase (SDR Family) Member 2) is a Protein Coding gene. Diseases associated with DHRS2 include hepatoblastoma. GO annotations related to this gene include oxidoreductase activity and carbonyl reductase (NADPH) activity. An important paralog of this gene is DECR2.

UniProtKB/Swiss-Prot for DHRS2 Gene

  • Displays NADPH-dependent dicarbonyl reductase activity in vitro with 3,4-Hexanedione, 2,3-Heptanedione and 1-Phenyl-1,2-propanedione as substrates. No reductase activity is displayed in vitro with steroids, retinoids and sugars as substrates. Attenuates MDM2-mediated p53/TP53 degradation, leading to p53/TP53 stabilization and increased transcription activity, resulting in the accumulation of MDM2 and CDKN1A/p21.

Gene Wiki entry for DHRS2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DHRS2 Gene

Genomics for DHRS2 Gene

Regulatory Elements for DHRS2 Gene

Genomic Location for DHRS2 Gene

Chromosome:
14
Start:
23,630,115 bp from pter
End:
23,645,639 bp from pter
Size:
15,525 bases
Orientation:
Plus strand

Genomic View for DHRS2 Gene

Genes around DHRS2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DHRS2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DHRS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DHRS2 Gene

Proteins for DHRS2 Gene

  • Protein details for DHRS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13268-DHRS2_HUMAN
    Recommended name:
    Dehydrogenase/reductase SDR family member 2, mitochondrial
    Protein Accession:
    Q13268
    Secondary Accessions:
    • D3DS54
    • Q53GS4
    • Q7Z789
    • Q9H2R2

    Protein attributes for DHRS2 Gene

    Size:
    280 amino acids
    Molecular mass:
    29927 Da
    Quaternary structure:
    • Directly interacts with MDM2; this interaction occurs in the nucleus and does not target DHRS2 to degradation.

    Alternative splice isoforms for DHRS2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DHRS2 Gene

Proteomics data for DHRS2 Gene at MOPED

Selected DME Specific Peptides for DHRS2 Gene

Post-translational modifications for DHRS2 Gene

  • Ubiquitination at Lys 224 and Lys 234
  • Modification sites at PhosphoSitePlus

Other Protein References for DHRS2 Gene

Antibody Products

Domains & Families for DHRS2 Gene

Gene Families for DHRS2 Gene

Suggested Antigen Peptide Sequences for DHRS2 Gene

Graphical View of Domain Structure for InterPro Entry

Q13268

UniProtKB/Swiss-Prot:

DHRS2_HUMAN :
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Family:
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
genes like me logo Genes that share domains with DHRS2: view

Function for DHRS2 Gene

Molecular function for DHRS2 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=0.3 mM for 1-Phenyl-1,2-propanedione {ECO:0000269 PubMed:16685466}; KM=1.1 mM for 2,3-Heptanedione {ECO:0000269 PubMed:16685466}; KM=0.8 mM for 3,4-Hexanedione {ECO:0000269 PubMed:16685466}; Vmax=0.52 mmol/min/mg enzyme with 1-Phenyl-1,2-propanedione as substrate {ECO:0000269 PubMed:16685466}; Vmax=0.64 mmol/min/mg enzyme with 2,3-Heptanedione as substrate {ECO:0000269 PubMed:16685466}; Vmax=0.35 mmol/min/mg enzyme with 3,4-Hexanedione as substrate {ECO:0000269 PubMed:16685466};
UniProtKB/Swiss-Prot Function:
Displays NADPH-dependent dicarbonyl reductase activity in vitro with 3,4-Hexanedione, 2,3-Heptanedione and 1-Phenyl-1,2-propanedione as substrates. No reductase activity is displayed in vitro with steroids, retinoids and sugars as substrates. Attenuates MDM2-mediated p53/TP53 degradation, leading to p53/TP53 stabilization and increased transcription activity, resulting in the accumulation of MDM2 and CDKN1A/p21.
UniProtKB/Swiss-Prot Induction:
Up-regulated by IL4 and CSF2 in monocytes/macrophages. Down-regulated by bacterial lipopolysaccharides (LPS) and TNF in monocytice-derived dendritic cells. Up-regulated by MYB.

Enzyme Numbers (IUBMB) for DHRS2 Gene

Gene Ontology (GO) - Molecular Function for DHRS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with DHRS2: view
genes like me logo Genes that share phenotypes with DHRS2: view

Animal Model Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DHRS2 Gene

Localization for DHRS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DHRS2 Gene

Mitochondrion matrix. Nucleus. Note=A minor fraction of the protein is translocated from the mitochondria to the nucleus, after cleavage of the targeting signal.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DHRS2 Gene COMPARTMENTS Subcellular localization image for DHRS2 gene
Compartment Confidence
extracellular 5
mitochondrion 5
nucleus 5
cytosol 1

Gene Ontology (GO) - Cellular Components for DHRS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with DHRS2: view

Pathways & Interactions for DHRS2 Gene

SuperPathways for DHRS2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DHRS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
GO:0009636 response to toxic substance IDA 16685466
GO:0055114 oxidation-reduction process IDA 16685466
genes like me logo Genes that share ontologies with DHRS2: view

No data available for Pathways by source and SIGNOR curated interactions for DHRS2 Gene

Drugs & Compounds for DHRS2 Gene

(2) Drugs for DHRS2 Gene - From: Novoseek and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cortisone Pharma 53

(9) Additional Compounds for DHRS2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with DHRS2: view

Transcripts for DHRS2 Gene

Unigene Clusters for DHRS2 Gene

Dehydrogenase/reductase (SDR family) member 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DHRS2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9 ^ 10a · 10b · 10c · 10d
SP1: - - -
SP2: - -
SP3: - - - -
SP4: - - - - -
SP5: - -
SP6: - - -
SP7: -
SP8: - - - - - -

Relevant External Links for DHRS2 Gene

GeneLoc Exon Structure for
DHRS2
ECgene alternative splicing isoforms for
DHRS2

Expression for DHRS2 Gene

mRNA expression in normal human tissues for DHRS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DHRS2 Gene

This gene is overexpressed in Bladder (x42.8).

Protein differential expression in normal tissues from HIPED for DHRS2 Gene

This gene is overexpressed in Breast (55.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DHRS2 Gene



SOURCE GeneReport for Unigene cluster for DHRS2 Gene Hs.272499

mRNA Expression by UniProt/SwissProt for DHRS2 Gene

Q13268-DHRS2_HUMAN
Tissue specificity: Widely expressed, with highest levels in liver and kidney, followed by heart, spleen, skeletal muscle and placenta. In hemopoietic cells, expressed in dendritic cells, but not in monocytes, macrophages, granulocytes, nor in B and T lymphocytes.
genes like me logo Genes that share expression patterns with DHRS2: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for DHRS2 Gene

Orthologs for DHRS2 Gene

This gene was present in the common ancestor of animals.

Orthologs for DHRS2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DHRS2 35
  • 97.54 (n)
  • 96.31 (a)
DHRS2 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DCXR 36
  • 23 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia DHRS2 36
  • 70 (a)
OneToOne
LOC490616 35
  • 82.26 (n)
  • 77.86 (a)
mouse
(Mus musculus)
Mammalia Dhrs2 36
  • 58 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 63 (a)
OneToMany
-- 36
  • 61 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 46 (a)
ManyToMany
-- 36
  • 36 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 47 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii DHRS2 36
  • 46 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG10672 36
  • 38 (a)
OneToMany
CG10672 37
  • 51 (a)
worm
(Caenorhabditis elegans)
Secernentea dhs-13 36
  • 39 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 43 (a)
ManyToMany
-- 36
  • 23 (a)
ManyToMany
Species with no ortholog for DHRS2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for DHRS2 Gene

ENSEMBL:
Gene Tree for DHRS2 (if available)
TreeFam:
Gene Tree for DHRS2 (if available)

Paralogs for DHRS2 Gene

(7) SIMAP similar genes for DHRS2 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for DHRS2 Gene

genes like me logo Genes that share paralogs with DHRS2: view

Variants for DHRS2 Gene

Sequence variations from dbSNP and Humsavar for DHRS2 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
VAR_035846 A colorectal cancer sample
rs222605 -- 23,645,545(-) GCTTC(C/T)ACTCC downstream-variant-500B, utr-variant-3-prime
rs222606 -- 23,645,866(-) TAGCC(A/T)GGAGG downstream-variant-500B
rs222721 -- 23,628,316(+) ggccg(A/G)gcacg upstream-variant-2KB
rs222722 -- 23,629,360(+) ggcat(C/T)ggtca upstream-variant-2KB

Variation tolerance for DHRS2 Gene

Residual Variation Intolerance Score: 97.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.62; 45.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DHRS2 Gene

HapMap Linkage Disequilibrium report
DHRS2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for DHRS2 Gene

Disorders for DHRS2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DHRS2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
hepatoblastoma
  • hbl
- elite association - COSMIC cancer census association via MalaCards
Search DHRS2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for DHRS2

Genetic Association Database (GAD)
DHRS2
Human Genome Epidemiology (HuGE) Navigator
DHRS2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DHRS2
genes like me logo Genes that share disorders with DHRS2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DHRS2 Gene

Publications for DHRS2 Gene

  1. A nuclear protein, synthesized in growth-arrested human hepatoblastoma cells, is a novel member of the short-chain alcohol dehydrogenase family. (PMID: 7556196) Gabrielli F. … Melli M. (Eur. J. Biochem. 1995) 2 3 4 23 67
  2. Genomic organization of the human gene HEP27: alternative promoter usage in HepG2 cells and monocyte-derived dendritic cells. (PMID: 11944995) Heinz S. … Rehli M. (Genomics 2002) 2 3 23
  3. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PMID: 19027726) Persson B. … Oppermann U. (Chem. Biol. Interact. 2009) 2 3
  4. Hep27, a member of the short-chain dehydrogenase/reductase family, is an NADPH-dependent dicarbonyl reductase expressed in vascular endothelial tissue. (PMID: 16685466) Shafqat N. … Oppermann U. (Cell. Mol. Life Sci. 2006) 2 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for DHRS2 Gene

Sources for DHRS2 Gene

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