Aliases for DHRS2 Gene
External Ids for DHRS2 Gene
Previous GeneCards Identifiers for DHRS2 Gene
GeneCards Summary for DHRS2 Gene
DHRS2 (Dehydrogenase/Reductase (SDR Family) Member 2) is a Protein Coding gene. Diseases associated with DHRS2 include hepatoblastoma. GO annotations related to this gene include oxidoreductase activity and carbonyl reductase (NADPH) activity. An important paralog of this gene is DECR2.
UniProtKB/Swiss-Prot for DHRS2 Gene
Displays NADPH-dependent dicarbonyl reductase activity in vitro with 3,4-Hexanedione, 2,3-Heptanedione and 1-Phenyl-1,2-propanedione as substrates. No reductase activity is displayed in vitro with steroids, retinoids and sugars as substrates. Attenuates MDM2-mediated p53/TP53 degradation, leading to p53/TP53 stabilization and increased transcription activity, resulting in the accumulation of MDM2 and CDKN1A/p21.