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Aliases for PSME3 Gene

Aliases for PSME3 Gene

  • Proteasome Activator Subunit 3 2 3 5
  • Proteasome (Prosome, Macropain) Activator Subunit 3 (PA28 Gamma; Ki) 2 3
  • Activator Of Multicatalytic Protease Subunit 3 3 4
  • Proteasome Activator 28 Subunit Gamma 3 4
  • 11S Regulator Complex Subunit Gamma 3 4
  • Ki Nuclear Autoantigen 3 4
  • REG-GAMMA 3 4
  • PA28gamma 3 4
  • PA28G 3 4
  • 11S Regulator Complex Gamma Subunit 3
  • Epididymis Secretory Protein Li 283 3
  • Proteasome Activator 28-Gamma 3
  • PA28 Gamma Variant 5 3
  • REG Gamma-3 3
  • Ki Antigen 3
  • PA28-Gamma 3
  • HEL-S-283 3
  • Ki 3

External Ids for PSME3 Gene

Previous GeneCards Identifiers for PSME3 Gene

  • GC17M040635
  • GC17P043138
  • GC17P040885
  • GC17P041358
  • GC17P038238
  • GC17P040985
  • GC17P036749

Summaries for PSME3 Gene

Entrez Gene Summary for PSME3 Gene

  • The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the gamma subunit of the 11S regulator. Six gamma subunits combine to form a homohexameric ring. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2012]

GeneCards Summary for PSME3 Gene

PSME3 (Proteasome Activator Subunit 3) is a Protein Coding gene. Among its related pathways are Gene Expression and Signaling by GPCR. GO annotations related to this gene include identical protein binding and MDM2/MDM4 family protein binding. An important paralog of this gene is PSME1.

UniProtKB/Swiss-Prot for PSME3 Gene

  • Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation. Mediates CCAR2 and CHEK2-dependent SIRT1 inhibition (PubMed:25361978).

Gene Wiki entry for PSME3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSME3 Gene

Genomics for PSME3 Gene

Regulatory Elements for PSME3 Gene

Promoters for PSME3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PSME3 on UCSC Golden Path with GeneCards custom track

Genomic Location for PSME3 Gene

Chromosome:
17
Start:
42,824,385 bp from pter
End:
42,843,760 bp from pter
Size:
19,376 bases
Orientation:
Plus strand

Genomic View for PSME3 Gene

Genes around PSME3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSME3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSME3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSME3 Gene

Proteins for PSME3 Gene

  • Protein details for PSME3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61289-PSME3_HUMAN
    Recommended name:
    Proteasome activator complex subunit 3
    Protein Accession:
    P61289
    Secondary Accessions:
    • A8K9A3
    • O35563
    • P97373
    • Q12920
    • Q13172
    • Q9BQD9

    Protein attributes for PSME3 Gene

    Size:
    254 amino acids
    Molecular mass:
    29506 Da
    Quaternary structure:
    • Homoheptamer; the stability of the heptamer is essential for the specific activation of the trypsine-like subunit and inhibition of the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits of the proteasome. Interacts with p53/TP53 and MDM2. Interacts with MAP3K3 (By similarity). Associates with the proteasome. Interacts with human cytomegalovirus UL27. Interacts with CCAR2.

    Alternative splice isoforms for PSME3 Gene

neXtProt entry for PSME3 Gene

Proteomics data for PSME3 Gene at MOPED

Post-translational modifications for PSME3 Gene

  • Acetylation at the major site Lys-195 is important for oligomerization and ability to degrade its target substrates. Deacetylated by SIRT1.
  • Phosphorylated by MAP3K3 (By similarity). Phosphorylation at Ser-247 promotes its association with CCAR2.
  • Ubiquitination at Lys 14, Lys 37, Lys 100, Lys 110, Lys 121, and Lys 195
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PSME3 (PSME3)

No data available for DME Specific Peptides for PSME3 Gene

Domains & Families for PSME3 Gene

Gene Families for PSME3 Gene

Graphical View of Domain Structure for InterPro Entry

P61289

UniProtKB/Swiss-Prot:

PSME3_HUMAN :
  • The C-terminal sequences affect heptamer stability and proteasome affinity.
  • Belongs to the PA28 family.
Domain:
  • The C-terminal sequences affect heptamer stability and proteasome affinity.
Family:
  • Belongs to the PA28 family.
genes like me logo Genes that share domains with PSME3: view

Function for PSME3 Gene

Molecular function for PSME3 Gene

GENATLAS Biochemistry:
proteasome (prosome,macropain) activator subunit 3 (PA28-gamma)
UniProtKB/Swiss-Prot Function:
Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation. Mediates CCAR2 and CHEK2-dependent SIRT1 inhibition (PubMed:25361978).
UniProtKB/Swiss-Prot Induction:
Up-regulated in thyroid carcinoma cells.
genes like me logo Genes that share phenotypes with PSME3: view

Animal Models for PSME3 Gene

MGI Knock Outs for PSME3:

Animal Model Products

miRNA for PSME3 Gene

miRTarBase miRNAs that target PSME3

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PSME3 Gene

Localization for PSME3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSME3 Gene

Nucleus. Cytoplasm. Note=Localizes to the cytoplasm during mitosis following nuclear envelope breakdown at this distinct stage of the cell cycle which allows its interaction with MAP3K3 kinase. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PSME3 Gene COMPARTMENTS Subcellular localization image for PSME3 gene
Compartment Confidence
cytosol 5
nucleus 5
mitochondrion 1

Gene Ontology (GO) - Cellular Components for PSME3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with PSME3: view

Pathways & Interactions for PSME3 Gene

SuperPathways for PSME3 Gene

Superpath Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
.78
2 Interleukin-3, 5 and GM-CSF signaling
3 Infectious disease
.48
4 Immune System
5 Cell Cycle, Mitotic
.61
genes like me logo Genes that share pathways with PSME3: view

Pathways by source for PSME3 Gene

1 BioSystems pathway for PSME3 Gene
1 GeneGo (Thomson Reuters) pathway for PSME3 Gene

Gene Ontology (GO) - Biological Process for PSME3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000186 activation of MAPKK activity TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I TAS --
genes like me logo Genes that share ontologies with PSME3: view

No data available for SIGNOR curated interactions for PSME3 Gene

Drugs & Compounds for PSME3 Gene

(5) Drugs for PSME3 Gene - From: ApexBio and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bortezomib Approved, Experimental, Investigational Pharma inhibitor, other Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors 769
carfilzomib Approved Pharma other, Inhibitor Other, 20S Proteasome Inhibitor 0
AM 114 Pharma 20S proteasome inhibitor 0
CEP-18770 Pharma Proteasome inhibitor 0
MLN9708 Pharma Proteasome inhibitor, 20S Proteasome Inhibitor 0

(3) ApexBio Compounds for PSME3 Gene

Compound Action Cas Number
AM 114 20S proteasome inhibitor 856849-35-9
CEP-18770 Proteasome inhibitor 847499-27-8
MLN9708 Proteasome inhibitor 1201902-80-8
genes like me logo Genes that share compounds with PSME3: view

Transcripts for PSME3 Gene

Unigene Clusters for PSME3 Gene

Proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PSME3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d
SP1: - -
SP2: - - - -
SP3: -
SP4: -
SP5: - - -
SP6: - - - - - -
SP7: - - - -
SP8: -
SP9: - - - - - - -
SP10:
SP11:

Relevant External Links for PSME3 Gene

GeneLoc Exon Structure for
PSME3
ECgene alternative splicing isoforms for
PSME3

Expression for PSME3 Gene

mRNA expression in normal human tissues for PSME3 Gene

Protein differential expression in normal tissues from HIPED for PSME3 Gene

This gene is overexpressed in Bone (13.9) and Peripheral blood mononuclear cells (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PSME3 Gene



SOURCE GeneReport for Unigene cluster for PSME3 Gene Hs.152978

genes like me logo Genes that share expression patterns with PSME3: view

Protein tissue co-expression partners for PSME3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PSME3 Gene

Orthologs for PSME3 Gene

This gene was present in the common ancestor of animals.

Orthologs for PSME3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PSME3 35
  • 96.59 (n)
  • 100 (a)
PSME3 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PSME3 35
  • 94.13 (n)
  • 97 (a)
PSME3 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Psme3 35
  • 94.09 (n)
  • 100 (a)
Psme3 16
Psme3 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PSME3 35
  • 99.74 (n)
  • 99.61 (a)
PSME3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Psme3 35
  • 94.62 (n)
  • 100 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia PSME3 36
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves PSME3 35
  • 85.96 (n)
  • 96.46 (a)
PSME3 36
  • 96 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 72 (a)
OneToMany
-- 36
  • 96 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia psme3 35
  • 77.3 (n)
  • 92.13 (a)
Str.3210 35
zebrafish
(Danio rerio)
Actinopterygii psme3 35
  • 73.62 (n)
  • 80.71 (a)
psme3 36
  • 80 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10191 35
fruit fly
(Drosophila melanogaster)
Insecta REG 37
  • 46 (a)
REG 35
  • 54.95 (n)
  • 49.37 (a)
REG 36
  • 47 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000308 35
  • 54.43 (n)
  • 48.95 (a)
worm
(Caenorhabditis elegans)
Secernentea Y66D12A.9 37
  • 48 (a)
Y66D12A.9 35
  • 53.22 (n)
  • 52.36 (a)
Y66D12A.9 36
  • 48 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.73 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9143 36
  • 53 (a)
OneToOne
Species with no ortholog for PSME3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PSME3 Gene

ENSEMBL:
Gene Tree for PSME3 (if available)
TreeFam:
Gene Tree for PSME3 (if available)

Paralogs for PSME3 Gene

Paralogs for PSME3 Gene

Pseudogenes.org Pseudogenes for PSME3 Gene

genes like me logo Genes that share paralogs with PSME3: view

Variants for PSME3 Gene

Sequence variations from dbSNP and Humsavar for PSME3 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs190120 -- 42,836,225(-) gagtt(C/G/T)gagac intron-variant
rs691884 -- 42,841,193(-) agttt(C/T)taaga intron-variant
rs471762 -- 42,836,218(-) agacc(A/G)gcctg intron-variant
rs380455 -- 42,836,215(-) ccagt(C/T)tggac intron-variant
rs593648 -- 42,831,190(-) ACTTA(A/C)CAATA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PSME3 Gene

Variant ID Type Subtype PubMed ID
esv33998 OTHER Inversion 15654335
nsv483009 CNV Gain 15286789

Variation tolerance for PSME3 Gene

Residual Variation Intolerance Score: 31.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.09; 1.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PSME3 Gene

HapMap Linkage Disequilibrium report
PSME3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSME3 Gene

Disorders for PSME3 Gene

Relevant External Links for PSME3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PSME3

No disorders were found for PSME3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PSME3 Gene

Publications for PSME3 Gene

  1. A physical map and candidate genes in the BRCA1 region on chromosome 17q12-21. (PMID: 7951316) Albertsen H.M. … White R. (Nat. Genet. 1994) 2 3 4 67
  2. REGgamma proteasome activator is involved in the maintenance of chromosomal stability. (PMID: 18235248) Zannini L. … Delia D. (Cell Cycle 2008) 3 23
  3. The SRC-3/AIB1 coactivator is degraded in a ubiquitin- and ATP-independent manner by the REGgamma proteasome. (PMID: 16439211) Li X. … O'Malley B.W. (Cell 2006) 3 23
  4. Relationships between autoantibody responses to deletion mutants of Ki antigen and clinical manifestations of lupus. (PMID: 12784391) Matsudaira R. … Hashimoto H. (J. Rheumatol. 2003) 3 23
  5. Proteasome activator PA28gamma-dependent nuclear retention and degradation of hepatitis C virus core protein. (PMID: 12970408) Moriishi K. … Matsuura Y. (J. Virol. 2003) 3 23

Products for PSME3 Gene

Sources for PSME3 Gene

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