Aliases for TENM1 Gene
External Ids for TENM1 Gene
Previous HGNC Symbols for TENM1 Gene
Previous GeneCards Identifiers for TENM1 Gene
The protein encoded by this gene belongs to the tenascin family and teneurin subfamily. It is expressed in the neurons and may function as a cellular signal transducer. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
GeneCards Summary for TENM1 Gene
TENM1 (Teneurin Transmembrane Protein 1) is a Protein Coding gene. Diseases associated with TENM1 include microphthalmia, isolated, with coloboma 9 and anal margin carcinoma. GO annotations related to this gene include protein homodimerization activity and heparin binding. An important paralog of this gene is WIF1.
UniProtKB/Swiss-Prot for TENM1 Gene
Involved in neural development, regulating the establishment of proper connectivity within the nervous system. May function as a cellular signal transducer (By similarity).
Teneurin C-terminal-associated peptide: Plays a role in the regulation of neuroplasticity in the limbic system. Mediates a rapid reorganization of actin- and tubulin-based cytoskeleton elements with an increase in dendritic arborization and spine density formation of neurons in the hippocampus and amygdala. Induces BDNF transcription inhibition in neurons. Activates the mitogen-activated protein (MAP) kinase 2 (MEK2) and extracellular signal-regulated kinase (ERK) cascade. Acts also as a bioactive neuroprotective peptide on limbic neurons of the brain and regulates stress-induced behavior: attenuates alkalosis-associated necrotic cell death and the effects of corticotropin-releasing factor (CRF) on c-fos/FOS induction and on the reinstatement of cocaine seeking (By similarity).
Ten-1 intracellular domain: Induces gene transcription activation.