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Aliases for CDK2 Gene

Aliases for CDK2 Gene

  • Cyclin-Dependent Kinase 2 2 3 5
  • Cell Division Protein Kinase 2 3 4
  • P33 Protein Kinase 3 4
  • EC 2.7.11.22 4 63
  • CDKN2 3 4
  • CDC2-Related Protein Kinase 3
  • P33(CDK2) 3
  • EC 2.7.11 63

External Ids for CDK2 Gene

Previous GeneCards Identifiers for CDK2 Gene

  • GC12M056216
  • GC12P056923
  • GC12P056077
  • GC12P054646
  • GC12P056360
  • GC12P053399

Summaries for CDK2 Gene

Entrez Gene Summary for CDK2 Gene

  • This gene encodes a member of a family of serine/threonine protein kinases that participate in cell cycle regulation. The encoded protein is the catalytic subunit of the cyclin-dependent protein kinase complex, which regulates progression through the cell cycle. Activity of this protein is especially critical during the G1 to S phase transition. This protein associates with and regulated by other subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A), and p27Kip1 (CDKN1B). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

GeneCards Summary for CDK2 Gene

CDK2 (Cyclin-Dependent Kinase 2) is a Protein Coding gene. Diseases associated with CDK2 include glioblastoma and retinal cancer. Among its related pathways are Platelet activation, signaling and aggregation and Gene Expression. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CDK4.

UniProtKB/Swiss-Prot for CDK2 Gene

  • Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Interacts with cyclins A, B1, B3, D, or E. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK1 at the centrosome and in the nucleus. Crucial role in orchestrating a fine balance between cellular proliferation, cell death, and DNA repair in human embryonic stem cells (hESCs). Activity of CDK2 is maximal during S phase and G2; activated by interaction with cyclin E during the early stages of DNA synthesis to permit G1-S transition, and subsequently activated by cyclin A2 (cyclin A1 in germ cells) during the late stages of DNA replication to drive the transition from S phase to mitosis, the G2 phase. EZH2 phosphorylation promotes H3K27me3 maintenance and epigenetic gene silencing. Phosphorylates CABLES1 (By similarity). Cyclin E/CDK2 prevents oxidative stress-mediated Ras-induced senescence by phosphorylating MYC. Involved in G1-S phase DNA damage checkpoint that prevents cells with damaged DNA from initiating mitosis; regulates homologous recombination-dependent repair by phosphorylating BRCA2, this phosphorylation is low in S phase when recombination is active, but increases as cells progress towards mitosis. In response to DNA damage, double-strand break repair by homologous recombination a reduction of CDK2-mediated BRCA2 phosphorylation. Phosphorylation of RB1 disturbs its interaction with E2F1. NPM1 phosphorylation by cyclin E/CDK2 promotes its dissociates from unduplicated centrosomes, thus initiating centrosome duplication. Cyclin E/CDK2-mediated phosphorylation of NPAT at G1-S transition and until prophase stimulates the NPAT-mediated activation of histone gene transcription during S phase. Required for vitamin D-mediated growth inhibition by being itself inactivated. Involved in the nitric oxide- (NO) mediated signaling in a nitrosylation/activation-dependent manner. USP37 is activated by phosphorylation and thus triggers G1-S transition. CTNNB1 phosphorylation regulates insulin internalization. Phosphorylates FOXP3 and negatively regulates its transcriptional activity and protein stability (By similarity).

Tocris Summary for CDK2 Gene

  • Cdks (cyclin-dependent kinases) are heteromeric serine/threonine kinases that control progression through the cell cycle in concert with their regulatory subunits, the cyclins. Although there are 12 different cdk genes, only 5 have been shown to directly drive the cell cycle.

Gene Wiki entry for CDK2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDK2 Gene

Genomics for CDK2 Gene

Regulatory Elements for CDK2 Gene

Promoters for CDK2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CDK2 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the CDK2 gene promoter:

Genomic Location for CDK2 Gene

Chromosome:
12
Start:
55,966,769 bp from pter
End:
55,972,789 bp from pter
Size:
6,021 bases
Orientation:
Plus strand

Genomic View for CDK2 Gene

Genes around CDK2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDK2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDK2 Gene

Proteins for CDK2 Gene

  • Protein details for CDK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P24941-CDK2_HUMAN
    Recommended name:
    Cyclin-dependent kinase 2
    Protein Accession:
    P24941
    Secondary Accessions:
    • A8K7C6
    • O75100

    Protein attributes for CDK2 Gene

    Size:
    298 amino acids
    Molecular mass:
    33930 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Found in a complex with CABLES1, CCNA1 and CCNE1. Interacts with CABLES1 (By similarity). Interacts with UHRF2. Part of a complex consisting of UHRF2, CDK2 and CCNE1. Interacts with the Speedy/Ringo proteins SPDYA and SPDYC. Found in a complex with both SPDYA and CDKN1B/KIP1. Binds to RB1 and CDK7. Binding to CDKN1A (p21) leads to CDK2/cyclin E inactivation at the G1-S phase DNA damage checkpoint, thereby arresting cells at the G1-S transition during DNA repair. Associated with PTPN6 and beta-catenin/CTNNB1. Interacts with CACUL1. May interact with CEP63. Interacts with ANKRD17. Interacts with CEBPA (when phosphorylated) (PubMed:15107404).

    Three dimensional structures from OCA and Proteopedia for CDK2 Gene

    Alternative splice isoforms for CDK2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDK2 Gene

Proteomics data for CDK2 Gene at MOPED

Post-translational modifications for CDK2 Gene

  • Nitrosylated after treatment with nitric oxide (DETA-NO).
  • Phosphorylated at Thr-160 by CDK7 in a CAK complex. Phosphorylation at Thr-160 promotes kinase activity, whereas phosphorylation at Tyr-15 by WEE1 reduces slightly kinase activity. Phosphorylated on Thr-14 and Tyr-15 during S and G2 phases before being dephosphorylated by CDC25A.
  • Ubiquitination at Lys 6, Lys 56, Lys 129, Lys 142, Lys 237, and Lys 291
  • Modification sites at PhosphoSitePlus

Other Protein References for CDK2 Gene

Domains & Families for CDK2 Gene

Gene Families for CDK2 Gene

Suggested Antigen Peptide Sequences for CDK2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P24941

UniProtKB/Swiss-Prot:

CDK2_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
genes like me logo Genes that share domains with CDK2: view

Function for CDK2 Gene

Molecular function for CDK2 Gene

GENATLAS Biochemistry:
cyclin dependent kinase 2,involved in cell cycle regulation (G1 to S transition),complexing with cyclin E for the regulation of chromosome stability,activated in apoptosis by TP53 regulated,BAX and BCL2,putative checkpoint between cell cycle and cell death pathway
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Phosphorylation at Thr-14 or Tyr-15 inactivates the enzyme, while phosphorylation at Thr-160 activates it. Inhibited by 1,25-dihydroxyvitamin D(3) (1,25-(OH)(2)D(3)), AG-024322, N-(4-Piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide (AT7519), R547 (Ro-4584820), purine, pyrimidine and pyridine derivatives, 2-aminopyrimidines, paullones, thiazo derivatives, macrocyclic quinoxalin-2-one, pyrazolo[1,5-a]-1,3,5-triazine, pyrazolo[1,5-a]pyrimidine, 2-(1-ethyl-2-hydroxyethylamino)-6-benzylamino-9-isopropylpurine (roscovitine, seliciclib and CYC202), SNS-032 (BMS-387032), triazolo[1,5-a]pyrimidines, staurosporine and olomoucine. Stimulated by MYC. Inactivated by CDKN1A (p21).
UniProtKB/Swiss-Prot Function:
Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Interacts with cyclins A, B1, B3, D, or E. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK1 at the centrosome and in the nucleus. Crucial role in orchestrating a fine balance between cellular proliferation, cell death, and DNA repair in human embryonic stem cells (hESCs). Activity of CDK2 is maximal during S phase and G2; activated by interaction with cyclin E during the early stages of DNA synthesis to permit G1-S transition, and subsequently activated by cyclin A2 (cyclin A1 in germ cells) during the late stages of DNA replication to drive the transition from S phase to mitosis, the G2 phase. EZH2 phosphorylation promotes H3K27me3 maintenance and epigenetic gene silencing. Phosphorylates CABLES1 (By similarity). Cyclin E/CDK2 prevents oxidative stress-mediated Ras-induced senescence by phosphorylating MYC. Involved in G1-S phase DNA damage checkpoint that prevents cells with damaged DNA from initiating mitosis; regulates homologous recombination-dependent repair by phosphorylating BRCA2, this phosphorylation is low in S phase when recombination is active, but increases as cells progress towards mitosis. In response to DNA damage, double-strand break repair by homologous recombination a reduction of CDK2-mediated BRCA2 phosphorylation. Phosphorylation of RB1 disturbs its interaction with E2F1. NPM1 phosphorylation by cyclin E/CDK2 promotes its dissociates from unduplicated centrosomes, thus initiating centrosome duplication. Cyclin E/CDK2-mediated phosphorylation of NPAT at G1-S transition and until prophase stimulates the NPAT-mediated activation of histone gene transcription during S phase. Required for vitamin D-mediated growth inhibition by being itself inactivated. Involved in the nitric oxide- (NO) mediated signaling in a nitrosylation/activation-dependent manner. USP37 is activated by phosphorylation and thus triggers G1-S transition. CTNNB1 phosphorylation regulates insulin internalization. Phosphorylates FOXP3 and negatively regulates its transcriptional activity and protein stability (By similarity).
UniProtKB/Swiss-Prot Induction:
Induced transiently by TGFB1 at an early phase of TGFB1-mediated apoptosis.

Enzyme Numbers (IUBMB) for CDK2 Gene

genes like me logo Genes that share phenotypes with CDK2: view

Animal Models for CDK2 Gene

MGI Knock Outs for CDK2:

Animal Model Products

  • Taconic Biosciences Mouse Models for CDK2

miRNA for CDK2 Gene

miRTarBase miRNAs that target CDK2

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CDK2 Gene

Localization for CDK2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDK2 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus, Cajal body. Cytoplasm. Endosome. Note=Localized at the centrosomes in late G2 phase after separation of the centrosomes but before the start of prophase. Nuclear-cytoplasmic trafficking is mediated during the inhibition by 1,25-(OH)(2)D(3).

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDK2 Gene COMPARTMENTS Subcellular localization image for CDK2 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
endosome 5
nucleus 5
mitochondrion 2
peroxisome 2
endoplasmic reticulum 1
extracellular 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CDK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with CDK2: view

Pathways & Interactions for CDK2 Gene

SuperPathways for CDK2 Gene

Superpath Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
.78
2 DNA Double-Strand Break Repair
3 Cell cycle Cell cycle (generic schema)
4 Cell cycle Role of SCF complex in cell cycle regulation
5 Cyclins and Cell Cycle Regulation
genes like me logo Genes that share pathways with CDK2: view

Gene Ontology (GO) - Biological Process for CDK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle TAS --
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0006260 DNA replication TAS 19238148
GO:0006468 protein phosphorylation IEA --
GO:0006813 potassium ion transport IEA --
genes like me logo Genes that share ontologies with CDK2: view

Drugs & Compounds for CDK2 Gene

(120) Drugs for CDK2 Gene - From: Novoseek, DGIdb, Tocris, ApexBio, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Deferasirox Approved, Investigational Pharma Oral iron chelator 86
Purvalanol A Experimental Pharma Cyclin-dependent kinase inhibitor 0
Olomoucine Experimental Pharma Cyclin-dependent kinase inhibitor 0
Flavopiridol Experimental, Investigational Pharma inhibitor Kinase Inhibitors 60
SU9516 Experimental Pharma 0

(71) Additional Compounds for CDK2 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
10Z-Hymenialdisine
82005-12-7
genes like me logo Genes that share compounds with CDK2: view

Drug Products

Transcripts for CDK2 Gene

Unigene Clusters for CDK2 Gene

Cyclin-dependent kinase 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDK2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9
SP1: - - - -
SP2: - - - - -
SP3: -
SP4: - - - - -
SP5: - -
SP6:
SP7: - - - - -

Relevant External Links for CDK2 Gene

GeneLoc Exon Structure for
CDK2
ECgene alternative splicing isoforms for
CDK2

Expression for CDK2 Gene

mRNA expression in normal human tissues for CDK2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CDK2 Gene

This gene is overexpressed in Breast (12.5), Peripheral blood mononuclear cells (10.7), Lymph node (9.2), and Fetal gut (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CDK2 Gene



SOURCE GeneReport for Unigene cluster for CDK2 Gene Hs.19192

genes like me logo Genes that share expression patterns with CDK2: view

Protein tissue co-expression partners for CDK2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CDK2 Gene

Orthologs for CDK2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CDK2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDK2 36
  • 100 (a)
OneToOne
CDK2 35
  • 99.89 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia CDK2 36
  • 99 (a)
OneToOne
CDK2 35
  • 93.62 (n)
  • 98.66 (a)
dog
(Canis familiaris)
Mammalia CDK2 35
  • 93.29 (n)
  • 98.99 (a)
CDK2 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdk2 16
Cdk2 36
  • 85 (a)
OneToOne
Cdk2 35
  • 92.51 (n)
  • 98.99 (a)
rat
(Rattus norvegicus)
Mammalia Cdk2 35
  • 91.5 (n)
  • 98.99 (a)
chicken
(Gallus gallus)
Aves CDK2 35
  • 79.75 (n)
  • 93.29 (a)
CDK2 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDK2 36
  • 93 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.4227 35
tropical clawed frog
(Silurana tropicalis)
Amphibia cdk2 35
  • 77.36 (n)
  • 89.86 (a)
Str.2871 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9226 35
zebrafish
(Danio rerio)
Actinopterygii cdk2 36
  • 90 (a)
OneToOne
cdk2 35
  • 75.84 (n)
  • 90.27 (a)
Dr.17883 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004579 35
  • 60.94 (n)
  • 60.14 (a)
fruit fly
(Drosophila melanogaster)
Insecta cdc2 37
  • 64 (a)
cdc2c 37
  • 64 (a)
Cdk4 37
  • 47 (a)
cdc2c 35
  • 62.81 (n)
  • 65.65 (a)
cdc2c 36
  • 60 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cdk-1 37
  • 60 (a)
cdk-4 37
  • 38 (a)
H01G02.2 37
  • 34 (a)
cdk-2 36
  • 40 (a)
ManyToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR058C 35
  • 63.3 (n)
  • 64.11 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC28 36
  • 61 (a)
OneToMany
CDC28 38
CDC28 35
  • 61.37 (n)
  • 65.37 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B09790g 35
  • 59.7 (n)
  • 62.37 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.6720 35
thale cress
(Arabidopsis thaliana)
eudicotyledons CDC2 35
  • 63.21 (n)
  • 68.86 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.10992 35
corn
(Zea mays)
Liliopsida Zm.12226 35
rice
(Oryza sativa)
Liliopsida Os.3428 35
Os03g0118400 35
  • 64.71 (n)
  • 69.2 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU09778 35
  • 64.98 (n)
  • 68.01 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cdc2 35
  • 61.69 (n)
  • 67.36 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5905 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5702 36
  • 67 (a)
OneToMany
Species with no ortholog for CDK2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CDK2 Gene

ENSEMBL:
Gene Tree for CDK2 (if available)
TreeFam:
Gene Tree for CDK2 (if available)

Paralogs for CDK2 Gene

Paralogs for CDK2 Gene

genes like me logo Genes that share paralogs with CDK2: view

Variants for CDK2 Gene

Sequence variations from dbSNP and Humsavar for CDK2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs12312438 -- 55,970,356(+) TTTCA(A/G)ACTGA intron-variant
rs12312505 -- 55,970,504(+) CATTA(A/G)CCTAT intron-variant
rs73123218 -- 55,969,438(+) ACCCT(A/G)TAAAC intron-variant
rs75006282 -- 55,971,366(+) CCTGC(C/T)CTCCC intron-variant
rs78078972 -- 55,971,598(-) GGCTT(G/T)GTCAC reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for CDK2 Gene

Variant ID Type Subtype PubMed ID
nsv832424 CNV Loss 17160897

Variation tolerance for CDK2 Gene

Residual Variation Intolerance Score: 39.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.15; 23.17% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDK2 Gene

HapMap Linkage Disequilibrium report
CDK2
Human Gene Mutation Database (HGMD)
CDK2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDK2 Gene

Disorders for CDK2 Gene

MalaCards: The human disease database

(23) MalaCards diseases for CDK2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
glioblastoma
  • glioblastoma multiforme
retinal cancer
  • malignant neoplasm of retina
sensory system cancer
star syndrome
  • syndactyly, telecanthus, anogenital and renal malformations
retinoblastoma
  • retinoblastoma, trilateral
- elite association - COSMIC cancer census association via MalaCards
Search CDK2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CDK2

Genetic Association Database (GAD)
CDK2
Human Genome Epidemiology (HuGE) Navigator
CDK2
Tumor Gene Database (TGDB):
CDK2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CDK2
genes like me logo Genes that share disorders with CDK2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CDK2 Gene

Publications for CDK2 Gene

  1. Cloning of a human cDNA encoding a CDC2-related kinase by complementation of a budding yeast cdc28 mutation. (PMID: 1717994) Ninomiya-Tsuji J. … Matsumoto K. (Proc. Natl. Acad. Sci. U.S.A. 1991) 2 3 4 67
  2. Structural and functional relationship between the Ph1 locus protein 5B2 in wheat and CDK2 in mammals. (PMID: 20422243) Yousafzai F.K. … Moore G. (Funct. Integr. Genomics 2010) 3 23
  3. Nuclear targeting of cyclin-dependent kinase 2 reveals essential roles of cyclin-dependent kinase 2 localization and cyclin E in vitamin D-mediated growth inhibition. (PMID: 20147522) Flores O. … Burnstein K.L. (Endocrinology 2010) 3 23
  4. Cdk2 nitrosylation and loss of mitochondrial potential mediate NO- dependent biphasic effect on HL-60 cell cycle. (PMID: 20079829) Kumar S. … Dikshit M. (Free Radic. Biol. Med. 2010) 3 23
  5. DNA damage induces Chk1-dependent threonine-160 phosphorylation and activation of Cdk2. (PMID: 19838212) Bourke E. … Morrison C.G. (Oncogene 2010) 3 23

Products for CDK2 Gene

  • Addgene plasmids for CDK2

Sources for CDK2 Gene

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