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Aliases for TRAP1 Gene

Aliases for TRAP1 Gene

  • TNF Receptor Associated Protein 1 2 3
  • TNF Receptor-Associated Protein 1 2 3 5
  • Tumor Necrosis Factor Type 1 Receptor-Associated Protein 3 4
  • TNFR-Associated Protein 1 3 4
  • TRAP-1 3 4
  • HSP 75 3 4
  • HSP75 3 4
  • Testicular Tissue Protein Li 209 3
  • HSP90L 3

External Ids for TRAP1 Gene

Previous GeneCards Identifiers for TRAP1 Gene

  • GC15U990048
  • GC16M003648
  • GC16M003709
  • GC16M003677
  • GC16M003710

Summaries for TRAP1 Gene

Entrez Gene Summary for TRAP1 Gene

  • This gene encodes a mitochondrial chaperone protein that is member of the heat shock protein 90 (HSP90) family. The encoded protein has ATPase activity and interacts with tumor necrosis factor type I. This protein may function in regulating cellular stress responses. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]

GeneCards Summary for TRAP1 Gene

TRAP1 (TNF Receptor Associated Protein 1) is a Protein Coding gene. Diseases associated with TRAP1 include cakut with or without vacterl and brain glioblastoma multiforme. Among its related pathways are Development VEGF signaling via VEGFR2 - generic cascades and TGF-beta Receptor Signaling Pathway. GO annotations related to this gene include poly(A) RNA binding and unfolded protein binding. An important paralog of this gene is HSP90AB1.

UniProtKB/Swiss-Prot for TRAP1 Gene

  • Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, most likely through stabilization of mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA.

Gene Wiki entry for TRAP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRAP1 Gene

Genomics for TRAP1 Gene

Regulatory Elements for TRAP1 Gene

Promoters for TRAP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TRAP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for TRAP1 Gene

Chromosome:
16
Start:
3,651,639 bp from pter
End:
3,717,597 bp from pter
Size:
65,959 bases
Orientation:
Minus strand

Genomic View for TRAP1 Gene

Genes around TRAP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRAP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRAP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRAP1 Gene

Proteins for TRAP1 Gene

  • Protein details for TRAP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q12931-TRAP1_HUMAN
    Recommended name:
    Heat shock protein 75 kDa, mitochondrial
    Protein Accession:
    Q12931
    Secondary Accessions:
    • B4DR68
    • D3DUC8
    • F5H897
    • O43642
    • O75235
    • Q9UHL5

    Protein attributes for TRAP1 Gene

    Size:
    704 amino acids
    Molecular mass:
    80110 Da
    Quaternary structure:
    • Binds to the intracellular domain of tumor necrosis factor type 1 receptor. Binds to RB1. Interacts with SRC. Interacts with SDHA.
    SequenceCaution:
    • Sequence=AAA87704.1; Type=Frameshift; Positions=656; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TRAP1 Gene

    Alternative splice isoforms for TRAP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRAP1 Gene

Proteomics data for TRAP1 Gene at MOPED

Post-translational modifications for TRAP1 Gene

  • Ubiquitination at Lys 109 and Lys 699
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for TRAP1 (HSP75)
  • Cloud-Clone Corp. Antibodies for TRAP1

No data available for DME Specific Peptides for TRAP1 Gene

Domains & Families for TRAP1 Gene

Gene Families for TRAP1 Gene

Protein Domains for TRAP1 Gene

Graphical View of Domain Structure for InterPro Entry

Q12931

UniProtKB/Swiss-Prot:

TRAP1_HUMAN :
  • Belongs to the heat shock protein 90 family.
Family:
  • Belongs to the heat shock protein 90 family.
genes like me logo Genes that share domains with TRAP1: view

Function for TRAP1 Gene

Molecular function for TRAP1 Gene

GENATLAS Biochemistry:
tumor rejection antigen (gp96),pseudogene 1
UniProtKB/Swiss-Prot Function:
Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, most likely through stabilization of mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA.

Gene Ontology (GO) - Molecular Function for TRAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019901 protein kinase binding IPI 17579517
GO:0051082 unfolded protein binding IEA --
genes like me logo Genes that share ontologies with TRAP1: view
genes like me logo Genes that share phenotypes with TRAP1: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRAP1 Gene

Localization for TRAP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRAP1 Gene

Mitochondrion. Mitochondrion inner membrane. Mitochondrion matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRAP1 Gene COMPARTMENTS Subcellular localization image for TRAP1 gene
Compartment Confidence
extracellular 5
mitochondrion 5
nucleus 5
cytosol 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for TRAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005739 mitochondrion IDA 17579517
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with TRAP1: view

Pathways & Interactions for TRAP1 Gene

genes like me logo Genes that share pathways with TRAP1: view

Gene Ontology (GO) - Biological Process for TRAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding IEA --
GO:0006950 response to stress IEA --
GO:0009386 translational attenuation IMP 24113185
GO:0061077 chaperone-mediated protein folding TAS 24522549
genes like me logo Genes that share ontologies with TRAP1: view

No data available for SIGNOR curated interactions for TRAP1 Gene

Drugs & Compounds for TRAP1 Gene

(1) Drugs for TRAP1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for TRAP1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TRAP1: view

Transcripts for TRAP1 Gene

Unigene Clusters for TRAP1 Gene

TNF receptor-associated protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRAP1 Gene

No ASD Table

Relevant External Links for TRAP1 Gene

GeneLoc Exon Structure for
TRAP1
ECgene alternative splicing isoforms for
TRAP1

Expression for TRAP1 Gene

mRNA expression in normal human tissues for TRAP1 Gene

Protein differential expression in normal tissues from HIPED for TRAP1 Gene

This gene is overexpressed in Lymph node (7.6) and Brain (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TRAP1 Gene



SOURCE GeneReport for Unigene cluster for TRAP1 Gene Hs.30345

mRNA Expression by UniProt/SwissProt for TRAP1 Gene

Q12931-TRAP1_HUMAN
Tissue specificity: Found in skeletal muscle, liver, heart, brain, kidney, pancreas, lung, placenta and bladder. Expression is higly reduced in bladder cancer and renal cell carcinoma specimens compared to healthy tissues, but it is increased in other type of tumors.
genes like me logo Genes that share expression patterns with TRAP1: view

Protein tissue co-expression partners for TRAP1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for TRAP1 Gene

Orthologs for TRAP1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TRAP1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TRAP1 35
  • 86.57 (n)
  • 88 (a)
TRAP1 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRAP1 35
  • 87.81 (n)
  • 90 (a)
TRAP1 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trap1 35
  • 84.37 (n)
  • 88.49 (a)
Trap1 16
Trap1 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TRAP1 35
  • 98.86 (n)
  • 99.15 (a)
TRAP1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trap1 35
  • 84.8 (n)
  • 88.49 (a)
oppossum
(Monodelphis domestica)
Mammalia TRAP1 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 92 (a)
OneToMany
-- 36
  • 84 (a)
OneToMany
-- 36
  • 85 (a)
OneToMany
chicken
(Gallus gallus)
Aves TRAP1 35
  • 78.44 (n)
  • 83.58 (a)
TRAP1 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TRAP1 36
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.16680 35
trap1 35
  • 73.5 (n)
  • 80.97 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.9148 35
zebrafish
(Danio rerio)
Actinopterygii LOC101884569 35
  • 74.85 (n)
  • 80.56 (a)
wufc85a11 35
trap1 36
  • 67 (a)
OneToMany
trap1 36
  • 73 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.291 35
fruit fly
(Drosophila melanogaster)
Insecta Trap1 37
  • 52 (a)
Trap1 35
  • 57.6 (n)
  • 54.4 (a)
Trap1 36
  • 49 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010691 35
  • 59.43 (n)
  • 56.6 (a)
worm
(Caenorhabditis elegans)
Secernentea R151.7a 37
  • 46 (a)
R151.7b 37
  • 48 (a)
R151.7 35
  • 52.37 (n)
  • 47.52 (a)
R151.7 36
  • 41 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HSC82 36
  • 29 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 48 (a)
OneToOne
Species with no ortholog for TRAP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRAP1 Gene

ENSEMBL:
Gene Tree for TRAP1 (if available)
TreeFam:
Gene Tree for TRAP1 (if available)

Paralogs for TRAP1 Gene

Paralogs for TRAP1 Gene

genes like me logo Genes that share paralogs with TRAP1: view

Variants for TRAP1 Gene

Sequence variations from dbSNP and Humsavar for TRAP1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs13926 - 3,674,464(-) ATGTC(A/C/G)GTGAG reference, missense
rs1136948 - 3,671,772(-) GAGGA(C/G)ATTCC reference, missense
VAR_049626 -
VAR_061272 -
rs38024 -- 3,710,881(+) tatat(A/T)ttttt intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TRAP1 Gene

Variant ID Type Subtype PubMed ID
nsv905213 CNV Loss 21882294
nsv833128 CNV Loss 17160897
nsv905216 CNV Loss 21882294
nsv518509 CNV Gain 19592680
esv2659167 CNV Deletion 23128226
nsv457359 CNV Loss 19166990
nsv525301 CNV Loss 19592680
nsv833129 CNV Loss 17160897
nsv516876 CNV Loss 19592680
nsv1717 CNV Insertion 18451855
esv2666403 CNV Deletion 23128226

Variation tolerance for TRAP1 Gene

Residual Variation Intolerance Score: 95.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.80; 86.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRAP1 Gene

HapMap Linkage Disequilibrium report
TRAP1
Human Gene Mutation Database (HGMD)
TRAP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRAP1 Gene

Disorders for TRAP1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for TRAP1 Gene - From: GeneTests, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
cakut with or without vacterl
  • renal hypodysplasia, nonsyndromic, 1
brain glioblastoma multiforme
  • brain glioblastoma
vacterl association
  • vacterl/vater association
- elite association - COSMIC cancer census association via MalaCards
Search TRAP1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TRAP1

Genetic Association Database (GAD)
TRAP1
Human Genome Epidemiology (HuGE) Navigator
TRAP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRAP1
genes like me logo Genes that share disorders with TRAP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TRAP1 Gene

Publications for TRAP1 Gene

  1. The hsp90-related protein TRAP1 is a mitochondrial protein with distinct functional properties. (PMID: 10652318) Felts S.J. … Toft D.O. (J. Biol. Chem. 2000) 2 3 4 23 67
  2. Identification of a protein with homology to hsp90 that binds the type 1 tumor necrosis factor receptor. (PMID: 7876093) Song H.Y. … Donner D.B. (J. Biol. Chem. 1995) 2 3 23
  3. Overexpression of mitochondrial Hsp70/Hsp75 protects astrocytes against ischemic injury in vitro. (PMID: 18091755) Voloboueva L.A. … Giffard R.G. (J. Cereb. Blood Flow Metab. 2008) 3 23
  4. Iron chelation study in a normal human hepatocyte cell line suggests that tumor necrosis factor receptor-associated protein 1 (TRAP1) regulates production of reactive oxygen species. (PMID: 16927372) Im C.N. … Seo J.S. (J. Cell. Biochem. 2007) 3 23
  5. PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1. (PMID: 17579517) Pridgeon J.W. … Li L. (PLoS Biol. 2007) 3 23

Products for TRAP1 Gene

Sources for TRAP1 Gene

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