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Aliases for CDH15 Gene

Aliases for CDH15 Gene

  • Cadherin 15, Type 1, M-Cadherin (Myotubule) 2 3
  • CDH14 3 4 6
  • CDH3 3 4 6
  • Cadherin-14 3 4
  • MRD3 3 6
  • Cadherin 15, M-Cadherin (Myotubule) 2
  • Muscle-Cadherin 3
  • Muscle Cadherin 4
  • Cadherin-15 3
  • Cadherin-3 3
  • M-Cadherin 4
  • CDHM 3
  • MCAD 3

External Ids for CDH15 Gene

Previous Symbols for CDH15 Gene

  • CDH3
  • CDH14

Summaries for CDH15 Gene

Entrez Gene Summary for CDH15 Gene

  • This gene is a member of the cadherin superfamily of genes, encoding calcium-dependent intercellular adhesion glycoproteins. Cadherins consist of an extracellular domain containing 5 cadherin domains, a transmembrane region, and a conserved cytoplasmic domain. Transcripts from this particular cadherin are expressed in myoblasts and upregulated in myotubule-forming cells. The protein is thought to be essential for the control of morphogenetic processes, specifically myogenesis, and may provide a trigger for terminal muscle cell differentiation. [provided by RefSeq, Jul 2008]

GeneCards Summary for CDH15 Gene

CDH15 (Cadherin 15, Type 1, M-Cadherin (Myotubule)) is a Protein Coding gene. Diseases associated with CDH15 include autosomal dominant non-syndromic intellectual disability and nemaline myopathy. Among its related pathways are L1CAM interactions and ERK Signaling. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is CDH13.

UniProtKB/Swiss-Prot for CDH15 Gene

  • Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. M-cadherin is part of the myogenic program and may provide a trigger for terminal muscle differentiation

Gene Wiki entry for CDH15 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDH15 Gene

Genomics for CDH15 Gene

Genomic Location for CDH15 Gene

89,171,755 bp from pter
89,195,492 bp from pter
23,738 bases
Plus strand

Genomic View for CDH15 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CDH15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDH15 Gene

Regulatory Elements for CDH15 Gene

Transcription factor binding sites by QIAGEN in the CDH15 gene promoter:

Proteins for CDH15 Gene

  • Protein details for CDH15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:

    Protein attributes for CDH15 Gene

    814 amino acids
    Molecular mass:
    88916 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CDH15 Gene

Proteomics data for CDH15 Gene at MOPED

Post-translational modifications for CDH15 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn227, Asn531, Asn538, and Asn576

Other Protein References for CDH15 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CDH15 Gene

Domains for CDH15 Gene

Gene Families for CDH15 Gene

  • MCDH :Cadherins / Major cadherins


  • Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.:
    • P55291
  • Contains 5 cadherin domains.:
    • P55291
genes like me logo Genes that share domains with CDH15: view

Function for CDH15 Gene

Molecular function for CDH15 Gene

GENATLAS Biochemistry: cadherin 15,M-cadherin,transmembrane glycoprotein component of adherens junction,expressed in the myotubule,deleted in breast carcinoma (see TSG16H)
UniProtKB/Swiss-Prot Function: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. M-cadherin is part of the myogenic program and may provide a trigger for terminal muscle differentiation

Gene Ontology (GO) - Molecular Function for CDH15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with CDH15: view

Phenotypes for CDH15 Gene

MGI mutant phenotypes for CDH15:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with CDH15: view

miRNA for CDH15 Gene

miRTarBase miRNAs that target CDH15

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CDH15 Gene

Localization for CDH15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDH15 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for CDH15 Gene COMPARTMENTS Subcellular localization image for CDH15 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 1
extracellular 1
golgi apparatus 1
lysosome 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CDH15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005901 caveola IEA --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
GO:0031594 neuromuscular junction IEA --
genes like me logo Genes that share ontologies with CDH15: view

Pathways for CDH15 Gene

genes like me logo Genes that share pathways with CDH15: view

Pathways by source for CDH15 Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for CDH15 Gene
1 Sino Biological pathway for CDH15 Gene
1 Cell Signaling Technology pathway for CDH15 Gene
1 KEGG pathway for CDH15 Gene

Gene Ontology (GO) - Biological Process for CDH15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion TAS 9545347
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IEA --
GO:0034329 cell junction assembly TAS --
GO:0034332 adherens junction organization TAS --
GO:0042692 muscle cell differentiation TAS --
genes like me logo Genes that share ontologies with CDH15: view

Compounds for CDH15 Gene

(1) HMDB Compounds for CDH15 Gene

Compound Synonyms Cas Number PubMed IDs
  • Ca
genes like me logo Genes that share compounds with CDH15: view

Transcripts for CDH15 Gene

mRNA/cDNA for CDH15 Gene

Unigene Clusters for CDH15 Gene

Cadherin 15, type 1, M-cadherin (myotubule):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CDH15 Gene

No ASD Table

Relevant External Links for CDH15 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CDH15 Gene

mRNA expression in normal human tissues for CDH15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CDH15 Gene

This gene is overexpressed in Brain - Cerebellum (17.8), Brain - Cerebellar Hemisphere (16.5), and Muscle - Skeletal (13.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CDH15 Gene

SOURCE GeneReport for Unigene cluster for CDH15 Gene Hs.148090

mRNA Expression by UniProt/SwissProt for CDH15 Gene

Tissue specificity: Expressed in the brain and cerebellum.
genes like me logo Genes that share expressions with CDH15: view

Orthologs for CDH15 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CDH15 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CDH15 36
  • 98.41 (n)
  • 97.84 (a)
CDH15 37
  • 99 (a)
(Bos Taurus)
Mammalia CDH15 36
  • 85.8 (n)
  • 87.5 (a)
CDH15 37
  • 79 (a)
(Canis familiaris)
Mammalia CDH15 36
  • 83.4 (n)
  • 84.46 (a)
CDH15 37
  • 85 (a)
(Mus musculus)
Mammalia Cdh15 36
  • 82.69 (n)
  • 86.28 (a)
Cdh15 16
Cdh15 37
  • 86 (a)
(Monodelphis domestica)
Mammalia CDH15 37
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia CDH15 37
  • 71 (a)
(Rattus norvegicus)
Mammalia Cdh15 36
  • 82.29 (n)
  • 86.04 (a)
(Anolis carolinensis)
Reptilia CDH15 37
  • 58 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.10256 36
tropical clawed frog
(Silurana tropicalis)
Amphibia cdh15 36
  • 60.09 (n)
  • 57.69 (a)
(Danio rerio)
Actinopterygii cdh15 36
  • 53.71 (n)
  • 46.52 (a)
cdh15 37
  • 44 (a)
wufb48f12 36
Species with no ortholog for CDH15:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CDH15 Gene

Gene Tree for CDH15 (if available)
Gene Tree for CDH15 (if available)

Paralogs for CDH15 Gene

Paralogs for CDH15 Gene

Selected SIMAP similar genes for CDH15 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CDH15: view

Variants for CDH15 Gene

Sequence variations from dbSNP and Humsavar for CDH15 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs729200 -- 89,175,051(-) GGGTG(G/T)GGGTG intron-variant
rs729201 -- 89,174,375(+) CCACC(A/G)AGCGT intron-variant
rs729202 -- 89,174,530(+) CAAGC(A/G)CCCAG intron-variant
rs882650 -- 89,172,320(-) GGACA(A/T)AACCC intron-variant
rs1109821 -- 89,172,319(-) GACAA(A/C)ACCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CDH15 Gene

Variant ID Type Subtype PubMed ID
nsv907268 CNV Loss 21882294
nsv471115 CNV Loss 18288195
nsv521217 CNV Loss 19592680
dgv2998n71 CNV Loss 21882294
nsv907357 CNV Loss 21882294
nsv907360 CNV Loss 21882294
dgv3001n71 CNV Loss 21882294
dgv3002n71 CNV Loss 21882294
nsv907384 CNV Gain 21882294
nsv457620 CNV Gain 19166990
dgv3004n71 CNV Loss 21882294
nsv519104 CNV Loss 19592680
nsv457621 CNV Loss 19166990
nsv907389 CNV Loss 21882294
dgv3005n71 CNV Gain+Loss 21882294
nsv907391 CNV Loss 21882294
nsv907394 CNV Loss 21882294
nsv509638 CNV Insertion 20534489
dgv3006n71 CNV Loss 21882294
dgv420e201 CNV Deletion 23290073
esv25612 CNV Gain 19812545
esv2715126 CNV Deletion 23290073

Relevant External Links for CDH15 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

Disorders for CDH15 Gene

(1) OMIM Diseases for CDH15 Gene (114019)


  • Note=A chromosomal aberration involving CDH15 and KIRREL3 is found in a patient with severe mental retardation and dysmorphic facial features. Translocation t(11;16)(q24.2;q24).
  • Mental retardation, autosomal dominant 3 (MRD3) [MIM:612580]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. {ECO:0000269 PubMed:19012874}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(2) Novoseek inferred disease relationships for CDH15 Gene

Disease -log(P) Hits PubMed IDs
tumors 0 2
cancer 0 1

Relevant External Links for CDH15

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with CDH15: view

Publications for CDH15 Gene

  1. The gene for the cell adhesion molecule M-cadherin maps to mouse chromosome 8 and human chromosome 16q24.1-qter and is near the E-cadherin (uvomorulin) locus in both species. (PMID: 1427864) Kaupmann K. … Starzinski-Powitz A. (Genomics 1992) 2 3 23
  2. Molecular cloning and characterization of a novel human classic cadherin homologous with mouse muscle cadherin. (PMID: 9545347) Shimoyama Y. … Hirohashi S. (J. Biol. Chem. 1998) 3 23
  3. Localization of human cadherin genes to chromosome regions exhibiting cancer-related loss of heterozygosity. (PMID: 9615235) Kremmidiotis G. … Callen D.F. (Genomics 1998) 3 23
  4. Identification of human cadherin-14, a novel neurally specific type II cadherin, by protein interaction cloning. (PMID: 9030594) Shibata T. … Hirohashi S. (J. Biol. Chem. 1997) 3 4
  5. Alterations in CDH15 and KIRREL3 in patients with mild to severe intellectual disability. (PMID: 19012874) Bhalla K. … Srivastava A.K. (Am. J. Hum. Genet. 2008) 3 4

Products for CDH15 Gene

Sources for CDH15 Gene

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