Aliases for CDH15 Gene
External Ids for CDH15 Gene
Previous Symbols for CDH15 Gene
This gene is a member of the cadherin superfamily of genes, encoding calcium-dependent intercellular adhesion glycoproteins. Cadherins consist of an extracellular domain containing 5 cadherin domains, a transmembrane region, and a conserved cytoplasmic domain. Transcripts from this particular cadherin are expressed in myoblasts and upregulated in myotubule-forming cells. The protein is thought to be essential for the control of morphogenetic processes, specifically myogenesis, and may provide a trigger for terminal muscle cell differentiation. [provided by RefSeq, Jul 2008]
GeneCards Summary for CDH15 Gene
CDH15 (Cadherin 15, Type 1, M-Cadherin (Myotubule)) is a Protein Coding gene. Diseases associated with CDH15 include autosomal dominant non-syndromic intellectual disability and nemaline myopathy. Among its related pathways are L1CAM interactions and ERK Signaling. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is CDH13.
UniProtKB/Swiss-Prot for CDH15 Gene
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. M-cadherin is part of the myogenic program and may provide a trigger for terminal muscle differentiation