Aliases for PREB Gene
External Ids for PREB Gene
Previous GeneCards Identifiers for PREB Gene
This gene encodes a protein that specifically binds to a Pit1-binding element of the prolactin (PRL) promoter. This protein may act as a transcriptional regulator and is thought to be involved in some of the developmental abnormalities observed in patients with partial trisomy 2p. This gene overlaps the abhydrolase domain containing 1 (ABHD1) gene on the opposite strand. [provided by RefSeq, Jul 2008]
GeneCards Summary for PREB Gene
PREB (Prolactin Regulatory Element Binding) is a Protein Coding gene. Diseases associated with PREB include Testicular Leukemia. Among its related pathways are Protein processing in endoplasmic reticulum and wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF).
UniProtKB/Swiss-Prot for PREB Gene
Guanine nucleotide exchange factor that specifically activates the small GTPase SAR1B. Mediates the recruitement of SAR1B and other COPII coat components to endoplasmic reticulum membranes and is therefore required for the formation of COPII transport vesicles from the ER.
Was first identified based on its probable role in the regulation of pituitary gene transcription. Binds to the prolactin gene (PRL) promoter and seems to activate transcription.