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Aliases for KIF20A Gene

Aliases for KIF20A Gene

  • Kinesin Family Member 20A 2 3
  • RAB6KIFL 3 4 6
  • RAB6 Interacting, Kinesin-Like (Rabkinesin6) 2 3
  • Rab6-Interacting Kinesin-Like Protein 3 4
  • Mitotic Kinesin-Like Protein 2 3 4
  • Rabkinesin-6 3 4
  • GG10_2 3 4
  • MKLP2 3 4
  • Kinesin-Like Protein KIF20A 3

External Ids for KIF20A Gene

Previous Symbols for KIF20A Gene

  • RAB6KIFL

Summaries for KIF20A Gene

GeneCards Summary for KIF20A Gene

KIF20A (Kinesin Family Member 20A) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Cell Cycle, Mitotic. GO annotations related to this gene include protein kinase binding and microtubule binding. An important paralog of this gene is KIF20B.

UniProtKB/Swiss-Prot for KIF20A Gene

  • Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the central spindle. Interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. May act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. Has a microtubule plus end-directed motility.

Gene Wiki entry for KIF20A Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIF20A Gene

Genomics for KIF20A Gene

Genomic Location for KIF20A Gene

Start:
138,178,719 bp from pter
End:
138,187,715 bp from pter
Size:
8,997 bases
Orientation:
Plus strand

Genomic View for KIF20A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KIF20A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIF20A Gene

Regulatory Elements for KIF20A Gene

Proteins for KIF20A Gene

  • Protein details for KIF20A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95235-KI20A_HUMAN
    Recommended name:
    Kinesin-like protein KIF20A
    Protein Accession:
    O95235
    Secondary Accessions:
    • B4DL79
    • D3DQB6

    Protein attributes for KIF20A Gene

    Size:
    890 amino acids
    Molecular mass:
    100278 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for KIF20A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KIF20A Gene

Proteomics data for KIF20A Gene at MOPED

Post-translational modifications for KIF20A Gene

  • Phosphorylated by PLK1 at Ser-528 during mitosis, creating a docking site for PLK1 and recruiting PLK1 at central spindle.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys108, Lys150, Lys175, Lys215, Lys242, and Lys425

Other Protein References for KIF20A Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for KIF20A Gene

Domains for KIF20A Gene

Gene Families for KIF20A Gene

HGNC:
  • KIF :Kinesins

Protein Domains for KIF20A Gene

UniProtKB/Swiss-Prot:

KI20A_HUMAN
Domain:
  • Contains 1 kinesin motor domain.:
    • O95235
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.:
    • O95235
genes like me logo Genes that share domains with KIF20A: view

Function for KIF20A Gene

Molecular function for KIF20A Gene

UniProtKB/Swiss-Prot Function: Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the central spindle. Interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. May act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. Has a microtubule plus end-directed motility.

Gene Ontology (GO) - Molecular Function for KIF20A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003777 microtubule motor activity IBA --
GO:0005215 transporter activity TAS 9438855
GO:0005515 protein binding IPI 16431929
GO:0005524 ATP binding IEA --
GO:0008017 microtubule binding IEA --
genes like me logo Genes that share ontologies with KIF20A: view

Phenotypes for KIF20A Gene

genes like me logo Genes that share phenotypes with KIF20A: view

miRNA for KIF20A Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for KIF20A Gene

Localization for KIF20A Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIF20A Gene

Golgi apparatus. Cytoplasm, cytoskeleton, spindle.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KIF20A Gene COMPARTMENTS Subcellular localization image for KIF20A gene
Compartment Confidence
cytoskeleton 5
golgi apparatus 4
nucleus 4
cytosol 3
mitochondrion 2

Gene Ontology (GO) - Cellular Components for KIF20A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005794 Golgi apparatus IEA --
GO:0005819 spindle IDA 12939256
GO:0005871 kinesin complex IBA --
GO:0005874 microtubule IEA --
genes like me logo Genes that share ontologies with KIF20A: view

Pathways for KIF20A Gene

genes like me logo Genes that share pathways with KIF20A: view

Pathways by source for KIF20A Gene

2 BioSystems pathways for KIF20A Gene

Gene Ontology (GO) - Biological Process for KIF20A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS --
GO:0000281 mitotic cytokinesis IMP 15843429
GO:0000910 cytokinesis IDA 12939256
GO:0000920 cell separation after cytokinesis IMP 15843429
GO:0001578 microtubule bundle formation IDA 12939256
genes like me logo Genes that share ontologies with KIF20A: view

Compounds for KIF20A Gene

(1) HMDB Compounds for KIF20A Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1
genes like me logo Genes that share compounds with KIF20A: view

Transcripts for KIF20A Gene

Unigene Clusters for KIF20A Gene

Kinesin family member 20A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KIF20A Gene

No ASD Table

Relevant External Links for KIF20A Gene

GeneLoc Exon Structure for
KIF20A
ECgene alternative splicing isoforms for
KIF20A

Expression for KIF20A Gene

mRNA expression in normal human tissues for KIF20A Gene

mRNA differential expression in normal tissues according to GTEx for KIF20A Gene

This gene is overexpressed in Testis (5.1) and Esophagus - Mucosa (4.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for KIF20A Gene

SOURCE GeneReport for Unigene cluster for KIF20A Gene Hs.718626

genes like me logo Genes that share expressions with KIF20A: view

Orthologs for KIF20A Gene

This gene was present in the common ancestor of animals.

Orthologs for KIF20A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIF20A 36
  • 99.81 (n)
  • 99.66 (a)
KIF20A 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KIF20A 36
  • 90.02 (n)
  • 92.34 (a)
KIF20A 37
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KIF20A 37
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kif20a 36
  • 85.23 (n)
  • 87.26 (a)
Kif20a 16
Kif20a 37
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KIF20A 37
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 10 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Kif20a 36
  • 85.74 (n)
  • 87.5 (a)
chicken
(Gallus gallus)
Aves KIF20A 36
  • 69.68 (n)
  • 71.51 (a)
KIF20A 37
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KIF20A 37
  • 61 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.6107 36
tropical clawed frog
(Silurana tropicalis)
Amphibia kif20a 36
  • 63.56 (n)
  • 63.22 (a)
zebrafish
(Danio rerio)
Actinopterygii kif20a 37
  • 45 (a)
OneToOne
LOC325449 36
  • 55.81 (n)
  • 50.83 (a)
fruit fly
(Drosophila melanogaster)
Insecta sub 37
  • 27 (a)
OneToMany
Species with no ortholog for KIF20A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KIF20A Gene

ENSEMBL:
Gene Tree for KIF20A (if available)
TreeFam:
Gene Tree for KIF20A (if available)

Paralogs for KIF20A Gene

Paralogs for KIF20A Gene

Selected SIMAP similar genes for KIF20A Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with KIF20A: view

Variants for KIF20A Gene

Sequence variations from dbSNP and Humsavar for KIF20A Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs1048957 -- 138,181,665(+) GACTC(G/T)TTTGC synonymous-codon, reference
rs3734116 - 138,181,443(-) CTTCT(C/T)CATAC missense, reference
rs12517918 -- 138,181,815(+) CCTGA(C/T)TGTGA intron-variant
rs17171775 -- 138,182,024(+) CTGAG(C/T)CTAGA intron-variant
rs17171776 -- 138,184,450(+) TGGTA(A/C)CTCTA intron-variant

Relevant External Links for KIF20A Gene

HapMap Linkage Disequilibrium report
KIF20A

No data available for Structural Variations from Database of Genomic Variants (DGV) for KIF20A Gene

Disorders for KIF20A Gene

No disorders were found for KIF20A Gene.

No data available for UniProtKB/Swiss-Prot for KIF20A Gene

Publications for KIF20A Gene

  1. cDNA cloning, expression pattern, genomic structure and chromosomal location of RAB6KIFL, a human kinesin-like gene. (PMID: 10806357) Lai F. … Le Beau M.M. (Gene 2000) 2 3 4 23
  2. Vascular endothelial genes that are responsive to tumor necrosis factor-alpha in vitro are expressed in atherosclerotic lesions, including inhibitor of apoptosis protein-1, stannin, and two novel genes. (PMID: 10233894) Horrevoets A.J.G. … Pannekoek H. (Blood 1999) 3 4 23
  3. The Rab6-binding kinesin, Rab6-KIFL, is required for cytokinesis. (PMID: 11060022) Hill E. … Barr F.A. (EMBO J. 2000) 3 23
  4. The kinesin superfamily protein Rab6KIFL is not involved in the pathophysiology of Charcot-Marie-Tooth disease type 4C. (PMID: 12469216) Nagura M. … Hayashi Y. (Int. J. Mol. Med. 2003) 3 23
  5. All kinesin superfamily protein, KIF, genes in mouse and human. (PMID: 11416179) Miki H. … Hirokawa N. (Proc. Natl. Acad. Sci. U.S.A. 2001) 2 3

Products for KIF20A Gene

Sources for KIF20A Gene

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