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Aliases for KIF20A Gene

Aliases for KIF20A Gene

  • Kinesin Family Member 20A 2 3 5
  • RAB6 Interacting, Kinesin-Like (Rabkinesin6) 2 3
  • Rab6-Interacting Kinesin-Like Protein 3 4
  • Mitotic Kinesin-Like Protein 2 3 4
  • Rabkinesin-6 3 4
  • RAB6KIFL 3 4
  • GG10_2 3 4
  • MKLP2 3 4
  • Kinesin-Like Protein KIF20A 3

External Ids for KIF20A Gene

Previous HGNC Symbols for KIF20A Gene

  • RAB6KIFL

Previous GeneCards Identifiers for KIF20A Gene

  • GC05P137545
  • GC05P137591
  • GC05P137542
  • GC05P132705

Summaries for KIF20A Gene

GeneCards Summary for KIF20A Gene

KIF20A (Kinesin Family Member 20A) is a Protein Coding gene. Diseases associated with KIF20A include Charcot-Marie-Tooth Disease. Among its related pathways are PLK1 signaling events and Innate Immune System. GO annotations related to this gene include protein kinase binding and ATPase activity. An important paralog of this gene is KIF20B.

UniProtKB/Swiss-Prot for KIF20A Gene

  • Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the central spindle. Interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. May act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. Has a microtubule plus end-directed motility.

Gene Wiki entry for KIF20A Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIF20A Gene

Genomics for KIF20A Gene

Regulatory Elements for KIF20A Gene

Enhancers for KIF20A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05G138350 1.4 ENCODE dbSUPER 10.1 +174.6 174616 4.7 PKNOX1 ARNT CREB3L1 AGO1 ARID4B SIN3A FEZF1 ZNF2 YY1 SLC30A9 KDM3B CDC23 FAM53C FAM13B BRD8 KIF20A GFRA3 REEP2 GC05P138377
GH05G138222 1.2 Ensembl ENCODE 11.3 +44.2 44241 0.5 ELF3 TBP FOXA2 CBX3 ARNT ARID4B ZNF48 ZSCAN9 RAD21 RARA GFRA3 BRD8 KIF20A CDC23 GC05M138210
GH05G138368 1.1 Ensembl ENCODE dbSUPER 10.4 +191.2 191183 3.8 FOXA2 ATF2 NR2F2 ZNF121 ZNF316 EGR1 FOS EMSY MAFK WT1 FAM53C CDC25C ENSG00000249971 BRD8 KIF20A HSPA9 GFRA3 KDM3B REEP2 GC05P138377
GH05G138095 0.8 ENCODE 9.3 -83.1 -83053 0.2 SOX13 FOXA2 SAP130 TEAD4 CHD7 RARA GATA4 POLR2A RERE NCOR1 RNU6-460P NME5 RNU6-888P BRD8 KIF20A PIR31393 GC05P138118
GH05G138486 0.7 FANTOM5 9.5 +307.9 307908 0.1 CTCF ZNF654 HLF CEBPG REST ZBTB7A RAD21 CEBPA SMC3 EGR1 ENSG00000222937 SNORD63 HSPA9 BRD8 KIF20A GC05P138492 RPL7P19
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KIF20A on UCSC Golden Path with GeneCards custom track

Promoters for KIF20A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000187462 81 2401 PKNOX1 FOXA2 CREB3L1 ARNT WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1

Genomic Location for KIF20A Gene

Chromosome:
5
Start:
138,178,719 bp from pter
End:
138,187,715 bp from pter
Size:
8,997 bases
Orientation:
Plus strand

Genomic View for KIF20A Gene

Genes around KIF20A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIF20A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIF20A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIF20A Gene

Proteins for KIF20A Gene

  • Protein details for KIF20A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95235-KI20A_HUMAN
    Recommended name:
    Kinesin-like protein KIF20A
    Protein Accession:
    O95235
    Secondary Accessions:
    • B4DL79
    • D3DQB6

    Protein attributes for KIF20A Gene

    Size:
    890 amino acids
    Molecular mass:
    100278 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for KIF20A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KIF20A Gene

Post-translational modifications for KIF20A Gene

  • Phosphorylated by PLK1 at Ser-528 during mitosis, creating a docking site for PLK1 and recruiting PLK1 at central spindle.
  • Ubiquitination at posLast=108108, posLast=150150, isoforms=2175, isoforms=2215, isoforms=2242, and posLast=425425
  • Modification sites at PhosphoSitePlus

Other Protein References for KIF20A Gene

No data available for DME Specific Peptides for KIF20A Gene

Domains & Families for KIF20A Gene

Gene Families for KIF20A Gene

Protein Domains for KIF20A Gene

Suggested Antigen Peptide Sequences for KIF20A Gene

Graphical View of Domain Structure for InterPro Entry

O95235

UniProtKB/Swiss-Prot:

KI20A_HUMAN :
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
genes like me logo Genes that share domains with KIF20A: view

Function for KIF20A Gene

Molecular function for KIF20A Gene

UniProtKB/Swiss-Prot Function:
Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the central spindle. Interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. May act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. Has a microtubule plus end-directed motility.

Gene Ontology (GO) - Molecular Function for KIF20A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003774 motor activity IEA --
GO:0003777 microtubule motor activity IEA,IBA --
GO:0005215 transporter activity TAS 9438855
GO:0005515 protein binding IPI 16431929
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with KIF20A: view
genes like me logo Genes that share phenotypes with KIF20A: view

Animal Models for KIF20A Gene

MGI Knock Outs for KIF20A:

Animal Model Products

miRNA for KIF20A Gene

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KIF20A Gene

Localization for KIF20A Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIF20A Gene

Golgi apparatus. Cytoplasm, cytoskeleton, spindle.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KIF20A gene
Compartment Confidence
cytoskeleton 5
nucleus 5
golgi apparatus 5
cytosol 3
mitochondrion 2

Gene Ontology (GO) - Cellular Components for KIF20A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
GO:0005794 Golgi apparatus IEA --
GO:0005819 spindle IEA,IDA 12939256
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with KIF20A: view

Pathways & Interactions for KIF20A Gene

genes like me logo Genes that share pathways with KIF20A: view

Gene Ontology (GO) - Biological Process for KIF20A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000281 mitotic cytokinesis IMP 15843429
GO:0000910 cytokinesis IEA,IDA 12939256
GO:0000920 cell separation after cytokinesis IMP 15843429
GO:0001578 microtubule bundle formation IDA 12939256
GO:0006810 transport IEA --
genes like me logo Genes that share ontologies with KIF20A: view

No data available for SIGNOR curated interactions for KIF20A Gene

Drugs & Compounds for KIF20A Gene

(6) Drugs for KIF20A Gene - From: ClinicalTrials and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
chenodeoxycholic acid Approved Pharma Antagonist 34
Guanosine triphosphate Experimental Pharma 0
Cathartics Pharma 537
Gastrointestinal Agents Pharma 8402
Laxatives Pharma 537
genes like me logo Genes that share compounds with KIF20A: view

Transcripts for KIF20A Gene

Unigene Clusters for KIF20A Gene

Kinesin family member 20A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KIF20A Gene

No ASD Table

Relevant External Links for KIF20A Gene

GeneLoc Exon Structure for
KIF20A
ECgene alternative splicing isoforms for
KIF20A

Expression for KIF20A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KIF20A Gene

mRNA differential expression in normal tissues according to GTEx for KIF20A Gene

This gene is overexpressed in Testis (x5.1) and Esophagus - Mucosa (x4.7).

Protein differential expression in normal tissues from HIPED for KIF20A Gene

This gene is overexpressed in Salivary gland (42.3), Testis (13.7), and Fetal heart (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for KIF20A Gene



Protein tissue co-expression partners for KIF20A Gene

NURSA nuclear receptor signaling pathways regulating expression of KIF20A Gene:

KIF20A

SOURCE GeneReport for Unigene cluster for KIF20A Gene:

Hs.718626

Evidence on tissue expression from TISSUES for KIF20A Gene

  • Heart(4.2)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with KIF20A: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KIF20A Gene

Orthologs for KIF20A Gene

This gene was present in the common ancestor of animals.

Orthologs for KIF20A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIF20A 34 35
  • 99.81 (n)
cow
(Bos Taurus)
Mammalia KIF20A 34 35
  • 90.02 (n)
dog
(Canis familiaris)
Mammalia KIF20A 35
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kif20a 34
  • 85.74 (n)
mouse
(Mus musculus)
Mammalia Kif20a 34 16 35
  • 85.23 (n)
oppossum
(Monodelphis domestica)
Mammalia KIF20A 35
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 10 (a)
ManyToMany
chicken
(Gallus gallus)
Aves KIF20A 34 35
  • 69.68 (n)
lizard
(Anolis carolinensis)
Reptilia KIF20A 35
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kif20a 34
  • 63.56 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.6107 34
zebrafish
(Danio rerio)
Actinopterygii LOC325449 34
  • 55.81 (n)
kif20a 35
  • 45 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta sub 35
  • 27 (a)
OneToMany
Species where no ortholog for KIF20A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KIF20A Gene

ENSEMBL:
Gene Tree for KIF20A (if available)
TreeFam:
Gene Tree for KIF20A (if available)

Paralogs for KIF20A Gene

Paralogs for KIF20A Gene

(6) SIMAP similar genes for KIF20A Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with KIF20A: view

Variants for KIF20A Gene

Sequence variations from dbSNP and Humsavar for KIF20A Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000082651 -- 138,186,697(+) GATTA(-/T)TAAGA intron-variant
rs1000818590 -- 138,186,699(+) ATTAT(A/G)AGAAA intron-variant
rs1001042088 -- 138,179,912(+) ACAGG(A/G)TAGTA intron-variant, upstream-variant-2KB
rs1001623027 -- 138,178,892(+) TTGGA(A/G)GAATC upstream-variant-2KB, utr-variant-5-prime
rs1001886168 -- 138,185,395(+) ATTAA(G/T)TGCTA intron-variant

Variation tolerance for KIF20A Gene

Residual Variation Intolerance Score: 29.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.84; 47.97% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KIF20A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KIF20A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for KIF20A Gene

Disorders for KIF20A Gene

MalaCards: The human disease database

(1) MalaCards diseases for KIF20A Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
charcot-marie-tooth disease
  • charcot marie tooth muscular atrophy
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for KIF20A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KIF20A
genes like me logo Genes that share disorders with KIF20A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KIF20A Gene

Publications for KIF20A Gene

  1. cDNA cloning, expression pattern, genomic structure and chromosomal location of RAB6KIFL, a human kinesin-like gene. (PMID: 10806357) Lai F. … Le Beau M.M. (Gene 2000) 2 3 4 22 64
  2. Vascular endothelial genes that are responsive to tumor necrosis factor-alpha in vitro are expressed in atherosclerotic lesions, including inhibitor of apoptosis protein-1, stannin, and two novel genes. (PMID: 10233894) Horrevoets A.J.G. … Pannekoek H. (Blood 1999) 3 4 22 64
  3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Phosphorylation of mitotic kinesin-like protein 2 by polo-like kinase 1 is required for cytokinesis. (PMID: 12939256) Neef R. … Barr F.A. (J. Cell Biol. 2003) 3 4 64

Products for KIF20A Gene

Sources for KIF20A Gene

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