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Aliases for PPIF Gene

Aliases for PPIF Gene

  • Peptidylprolyl Isomerase F 2 3 5
  • Cyclophilin D 2 3 4
  • Mitochondrial Cyclophilin 3 4
  • Cyclophilin F 3 4
  • Rotamase F 3 4
  • EC 5.2.1.8 4 61
  • PPIase F 3 4
  • CYP-M 3 4
  • Cyp-D 3 4
  • CYPD 3 4
  • CYP3 3 4
  • Peptidyl-Prolyl Cis-Trans Isomerase F, Mitochondrial 3
  • Peptidyl-Prolyl Cis-Trans Isomerase, Mitochondrial 3
  • Peptidylprolyl Isomerase F (Cyclophilin F) 2
  • Cyclophilin 3 3

External Ids for PPIF Gene

Previous GeneCards Identifiers for PPIF Gene

  • GC10P080064
  • GC10P080316
  • GC10P080999
  • GC10P080451
  • GC10P080777
  • GC10P081107
  • GC10P075101
  • GC10P079349

Summaries for PPIF Gene

Entrez Gene Summary for PPIF Gene

  • The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein is part of the mitochondrial permeability transition pore in the inner mitochondrial membrane. Activation of this pore is thought to be involved in the induction of apoptotic and necrotic cell death. [provided by RefSeq, Jul 2008]

GeneCards Summary for PPIF Gene

PPIF (Peptidylprolyl Isomerase F) is a Protein Coding gene. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Calcium signaling pathway. GO annotations related to this gene include peptide binding and cyclosporin A binding. An important paralog of this gene is PPIA.

UniProtKB/Swiss-Prot for PPIF Gene

  • PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Involved in regulation of the mitochondrial permeability transition pore (mPTP). It is proposed that its association with the mPTP is masking a binding site for inhibiting inorganic phosphate (Pi) and promotes the open probability of the mPTP leading to apoptosis or necrosis; the requirement of the PPIase activity for this function is debated. In cooperation with mitochondrial TP53 is involved in activating oxidative stress-induced necrosis. Involved in modulation of mitochondrial membrane F(1)F(0) ATP synthase activity and regulation of mitochondrial matrix adenine nucleotide levels. Has anti-apoptotic activity independently of mPTP and in cooperation with BCL2 inhibits cytochrome c-dependent apoptosis.

Gene Wiki entry for PPIF Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPIF Gene

Genomics for PPIF Gene

Regulatory Elements for PPIF Gene

Enhancers for PPIF Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10G079316 1.9 FANTOM5 Ensembl ENCODE dbSUPER 50.9 -29.5 -29457 2.6 HDGF PKNOX1 ATF1 ARNT SIN3A GLI4 ZNF766 ZNF143 FOS ZNF263 PPIF ZMIZ1-AS1 ENSG00000272489 ZMIZ1 GC10P079285
GH10G079330 2 FANTOM5 Ensembl ENCODE dbSUPER 45 -13.8 -13816 5.4 HDGF PKNOX1 FOXA2 ATF1 MLX ZFP64 ARID4B DMAP1 ZNF48 TCF12 PPIF ZMIZ1 SFTPD-AS1 GC10P079285
GH10G079263 1.9 FANTOM5 Ensembl ENCODE dbSUPER 41.3 -79.9 -79936 8.5 PKNOX1 CREB3L1 SIN3A GTF3C2 ZNF766 GATA2 FOS ZNF263 ZHX2 JUNB PPIF ENSG00000272489 ZMIZ1-AS1 ZMIZ1 GC10P079285
GH10G079319 1.8 FANTOM5 Ensembl ENCODE dbSUPER 42.4 -25.7 -25678 4.4 TBP PKNOX1 RAD21 ZEB1 ZSCAN5C RCOR1 RELB FOS IKZF2 DEK PPIF ZMIZ1 GC10P079285
GH10G079135 2.1 FANTOM5 Ensembl ENCODE dbSUPER 34.8 -196.6 -196553 31.6 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 TBX21 PPIF LOC642361 ZMIZ1-AS1 ZMIZ1 GC10M079169
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PPIF on UCSC Golden Path with GeneCards custom track

Promoters for PPIF Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000030653 436 1401 HDGF PKNOX1 MLX CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 CBX5

Genomic Location for PPIF Gene

Chromosome:
10
Start:
79,347,464 bp from pter
End:
79,355,337 bp from pter
Size:
7,874 bases
Orientation:
Plus strand

Genomic View for PPIF Gene

Genes around PPIF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPIF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPIF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPIF Gene

Proteins for PPIF Gene

  • Protein details for PPIF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P30405-PPIF_HUMAN
    Recommended name:
    Peptidyl-prolyl cis-trans isomerase F, mitochondrial
    Protein Accession:
    P30405
    Secondary Accessions:
    • Q2YDB7
    • Q5W131

    Protein attributes for PPIF Gene

    Size:
    207 amino acids
    Molecular mass:
    22040 Da
    Quaternary structure:
    • Believed to associate with the mitochondrial permeability transition pore complex (PTPC). Associates with the mitochondrial membrane ATP synthase F(1)F(0) ATP synthase; the association is increased by inorganic phosphate (Pi) and decreased by cyclosporin A (CsA). Interacts with ATP5B; ATP5H and ATP5O. Interacts with SLC25A3; the interaction is impaired by CsA. Interacts with BCL2; the interaction is impaired by CsA. Interacts with TP53; the association implicates preferentially tetrameric TP53, is induced by oxidative stress and is impaired by CsA. Interacts with C1QBP. Interacts with MCUR1 (PubMed:26976564).

    Three dimensional structures from OCA and Proteopedia for PPIF Gene

    Alternative splice isoforms for PPIF Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPIF Gene

Selected DME Specific Peptides for PPIF Gene

P30405:
  • VKKIESFGS
  • LSMANAG
  • TNGSQFF
  • GVLSMAN
  • TAENFRAL
  • TGEKGFGY
  • GDFTNHNGTGG
  • GSTFHRVI
  • GPNTNGSQ
  • DVVPKTA
  • GFGYKGS
  • PKTAENF
  • DENFTLKH
  • GGKSIYG
  • LDGKHVVFG
  • DVVKKIES
  • LCTGEKG

Post-translational modifications for PPIF Gene

Other Protein References for PPIF Gene

Antibody Products

Domains & Families for PPIF Gene

Gene Families for PPIF Gene

Suggested Antigen Peptide Sequences for PPIF Gene

Graphical View of Domain Structure for InterPro Entry

P30405

UniProtKB/Swiss-Prot:

PPIF_HUMAN :
  • Belongs to the cyclophilin-type PPIase family.
Family:
  • Belongs to the cyclophilin-type PPIase family.
genes like me logo Genes that share domains with PPIF: view

Function for PPIF Gene

Molecular function for PPIF Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Peptidylproline (omega=180) = peptidylproline (omega=0).
UniProtKB/Swiss-Prot EnzymeRegulation:
Binds cyclosporin A (CsA). Is displaced by CsA from the mPTP leading to a lower open probability of the mPTP.
UniProtKB/Swiss-Prot Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Involved in regulation of the mitochondrial permeability transition pore (mPTP). It is proposed that its association with the mPTP is masking a binding site for inhibiting inorganic phosphate (Pi) and promotes the open probability of the mPTP leading to apoptosis or necrosis; the requirement of the PPIase activity for this function is debated. In cooperation with mitochondrial TP53 is involved in activating oxidative stress-induced necrosis. Involved in modulation of mitochondrial membrane F(1)F(0) ATP synthase activity and regulation of mitochondrial matrix adenine nucleotide levels. Has anti-apoptotic activity independently of mPTP and in cooperation with BCL2 inhibits cytochrome c-dependent apoptosis.

Enzyme Numbers (IUBMB) for PPIF Gene

Gene Ontology (GO) - Molecular Function for PPIF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003755 peptidyl-prolyl cis-trans isomerase activity IEA --
GO:0005515 protein binding IPI 22726440
GO:0016018 cyclosporin A binding IEA --
GO:0016853 isomerase activity IEA --
GO:0042277 peptide binding IEA --
genes like me logo Genes that share ontologies with PPIF: view
genes like me logo Genes that share phenotypes with PPIF: view

Animal Models for PPIF Gene

MGI Knock Outs for PPIF:

Animal Model Products

  • Taconic Biosciences Mouse Models for PPIF

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PPIF Gene

Localization for PPIF Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPIF Gene

Mitochondrion matrix.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PPIF gene
Compartment Confidence
mitochondrion 5
peroxisome 2
cytosol 2
extracellular 1
nucleus 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for PPIF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA --
GO:0005743 mitochondrial inner membrane IEA --
GO:0005753 colocalizes_with mitochondrial proton-transporting ATP synthase complex ISS --
GO:0005759 mitochondrial matrix IEA --
GO:0016020 membrane TAS 1744118
genes like me logo Genes that share ontologies with PPIF: view

Pathways & Interactions for PPIF Gene

genes like me logo Genes that share pathways with PPIF: view

Pathways by source for PPIF Gene

1 Sino Biological pathway for PPIF Gene

Gene Ontology (GO) - Biological Process for PPIF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000413 protein peptidyl-prolyl isomerization IEA --
GO:0002931 response to ischemia ISS --
GO:0006457 protein folding IEA --
GO:0006915 apoptotic process IEA --
GO:0006979 response to oxidative stress IEA --
genes like me logo Genes that share ontologies with PPIF: view

No data available for SIGNOR curated interactions for PPIF Gene

Drugs & Compounds for PPIF Gene

(4) Drugs for PPIF Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-Proline Approved Nutra Target 0
Cyclosporine Approved, Investigational, Vet_approved Pharma Antagonist, Target, binder Immunosuppressant drug, Immunosuppressive agent, Calcineurin inhibitor 922
1-Methoxy-2-[2-(2-Methoxy-Ethoxy]-Ethane Experimental Pharma Target 0
7-AMINO-4-METHYL-CHROMEN-2-ONE Experimental Pharma Target 0
genes like me logo Genes that share compounds with PPIF: view

Transcripts for PPIF Gene

Unigene Clusters for PPIF Gene

Peptidylprolyl isomerase F:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPIF Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c
SP1: - - -
SP2: - - -
SP3: - - - -
SP4: - -
SP5: - - - - -
SP6:

Relevant External Links for PPIF Gene

GeneLoc Exon Structure for
PPIF
ECgene alternative splicing isoforms for
PPIF

Expression for PPIF Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PPIF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PPIF Gene

This gene is overexpressed in Adrenal Gland (x5.2).

Protein differential expression in normal tissues from HIPED for PPIF Gene

This gene is overexpressed in Monocytes (9.1) and Liver, secretome (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PPIF Gene



Protein tissue co-expression partners for PPIF Gene

NURSA nuclear receptor signaling pathways regulating expression of PPIF Gene:

PPIF

SOURCE GeneReport for Unigene cluster for PPIF Gene:

Hs.381072

Evidence on tissue expression from TISSUES for PPIF Gene

  • Nervous system(4.7)
  • Blood(4.6)
  • Lung(3.8)
  • Heart(3.4)
  • Liver(3.3)
  • Muscle(3.1)
  • Intestine(2.9)
  • Kidney(2.4)
  • Skin(2.2)
  • Stomach(2)
genes like me logo Genes that share expression patterns with PPIF: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PPIF Gene

Orthologs for PPIF Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPIF Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PPIF 34 35
  • 99.52 (n)
dog
(Canis familiaris)
Mammalia PPIF 34 35
  • 90.61 (n)
cow
(Bos Taurus)
Mammalia PPIF 34 35
  • 88.32 (n)
mouse
(Mus musculus)
Mammalia Ppif 34 16 35
  • 87.86 (n)
rat
(Rattus norvegicus)
Mammalia Ppif 34
  • 87.86 (n)
oppossum
(Monodelphis domestica)
Mammalia PPIF 35
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PPIF 35
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves PPIF 34 35
  • 72.64 (n)
lizard
(Anolis carolinensis)
Reptilia PPIF 35
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ppif 34
  • 68.1 (n)
MGC75715 34
zebrafish
(Danio rerio)
Actinopterygii ppifb 34 35
  • 71.4 (n)
Dr.26827 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8555 34
fruit fly
(Drosophila melanogaster)
Insecta CG7768 36 35
  • 75 (a)
Cyp1 36 34 35
  • 72.67 (n)
ninaA 36
  • 44 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000462 34
  • 70.6 (n)
worm
(Caenorhabditis elegans)
Secernentea cyp-3 36
  • 68 (a)
cyp-7 36
  • 64 (a)
cyn-13 35
  • 34 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL177C 34
  • 67.51 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D16676g 34
  • 65.2 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CPR1 34 35 37
  • 64.57 (n)
CPR3 35
  • 59 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons CYP5 34
  • 61.64 (n)
soybean
(Glycine max)
eudicotyledons Gma.5851 34
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7462 34
rice
(Oryza sativa)
Liliopsida Os06g0708500 34
  • 63.1 (n)
barley
(Hordeum vulgare)
Liliopsida Hv.3465 34
wheat
(Triticum aestivum)
Liliopsida Ta.1078 34
bread mold
(Neurospora crassa)
Ascomycetes NCU00726 34
  • 65.76 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ppi1 34
  • 65.61 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5180 35
  • 61 (a)
ManyToMany
Species where no ortholog for PPIF was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for PPIF Gene

ENSEMBL:
Gene Tree for PPIF (if available)
TreeFam:
Gene Tree for PPIF (if available)

Paralogs for PPIF Gene

Pseudogenes.org Pseudogenes for PPIF Gene

genes like me logo Genes that share paralogs with PPIF: view

Variants for PPIF Gene

Sequence variations from dbSNP and Humsavar for PPIF Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1000075639 -- 79,348,807(+) GCTGT(G/T)TCCAC intron-variant
rs1000269118 -- 79,355,250(+) AGGCC(A/T)CCCTG utr-variant-3-prime
rs1000576438 -- 79,355,553(+) TCTGA(A/G)GTTAG downstream-variant-500B
rs1000613949 -- 79,353,900(+) GTGGC(C/T)GCGTT utr-variant-3-prime
rs1000623957 -- 79,353,535(+) CTGGG(A/G)TGTAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PPIF Gene

Variant ID Type Subtype PubMed ID
nsv1161981 CNV duplication 26073780
nsv819846 CNV loss 19587683

Variation tolerance for PPIF Gene

Residual Variation Intolerance Score: 84.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.93; 19.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PPIF Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PPIF

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPIF Gene

Disorders for PPIF Gene

Relevant External Links for PPIF

Genetic Association Database (GAD)
PPIF
Human Genome Epidemiology (HuGE) Navigator
PPIF
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PPIF

No disorders were found for PPIF Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPIF Gene

Publications for PPIF Gene

  1. The cyclophilin multigene family of peptidyl-prolyl isomerases. Characterization of three separate human isoforms. (PMID: 1744118) Bergsma D.J. … Levy M.A. (J. Biol. Chem. 1991) 2 3 4 64
  2. p53 opens the mitochondrial permeability transition pore to trigger necrosis. (PMID: 22726440) Vaseva A.V. … Moll U.M. (Cell 2012) 3 4 64
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  4. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PMID: 20734064) He C. … Hunter D.J. (Hum. Genet. 2010) 3 46 64
  5. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64

Products for PPIF Gene

Sources for PPIF Gene

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