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Aliases for PPIF Gene

Aliases for PPIF Gene

  • Peptidylprolyl Isomerase F 2 3
  • Cyclophilin D 2 3 4
  • CYP3 3 4 6
  • Mitochondrial Cyclophilin 3 4
  • Cyclophilin F 3 4
  • Rotamase F 3 4
  • EC 5.2.1.8 4 64
  • PPIase F 3 4
  • CYP-M 3 4
  • Cyp-D 3 4
  • CypD 3 4
  • Peptidyl-Prolyl Cis-Trans Isomerase F, Mitochondrial 3
  • Peptidyl-Prolyl Cis-Trans Isomerase, Mitochondrial 3
  • Peptidylprolyl Isomerase F (Cyclophilin F) 2
  • Cyclophilin 3 3

External Ids for PPIF Gene

Summaries for PPIF Gene

Entrez Gene Summary for PPIF Gene

  • The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein is part of the mitochondrial permeability transition pore in the inner mitochondrial membrane. Activation of this pore is thought to be involved in the induction of apoptotic and necrotic cell death. [provided by RefSeq, Jul 2008]

GeneCards Summary for PPIF Gene

PPIF (Peptidylprolyl Isomerase F) is a Protein Coding gene. Diseases associated with PPIF include dilated cardiomyopathy and ullrich congenital muscular dystrophy. Among its related pathways are Calcium signaling pathway and Leishmaniasis. GO annotations related to this gene include peptidyl-prolyl cis-trans isomerase activity and cyclosporin A binding. An important paralog of this gene is PPIE.

UniProtKB/Swiss-Prot for PPIF Gene

  • PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Involved in regulation of the mitochondrial permeability transition pore (mPTP). It is proposed that its association with the mPTP is masking a binding site for inhibiting inorganic phosphate (Pi) and promotes the open probability of the mPTP leading to apoptosis or necrosis; the requirement of the PPIase activity for this function is debated. In cooperation with mitochondrial TP53 is involved in activating oxidative stress-induced necrosis. Involved in modulation of mitochondrial membrane F(1)F(0) ATP synthase activity and regulation of mitochondrial matrix adenine nucleotide levels. Has anti-apoptotic activity independently of mPTP and in cooperation with BCL2 inhibits cytochrome c-dependent apoptosis.

Gene Wiki entry for PPIF Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPIF Gene

Genomics for PPIF Gene

Genomic Location for PPIF Gene

Start:
79,347,464 bp from pter
End:
79,355,337 bp from pter
Size:
7,874 bases
Orientation:
Plus strand

Genomic View for PPIF Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PPIF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPIF Gene

Regulatory Elements for PPIF Gene

Proteins for PPIF Gene

  • Protein details for PPIF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P30405-PPIF_HUMAN
    Recommended name:
    Peptidyl-prolyl cis-trans isomerase F, mitochondrial
    Protein Accession:
    P30405
    Secondary Accessions:
    • Q2YDB7
    • Q5W131

    Protein attributes for PPIF Gene

    Size:
    207 amino acids
    Molecular mass:
    22040 Da
    Quaternary structure:
    • Believed to associate with the mitochondrial permeability transition pore complex (PTPC). Associates with the mitochondrial membrane ATP synthase F(1)F(0) ATP synthase; the association is increased by inorganic phosphate (Pi) and decreased by cyclosporin A (CsA). Interacts with ATP5B; ATP5H and ATP5O. Interacts with SLC25A3; the interaction is impaired by CsA. Interacts with BCL2; the interaction is impaired by CsA. Interacts with TP53; the association implicates preferentially tetrameric TP53, is induced by oxidative stress and is impaired by CsA. Interacts with C1QBP.

    Three dimensional structures from OCA and Proteopedia for PPIF Gene

    Alternative splice isoforms for PPIF Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPIF Gene

Proteomics data for PPIF Gene at MOPED

Post-translational modifications for PPIF Gene

Other Protein References for PPIF Gene

Domains for PPIF Gene

UniProtKB/Swiss-Prot:

PPIF_HUMAN
Domain:
  • Contains 1 PPIase cyclophilin-type domain.:
    • P30405
Family:
  • Belongs to the cyclophilin-type PPIase family.:
    • P30405
genes like me logo Genes that share domains with PPIF: view

No data available for Gene Families for PPIF Gene

Function for PPIF Gene

Molecular function for PPIF Gene

UniProtKB/Swiss-Prot CatalyticActivity: Peptidylproline (omega=180) = peptidylproline (omega=0)
UniProtKB/Swiss-Prot EnzymeRegulation: Binds cyclosporin A (CsA). Is displaced by CsA from the mPTP leading to a lower open probability of the mPTP
UniProtKB/Swiss-Prot Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Involved in regulation of the mitochondrial permeability transition pore (mPTP). It is proposed that its association with the mPTP is masking a binding site for inhibiting inorganic phosphate (Pi) and promotes the open probability of the mPTP leading to apoptosis or necrosis; the requirement of the PPIase activity for this function is debated. In cooperation with mitochondrial TP53 is involved in activating oxidative stress-induced necrosis. Involved in modulation of mitochondrial membrane F(1)F(0) ATP synthase activity and regulation of mitochondrial matrix adenine nucleotide levels. Has anti-apoptotic activity independently of mPTP and in cooperation with BCL2 inhibits cytochrome c-dependent apoptosis.

Enzyme Numbers (IUBMB) for PPIF Gene

Gene Ontology (GO) - Molecular Function for PPIF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003755 peptidyl-prolyl cis-trans isomerase activity IBA --
GO:0005515 protein binding IPI 22726440
GO:0016018 cyclosporin A binding IEA --
GO:0042277 peptide binding --
genes like me logo Genes that share ontologies with PPIF: view
genes like me logo Genes that share phenotypes with PPIF: view

Animal Models for PPIF Gene

MGI Knock Outs for PPIF:

No data available for Transcription Factor Targeting and HOMER Transcription for PPIF Gene

Localization for PPIF Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPIF Gene

Mitochondrion matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PPIF Gene COMPARTMENTS Subcellular localization image for PPIF gene
Compartment Confidence
mitochondrion 5
peroxisome 2
plasma membrane 2
cytosol 1
endoplasmic reticulum 1
extracellular 1

Gene Ontology (GO) - Cellular Components for PPIF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion --
GO:0005743 mitochondrial inner membrane --
GO:0005753 colocalizes_with mitochondrial proton-transporting ATP synthase complex ISS --
GO:0005759 mitochondrial matrix IBA --
GO:0016020 membrane TAS 1744118
genes like me logo Genes that share ontologies with PPIF: view

Pathways for PPIF Gene

genes like me logo Genes that share pathways with PPIF: view

Pathways by source for PPIF Gene

Gene Ontology (GO) - Biological Process for PPIF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000413 protein peptidyl-prolyl isomerization IBA --
GO:0002931 response to ischemia ISS --
GO:0006457 protein folding IEA --
GO:0006979 response to oxidative stress --
GO:0008637 apoptotic mitochondrial changes IEA --
genes like me logo Genes that share ontologies with PPIF: view

Compounds for PPIF Gene

(2) HMDB Compounds for PPIF Gene

Compound Synonyms Cas Number PubMed IDs
Dimethyl sulfoxide
  • (methylsulfinyl)methane
67-68-5
L-Proline
  • (-)-(S)-Proline
147-85-3

(3) Drugbank Compounds for PPIF Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
1-Methoxy-2-[2-(2-Methoxy-Ethoxy]-Ethane
target
7-AMINO-4-METHYL-CHROMEN-2-ONE
target
L-Proline
  • (-)-2-Pyrrolidinecarboxylic acid
147-85-3 target
genes like me logo Genes that share compounds with PPIF: view

Transcripts for PPIF Gene

Unigene Clusters for PPIF Gene

Peptidylprolyl isomerase F:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PPIF Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c
SP1: - - -
SP2: - - -
SP3: - - - -
SP4: - -
SP5: - - - - -
SP6:

Relevant External Links for PPIF Gene

GeneLoc Exon Structure for
PPIF
ECgene alternative splicing isoforms for
PPIF

Expression for PPIF Gene

mRNA expression in normal human tissues for PPIF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PPIF Gene

This gene is overexpressed in Adrenal Gland (5.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PPIF Gene

SOURCE GeneReport for Unigene cluster for PPIF Gene Hs.381072

genes like me logo Genes that share expressions with PPIF: view

Orthologs for PPIF Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPIF Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PPIF 36
  • 99.52 (n)
  • 99.52 (a)
PPIF 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PPIF 36
  • 88.32 (n)
  • 91.37 (a)
PPIF 37
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PPIF 36
  • 90.61 (n)
  • 96.48 (a)
PPIF 37
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ppif 36
  • 87.86 (n)
  • 89.32 (a)
Ppif 16
Ppif 37
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PPIF 37
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PPIF 37
  • 80 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ppif 36
  • 87.86 (n)
  • 89.32 (a)
chicken
(Gallus gallus)
Aves PPIF 36
  • 72.64 (n)
  • 83.08 (a)
PPIF 37
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PPIF 37
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75715 36
ppif 36
  • 68.1 (n)
  • 79.14 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8555 36
zebrafish
(Danio rerio)
Actinopterygii Dr.26827 36
ppifb 36
  • 71.4 (n)
  • 78.4 (a)
ppifb 37
  • 70 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000462 36
  • 70.6 (n)
  • 73.91 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7768 37
  • 74 (a)
OneToMany
Cyp1 36
  • 72.67 (n)
  • 77.02 (a)
Cyp1 37
  • 58 (a)
OneToMany
CG7768 38
  • 75 (a)
ninaA 38
  • 44 (a)
Cyp1 38
  • 77 (a)
worm
(Caenorhabditis elegans)
Secernentea cyn-13 37
  • 34 (a)
OneToMany
cyp-3 38
  • 68 (a)
cyp-7 38
  • 64 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL177C 36
  • 67.51 (n)
  • 70.44 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CPR1 36
  • 64.57 (n)
  • 70.44 (a)
CPR1 37
  • 69 (a)
ManyToMany
CPR1 39
CPR3 37
  • 59 (a)
ManyToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D16676g 36
  • 65.2 (n)
  • 69.81 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7462 36
soybean
(Glycine max)
eudicotyledons Gma.5851 36
thale cress
(Arabidopsis thaliana)
eudicotyledons CYP5 36
  • 61.64 (n)
  • 68.55 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.3465 36
rice
(Oryza sativa)
Liliopsida Os06g0708500 36
  • 63.1 (n)
  • 67.92 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.1078 36
bread mold
(Neurospora crassa)
Ascomycetes NCU00726 36
  • 65.76 (n)
  • 69.39 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ppi1 36
  • 65.61 (n)
  • 74.68 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5180 37
  • 61 (a)
ManyToMany
Species with no ortholog for PPIF:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for PPIF Gene

ENSEMBL:
Gene Tree for PPIF (if available)
TreeFam:
Gene Tree for PPIF (if available)

Paralogs for PPIF Gene

genes like me logo Genes that share paralogs with PPIF: view

Variants for PPIF Gene

Sequence variations from dbSNP and Humsavar for PPIF Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs7332 -- 79,354,304(-) CAGCA(C/T)GGGGA utr-variant-3-prime
rs7898 -- 79,355,203(-) ATCAG(A/G)CATGT utr-variant-3-prime
rs8837 -- 79,355,057(-) tcgta(C/G)caggc utr-variant-3-prime
rs753121 -- 79,354,059(+) GGCAT(C/T)TTTGT utr-variant-3-prime
rs875427 -- 79,352,268(-) CCTGC(C/T)TGGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PPIF Gene

Variant ID Type Subtype PubMed ID
nsv819846 CNV Loss 19587683

Relevant External Links for PPIF Gene

HapMap Linkage Disequilibrium report
PPIF

Disorders for PPIF Gene

(2) University of Copenhagen DISEASES for PPIF Gene

Relevant External Links for PPIF

Genetic Association Database (GAD)
PPIF
Human Genome Epidemiology (HuGE) Navigator
PPIF
genes like me logo Genes that share disorders with PPIF: view

No data available for UniProtKB/Swiss-Prot for PPIF Gene

Publications for PPIF Gene

  1. The cyclophilin multigene family of peptidyl-prolyl isomerases. Characterization of three separate human isoforms. (PMID: 1744118) Bergsma D.J. … Levy M.A. (J. Biol. Chem. 1991) 2 3 4
  2. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 49
  5. Cyclophilin D interacts with Bcl2 and exerts an anti-apoptotic effect. (PMID: 19228691) Eliseev R.A. … Gunter T.E. (J. Biol. Chem. 2009) 3 4

Products for PPIF Gene

Sources for PPIF Gene

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