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Aliases for TSPAN2 Gene

Aliases for TSPAN2 Gene

  • Tetraspanin 2 2 3 5
  • Tetraspan NET-3 3 4
  • TSPAN-2 3 4
  • Tetraspanin 2 Isoform 3
  • New EST Tetraspan 3 3
  • Tetraspan TM4SF 3
  • Tetraspanin-2 3
  • Tetraspan 2 3
  • NET3 3
  • TSN2 3

External Ids for TSPAN2 Gene

Previous GeneCards Identifiers for TSPAN2 Gene

  • GC01M115303
  • GC01M115590
  • GC01M113448

Summaries for TSPAN2 Gene

Entrez Gene Summary for TSPAN2 Gene

  • The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]

GeneCards Summary for TSPAN2 Gene

TSPAN2 (Tetraspanin 2) is a Protein Coding gene. Diseases associated with TSPAN2 include Migraine With Or Without Aura 1. An important paralog of this gene is CD9.

UniProtKB/Swiss-Prot for TSPAN2 Gene

  • May play a role in signalling in oligodendrocytes in the early stages of their terminal differentiation into myelin-forming glia and may also function in stabilizing the mature sheath.

Gene Wiki entry for TSPAN2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSPAN2 Gene

Genomics for TSPAN2 Gene

Regulatory Elements for TSPAN2 Gene

Enhancers for TSPAN2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G115061 1.7 FANTOM5 Ensembl ENCODE dbSUPER 19.8 +26.6 26586 2.3 ZNF146 MXI1 TAF1 JUN MAX SIN3A EBF1 RFX5 ZNF507 ZKSCAN1 TSPAN2 TSHB AMPD1 BCAS2 SIKE1
GH01G114508 1.7 FANTOM5 ENCODE dbSUPER 17.3 +578.4 578411 4.2 HDGF PKNOX1 CREB3L1 ARID4B SIN3A YBX1 DMAP1 ZNF2 YY1 SLC30A9 TSPAN2 TRIM33 SIKE1 AP4B1 OLFML3 RSBN1 TSHB BCAS2 ENSG00000201114
GH01G115067 1.2 Ensembl ENCODE dbSUPER 18.2 +20.8 20777 3.4 CTCF MAX USF2 CEBPB RAD21 EP300 FOXA1 CTBP1 JUND GATA3 TSPAN2 TSHB AMPD1
GH01G115084 1.3 FANTOM5 Ensembl ENCODE dbSUPER 13.4 +3.8 3833 2.7 SREBF1 ZNF263 CTCF JUN TSPAN2 TSHB
GH01G115056 1.2 Ensembl ENCODE dbSUPER 11.5 +32.8 32763 1.0 MTA2 TEAD1 BHLHE40 TEAD4 BMI1 RBBP5 DPF2 TEAD3 IKZF1 NBN TSPAN2 TSHB
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TSPAN2 on UCSC Golden Path with GeneCards custom track

Promoters for TSPAN2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000011727 0 1401 KLF17 ZNF2 GLIS2 SP3 REST ZEB2 GATAD2B ZNF398 ZFP69B KLF16

Genomic Location for TSPAN2 Gene

Chromosome:
1
Start:
115,048,011 bp from pter
End:
115,089,500 bp from pter
Size:
41,490 bases
Orientation:
Minus strand

Genomic View for TSPAN2 Gene

Genes around TSPAN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TSPAN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TSPAN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSPAN2 Gene

Proteins for TSPAN2 Gene

  • Protein details for TSPAN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60636-TSN2_HUMAN
    Recommended name:
    Tetraspanin-2
    Protein Accession:
    O60636
    Secondary Accessions:
    • D6PTH4
    • Q5TET2
    • Q8WU05

    Protein attributes for TSPAN2 Gene

    Size:
    221 amino acids
    Molecular mass:
    24148 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TSPAN2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TSPAN2 Gene

Post-translational modifications for TSPAN2 Gene

  • Glycosylation at isoforms=2139
  • Modification sites at PhosphoSitePlus

Other Protein References for TSPAN2 Gene

No data available for DME Specific Peptides for TSPAN2 Gene

Domains & Families for TSPAN2 Gene

Gene Families for TSPAN2 Gene

Suggested Antigen Peptide Sequences for TSPAN2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O60636

UniProtKB/Swiss-Prot:

TSN2_HUMAN :
  • Belongs to the tetraspanin (TM4SF) family.
Family:
  • Belongs to the tetraspanin (TM4SF) family.
genes like me logo Genes that share domains with TSPAN2: view

Function for TSPAN2 Gene

Molecular function for TSPAN2 Gene

UniProtKB/Swiss-Prot Function:
May play a role in signalling in oligodendrocytes in the early stages of their terminal differentiation into myelin-forming glia and may also function in stabilizing the mature sheath.

Gene Ontology (GO) - Molecular Function for TSPAN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25814554
genes like me logo Genes that share ontologies with TSPAN2: view
genes like me logo Genes that share phenotypes with TSPAN2: view

Animal Models for TSPAN2 Gene

MGI Knock Outs for TSPAN2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TSPAN2 Gene

Localization for TSPAN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSPAN2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TSPAN2 gene
Compartment Confidence
plasma membrane 5
nucleus 2

Gene Ontology (GO) - Cellular Components for TSPAN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA,TAS 9714763
GO:0043209 myelin sheath IEA --
genes like me logo Genes that share ontologies with TSPAN2: view

Pathways & Interactions for TSPAN2 Gene

SuperPathways for TSPAN2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TSPAN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006954 inflammatory response IEA --
GO:0007166 cell surface receptor signaling pathway IBA --
GO:0007420 brain development IEA --
GO:0014002 astrocyte development IEA --
GO:0014005 microglia development IEA --
genes like me logo Genes that share ontologies with TSPAN2: view

No data available for Pathways by source and SIGNOR curated interactions for TSPAN2 Gene

Drugs & Compounds for TSPAN2 Gene

No Compound Related Data Available

Transcripts for TSPAN2 Gene

Unigene Clusters for TSPAN2 Gene

Tetraspanin 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TSPAN2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b
SP1:
SP2: -

Relevant External Links for TSPAN2 Gene

GeneLoc Exon Structure for
TSPAN2
ECgene alternative splicing isoforms for
TSPAN2

Expression for TSPAN2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TSPAN2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TSPAN2 Gene

This gene is overexpressed in Colon - Sigmoid (x5.5), Whole Blood (x5.0), Artery - Tibial (x4.4), and Uterus (x4.3).

Protein differential expression in normal tissues from HIPED for TSPAN2 Gene

This gene is overexpressed in Colon (16.6), Fetal Brain (12.6), Platelet (8.6), Peripheral blood mononuclear cells (7.2), and Prostate (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TSPAN2 Gene



NURSA nuclear receptor signaling pathways regulating expression of TSPAN2 Gene:

TSPAN2

SOURCE GeneReport for Unigene cluster for TSPAN2 Gene:

Hs.310458

Evidence on tissue expression from TISSUES for TSPAN2 Gene

  • Kidney(4.2)
genes like me logo Genes that share expression patterns with TSPAN2: view

Primer Products

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TSPAN2 Gene

Orthologs for TSPAN2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TSPAN2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TSPAN2 34 35
  • 99.24 (n)
dog
(Canis familiaris)
Mammalia TSPAN2 34 35
  • 91.25 (n)
cow
(Bos Taurus)
Mammalia TSPAN2 34 35
  • 90.55 (n)
rat
(Rattus norvegicus)
Mammalia Tspan2 34
  • 88.99 (n)
mouse
(Mus musculus)
Mammalia Tspan2 34 16 35
  • 88.84 (n)
oppossum
(Monodelphis domestica)
Mammalia TSPAN2 35
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TSPAN2 35
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves TSPAN2 34 35
  • 69.23 (n)
lizard
(Anolis carolinensis)
Reptilia TSPAN2 35
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tspan2 34
  • 62.73 (n)
Str.12918 34
zebrafish
(Danio rerio)
Actinopterygii tspan2 35
  • 55 (a)
OneToMany
TSPAN2 (2 of 2) 35
  • 47 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Tsp96F 35
  • 21 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea tsp-9 35
  • 26 (a)
OneToMany
Species where no ortholog for TSPAN2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TSPAN2 Gene

ENSEMBL:
Gene Tree for TSPAN2 (if available)
TreeFam:
Gene Tree for TSPAN2 (if available)

Paralogs for TSPAN2 Gene

Paralogs for TSPAN2 Gene

(12) SIMAP similar genes for TSPAN2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TSPAN2: view

Variants for TSPAN2 Gene

Sequence variations from dbSNP and Humsavar for TSPAN2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000107197 -- 115,080,813(+) TGGAA(C/T)ATCCA intron-variant
rs1000176303 -- 115,082,132(+) GCACC(C/T)ATGGC intron-variant
rs1000191946 -- 115,075,200(+) ATAAT(C/G/T)GAAAA intron-variant
rs1000301851 -- 115,081,538(+) AAGGA(C/G)TTGTA intron-variant
rs1000378698 -- 115,069,719(+) AATAC(A/G)AAGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TSPAN2 Gene

Variant ID Type Subtype PubMed ID
esv26121 CNV loss 19812545
esv3587278 CNV loss 21293372
nsv463295 CNV loss 19166990
nsv528883 CNV loss 19592680
nsv547570 CNV loss 21841781

Variation tolerance for TSPAN2 Gene

Residual Variation Intolerance Score: 59.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.70; 46.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TSPAN2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TSPAN2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TSPAN2 Gene

Disorders for TSPAN2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TSPAN2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
migraine with or without aura 1
  • migraine
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TSPAN2

Genetic Association Database (GAD)
TSPAN2
Human Genome Epidemiology (HuGE) Navigator
TSPAN2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TSPAN2
genes like me logo Genes that share disorders with TSPAN2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TSPAN2 Gene

Publications for TSPAN2 Gene

  1. Sequences and expression of six new members of the tetraspanin/TM4SF family. (PMID: 9714763) Todd S.C. … Levy S. (Biochim. Biophys. Acta 1998) 2 3 4 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Complexes of tetraspanins with integrins: more than meets the eye. (PMID: 11739647) Berditchevski F. (J. Cell. Sci. 2001) 2 3 64

Products for TSPAN2 Gene

Sources for TSPAN2 Gene

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