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Aliases for TSPAN2 Gene

Aliases for TSPAN2 Gene

  • Tetraspanin 2 2 3
  • Tetraspan NET-3 3 4
  • TSPAN-2 3 4
  • NET3 3 6
  • Tetraspanin 2 Isoform 3
  • New EST Tetraspan 3 3
  • Tetraspan TM4SF 3
  • Tetraspanin-2 3
  • Tetraspan 2 3
  • TSN2 3

External Ids for TSPAN2 Gene

Summaries for TSPAN2 Gene

Entrez Gene Summary for TSPAN2 Gene

  • The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. [provided by RefSeq, Jul 2008]

GeneCards Summary for TSPAN2 Gene

TSPAN2 (Tetraspanin 2) is a Protein Coding gene. Diseases associated with TSPAN2 include clonorchiasis. An important paralog of this gene is TSPAN9.

UniProtKB/Swiss-Prot for TSPAN2 Gene

  • May play a role in signalling in oligodendrocytes in the early stages of their terminal differentiation into myelin-forming glia and may also function in stabilizing the mature sheath.

Gene Wiki entry for TSPAN2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSPAN2 Gene

Genomics for TSPAN2 Gene

Genomic Location for TSPAN2 Gene

Start:
115,048,011 bp from pter
End:
115,089,500 bp from pter
Size:
41,490 bases
Orientation:
Minus strand

Genomic View for TSPAN2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TSPAN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSPAN2 Gene

Proteins for TSPAN2 Gene

  • Protein details for TSPAN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60636-TSN2_HUMAN
    Recommended name:
    Tetraspanin-2
    Protein Accession:
    O60636
    Secondary Accessions:
    • D6PTH4
    • Q5TET2
    • Q8WU05

    Protein attributes for TSPAN2 Gene

    Size:
    221 amino acids
    Molecular mass:
    24148 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TSPAN2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TSPAN2 Gene

Proteomics data for TSPAN2 Gene at MOPED

Post-translational modifications for TSPAN2 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn139

Other Protein References for TSPAN2 Gene

No data available for DME Specific Peptides for TSPAN2 Gene

Domains for TSPAN2 Gene

Gene Families for TSPAN2 Gene

HGNC:

Suggested Antigen Peptide Sequences for TSPAN2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O60636

UniProtKB/Swiss-Prot:

TSN2_HUMAN
Family:
  • Belongs to the tetraspanin (TM4SF) family.:
    • O60636
genes like me logo Genes that share domains with TSPAN2: view

Function for TSPAN2 Gene

Molecular function for TSPAN2 Gene

UniProtKB/Swiss-Prot Function: May play a role in signalling in oligodendrocytes in the early stages of their terminal differentiation into myelin-forming glia and may also function in stabilizing the mature sheath.
genes like me logo Genes that share phenotypes with TSPAN2: view

Animal Models for TSPAN2 Gene

MGI Knock Outs for TSPAN2:

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , miRNA , Transcription Factor Targeting and HOMER Transcription for TSPAN2 Gene

Localization for TSPAN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSPAN2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TSPAN2 Gene COMPARTMENTS Subcellular localization image for TSPAN2 gene
Compartment Confidence
plasma membrane 3
nucleus 1

Gene Ontology (GO) - Cellular Components for TSPAN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0043209 myelin sheath IEA --
genes like me logo Genes that share ontologies with TSPAN2: view

Pathways for TSPAN2 Gene

SuperPathways for TSPAN2 Gene

No Data Available

Interacting Proteins for TSPAN2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000358529%0d%0a9606.ENSP00000306245%0d%0a
Selected Interacting proteins: ENSP00000358529 for TSPAN2 Gene via STRING

Symbol External ID(s) Details
FOS

Gene Ontology (GO) - Biological Process for TSPAN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006954 inflammatory response IEA --
GO:0007420 brain development IEA --
GO:0014002 astrocyte development IEA --
GO:0014005 microglia development IEA --
GO:0042552 myelination IEA --
genes like me logo Genes that share ontologies with TSPAN2: view

No data available for Pathways by source for TSPAN2 Gene

Transcripts for TSPAN2 Gene

Unigene Clusters for TSPAN2 Gene

Tetraspanin 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TSPAN2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b
SP1:
SP2: -

Relevant External Links for TSPAN2 Gene

GeneLoc Exon Structure for
TSPAN2
ECgene alternative splicing isoforms for
TSPAN2

Expression for TSPAN2 Gene

mRNA expression in normal human tissues for TSPAN2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TSPAN2 Gene

This gene is overexpressed in Colon - Sigmoid (5.5), Whole Blood (5.0), Artery - Tibial (4.4), and Uterus (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TSPAN2 Gene

SOURCE GeneReport for Unigene cluster for TSPAN2 Gene Hs.310458

genes like me logo Genes that share expressions with TSPAN2: view

No data available for mRNA Expression by UniProt/SwissProt for TSPAN2 Gene

Orthologs for TSPAN2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TSPAN2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TSPAN2 35
  • 99.24 (n)
  • 99.09 (a)
TSPAN2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TSPAN2 35
  • 90.55 (n)
  • 93.53 (a)
TSPAN2 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TSPAN2 35
  • 91.25 (n)
  • 95.02 (a)
TSPAN2 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tspan2 35
  • 88.84 (n)
  • 93.67 (a)
Tspan2 16
Tspan2 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TSPAN2 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TSPAN2 36
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tspan2 35
  • 88.99 (n)
  • 94.57 (a)
chicken
(Gallus gallus)
Aves TSPAN2 35
  • 69.23 (n)
  • 64.25 (a)
TSPAN2 36
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TSPAN2 36
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.12918 35
tspan2 35
  • 62.73 (n)
  • 56.36 (a)
zebrafish
(Danio rerio)
Actinopterygii tspan2 36
  • 55 (a)
OneToMany
TSPAN2 (2 of 2) 36
  • 47 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Tsp96F 36
  • 21 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea tsp-9 36
  • 26 (a)
OneToMany
Species with no ortholog for TSPAN2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TSPAN2 Gene

ENSEMBL:
Gene Tree for TSPAN2 (if available)
TreeFam:
Gene Tree for TSPAN2 (if available)

Paralogs for TSPAN2 Gene

Paralogs for TSPAN2 Gene

Selected SIMAP similar genes for TSPAN2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TSPAN2: view

Variants for TSPAN2 Gene

Sequence variations from dbSNP and Humsavar for TSPAN2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs717275 -- 115,067,470(+) AATGC(C/T)CTGGA intron-variant
rs717276 -- 115,067,770(+) TGGAG(A/T)AAACC intron-variant
rs747529 -- 115,072,055(+) CACCT(C/T)TAATG intron-variant
rs747530 -- 115,072,119(+) ATGAG(A/G)AAAGG intron-variant
rs747531 -- 115,072,143(+) TAGAA(G/T)TAGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TSPAN2 Gene

Variant ID Type Subtype PubMed ID
nsv528883 CNV Loss 19592680
esv26121 CNV Loss 19812545
nsv463295 CNV Loss 19166990
nsv872165 CNV Loss 21882294

Relevant External Links for TSPAN2 Gene

HapMap Linkage Disequilibrium report
TSPAN2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TSPAN2 Gene

Disorders for TSPAN2 Gene

(1) MalaCards Diseases for TSPAN2 Gene

Search for TSPAN2 Gene in MalaCards »

(2) University of Copenhagen DISEASES for TSPAN2 Gene

Relevant External Links for TSPAN2

Genetic Association Database (GAD)
TSPAN2
Human Genome Epidemiology (HuGE) Navigator
TSPAN2
genes like me logo Genes that share disorders with TSPAN2: view

No data available for UniProtKB/Swiss-Prot for TSPAN2 Gene

Publications for TSPAN2 Gene

  1. Sequences and expression of six new members of the tetraspanin/TM4SF family. (PMID: 9714763) Todd S.C. … Levy S. (Biochim. Biophys. Acta 1998) 2 3 4
  2. Complexes of tetraspanins with integrins: more than meets the eye. (PMID: 11739647) Berditchevski F. (J. Cell. Sci. 2001) 2 3
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4

Products for TSPAN2 Gene

Sources for TSPAN2 Gene

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