Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TSPAN3 Gene

Aliases for TSPAN3 Gene

  • Tetraspanin 3 2 3 5
  • Transmembrane 4 Superfamily Member 8 2 3 4
  • Tetraspanin TM4-A 3 4
  • TSPAN-3 3 4
  • TM4SF8 3 4
  • Tetraspan TM4SF 3
  • Tetraspan 3 3
  • TM4-A 3

External Ids for TSPAN3 Gene

Previous HGNC Symbols for TSPAN3 Gene

  • TM4SF8

Previous GeneCards Identifiers for TSPAN3 Gene

  • GC15M075126
  • GC15M075127
  • GC15M077336
  • GC15M054093

Summaries for TSPAN3 Gene

Entrez Gene Summary for TSPAN3 Gene

  • The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The use of alternate polyadenylation sites has been found for this gene. Multiple alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Dec 2009]

GeneCards Summary for TSPAN3 Gene

TSPAN3 (Tetraspanin 3) is a Protein Coding gene. An important paralog of this gene is ENSG00000250349.

UniProtKB/Swiss-Prot for TSPAN3 Gene

  • Regulates the proliferation and migration of oligodendrocytes, a process essential for normal myelination and repair.

Gene Wiki entry for TSPAN3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSPAN3 Gene

Genomics for TSPAN3 Gene

Regulatory Elements for TSPAN3 Gene

Enhancers for TSPAN3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TSPAN3 on UCSC Golden Path with GeneCards custom track

Promoters for TSPAN3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TSPAN3 on UCSC Golden Path with GeneCards custom track

Genomic Location for TSPAN3 Gene

77,041,404 bp from pter
77,083,984 bp from pter
42,581 bases
Minus strand

Genomic View for TSPAN3 Gene

Genes around TSPAN3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TSPAN3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TSPAN3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSPAN3 Gene

Proteins for TSPAN3 Gene

  • Protein details for TSPAN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A6NEH4
    • B3KQQ2
    • B4DP19
    • Q9BW22
    • Q9NVX9

    Protein attributes for TSPAN3 Gene

    253 amino acids
    Molecular mass:
    28018 Da
    Quaternary structure:
    • Interacts with claudin-11/CLDN11 and integrins.

    Alternative splice isoforms for TSPAN3 Gene


neXtProt entry for TSPAN3 Gene

Proteomics data for TSPAN3 Gene at MOPED

Post-translational modifications for TSPAN3 Gene

  • Ubiquitination at Lys 124
  • Glycosylation at Asn 127, Asn 152, Asn 167, and Asn 183
  • Modification sites at PhosphoSitePlus

Other Protein References for TSPAN3 Gene

Antibody Products

No data available for DME Specific Peptides for TSPAN3 Gene

Domains & Families for TSPAN3 Gene

Gene Families for TSPAN3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the tetraspanin (TM4SF) family.
  • Belongs to the tetraspanin (TM4SF) family.
genes like me logo Genes that share domains with TSPAN3: view

Function for TSPAN3 Gene

Molecular function for TSPAN3 Gene

UniProtKB/Swiss-Prot Function:
Regulates the proliferation and migration of oligodendrocytes, a process essential for normal myelination and repair.

Phenotypes for TSPAN3 Gene

genes like me logo Genes that share phenotypes with TSPAN3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TSPAN3

miRNA for TSPAN3 Gene

miRTarBase miRNAs that target TSPAN3

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TSPAN3 Gene

Localization for TSPAN3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSPAN3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for TSPAN3 Gene COMPARTMENTS Subcellular localization image for TSPAN3 gene
Compartment Confidence
extracellular 5
plasma membrane 5
golgi apparatus 2
nucleus 2

Gene Ontology (GO) - Cellular Components for TSPAN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TSPAN3: view

Pathways & Interactions for TSPAN3 Gene

SuperPathways for TSPAN3 Gene

No Data Available

Interacting Proteins for TSPAN3 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: O60637-TSN3_HUMAN ENSP00000267970 for TSPAN3 Gene via MINT STRING I2D

Gene Ontology (GO) - Biological Process for TSPAN3 Gene


No data available for Pathways by source and SIGNOR curated interactions for TSPAN3 Gene

Drugs & Compounds for TSPAN3 Gene

No Compound Related Data Available

Transcripts for TSPAN3 Gene

Unigene Clusters for TSPAN3 Gene

Tetraspanin 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TSPAN3 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8
SP1: -
SP2: - - -
SP3: - -
SP5: - -

Relevant External Links for TSPAN3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TSPAN3 Gene

mRNA expression in normal human tissues for TSPAN3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TSPAN3 Gene

This gene is overexpressed in Nasal epithelium (61.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TSPAN3 Gene

SOURCE GeneReport for Unigene cluster for TSPAN3 Gene Hs.744863

genes like me logo Genes that share expression patterns with TSPAN3: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TSPAN3 Gene

Orthologs for TSPAN3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TSPAN3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TSPAN3 35
  • 93.28 (n)
  • 98.81 (a)
  • 99 (a)
(Mus musculus)
Mammalia Tspan3 35
  • 90.91 (n)
  • 97.23 (a)
Tspan3 16
Tspan3 36
  • 97 (a)
(Pan troglodytes)
Mammalia TSPAN3 35
  • 99.74 (n)
  • 100 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Tspan3 35
  • 89.99 (n)
  • 96.84 (a)
(Canis familiaris)
Mammalia TSPAN3 36
  • 94 (a)
(Monodelphis domestica)
Mammalia TSPAN3 36
  • 94 (a)
(Ornithorhynchus anatinus)
Mammalia TSPAN3 36
  • 94 (a)
(Gallus gallus)
Aves TSPAN3 35
  • 82.06 (n)
  • 89.69 (a)
  • 86 (a)
(Anolis carolinensis)
Reptilia TSPAN3 36
  • 92 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.5967 35
tspan3 35
  • 76.42 (n)
  • 84.19 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.23773 35
(Danio rerio)
Actinopterygii tspan3a 35
  • 76.42 (n)
  • 87.35 (a)
tspan3a 36
  • 84 (a)
tspan3b 36
  • 77 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1062 35
Species with no ortholog for TSPAN3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TSPAN3 Gene

Gene Tree for TSPAN3 (if available)
Gene Tree for TSPAN3 (if available)

Paralogs for TSPAN3 Gene

(12) SIMAP similar genes for TSPAN3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with TSPAN3: view

Variants for TSPAN3 Gene

Sequence variations from dbSNP and Humsavar for TSPAN3 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs11737 -- 77,052,451(-) CTAGT(A/T)GTGAA reference, synonymous-codon
rs11858123 -- 77,058,545(+) CATGG(G/T)TCTAA intron-variant
rs12148612 -- 77,060,915(+) TTTTT(A/T)AAAAA intron-variant
rs12592735 -- 77,066,056(+) TTTTT(C/T)TAATA intron-variant
rs12901188 -- 77,072,557(+) AGGCA(C/G)AAGCC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TSPAN3 Gene

Variant ID Type Subtype PubMed ID
esv2749898 CNV Deletion 23290073
dgv757e1 CNV Complex 17122850
nsv833058 CNV Loss 17160897
nsv509576 CNV Insertion 20534489
nsv517068 CNV Gain+Loss 19592680
nsv904414 CNV Loss 21882294
nsv1622 CNV Insertion 18451855
nsv511547 CNV Loss 21212237

Variation tolerance for TSPAN3 Gene

Residual Variation Intolerance Score: 36.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.93; 19.27% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TSPAN3 Gene

Disorders for TSPAN3 Gene

Relevant External Links for TSPAN3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TSPAN3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TSPAN3 Gene

Publications for TSPAN3 Gene

  1. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Large-scale proteomics and phosphoproteomics of urinary exosomes. (PMID: 19056867) Gonzales P.A. … Knepper M.A. (J. Am. Soc. Nephrol. 2009) 3
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for TSPAN3 Gene

Sources for TSPAN3 Gene