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Aliases for PTPRU Gene

Aliases for PTPRU Gene

  • Protein Tyrosine Phosphatase, Receptor Type U 2 3
  • Receptor-Type Protein-Tyrosine Phosphatase Psi 3 4
  • Protein Tyrosine Phosphatase, Receptor Type, U 3 5
  • Protein-Tyrosine Phosphatase Receptor Omicron 3 4
  • Pancreatic Carcinoma Phosphatase 2 3 4
  • Protein-Tyrosine Phosphatase Pi 3 4
  • Protein-Tyrosine Phosphatase J 3 4
  • Pi R-PTP-Psi 2 3
  • EC 3.1.3.48 4 63
  • R-PTP-PSI 3 4
  • R-PTP-U 3 4
  • PTP Pi 3 4
  • PTP-RO 3 4
  • HPTP-J 3 4
  • PCP-2 3 4
  • PTP-J 3 4
  • PTPRO 3 4
  • FMI 3 4
  • Receptor Protein Tyrosine Phosphatase HPTP-J 3
  • PTP-PI 3
  • PTPPSI 3
  • PTPU2 3
  • PCP2 4
  • PTP 3

External Ids for PTPRU Gene

Previous GeneCards Identifiers for PTPRU Gene

  • GC01P029569
  • GC01P028728
  • GC01P029068
  • GC01P029383
  • GC01P027814

Summaries for PTPRU Gene

Entrez Gene Summary for PTPRU Gene

  • The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracellular catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP (MAM) domain, Ig-like and fibronectin type III-like repeats. This PTP was thought to play roles in cell-cell recognition and adhesion. Studies of the similar gene in mice suggested the role of this PTP in early neural development. The expression of this gene was reported to be regulated by phorbol myristate acetate (PMA) or calcium ionophore in Jurkat T lymphoma cells. Alternatively spliced transcript variants have been reported. [provided by RefSeq, Aug 2010]

GeneCards Summary for PTPRU Gene

PTPRU (Protein Tyrosine Phosphatase, Receptor Type U) is a Protein Coding gene. Diseases associated with PTPRU include Galloway-Mowat Syndrome. Among its related pathways are Development EPO-induced Jak-STAT pathway and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include phosphatase activity and beta-catenin binding. An important paralog of this gene is PTPRK.

UniProtKB/Swiss-Prot for PTPRU Gene

  • Tyrosine-protein phosphatase which dephosphorylates CTNNB1. Regulates CTNNB1 function both in cell adhesion and signaling. May function in cell proliferation and migration and play a role in the maintenance of epithelial integrity. May play a role in megakaryocytopoiesis.

Gene Wiki entry for PTPRU Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTPRU Gene

Genomics for PTPRU Gene

Regulatory Elements for PTPRU Gene

Enhancers for PTPRU Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PTPRU on UCSC Golden Path with GeneCards custom track

Promoters for PTPRU Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PTPRU on UCSC Golden Path with GeneCards custom track

Genomic Location for PTPRU Gene

Chromosome:
1
Start:
29,236,516 bp from pter
End:
29,326,813 bp from pter
Size:
90,298 bases
Orientation:
Plus strand

Genomic View for PTPRU Gene

Genes around PTPRU on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTPRU Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTPRU Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTPRU Gene

Proteins for PTPRU Gene

  • Protein details for PTPRU Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92729-PTPRU_HUMAN
    Recommended name:
    Receptor-type tyrosine-protein phosphatase U
    Protein Accession:
    Q92729
    Secondary Accessions:
    • A6H8L1
    • O00197
    • P78399
    • Q59HA4
    • Q5SYU4
    • Q5SYU5
    • Q92735
    • Q92850

    Protein attributes for PTPRU Gene

    Size:
    1446 amino acids
    Molecular mass:
    162423 Da
    Quaternary structure:
    • Forms homooligomeric complexes which mediate cell homotypic adhesion (Probable). Interacts (via the cytoplasmic juxtamembrane domain) with CTNNB1; may mediate interaction with the cadherin/catenin adhesion complex. Interacts with KIT. May interact with AP3B1.
    SequenceCaution:
    • Sequence=CAA65016.1; Type=Miscellaneous discrepancy; Note=Several sequencing problems.; Evidence={ECO:0000305}; Sequence=CAA65832.1; Type=Miscellaneous discrepancy; Note=Several sequencing problems.; Evidence={ECO:0000305};

    Alternative splice isoforms for PTPRU Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PTPRU Gene

Proteomics data for PTPRU Gene at MOPED

Post-translational modifications for PTPRU Gene

  • N-glycosylated.
  • Phosphorylated on tyrosine residues upon activation of KIT with stem cell factor (SCF). The 73 kDa proteolytic product is not phosphorylated.
  • The extracellular domain is proteolytically processed through cleavage within the fibronectin type-III 4 domain (By similarity). In addition to the 190 kDa full-length protein, proteolytic products of 100 kDa, 80 kDa and 73 kDa are observed.
  • Glycosylation at Asn 75, Asn 410, and Asn 685
  • Modification sites at PhosphoSitePlus

Other Protein References for PTPRU Gene

Antibody Products

Domains & Families for PTPRU Gene

Suggested Antigen Peptide Sequences for PTPRU Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q92729

UniProtKB/Swiss-Prot:

PTPRU_HUMAN :
  • Contains 4 fibronectin type-III domains.
  • Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily.
Domain:
  • Contains 4 fibronectin type-III domains.
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Contains 1 MAM domain.
  • Contains 2 tyrosine-protein phosphatase domains.
Family:
  • Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily.
genes like me logo Genes that share domains with PTPRU: view

Function for PTPRU Gene

Molecular function for PTPRU Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot Function:
Tyrosine-protein phosphatase which dephosphorylates CTNNB1. Regulates CTNNB1 function both in cell adhesion and signaling. May function in cell proliferation and migration and play a role in the maintenance of epithelial integrity. May play a role in megakaryocytopoiesis.
UniProtKB/Swiss-Prot Induction:
Up-regulated upon cell contact (at protein level). Down-regulated by phorbol ester (at protein level) and calcium ionophore but up-regulated by phorbol ester in megakaryocytic cells (PubMed:10397721).

Enzyme Numbers (IUBMB) for PTPRU Gene

Gene Ontology (GO) - Molecular Function for PTPRU Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008013 beta-catenin binding IPI 16574648
genes like me logo Genes that share ontologies with PTPRU: view
genes like me logo Genes that share phenotypes with PTPRU: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PTPRU

miRNA for PTPRU Gene

miRTarBase miRNAs that target PTPRU

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PTPRU Gene

Localization for PTPRU Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTPRU Gene

Cell junction. Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PTPRU Gene COMPARTMENTS Subcellular localization image for PTPRU gene
Compartment Confidence
plasma membrane 5
extracellular 3
endoplasmic reticulum 1
lysosome 1
nucleus 1
peroxisome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for PTPRU Gene

Pathways & Interactions for PTPRU Gene

genes like me logo Genes that share pathways with PTPRU: view

Pathways by source for PTPRU Gene

2 BioSystems pathways for PTPRU Gene
2 Reactome pathways for PTPRU Gene
1 Qiagen pathway for PTPRU Gene

Gene Ontology (GO) - Biological Process for PTPRU Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IEA,IDA 12501215
GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway NAS 8700514
GO:0008285 negative regulation of cell proliferation IDA 16574648
GO:0016337 single organismal cell-cell adhesion IDA 16574648
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with PTPRU: view

No data available for SIGNOR curated interactions for PTPRU Gene

Drugs & Compounds for PTPRU Gene

(13) Drugs for PTPRU Gene - From: ApexBio and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Etidronate Pharma Osteoclast function modifiers (important in bone metastasis) 0

(12) Additional Compounds for PTPRU Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5

(1) ApexBio Compounds for PTPRU Gene

Compound Action Cas Number
Etidronate 2809-21-4
genes like me logo Genes that share compounds with PTPRU: view

Transcripts for PTPRU Gene

Unigene Clusters for PTPRU Gene

Protein tyrosine phosphatase, receptor type, U:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PTPRU Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b · 20c ^
SP1: - - - -
SP2:
SP3: -
SP4:
SP5: -
SP6:
SP7:
SP8: -

ExUns: 21 ^ 22a · 22b ^ 23 ^ 24 ^ 25 ^ 26a · 26b ^ 27a · 27b ^ 28 ^ 29 ^ 30a · 30b · 30c
SP1: - -
SP2:
SP3:
SP4: -
SP5:
SP6:
SP7:
SP8:

Relevant External Links for PTPRU Gene

GeneLoc Exon Structure for
PTPRU
ECgene alternative splicing isoforms for
PTPRU

Expression for PTPRU Gene

mRNA expression in normal human tissues for PTPRU Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PTPRU Gene

This gene is overexpressed in Urinary Bladder (18.5), Salivary gland (16.6), Rectum (8.8), and Esophagus (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PTPRU Gene



SOURCE GeneReport for Unigene cluster for PTPRU Gene Hs.19718

mRNA Expression by UniProt/SwissProt for PTPRU Gene

Q92729-PTPRU_HUMAN
Tissue specificity: High levels in brain, pancreas, and skeletal muscle; less in colon, kidney, liver, stomach, and uterus; not expressed in placenta and spleen. Also detected in heart, prostate, lung, thymus, testis and ovary. Ubiquitously expressed in brain. Expressed by hematopoietic stem cells.
genes like me logo Genes that share expression patterns with PTPRU: view

Primer Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for PTPRU Gene

Orthologs for PTPRU Gene

This gene was present in the common ancestor of animals.

Orthologs for PTPRU Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PTPRU 35
  • 92.1 (n)
  • 97.28 (a)
PTPRU 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PTPRU 35
  • 91.81 (n)
  • 97.01 (a)
PTPRU 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ptpru 35
  • 89.01 (n)
  • 95.33 (a)
Ptpru 16
Ptpru 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PTPRU 35
  • 99.62 (n)
  • 99.86 (a)
PTPRU 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ptpru 35
  • 88.61 (n)
  • 94.98 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 89 (a)
OneToMany
-- 36
  • 92 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia PTPRU 36
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves PTPRU 35
  • 81.19 (n)
  • 85.68 (a)
PTPRU 36
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PTPRU 36
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ptpru 35
  • 66.05 (n)
  • 69.28 (a)
Str.9623 35
zebrafish
(Danio rerio)
Actinopterygii ptprub 35
  • 71.96 (n)
  • 75.56 (a)
wufj42a04 35
PTPRU (3 of 3) 36
  • 75 (a)
OneToMany
ptprua 36
  • 71 (a)
OneToMany
ptprub 36
  • 76 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG7180 37
  • 32 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1390 36
  • 37 (a)
OneToMany
Species with no ortholog for PTPRU:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PTPRU Gene

ENSEMBL:
Gene Tree for PTPRU (if available)
TreeFam:
Gene Tree for PTPRU (if available)

Paralogs for PTPRU Gene

Paralogs for PTPRU Gene

Pseudogenes.org Pseudogenes for PTPRU Gene

genes like me logo Genes that share paralogs with PTPRU: view

Variants for PTPRU Gene

Sequence variations from dbSNP and Humsavar for PTPRU Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_035650 A colorectal cancer sample
VAR_035651 A colorectal cancer sample
VAR_035652 A colorectal cancer sample
rs35332573 - 29,255,380(-) CCCGG(G/T)TGCCA reference, missense, utr-variant-5-prime
rs35745442 - 29,275,715(-) CTTTG(A/C/T)GCCCC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for PTPRU Gene

Variant ID Type Subtype PubMed ID
nsv871249 CNV Gain 21882294
nsv822220 CNV Gain 20364138
nsv834546 CNV Loss 17160897

Variation tolerance for PTPRU Gene

Residual Variation Intolerance Score: 1.86% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.04; 87.52% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PTPRU Gene

Disorders for PTPRU Gene

MalaCards: The human disease database

(1) MalaCards diseases for PTPRU Gene - From: GeneCards

Disorder Aliases PubMed IDs
galloway-mowat syndrome
  • galloway syndrome
- elite association - COSMIC cancer census association via MalaCards
Search PTPRU in MalaCards View complete list of genes associated with diseases

Relevant External Links for PTPRU

Genetic Association Database (GAD)
PTPRU
Human Genome Epidemiology (HuGE) Navigator
PTPRU
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PTPRU
genes like me logo Genes that share disorders with PTPRU: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PTPRU Gene

Publications for PTPRU Gene

  1. Characterization of PCP-2, a novel receptor protein tyrosine phosphatase of the MAM domain family. (PMID: 8700514) Wang H.-Y. … Ullrich A. (Oncogene 1996) 2 3 4 23 67
  2. Transcriptional regulation of a receptor protein tyrosine phosphatase gene hPTP-J by PKC-mediated signaling pathways in Jurkat and Molt-4 T lymphoma cells. (PMID: 10395944) Wang B. … Nomoto K. (Biochim. Biophys. Acta 1999) 3 23
  3. The receptor protein tyrosine phosphatase, PTP-RO, is upregulated during megakaryocyte differentiation and is associated with the c-Kit receptor. (PMID: 10397721) Taniguchi Y. … Avraham H. (Blood 1999) 3 23
  4. Characterization and chromosomal localization of PTPRO, a novel receptor protein tyrosine phosphatase, expressed in hematopoietic stem cells. (PMID: 9434160) Avraham S. … Avraham H. (Gene 1997) 2 3
  5. Molecular cloning and characterization of a novel human receptor protein tyrosine phosphatase gene, hPTP-J: down-regulation of gene expression by PMA and calcium ionophore in Jurkat T lymphoma cells. (PMID: 9070223) Wang B. … Nomoto K. (Biochem. Biophys. Res. Commun. 1997) 3 23

Products for PTPRU Gene

Sources for PTPRU Gene

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