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Aliases for PTPRU Gene

Aliases for PTPRU Gene

  • Protein Tyrosine Phosphatase, Receptor Type, U 2 3
  • Receptor-Type Protein-Tyrosine Phosphatase Psi 3 4
  • Protein-Tyrosine Phosphatase Receptor Omicron 3 4
  • Pancreatic Carcinoma Phosphatase 2 3 4
  • Protein-Tyrosine Phosphatase Pi 3 4
  • Protein-Tyrosine Phosphatase J 3 4
  • Pi R-PTP-Psi 2 3
  • EC 3.1.3.48 4 63
  • R-PTP-PSI 3 4
  • R-PTP-U 3 4
  • PTP Pi 3 4
  • PTP-RO 3 4
  • HPTP-J 3 4
  • PTPU2 3 6
  • PCP-2 3 4
  • PTP-J 3 4
  • PTPRO 3 4
  • FMI 3 4
  • Receptor Protein Tyrosine Phosphatase HPTP-J 3
  • Receptor-Type Tyrosine-Protein Phosphatase U 3
  • PTP-PI 3
  • PTPPSI 3
  • GLEPP1 6
  • PCP2 4
  • PTP 3

External Ids for PTPRU Gene

Previous GeneCards Identifiers for PTPRU Gene

  • GC01P029569
  • GC01P028728
  • GC01P029068
  • GC01P029383
  • GC01P027814

Summaries for PTPRU Gene

Entrez Gene Summary for PTPRU Gene

  • The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracellular catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP (MAM) domain, Ig-like and fibronectin type III-like repeats. This PTP was thought to play roles in cell-cell recognition and adhesion. Studies of the similar gene in mice suggested the role of this PTP in early neural development. The expression of this gene was reported to be regulated by phorbol myristate acetate (PMA) or calcium ionophore in Jurkat T lymphoma cells. Alternatively spliced transcript variants have been reported. [provided by RefSeq, Aug 2010]

GeneCards Summary for PTPRU Gene

PTPRU (Protein Tyrosine Phosphatase, Receptor Type, U) is a Protein Coding gene. Diseases associated with PTPRU include galloway-mowat syndrome. Among its related pathways are PI-3K cascade and Signaling by GPCR. GO annotations related to this gene include protein tyrosine phosphatase activity and transmembrane receptor protein tyrosine phosphatase activity. An important paralog of this gene is PTPRT.

UniProtKB/Swiss-Prot for PTPRU Gene

  • Tyrosine-protein phosphatase which dephosphorylates CTNNB1. Regulates CTNNB1 function both in cell adhesion and signaling. May function in cell proliferation and migration and play a role in the maintenance of epithelial integrity. May play a role in megakaryocytopoiesis.

Gene Wiki entry for PTPRU Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTPRU Gene

Genomics for PTPRU Gene

Regulatory Elements for PTPRU Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PTPRU Gene

Start:
29,236,516 bp from pter
End:
29,326,813 bp from pter
Size:
90,298 bases
Orientation:
Plus strand

Genomic View for PTPRU Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PTPRU Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTPRU Gene

Proteins for PTPRU Gene

  • Protein details for PTPRU Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92729-PTPRU_HUMAN
    Recommended name:
    Receptor-type tyrosine-protein phosphatase U
    Protein Accession:
    Q92729
    Secondary Accessions:
    • A6H8L1
    • O00197
    • P78399
    • Q59HA4
    • Q5SYU4
    • Q5SYU5
    • Q92735
    • Q92850

    Protein attributes for PTPRU Gene

    Size:
    1446 amino acids
    Molecular mass:
    162423 Da
    Quaternary structure:
    • Forms homooligomeric complexes which mediate cell homotypic adhesion (Probable). Interacts (via the cytoplasmic juxtamembrane domain) with CTNNB1; may mediate interaction with the cadherin/catenin adhesion complex. Interacts with KIT. May interact with AP3B1.
    SequenceCaution:
    • Sequence=CAA65016.1; Type=Miscellaneous discrepancy; Note=Several sequencing problems.; Evidence={ECO:0000305}; Sequence=CAA65832.1; Type=Miscellaneous discrepancy; Note=Several sequencing problems.; Evidence={ECO:0000305};

    Alternative splice isoforms for PTPRU Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PTPRU Gene

Proteomics data for PTPRU Gene at MOPED

Post-translational modifications for PTPRU Gene

  • N-glycosylated.
  • Phosphorylated on tyrosine residues upon activation of KIT with stem cell factor (SCF). The 73 kDa proteolytic product is not phosphorylated.
  • The extracellular domain is proteolytically processed through cleavage within the fibronectin type-III 4 domain (By similarity). In addition to the 190 kDa full-length protein, proteolytic products of 100 kDa, 80 kDa and 73 kDa are observed.
  • Glycosylation at Asn75, Asn410, and Asn685
  • Modification sites at PhosphoSitePlus

Other Protein References for PTPRU Gene

Domains for PTPRU Gene

Gene Families for PTPRU Gene

HGNC:
  • FN3 :Fibronectin type III domain containing
  • PTPR :Protein tyrosine phosphatases / Class I Cys-based PTPs : Transmembrane receptor-like
IUPHAR :

Suggested Antigen Peptide Sequences for PTPRU Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q92729

UniProtKB/Swiss-Prot:

PTPRU_HUMAN :
  • Q92729
Domain:
  • Contains 4 fibronectin type-III domains.
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Contains 1 MAM domain.
  • Contains 2 tyrosine-protein phosphatase domains.
Family:
  • Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily.
genes like me logo Genes that share domains with PTPRU: view

Function for PTPRU Gene

Molecular function for PTPRU Gene

UniProtKB/Swiss-Prot CatalyticActivity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot Function: Tyrosine-protein phosphatase which dephosphorylates CTNNB1. Regulates CTNNB1 function both in cell adhesion and signaling. May function in cell proliferation and migration and play a role in the maintenance of epithelial integrity. May play a role in megakaryocytopoiesis.
UniProtKB/Swiss-Prot Induction: Up-regulated upon cell contact (at protein level). Down-regulated by phorbol ester (at protein level) and calcium ionophore but up-regulated by phorbol ester in megakaryocytic cells (PubMed:10397721).

Enzyme Numbers (IUBMB) for PTPRU Gene

Gene Ontology (GO) - Molecular Function for PTPRU Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004725 protein tyrosine phosphatase activity IMP 16574648
GO:0005001 transmembrane receptor protein tyrosine phosphatase activity NAS 8700514
GO:0005515 protein binding IPI 10397721
GO:0008013 beta-catenin binding IPI 16574648
GO:0016791 phosphatase activity --
genes like me logo Genes that share ontologies with PTPRU: view

Phenotypes for PTPRU Gene

GenomeRNAi human phenotypes for PTPRU:
genes like me logo Genes that share phenotypes with PTPRU: view

Animal Model Products

CRISPR Products

miRNA for PTPRU Gene

miRTarBase miRNAs that target PTPRU

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PTPRU

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for PTPRU Gene

Localization for PTPRU Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTPRU Gene

Cell junction. Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PTPRU Gene COMPARTMENTS Subcellular localization image for PTPRU gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytoskeleton 1
cytosol 1
endoplasmic reticulum 1
lysosome 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for PTPRU Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane NAS 8700514
GO:0005911 cell-cell junction IDA 12501215
GO:0016020 membrane --
genes like me logo Genes that share ontologies with PTPRU: view

Pathways for PTPRU Gene

genes like me logo Genes that share pathways with PTPRU: view

Pathways by source for PTPRU Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for PTPRU Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IDA 12501215
GO:0007155 cell adhesion NAS 8700514
GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway NAS 8700514
GO:0008285 negative regulation of cell proliferation IDA 16574648
GO:0016311 dephosphorylation --
genes like me logo Genes that share ontologies with PTPRU: view

Compounds for PTPRU Gene

(2) HMDB Compounds for PTPRU Gene

Compound Synonyms Cas Number PubMed IDs
Phosphate
  • NFB Orthophosphate
14265-44-2
Water
  • Dihydrogen oxide
7732-18-5

(21) Novoseek inferred chemical compound relationships for PTPRU Gene

Compound -log(P) Hits PubMed IDs
tyrosine 81.2 129
phosphotyrosine 76.9 12
vanadate 67.6 14
phenylarsine oxide 62.9 5
threonine 35.7 3
genes like me logo Genes that share compounds with PTPRU: view

Transcripts for PTPRU Gene

Unigene Clusters for PTPRU Gene

Protein tyrosine phosphatase, receptor type, U:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PTPRU

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for PTPRU

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PTPRU Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b · 20c ^
SP1: - - - -
SP2:
SP3: -
SP4:
SP5: -
SP6:
SP7:
SP8: -

ExUns: 21 ^ 22a · 22b ^ 23 ^ 24 ^ 25 ^ 26a · 26b ^ 27a · 27b ^ 28 ^ 29 ^ 30a · 30b · 30c
SP1: - -
SP2:
SP3:
SP4: -
SP5:
SP6:
SP7:
SP8:

Relevant External Links for PTPRU Gene

GeneLoc Exon Structure for
PTPRU
ECgene alternative splicing isoforms for
PTPRU

Expression for PTPRU Gene

mRNA expression in normal human tissues for PTPRU Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PTPRU Gene

SOURCE GeneReport for Unigene cluster for PTPRU Gene Hs.19718

mRNA Expression by UniProt/SwissProt for PTPRU Gene

Q92729-PTPRU_HUMAN
Tissue specificity: High levels in brain, pancreas, and skeletal muscle; less in colon, kidney, liver, stomach, and uterus; not expressed in placenta and spleen. Also detected in heart, prostate, lung, thymus, testis and ovary. Ubiquitously expressed in brain. Expressed by hematopoietic stem cells.
genes like me logo Genes that share expressions with PTPRU: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for PTPRU Gene

Orthologs for PTPRU Gene

This gene was present in the common ancestor of animals.

Orthologs for PTPRU Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PTPRU 35
  • 99.62 (n)
  • 99.86 (a)
PTPRU 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PTPRU 35
  • 92.1 (n)
  • 97.28 (a)
PTPRU 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PTPRU 35
  • 91.81 (n)
  • 97.01 (a)
PTPRU 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ptpru 35
  • 89.01 (n)
  • 95.33 (a)
Ptpru 16
Ptpru 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 89 (a)
OneToMany
-- 36
  • 92 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia PTPRU 36
  • 68 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ptpru 35
  • 88.61 (n)
  • 94.98 (a)
chicken
(Gallus gallus)
Aves PTPRU 35
  • 81.19 (n)
  • 85.68 (a)
PTPRU 36
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PTPRU 36
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ptpru 35
  • 66.05 (n)
  • 69.28 (a)
Str.9623 35
zebrafish
(Danio rerio)
Actinopterygii PTPRU (3 of 3) 36
  • 75 (a)
OneToMany
ptprua 36
  • 71 (a)
OneToMany
ptprub 35
  • 71.96 (n)
  • 75.56 (a)
ptprub 36
  • 76 (a)
OneToMany
wufj42a04 35
fruit fly
(Drosophila melanogaster)
Insecta CG7180 37
  • 32 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1390 36
  • 37 (a)
OneToMany
Species with no ortholog for PTPRU:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PTPRU Gene

ENSEMBL:
Gene Tree for PTPRU (if available)
TreeFam:
Gene Tree for PTPRU (if available)

Paralogs for PTPRU Gene

Paralogs for PTPRU Gene

Pseudogenes.org Pseudogenes for PTPRU Gene

genes like me logo Genes that share paralogs with PTPRU: view

Variants for PTPRU Gene

Sequence variations from dbSNP and Humsavar for PTPRU Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs764253 -- 29,300,664(+) ACCAG(A/T)AATCC intron-variant
rs997550 -- 29,253,836(+) GTACA(C/T)ATAAG intron-variant
rs1032424 -- 29,249,154(-) GCACA(C/T)GTGCA intron-variant
rs1032425 -- 29,249,093(-) AAATG(G/T)GAGGC intron-variant
rs1045451 -- 29,282,729(+) GGAGC(C/G)AGGTG reference, missense, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PTPRU Gene

Variant ID Type Subtype PubMed ID
nsv871249 CNV Gain 21882294
nsv822220 CNV Gain 20364138
nsv834546 CNV Loss 17160897

Relevant External Links for PTPRU Gene

HapMap Linkage Disequilibrium report
PTPRU

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTPRU Gene

Disorders for PTPRU Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for PTPRU Gene including...

Search for PTPRU Gene in MalaCards »

(11) Novoseek inferred disease relationships for PTPRU Gene

Disease -log(P) Hits PubMed IDs
lymphoma t-cell 19.7 5
diabetes mellitus insulin-dependent 5.91 1
metastasis 5.37 1
leukemia 3.6 1
ischemia 0 1

Relevant External Links for PTPRU

Genetic Association Database (GAD)
PTPRU
Human Genome Epidemiology (HuGE) Navigator
PTPRU
genes like me logo Genes that share disorders with PTPRU: view

No data available for UniProtKB/Swiss-Prot for PTPRU Gene

Publications for PTPRU Gene

  1. Characterization of PCP-2, a novel receptor protein tyrosine phosphatase of the MAM domain family. (PMID: 8700514) Wang H.-Y. … Ullrich A. (Oncogene 1996) 2 3 4 23
  2. Characterization and chromosomal localization of PTPRO, a novel receptor protein tyrosine phosphatase, expressed in hematopoietic stem cells. (PMID: 9434160) Avraham S. … Avraham H. (Gene 1997) 2 3 4
  3. Molecular cloning and characterization of PTP pi, a novel receptor- like protein-tyrosine phosphatase. (PMID: 8870675) Crossland S. … Crompton M.R. (Biochem. J. 1996) 3 4 23
  4. Molecular cloning and characterization of a novel human receptor protein tyrosine phosphatase gene, hPTP-J: down-regulation of gene expression by PMA and calcium ionophore in Jurkat T lymphoma cells. (PMID: 9070223) Wang B. … Nomoto K. (Biochem. Biophys. Res. Commun. 1997) 3 4 23
  5. Transcriptional regulation of a receptor protein tyrosine phosphatase gene hPTP-J by PKC-mediated signaling pathways in Jurkat and Molt-4 T lymphoma cells. (PMID: 10395944) Wang B. … Nomoto K. (Biochim. Biophys. Acta 1999) 3 4 23

Products for PTPRU Gene

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