Aliases for COX17 Gene
- COX17 Cytochrome C Oxidase Copper Chaperone 2 3
- COX17 Homolog, Cytochrome C Oxidase Assembly Protein (S. Cerevisiae) 2
- COX17 (Yeast) Homolog, Cytochrome C Oxidase Assembly Protein 2
- COX17 Homolog, Cytochrome C Oxidase Assembly Protein (Yeast) 2
- COX17 Cytochrome C Oxidase Assembly Homolog (S. Cerevisiae) 2
- Cytochrome C Oxidase Assembly Homolog 17 (Yeast) 2
External Ids for COX17 Gene
Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit, but may be involved in the recruitment of copper to mitochondria for incorporation into the COX apoenzyme. This protein shares 92% amino acid sequence identity with mouse and rat Cox17 proteins. This gene is no longer considered to be a candidate gene for COX deficiency. A pseudogene COX17P has been found on chromosome 13. [provided by RefSeq, Jul 2008]
GeneCards Summary for COX17 Gene
COX17 (COX17 Cytochrome C Oxidase Copper Chaperone) is a Protein Coding gene. Diseases associated with COX17 include isolated cytochrome c oxidase deficiency. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Metabolism. GO annotations related to this gene include copper ion binding and copper chaperone activity.
UniProtKB/Swiss-Prot for COX17 Gene
Copper chaperone for cytochrome c oxidase (COX). Binds two copper ions and deliver them to the Cu(A) site of COX (By similarity).