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Aliases for CDH8 Gene

Aliases for CDH8 Gene

  • Cadherin 8 2 3
  • Cadherin 8, Type 2 2 3 5
  • Nbla04261 3

External Ids for CDH8 Gene

Previous GeneCards Identifiers for CDH8 Gene

  • GC16M052117
  • GC16M061772
  • GC16M061421
  • GC16M061462
  • GC16M060244
  • GC16M047556

Summaries for CDH8 Gene

Entrez Gene Summary for CDH8 Gene

  • This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. The extracellular domain consists of 5 subdomains, each containing a cadherin motif, and appears to determine the specificity of the protein's homophilic cell adhesion activity. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin is expressed in brain and is putatively involved in synaptic adhesion, axon outgrowth and guidance. [provided by RefSeq, Jul 2008]

GeneCards Summary for CDH8 Gene

CDH8 (Cadherin 8) is a Protein Coding gene. Among its related pathways are ERK Signaling and Cell junction organization. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is CDH19.

UniProtKB/Swiss-Prot for CDH8 Gene

  • Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

Gene Wiki entry for CDH8 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDH8 Gene

Genomics for CDH8 Gene

Regulatory Elements for CDH8 Gene

Genomic Location for CDH8 Gene

Chromosome:
16
Start:
61,647,242 bp from pter
End:
62,037,035 bp from pter
Size:
389,794 bases
Orientation:
Minus strand

Genomic View for CDH8 Gene

Genes around CDH8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDH8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDH8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDH8 Gene

Proteins for CDH8 Gene

  • Protein details for CDH8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P55286-CADH8_HUMAN
    Recommended name:
    Cadherin-8
    Protein Accession:
    P55286
    Secondary Accessions:
    • B3KWC1
    • Q14DC6
    • Q9ULB2

    Protein attributes for CDH8 Gene

    Size:
    799 amino acids
    Molecular mass:
    88253 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAA35628.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for CDH8 Gene

Proteomics data for CDH8 Gene at MOPED

Post-translational modifications for CDH8 Gene

  • Glycosylation at Asn 33, Asn 57, Asn 188, Asn 463, Asn 473, and Asn 544
  • Modification sites at PhosphoSitePlus

Other Protein References for CDH8 Gene

No data available for DME Specific Peptides for CDH8 Gene

Domains & Families for CDH8 Gene

Gene Families for CDH8 Gene

Suggested Antigen Peptide Sequences for CDH8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P55286

UniProtKB/Swiss-Prot:

CADH8_HUMAN :
  • Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.
Domain:
  • Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.
  • Contains 5 cadherin domains.
genes like me logo Genes that share domains with CDH8: view

Function for CDH8 Gene

Molecular function for CDH8 Gene

GENATLAS Biochemistry:
cadherin chicken cadherin 8,transmembrane glycoprotein component of adherens junction,expressed in brain,putatively involved in synaptic adhesion,axon outgrowth and guidance
UniProtKB/Swiss-Prot Function:
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
genes like me logo Genes that share phenotypes with CDH8: view

Animal Models for CDH8 Gene

MGI Knock Outs for CDH8:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CDH8 Gene

Localization for CDH8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDH8 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDH8 Gene COMPARTMENTS Subcellular localization image for CDH8 gene
Compartment Confidence
plasma membrane 5
extracellular 3
endoplasmic reticulum 1
nucleus 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for CDH8 Gene

Pathways & Interactions for CDH8 Gene

genes like me logo Genes that share pathways with CDH8: view

Gene Ontology (GO) - Biological Process for CDH8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IEA --
GO:0034332 adherens junction organization TAS --
GO:0045216 cell-cell junction organization TAS --
genes like me logo Genes that share ontologies with CDH8: view

No data available for SIGNOR curated interactions for CDH8 Gene

Drugs & Compounds for CDH8 Gene

(1) Drugs for CDH8 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with CDH8: view

Transcripts for CDH8 Gene

Unigene Clusters for CDH8 Gene

Cadherin 8, type 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CDH8 Gene

No ASD Table

Relevant External Links for CDH8 Gene

GeneLoc Exon Structure for
CDH8
ECgene alternative splicing isoforms for
CDH8

Expression for CDH8 Gene

mRNA expression in normal human tissues for CDH8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CDH8 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x6.5), Brain - Cortex (x5.4), Brain - Putamen (basal ganglia) (x5.3), Brain - Nucleus accumbens (basal ganglia) (x5.3), Brain - Caudate (basal ganglia) (x5.2), Brain - Anterior cingulate cortex (BA24) (x5.0), and Brain - Hippocampus (x4.3).

Protein differential expression in normal tissues from HIPED for CDH8 Gene

This gene is overexpressed in Testis (49.6) and Placenta (13.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CDH8 Gene



SOURCE GeneReport for Unigene cluster for CDH8 Gene Hs.368322

mRNA Expression by UniProt/SwissProt for CDH8 Gene

P55286-CADH8_HUMAN
Tissue specificity: Mainly expressed in brain. Found in certain nerve cell lines, such as retinoblasts, glioma cells and neuroblasts.
genes like me logo Genes that share expression patterns with CDH8: view

Protein tissue co-expression partners for CDH8 Gene

Primer Products

In Situ Assay Products

Orthologs for CDH8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CDH8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDH8 35
  • 99.71 (n)
  • 100 (a)
CDH8 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 74 (a)
OneToMany
CDH8 36
  • 92 (a)
OneToMany
dog
(Canis familiaris)
Mammalia CDH8 36
  • 92 (a)
OneToOne
CDH8 35
  • 85.77 (n)
  • 92.49 (a)
mouse
(Mus musculus)
Mammalia Cdh8 16
Cdh8 35
  • 91.36 (n)
  • 97 (a)
Cdh8 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CDH8 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDH8 36
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdh8 35
  • 91.2 (n)
  • 97.5 (a)
chicken
(Gallus gallus)
Aves CDH8 35
  • 82.77 (n)
  • 90.74 (a)
CDH8 36
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDH8 36
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdh8 35
  • 77.81 (n)
  • 85.48 (a)
zebrafish
(Danio rerio)
Actinopterygii CDH8 36
  • 78 (a)
OneToOne
cdh8 35
  • 69.25 (n)
  • 77.78 (a)
Species with no ortholog for CDH8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CDH8 Gene

ENSEMBL:
Gene Tree for CDH8 (if available)
TreeFam:
Gene Tree for CDH8 (if available)

Paralogs for CDH8 Gene

Paralogs for CDH8 Gene

genes like me logo Genes that share paralogs with CDH8: view

Variants for CDH8 Gene

Sequence variations from dbSNP and Humsavar for CDH8 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1012010 -- 61,978,686(+) ACTTG(C/G)GCAAG intron-variant
rs747928 -- 61,697,907(-) CATGA(A/G)CCTGT intron-variant
rs747929 -- 61,697,579(-) GAGGT(A/G)GAGCT intron-variant
rs934640 -- 61,833,473(-) ATAGC(A/G)TAAGT intron-variant
rs1397133 -- 61,976,007(-) GCATT(C/T)GTTAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CDH8 Gene

Variant ID Type Subtype PubMed ID
nsv906756 CNV Loss 21882294
nsv833256 CNV Gain 17160897
esv2665598 CNV Deletion 23128226
nsv817733 CNV Gain 17921354
nsv507822 CNV Insertion 20534489
nsv906758 CNV Loss 21882294
esv2662954 CNV Deletion 23128226
esv2714611 CNV Deletion 23290073
esv2353108 CNV Deletion 18987734
esv2677187 CNV Deletion 23128226
esv2714612 CNV Deletion 23290073
esv2714613 CNV Deletion 23290073
nsv457500 CNV Loss 19166990
esv2593208 CNV Deletion 19546169
esv1995444 CNV Deletion 18987734
esv5221 CNV Deletion 18987735
esv2714614 CNV Deletion 23290073
esv2658938 CNV Deletion 23128226
nsv103700 CNV Loss 16902084
esv6216 CNV Loss 19470904
nsv827699 CNV Loss 20364138
nsv827700 CNV Loss 20364138

Variation tolerance for CDH8 Gene

Residual Variation Intolerance Score: 5.58% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.53; 29.74% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDH8 Gene

HapMap Linkage Disequilibrium report
CDH8
Human Gene Mutation Database (HGMD)
CDH8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDH8 Gene

Disorders for CDH8 Gene

Relevant External Links for CDH8

Genetic Association Database (GAD)
CDH8
Human Genome Epidemiology (HuGE) Navigator
CDH8
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CDH8

No disorders were found for CDH8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CDH8 Gene

Publications for CDH8 Gene

  1. Diversity of the cadherin family: evidence for eight new cadherins in nervous tissue. (PMID: 2059658) Suzuki S. … Tanihara H. (Cell Regul. 1991) 2 3 4 67
  2. Localization of human cadherin genes to chromosome regions exhibiting cancer-related loss of heterozygosity. (PMID: 9615235) Kremmidiotis G. … Callen D.F. (Genomics 1998) 2 3
  3. Identification of candidate intergenic risk loci in autism spectrum disorder. (PMID: 23879678) Walker S. … Scherer S.W. (BMC Genomics 2013) 3
  4. An eQTL mapping approach reveals that rare variants in the SEMA5A regulatory network impact autism risk. (PMID: 23575222) Cheng Y. … Weiss L.A. (Hum. Mol. Genet. 2013) 3
  5. Pemphigus vulgaris autoantibody profiling by proteomic technique. (PMID: 23505434) Kalantari-Dehaghi M. … Grando S.A. (PLoS ONE 2013) 3

Products for CDH8 Gene

Sources for CDH8 Gene

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