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Aliases for ABCC5 Gene

Aliases for ABCC5 Gene

  • ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 5 2 3
  • MRP5 3 4 6
  • Multi-Specific Organic Anion Transporter C 3 4
  • ATP-Binding Cassette Sub-Family C Member 5 3 4
  • MOAT-C 3 4
  • PABC11 3 4
  • MOATC 3 6
  • SMRP 3 4
  • Canalicular Multispecific Organic Anion Transporter C 3
  • Multidrug Resistance-Associated Protein 5 3
  • EST277145 3
  • ABC33 3

External Ids for ABCC5 Gene

Previous GeneCards Identifiers for ABCC5 Gene

  • GC03M180375
  • GC03M184632
  • GC03M185039
  • GC03M184958
  • GC03M185120
  • GC03M183637
  • GC03M181047

Summaries for ABCC5 Gene

Entrez Gene Summary for ABCC5 Gene

  • The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing of this gene has been detected; however, the complete sequence and translation initiation site is unclear. [provided by RefSeq, Jul 2008]

GeneCards Summary for ABCC5 Gene

ABCC5 (ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 5) is a Protein Coding gene. Diseases associated with ABCC5 include lymphoblastic leukemia and dysembryoplastic neuroepithelial tumor. Among its related pathways are Disease and Metabolism. GO annotations related to this gene include ATPase activity, coupled to transmembrane movement of substances and organic anion transmembrane transporter activity. An important paralog of this gene is ABCC9.

UniProtKB/Swiss-Prot for ABCC5 Gene

  • Acts as a multispecific organic anion pump which can transport nucleotide analogs.

Gene Wiki entry for ABCC5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ABCC5 Gene

Genomics for ABCC5 Gene

Regulatory Elements for ABCC5 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ABCC5 Gene

Start:
183,919,934 bp from pter
End:
184,018,015 bp from pter
Size:
98,082 bases
Orientation:
Minus strand

Genomic View for ABCC5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ABCC5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ABCC5 Gene

Proteins for ABCC5 Gene

  • Protein details for ABCC5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15440-MRP5_HUMAN
    Recommended name:
    Multidrug resistance-associated protein 5
    Protein Accession:
    O15440
    Secondary Accessions:
    • B9EIQ2
    • O14517
    • Q29ZA9
    • Q29ZB1
    • Q86UX3
    • Q86W30
    • Q9UN85
    • Q9UNP5
    • Q9UQC3

    Protein attributes for ABCC5 Gene

    Size:
    1437 amino acids
    Molecular mass:
    160660 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ABCC5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ABCC5 Gene

Proteomics data for ABCC5 Gene at MOPED

Post-translational modifications for ABCC5 Gene

  • Ubiquitination at Lys383
  • Glycosylation at Asn494, Asn636, Asn684, Asn890, Asn897, Asn1044, Asn1329, and Asn1417
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ABCC5 Gene

Domains for ABCC5 Gene

Gene Families for ABCC5 Gene

HGNC:
  • ABCC :ATP binding cassette transporters / subfamily C
IUPHAR :

Protein Domains for ABCC5 Gene

Suggested Antigen Peptide Sequences for ABCC5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O15440

UniProtKB/Swiss-Prot:

MRP5_HUMAN :
  • O15440
Domain:
  • Contains 2 ABC transmembrane type-1 domains.
  • Contains 2 ABC transporter domains.
Family:
  • Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
genes like me logo Genes that share domains with ABCC5: view

Function for ABCC5 Gene

Molecular function for ABCC5 Gene

GENATLAS Biochemistry: ATP binding cassettte superfamily,subfamily C (CFTR/MRP),member 5
UniProtKB/Swiss-Prot Function: Acts as a multispecific organic anion pump which can transport nucleotide analogs.

Gene Ontology (GO) - Molecular Function for ABCC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
GO:0008514 organic anion transmembrane transporter activity IEA --
GO:0016887 ATPase activity --
GO:0042626 ATPase activity, coupled to transmembrane movement of substances IEA --
genes like me logo Genes that share ontologies with ABCC5: view

Phenotypes for ABCC5 Gene

MGI mutant phenotypes for ABCC5:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with ABCC5: view

Animal Models for ABCC5 Gene

MGI Knock Outs for ABCC5:

Animal Model Products

CRISPR Products

miRNA for ABCC5 Gene

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for ABCC5 Gene

Localization for ABCC5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ABCC5 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ABCC5 Gene COMPARTMENTS Subcellular localization image for ABCC5 gene
Compartment Confidence
plasma membrane 4
extracellular 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ABCC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 9827529
GO:0016020 membrane IDA 15297306
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with ABCC5: view

Pathways for ABCC5 Gene

genes like me logo Genes that share pathways with ABCC5: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for ABCC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS --
GO:0006200 obsolete ATP catabolic process --
GO:0006810 transport TAS 9827529
GO:0015711 organic anion transport IEA --
GO:0030203 glycosaminoglycan metabolic process TAS --
genes like me logo Genes that share ontologies with ABCC5: view

Compounds for ABCC5 Gene

(15) Drugbank Compounds for ABCC5 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Adefovir Dipivoxil
  • Adefovir
142340-99-6 transporter substrate
Alprostadil
745-65-3 transporter inhibitor
Atorvastatin
134523-00-5 transporter substrate
Cisplatin
  • CDDP
15663-27-1 transporter inducer
Cyclic Adenosine Monophosphate
  • 3'-5'-cyclic adenosine monophosphate
60-92-4 transporter inhibitor

(21) Novoseek inferred chemical compound relationships for ABCC5 Gene

Compound -log(P) Hits PubMed IDs
mk 571 80.5 2
s-(2,4-dinitrophenyl)glutathione 80.4 1
probenecid 71.2 1
adefovir 64.7 5
thiopurine 60.9 2
genes like me logo Genes that share compounds with ABCC5: view

Transcripts for ABCC5 Gene

Unigene Clusters for ABCC5 Gene

ATP-binding cassette, sub-family C (CFTR/MRP), member 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ABCC5

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ABCC5

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ABCC5 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b · 15c ^ 16a · 16b ^ 17 ^ 18 ^
SP1: - - - - - -
SP2: - - - - - -
SP3: -
SP4: - -
SP5: -
SP6: -
SP7:

ExUns: 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34a · 34b
SP1:
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for ABCC5 Gene

GeneLoc Exon Structure for
ABCC5
ECgene alternative splicing isoforms for
ABCC5

Expression for ABCC5 Gene

mRNA expression in normal human tissues for ABCC5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ABCC5 Gene

This gene is overexpressed in Muscle - Skeletal (4.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ABCC5 Gene

SOURCE GeneReport for Unigene cluster for ABCC5 Gene Hs.743953

mRNA Expression by UniProt/SwissProt for ABCC5 Gene

O15440-MRP5_HUMAN
Tissue specificity: All isoforms are equally expressed in retina.
genes like me logo Genes that share expressions with ABCC5: view

In Situ Assay Products

Orthologs for ABCC5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ABCC5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ABCC5 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ABCC5 35
  • 92.6 (n)
  • 96.31 (a)
ABCC5 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Abcc5 35
  • 88.83 (n)
  • 95.06 (a)
Abcc5 16
Abcc5 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ABCC5 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ABCC5 36
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Abcc5 35
  • 88.23 (n)
  • 94.85 (a)
chicken
(Gallus gallus)
Aves ABCC5 35
  • 79.75 (n)
  • 89.12 (a)
lizard
(Anolis carolinensis)
Reptilia ABCC5 36
  • 85 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC68608 35
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101732220 35
  • 73.67 (n)
  • 84.25 (a)
zebrafish
(Danio rerio)
Actinopterygii abcc5 35
  • 68.8 (n)
  • 73.91 (a)
abcc5 36
  • 74 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Sur 36
  • 18 (a)
OneToMany
Sur 37
  • 42 (a)
CG7806 37
  • 29 (a)
worm
(Caenorhabditis elegans)
Secernentea mrp-5 35
  • 48.41 (n)
  • 39 (a)
rice
(Oryza sativa)
Liliopsida Os02g0288400 35
  • 45.77 (n)
  • 37.22 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 45 (a)
OneToMany
Species with no ortholog for ABCC5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ABCC5 Gene

ENSEMBL:
Gene Tree for ABCC5 (if available)
TreeFam:
Gene Tree for ABCC5 (if available)

Paralogs for ABCC5 Gene

Paralogs for ABCC5 Gene

genes like me logo Genes that share paralogs with ABCC5: view

Variants for ABCC5 Gene

Sequence variations from dbSNP and Humsavar for ABCC5 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs562 -- 183,920,057(+) TTCAA(C/T)TGATG utr-variant-3-prime
rs3779 -- 183,983,782(+) AAATG(A/G)AAAAT utr-variant-3-prime, intron-variant
rs869335 -- 183,972,455(-) CTCTG(C/T)GGTAG intron-variant
rs869417 -- 183,971,350(-) TGATC(A/G)TTTTA intron-variant
rs939336 -- 183,967,746(+) CTGCC(A/G)CAGAT synonymous-codon, reference

Structural Variations from Database of Genomic Variants (DGV) for ABCC5 Gene

Variant ID Type Subtype PubMed ID
nsv520094 CNV Loss 19592680
nsv878050 CNV Loss 21882294
esv25219 CNV Loss 19812545
esv1002813 CNV Loss 20482838
esv2726293 CNV Deletion 23290073
esv2678542 CNV Deletion 23128226
esv2726294 CNV Deletion 23290073
dgv5353n71 CNV Loss 21882294

Relevant External Links for ABCC5 Gene

HapMap Linkage Disequilibrium report
ABCC5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ABCC5 Gene

Disorders for ABCC5 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for ABCC5 Gene including...

Search for ABCC5 Gene in MalaCards »

(12) Novoseek inferred disease relationships for ABCC5 Gene

Disease -log(P) Hits PubMed IDs
breast cancer 40.9 9
cancer 26.6 2
lymphoblastic leukemia acute 26.2 2
glioma 24.1 4
arteriovenous malformations 15.9 1

Relevant External Links for ABCC5

Genetic Association Database (GAD)
ABCC5
Human Genome Epidemiology (HuGE) Navigator
ABCC5
genes like me logo Genes that share disorders with ABCC5: view

No data available for UniProtKB/Swiss-Prot for ABCC5 Gene

Publications for ABCC5 Gene

  1. Characterization of MOAT-C and MOAT-D, new members of the MRP/cMOAT subfamily of transporter proteins. (PMID: 9827529) Belinsky M.G. … Kruh G.D. (J. Natl. Cancer Inst. 1998) 2 3 4 23
  2. Multidrug-resistance protein 5 is a multispecific organic anion transporter able to transport nucleotide analogs. (PMID: 10840050) Wijnholds J. … Borst P. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3 4 23 25
  3. Detailed structural analysis on both human MRP5 and mouse mrp5 transcripts. (PMID: 10721709) Suzuki T. … Nishio K. (Gene 2000) 3 4 23
  4. Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines. (PMID: 9270026) Kool M. … Borst P. (Cancer Res. 1997) 3 4 23
  5. Characterization of the transport of nucleoside analog drugs by the human multidrug resistance proteins MRP4 and MRP5. (PMID: 12695538) Reid G. … Borst P. (Mol. Pharmacol. 2003) 3 23 25

Products for ABCC5 Gene

Sources for ABCC5 Gene

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