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AP1M2 Gene(Protein Coding)

Adaptor Related Protein Complex 1 Mu 2 Subunit

GCID:
GC19M010572
GIFtS:
60
Genes Participants
UDN Logo

Aliases for AP1M2 Gene

Aliases for AP1M2 Gene

  • Adaptor Related Protein Complex 1 Mu 2 Subunit 2 3 5
  • Clathrin Assembly Protein Complex 1 Mu-2 Medium Chain 2 3 4
  • Adaptor-Related Protein Complex 1, Mu 2 Subunit 2 3
  • Adaptor-Related Protein Complex 1 Mu 2 Subunit 2 3
  • Golgi Adaptor HA1/AP1 Adaptin Mu-2 Subunit 3 4
  • AP-Mu Chain Family Member Mu1B 3 4
  • Mu-Adaptin 2 3 4
  • Mu1B-Adaptin 3 4
  • Adaptor-Related Protein Complex 1 Subunit Mu-2 4
  • Clathrin-Associated Adaptor Medium Chain Mu2 3
  • Adaptor Protein Complex AP-1 Mu-2 Subunit 3
  • Adaptor Protein Complex AP-1 Subunit Mu-2 4
  • Clathrin Coat Associated Protein AP47 2 3
  • Clathrin Coat Assembly Protein AP47 2 3
  • Golgi Adaptor AP-1 47 KDa Protein 3
  • HA1 47 KDa Subunit 2 3
  • AP1-Mu2 3
  • HSMU1B 3
  • MU-1B 3
  • MU1B 3
  • Mu2 3

External Ids for AP1M2 Gene

Previous GeneCards Identifiers for AP1M2 Gene

  • GC19M010814
  • GC19M010906
  • GC19M010528
  • GC19M010544
  • GC19M010683
  • GC19M010261

Summaries for AP1M2 Gene

Entrez Gene Summary for AP1M2 Gene

  • This gene encodes a subunit of the heterotetrameric adaptor-related protein comlex 1 (AP-1), which belongs to the adaptor complexes medium subunits family. This protein is capable of interacting with tyrosine-based sorting signals. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

GeneCards Summary for AP1M2 Gene

AP1M2 (Adaptor Related Protein Complex 1 Mu 2 Subunit) is a Protein Coding gene. Diseases associated with AP1M2 include Pain Agnosia and Agnosia. Among its related pathways are CTLA4 Signaling and Clathrin derived vesicle budding. An important paralog of this gene is AP4M1.

UniProtKB/Swiss-Prot for AP1M2 Gene

  • Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.

Gene Wiki entry for AP1M2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AP1M2 Gene

Genomics for AP1M2 Gene

Products:

  1. Regulatory Element

Regulatory Elements for AP1M2 Gene

Enhancers for AP1M2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around AP1M2 on UCSC Golden Path with GeneCards custom track

Promoters for AP1M2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around AP1M2 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the AP1M2 gene promoter:

Genomic Location for AP1M2 Gene

Chromosome:
19
Start:
10,572,671 bp from pter
End:
10,587,315 bp from pter
Size:
14,645 bases
Orientation:
Minus strand

Genomic View for AP1M2 Gene

Genes around AP1M2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AP1M2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AP1M2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for AP1M2 Gene

Proteins for AP1M2 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for AP1M2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6Q5-AP1M2_HUMAN
    Recommended name:
    AP-1 complex subunit mu-2
    Protein Accession:
    Q9Y6Q5
    Secondary Accessions:
    • B2RDV5
    • Q9BSI8

    Protein attributes for AP1M2 Gene

    Size:
    423 amino acids
    Molecular mass:
    48108 Da
    Quaternary structure:
    • Adaptor protein complex 1 (AP-1) is a heterotetramer composed of two large adaptins (gamma-type subunit AP1G1 and beta-type subunit AP1B1), a medium adaptin (mu-type subunit AP1M1 or AP1M2) and a small adaptin (sigma-type subunit AP1S1 or AP1S2 or AP1S3).

    Alternative splice isoforms for AP1M2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AP1M2 Gene

Proteomics data for AP1M2 Gene at MOPED

Protein Expression for AP1M2 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for AP1M2 Gene

  • Phosphorylation of membrane-bound AP1M1/AP1M2 increases its affinity for sorting signals.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for AP1M2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for AP1M2 Gene

Domains & Families for AP1M2 Gene

Protein Domains for AP1M2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for AP1M2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y6Q5

UniProtKB/Swiss-Prot:

AP1M2_HUMAN :
  • Contains 1 MHD (mu homology) domain.
  • Belongs to the adaptor complexes medium subunit family.
Domain:
  • Contains 1 MHD (mu homology) domain.
Family:
  • Belongs to the adaptor complexes medium subunit family.
genes like me logo Genes that share domains with AP1M2: view

No data available for Gene Families for AP1M2 Gene

Function for AP1M2 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for AP1M2 Gene

UniProtKB/Swiss-Prot Function:
Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.

Phenotypes for AP1M2 Gene

GenomeRNAi human phenotypes for AP1M2:
genes like me logo Genes that share phenotypes with AP1M2: view

Animal Model Products

miRNA for AP1M2 Gene

miRTarBase miRNAs that target AP1M2

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for AP1M2 Gene

Localization for AP1M2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AP1M2 Gene

Golgi apparatus. Cytoplasmic vesicle, clathrin-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AP1M2 Gene COMPARTMENTS Subcellular localization image for AP1M2 gene
Compartment Confidence
cytosol 5
golgi apparatus 5
lysosome 5
vacuole 5
endosome 2
nucleus 2
plasma membrane 2
endoplasmic reticulum 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for AP1M2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0030131 clathrin adaptor complex IEA --
GO:0032588 trans-Golgi network membrane TAS --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with AP1M2: view

Pathways & Interactions for AP1M2 Gene

genes like me logo Genes that share pathways with AP1M2: view

Pathways by source for AP1M2 Gene

1 KEGG pathway for AP1M2 Gene
1 GeneGo (Thomson Reuters) pathway for AP1M2 Gene
1 Qiagen pathway for AP1M2 Gene

Gene Ontology (GO) - Biological Process for AP1M2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006892 post-Golgi vesicle-mediated transport TAS --
GO:0006903 vesicle targeting TAS 10338135
GO:0016032 viral process TAS --
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II TAS --
genes like me logo Genes that share ontologies with AP1M2: view

No data available for SIGNOR curated interactions for AP1M2 Gene

Drugs & Compounds for AP1M2 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for AP1M2 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for AP1M2 Gene

(3) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(220) Selected AceView cDNA sequences:
(10) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for AP1M2 Gene

Adaptor-related protein complex 1, mu 2 subunit:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AP1M2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b · 12c
SP1:
SP2:
SP3:
SP4: -

Relevant External Links for AP1M2 Gene

GeneLoc Exon Structure for
AP1M2
ECgene alternative splicing isoforms for
AP1M2

Expression for AP1M2 Gene

Products:

  1. Primer

mRNA expression in normal human tissues for AP1M2 Gene

mRNA expression in normal human tissues for AP1M2 Gene
mRNA expression by BioGPS for AP1M2 GenemRNA expression by GTEx for AP1M2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AP1M2 Gene

This gene is overexpressed in Colon - Transverse (x5.8), Esophagus - Mucosa (x4.5), Kidney - Cortex (x4.2), and Pancreas (x4.1).

Protein differential expression in normal tissues from HIPED for AP1M2 Gene

This gene is overexpressed in Salivary gland (12.8), Nasal epithelium (12.5), Skin (11.1), Stomach (7.6), and Cervix (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for AP1M2 Gene



SOURCE GeneReport for Unigene cluster for AP1M2 Gene Hs.18894

genes like me logo Genes that share expression patterns with AP1M2: view

Protein tissue co-expression partners for AP1M2 Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for AP1M2 Gene

Orthologs for AP1M2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for AP1M2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia AP1M2 35
  • 90.78 (n)
  • 96.69 (a)
AP1M2 36
  • 97 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia AP1M2 35
  • 90.61 (n)
  • 96.84 (a)
AP1M2 36
  • 95 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Ap1m2 35
  • 87 (n)
  • 96.93 (a)
Ap1m2 16
Ap1m2 36
  • 96 (a)
 OneToOne
chimpanzee
(Pan troglodytes)
 Mammalia AP1M2 35
  • 99.68 (n)
  • 99.53 (a)
AP1M2 36
  • 100 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Ap1m2 35
  • 87.94 (n)
  • 97.16 (a)
oppossum
(Monodelphis domestica)
 Mammalia AP1M2 36
  • 92 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia AP1M2 36
  • 95 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves AP1M2 36
  • 69 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia AP1M2 36
  • 78 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia ap1m2 35
  • 78.25 (n)
  • 89.83 (a)
zebrafish
(Danio rerio)
 Actinopterygii ap1m2 35
  • 77.3 (n)
  • 82.74 (a)
Dr.20705 35
ap1m2 36
  • 83 (a)
 OneToOne
rainbow trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.9527 35
fruit fly
(Drosophila melanogaster)
 Insecta AP-47 37
  • 75 (a)
AP-47 36
  • 75 (a)
 OneToMany
worm
(Caenorhabditis elegans)
 Secernentea apm-1 37
  • 69 (a)
unc-101 37
  • 70 (a)
apm-1 35
  • 60.25 (n)
  • 69.83 (a)
apm-1 36
  • 69 (a)
 ManyToMany
unc-101 36
  • 70 (a)
 ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes APM1 36
  • 49 (a)
 OneToMany
APM2 38
soybean
(Glycine max)
 eudicotyledons Gma.3839 35
Alicante grape
(Vitis vinifera)
 eudicotyledons Vvi.10081 35
barley
(Hordeum vulgare)
 Liliopsida Hv.6301 35
rice
(Oryza sativa)
 Liliopsida Os.38379 35
wheat
(Triticum aestivum)
 Liliopsida Ta.8549 35
corn
(Zea mays)
 Liliopsida Zm.14288 35
sea squirt
(Ciona savignyi)
 Ascidiacea CSA.2288 36
  • 72 (a)
 OneToMany
Species with no ortholog for AP1M2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for AP1M2 Gene

ENSEMBL:
Gene Tree for AP1M2 (if available)
TreeFam:
Gene Tree for AP1M2 (if available)

Paralogs for AP1M2 Gene

Paralogs for AP1M2 Gene

(6) SIMAP similar genes for AP1M2 Gene using alignment to 8 proteins:

Pseudogenes.org Pseudogenes for AP1M2 Gene

genes like me logo Genes that share paralogs with AP1M2: view

Variants for AP1M2 Gene

Sequence variations from dbSNP and Humsavar for AP1M2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs12978228 -- 10,580,647(+) acgga(G/T)cgaga intron-variant
rs12978787 -- 10,580,881(+) GCCTC(A/G)GAGGT intron-variant
rs7508328 -- 10,586,115(+) catct(C/G)tacta intron-variant
rs12979033 -- 10,580,942(+) AGAGC(A/G)AGACC intron-variant
rs7508603 -- 10,583,131(+) TTTTT(C/T)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AP1M2 Gene

Variant ID Type Subtype PubMed ID
nsv833744 CNV Loss 17160897
nsv911042 CNV Loss 21882294
dgv3727n71 CNV Loss 21882294
nsv833745 CNV Loss 17160897
nsv911045 CNV Loss 21882294
nsv911046 CNV Loss 21882294
nsv911047 CNV Loss 21882294

Variation tolerance for AP1M2 Gene

Residual Variation Intolerance Score: 48.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.44; 28.15% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for AP1M2 Gene

Disorders for AP1M2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for AP1M2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
pain agnosia
  • analgesia
agnosia
  • alexia
- elite association - COSMIC cancer census association via MalaCards
Search AP1M2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for AP1M2

Human Genome Epidemiology (HuGE) Navigator
AP1M2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AP1M2
genes like me logo Genes that share disorders with AP1M2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for AP1M2 Gene

Publications for AP1M2 Gene

  1. Mu1B, a novel adaptor medium chain expressed in polarized epithelial cells. (PMID: 10338135) Ohno H. … Bonifacino J.S. (FEBS Lett. 1999) 2 3 4 67
  2. Genomic structure and chromosome mapping of the genes encoding clathrin-associated adaptor medium chains mu1A (Ap1m1) and mu1B (Ap1m2). (PMID: 10640811) Nakatsu F. … Ohno H. (Cytogenet. Cell Genet. 1999) 3 23
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

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