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AP1M2 Gene(Protein Coding)

Adaptor Related Protein Complex 1 Mu 2 Subunit

GCID:
GC19M010572
GIFtS:
56
Genes Participants
UDN Logo

Aliases for AP1M2 Gene

Aliases for AP1M2 Gene

  • Adaptor Related Protein Complex 1 Mu 2 Subunit 2 3 5
  • Clathrin Assembly Protein Complex 1 Mu-2 Medium Chain 2 3 4
  • Golgi Adaptor HA1/AP1 Adaptin Mu-2 Subunit 3 4
  • AP-Mu Chain Family Member Mu1B 3 4
  • Mu-Adaptin 2 3 4
  • Mu1B-Adaptin 3 4
  • Adaptor-Related Protein Complex 1, Mu 2 Subunit 2
  • Adaptor-Related Protein Complex 1 Mu 2 Subunit 2
  • Adaptor-Related Protein Complex 1 Subunit Mu-2 4
  • Clathrin-Associated Adaptor Medium Chain Mu2 3
  • Adaptor Protein Complex AP-1 Mu-2 Subunit 3
  • Adaptor Protein Complex AP-1 Subunit Mu-2 4
  • Clathrin Coat Associated Protein AP47 2 3
  • Clathrin Coat Assembly Protein AP47 2 3
  • Golgi Adaptor AP-1 47 KDa Protein 3
  • AP-1 Complex Subunit Mu-2 3
  • HA1 47 KDa Subunit 2 3
  • AP1-Mu2 3
  • HSMU1B 3
  • MU-1B 3
  • MU1B 3
  • Mu2 3

External Ids for AP1M2 Gene

Previous GeneCards Identifiers for AP1M2 Gene

  • GC19M010814
  • GC19M010906
  • GC19M010528
  • GC19M010544
  • GC19M010683
  • GC19M010261

Summaries for AP1M2 Gene

Entrez Gene Summary for AP1M2 Gene

  • This gene encodes a subunit of the heterotetrameric adaptor-related protein comlex 1 (AP-1), which belongs to the adaptor complexes medium subunits family. This protein is capable of interacting with tyrosine-based sorting signals. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

GeneCards Summary for AP1M2 Gene

AP1M2 (Adaptor Related Protein Complex 1 Mu 2 Subunit) is a Protein Coding gene. Diseases associated with AP1M2 include Pain Agnosia and Agnosia. Among its related pathways are CTLA4 Signaling and Clathrin derived vesicle budding. An important paralog of this gene is AP1M1.

UniProtKB/Swiss-Prot for AP1M2 Gene

  • Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.

Gene Wiki entry for AP1M2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AP1M2 Gene

Genomics for AP1M2 Gene

Products:

  1. Regulatory Element

Regulatory Elements for AP1M2 Gene

Enhancers for AP1M2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G010615 1.8 FANTOM5 Ensembl ENCODE dbSUPER 12.4 -30.0 -29972 4.1 HDGF PKNOX1 ATF1 CREB3L1 ARNT ZBTB7B TCF12 ZNF766 ELK1 GATA2 SLC44A2 AP1M2 ILF3-AS1 KRI1 PIR56383
GH19G010543 1.2 ENCODE 10 +42.9 42864 2.6 CREB3L1 MLX AGO1 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 ZNF263 SP3 KRI1 ZNF561 FBXL12 TIMM29 RAVER1 LOC100419831 CDC37 ZNF846 YIPF2 LOC100996288
GH19G010576 0.8 ENCODE 14 +10.0 9968 1.3 TBP FOXA2 SAP130 TAF1 JUN ARID4B MAX ZMYM3 SIN3A ZNF384 CDKN2D AP1M2 KRI1
GH19G010601 1.7 FANTOM5 ENCODE dbSUPER 5.1 -16.8 -16809 4.4 ARID4B DMAP1 ZNF2 ZNF766 ZNF143 SP3 SP5 REST TBX21 ZNF610 SLC44A2 CDKN2D KRI1 ICAM3 ILF3 QTRT1 ZNF627 PRKCSH RPL10P15 ILF3-AS1
GH19G010959 1.1 ENCODE 5.5 -374.7 -374742 4.9 PKNOX1 MLX ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 SMARCA4 ILF3-AS1 AP1M2 GC19P011005
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around AP1M2 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the AP1M2 gene promoter:

Genomic Location for AP1M2 Gene

Chromosome:
19
Start:
10,572,671 bp from pter
End:
10,587,315 bp from pter
Size:
14,645 bases
Orientation:
Minus strand

Genomic View for AP1M2 Gene

Genes around AP1M2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AP1M2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AP1M2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for AP1M2 Gene

Proteins for AP1M2 Gene

Products:

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  • Protein details for AP1M2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6Q5-AP1M2_HUMAN
    Recommended name:
    AP-1 complex subunit mu-2
    Protein Accession:
    Q9Y6Q5
    Secondary Accessions:
    • B2RDV5
    • Q9BSI8

    Protein attributes for AP1M2 Gene

    Size:
    423 amino acids
    Molecular mass:
    48108 Da
    Quaternary structure:
    • Adaptor protein complex 1 (AP-1) is a heterotetramer composed of two large adaptins (gamma-type subunit AP1G1 and beta-type subunit AP1B1), a medium adaptin (mu-type subunit AP1M1 or AP1M2) and a small adaptin (sigma-type subunit AP1S1 or AP1S2 or AP1S3).

    Alternative splice isoforms for AP1M2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AP1M2 Gene

Protein Expression for AP1M2 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for AP1M2 Gene

  • Phosphorylation of membrane-bound AP1M1/AP1M2 increases its affinity for sorting signals.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for AP1M2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for AP1M2 Gene

Domains & Families for AP1M2 Gene

Protein Domains for AP1M2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for AP1M2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y6Q5

UniProtKB/Swiss-Prot:

AP1M2_HUMAN :
  • Belongs to the adaptor complexes medium subunit family.
Family:
  • Belongs to the adaptor complexes medium subunit family.
genes like me logo Genes that share domains with AP1M2: view

No data available for Gene Families for AP1M2 Gene

Function for AP1M2 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for AP1M2 Gene

UniProtKB/Swiss-Prot Function:
Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.

Gene Ontology (GO) - Molecular Function for AP1M2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with AP1M2: view
genes like me logo Genes that share phenotypes with AP1M2: view

Animal Models for AP1M2 Gene

MGI Knock Outs for AP1M2:

Animal Model Products

CRISPR Products

miRNA for AP1M2 Gene

miRTarBase miRNAs that target AP1M2

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for AP1M2 Gene

Localization for AP1M2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AP1M2 Gene

Golgi apparatus. Cytoplasmic vesicle, clathrin-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AP1M2 gene
Compartment Confidence
cytosol 5
lysosome 5
golgi apparatus 5
plasma membrane 2
nucleus 2
endosome 2
mitochondrion 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for AP1M2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005765 lysosomal membrane TAS --
GO:0005794 Golgi apparatus IEA --
GO:0005829 cytosol TAS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with AP1M2: view

Pathways & Interactions for AP1M2 Gene

genes like me logo Genes that share pathways with AP1M2: view

Pathways by source for AP1M2 Gene

1 KEGG pathway for AP1M2 Gene
1 GeneGo (Thomson Reuters) pathway for AP1M2 Gene
1 Qiagen pathway for AP1M2 Gene

Gene Ontology (GO) - Biological Process for AP1M2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006605 protein targeting TAS 10338135
GO:0006810 transport IEA --
GO:0006886 intracellular protein transport IEA --
GO:0006903 vesicle targeting TAS 10338135
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with AP1M2: view

No data available for SIGNOR curated interactions for AP1M2 Gene

Drugs & Compounds for AP1M2 Gene

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  1. Drug
No Compound Related Data Available

Transcripts for AP1M2 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for AP1M2 Gene

(2) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(220) Selected AceView cDNA sequences:
(10) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for AP1M2 Gene

Adaptor-related protein complex 1, mu 2 subunit:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for AP1M2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b · 12c
SP1:
SP2:
SP3:
SP4: -

Relevant External Links for AP1M2 Gene

GeneLoc Exon Structure for
AP1M2
ECgene alternative splicing isoforms for
AP1M2

Expression for AP1M2 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for AP1M2 Gene

mRNA expression in normal human tissues for AP1M2 Gene
mRNA expression by BioGPS for AP1M2 GenemRNA expression by GTEx for AP1M2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AP1M2 Gene

This gene is overexpressed in Colon - Transverse (x5.8), Esophagus - Mucosa (x4.5), Kidney - Cortex (x4.2), and Pancreas (x4.1).

Protein differential expression in normal tissues from HIPED for AP1M2 Gene

This gene is overexpressed in Salivary gland (12.8), Nasal epithelium (12.5), Skin (11.1), Stomach (7.6), and Cervix (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for AP1M2 Gene



Protein tissue co-expression partners for AP1M2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of AP1M2 Gene:

AP1M2

SOURCE GeneReport for Unigene cluster for AP1M2 Gene:

Hs.18894

Evidence on tissue expression from TISSUES for AP1M2 Gene

  • Intestine(4.7)
  • Kidney(2.5)
  • Nervous system(2.4)
  • Blood(2.2)
genes like me logo Genes that share expression patterns with AP1M2: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for AP1M2 Gene

Orthologs for AP1M2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for AP1M2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia AP1M2 34 35
  • 99.68 (n)
platypus
(Ornithorhynchus anatinus)
 Mammalia AP1M2 35
  • 95 (a)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia AP1M2 35
  • 92 (a)
 OneToOne
cow
(Bos Taurus)
 Mammalia AP1M2 34 35
  • 90.78 (n)
dog
(Canis familiaris)
 Mammalia AP1M2 34 35
  • 90.61 (n)
rat
(Rattus norvegicus)
 Mammalia Ap1m2 34
  • 87.94 (n)
mouse
(Mus musculus)
 Mammalia Ap1m2 34 16 35
  • 87 (n)
chicken
(Gallus gallus)
 Aves AP1M2 35
  • 69 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia AP1M2 35
  • 78 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia ap1m2 34
  • 78.25 (n)
zebrafish
(Danio rerio)
 Actinopterygii ap1m2 34 35
  • 77.3 (n)
Dr.20705 34
rainbow trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.9527 34
fruit fly
(Drosophila melanogaster)
 Insecta AP-47 36 35
  • 75 (a)
worm
(Caenorhabditis elegans)
 Secernentea unc-101 36 35
  • 70 (a)
apm-1 36 34 35
  • 60.25 (n)
baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes APM1 35
  • 49 (a)
 OneToMany
APM2 37
soybean
(Glycine max)
 eudicotyledons Gma.3839 34
Alicante grape
(Vitis vinifera)
 eudicotyledons Vvi.10081 34
barley
(Hordeum vulgare)
 Liliopsida Hv.6301 34
rice
(Oryza sativa)
 Liliopsida Os.38379 34
wheat
(Triticum aestivum)
 Liliopsida Ta.8549 34
corn
(Zea mays)
 Liliopsida Zm.14288 34
sea squirt
(Ciona savignyi)
 Ascidiacea CSA.2288 35
  • 72 (a)
 OneToMany
Species where no ortholog for AP1M2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for AP1M2 Gene

ENSEMBL:
Gene Tree for AP1M2 (if available)
TreeFam:
Gene Tree for AP1M2 (if available)

Paralogs for AP1M2 Gene

Paralogs for AP1M2 Gene

(6) SIMAP similar genes for AP1M2 Gene using alignment to 8 proteins:

Pseudogenes.org Pseudogenes for AP1M2 Gene

genes like me logo Genes that share paralogs with AP1M2: view

Variants for AP1M2 Gene

Sequence variations from dbSNP and Humsavar for AP1M2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000058904 -- 10,588,020(+) TCTTT(A/C)TCCTC upstream-variant-2KB
rs1000243575 -- 10,580,925(+) ACTCC(A/G)GCCTG intron-variant
rs1000399459 -- 10,582,844(+) TTTTT(G/T)AGACT intron-variant
rs1000494719 -- 10,583,373(+) GTGAG(C/T)GTGGT intron-variant
rs1000515106 -- 10,588,421(+) CACCC(C/G)TAGTA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for AP1M2 Gene

Variant ID Type Subtype PubMed ID
nsv833744 CNV loss 17160897
nsv833745 CNV loss 17160897

Variation tolerance for AP1M2 Gene

Residual Variation Intolerance Score: 48.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.44; 28.15% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for AP1M2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
AP1M2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AP1M2 Gene

Disorders for AP1M2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for AP1M2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
pain agnosia
  • analgesia
agnosia
  • dyspraxia
- elite association - COSMIC cancer census association via MalaCards
Search AP1M2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for AP1M2

Human Genome Epidemiology (HuGE) Navigator
AP1M2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AP1M2
genes like me logo Genes that share disorders with AP1M2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for AP1M2 Gene

Publications for AP1M2 Gene

  1. Mu1B, a novel adaptor medium chain expressed in polarized epithelial cells. (PMID: 10338135) Ohno H. … Bonifacino J.S. (FEBS Lett. 1999) 2 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Genomic structure and chromosome mapping of the genes encoding clathrin-associated adaptor medium chains mu1A (Ap1m1) and mu1B (Ap1m2). (PMID: 10640811) Nakatsu F. … Ohno H. (Cytogenet. Cell Genet. 1999) 3 22 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for AP1M2 Gene

Sources for AP1M2 Gene

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