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Aliases for SMC4 Gene

Aliases for SMC4 Gene

  • Structural Maintenance Of Chromosomes 4 2 3 5
  • Chromosome-Associated Polypeptide C 3 4
  • XCAP-C Homolog 3 4
  • SMC Protein 4 3 4
  • SMC4L1 3 4
  • HCAP-C 3 4
  • SMC-4 3 4
  • CAPC 3 4
  • SMC4 (Structural Maintenance Of Chromosomes 4, Yeast)-Like 1 2
  • SMC4 Structural Maintenance Of Chromosomes 4-Like 1 (Yeast) 2
  • SMC4 Structural Maintenance Of Chromosomes 4-Like 1 3
  • CAP-C 3

External Ids for SMC4 Gene

Previous HGNC Symbols for SMC4 Gene

  • SMC4L1

Previous GeneCards Identifiers for SMC4 Gene

  • GC03P161601
  • GC03P160117
  • GC03P157516

Summaries for SMC4 Gene

Entrez Gene Summary for SMC4 Gene

  • Members of the structural maintenance of chromosomes, or SMC, family (e.g., SMC1A; MIM 300040) are critical for mitotic chromosome condensation in frogs and for DNA repair in mammals.[supplied by OMIM, Nov 2010]

GeneCards Summary for SMC4 Gene

SMC4 (Structural Maintenance Of Chromosomes 4) is a Protein Coding gene. Diseases associated with SMC4 include pleural empyema. Among its related pathways are Mitotic Prophase and Cell Cycle, Mitotic. GO annotations related to this gene include protein heterodimerization activity and transmembrane signaling receptor activity.

UniProtKB/Swiss-Prot for SMC4 Gene

  • Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.

Gene Wiki entry for SMC4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SMC4 Gene

Genomics for SMC4 Gene

Regulatory Elements for SMC4 Gene

Genomic Location for SMC4 Gene

Chromosome:
3
Start:
160,399,274 bp from pter
End:
160,434,962 bp from pter
Size:
35,689 bases
Orientation:
Plus strand

Genomic View for SMC4 Gene

Genes around SMC4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SMC4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SMC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SMC4 Gene

Proteins for SMC4 Gene

  • Protein details for SMC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NTJ3-SMC4_HUMAN
    Recommended name:
    Structural maintenance of chromosomes protein 4
    Protein Accession:
    Q9NTJ3
    Secondary Accessions:
    • A6NLT9
    • D3DNL8
    • O95752
    • Q8NDL4
    • Q9UNT9

    Protein attributes for SMC4 Gene

    Size:
    1288 amino acids
    Molecular mass:
    147182 Da
    Quaternary structure:
    • Forms a heterodimer with SMC2. Component of the condensin complex, which contains the SMC2 and SMC4 heterodimer, and three non SMC subunits that probably regulate the complex: BRRN1/CAPH, CNAP1/CAPD2 and CAPG.

    Three dimensional structures from OCA and Proteopedia for SMC4 Gene

    Alternative splice isoforms for SMC4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SMC4 Gene

Proteomics data for SMC4 Gene at MOPED

Post-translational modifications for SMC4 Gene

  • Ubiquitination at Lys 93, Lys 207, Lys 239, Lys 268, Lys 332, Lys 389, Lys 680, Lys 1112, Lys 1187, and Lys 1267
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for SMC4 (SMC4)

No data available for DME Specific Peptides for SMC4 Gene

Domains & Families for SMC4 Gene

Gene Families for SMC4 Gene

Protein Domains for SMC4 Gene

Suggested Antigen Peptide Sequences for SMC4 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NTJ3

UniProtKB/Swiss-Prot:

SMC4_HUMAN :
  • The hinge domain, which separates the large intramolecular coiled coil regions, allows the heterodimerization with SMC2, forming a V-shaped heterodimer.
  • Belongs to the SMC family. SMC4 subfamily.
Domain:
  • The hinge domain, which separates the large intramolecular coiled coil regions, allows the heterodimerization with SMC2, forming a V-shaped heterodimer.
Family:
  • Belongs to the SMC family. SMC4 subfamily.
genes like me logo Genes that share domains with SMC4: view

Function for SMC4 Gene

Molecular function for SMC4 Gene

UniProtKB/Swiss-Prot Function:
Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.
genes like me logo Genes that share phenotypes with SMC4: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SMC4 Gene

Localization for SMC4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SMC4 Gene

Nucleus. Cytoplasm. Chromosome. Note=In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDC2, leading to condensins association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SMC4 Gene COMPARTMENTS Subcellular localization image for SMC4 gene
Compartment Confidence
cytosol 5
nucleus 5
cytoskeleton 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SMC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000796 condensin complex TAS 11850403
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with SMC4: view

Pathways & Interactions for SMC4 Gene

genes like me logo Genes that share pathways with SMC4: view

Pathways by source for SMC4 Gene

1 BioSystems pathway for SMC4 Gene
1 GeneGo (Thomson Reuters) pathway for SMC4 Gene

Gene Ontology (GO) - Biological Process for SMC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010032 meiotic chromosome condensation IEA --
GO:0051276 chromosome organization IEA --
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with SMC4: view

No data available for SIGNOR curated interactions for SMC4 Gene

Drugs & Compounds for SMC4 Gene

(4) Drugs for SMC4 Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
KPT-185 Pharma CRM1 inhibitor,selective and irrversible 0
KPT-276 Pharma 0
KPT-330 Pharma 0
Verdinexor (KPT-335) Pharma 0

(4) ApexBio Compounds for SMC4 Gene

Compound Action Cas Number
KPT-185 CRM1 inhibitor,selective and irrversible 1333151-73-7
KPT-276 1421919-75-6
KPT-330 1393477-72-9
Verdinexor (KPT-335) 1392136-43-4
genes like me logo Genes that share compounds with SMC4: view

Transcripts for SMC4 Gene

Unigene Clusters for SMC4 Gene

Structural maintenance of chromosomes 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SMC4 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^
SP1:
SP2: - - - - -
SP3: - - - -
SP4: - - - -
SP5:
SP6: - - - - - - - - -
SP7: - - - - - - - - - - - - - - - -
SP8: - - - - - - -
SP9: - - - - - - - - - - - - -
SP10: - - - -
SP11: - - - - -
SP12: - - - -
SP13: -
SP14:
SP15:
SP16: - - - - - - -
SP17:
SP18:
SP19:
SP20:
SP21:

ExUns: 12a · 12b · 12c ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18a · 18b ^ 19a · 19b ^ 20 ^ 21 ^ 22a · 22b ^ 23 ^ 24 ^ 25 ^ 26 ^ 27a · 27b ^ 28 ^ 29
SP1: - -
SP2: -
SP3: -
SP4: -
SP5: -
SP6:
SP7: -
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:

Relevant External Links for SMC4 Gene

GeneLoc Exon Structure for
SMC4
ECgene alternative splicing isoforms for
SMC4

Expression for SMC4 Gene

mRNA expression in normal human tissues for SMC4 Gene

Protein differential expression in normal tissues from HIPED for SMC4 Gene

This gene is overexpressed in Lymph node (17.6), Bone (16.4), and Peripheral blood mononuclear cells (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SMC4 Gene



SOURCE GeneReport for Unigene cluster for SMC4 Gene Hs.58992

mRNA Expression by UniProt/SwissProt for SMC4 Gene

Q9NTJ3-SMC4_HUMAN
Tissue specificity: Widely expressed. Higher expression in testis, colon, thymus.
genes like me logo Genes that share expression patterns with SMC4: view

Protein tissue co-expression partners for SMC4 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for SMC4 Gene

Orthologs for SMC4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SMC4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SMC4 35
  • 92.31 (n)
  • 93.24 (a)
SMC4 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SMC4 35
  • 92.74 (n)
  • 94.4 (a)
SMC4 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Smc4 35
  • 87.64 (n)
  • 89.66 (a)
Smc4 16
Smc4 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SMC4 35
  • 99.59 (n)
  • 99.53 (a)
SMC4 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Smc4 35
  • 87.66 (n)
  • 89.66 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 75 (a)
OneToMany
-- 36
  • 81 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 81 (a)
OneToMany
-- 36
  • 81 (a)
OneToMany
chicken
(Gallus gallus)
Aves SMC4 35
  • 75.62 (n)
  • 76.97 (a)
SMC4 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SMC4 36
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia smc4 35
  • 73.5 (n)
  • 78.09 (a)
Str.8927 35
African clawed frog
(Xenopus laevis)
Amphibia XCAP-C 35
zebrafish
(Danio rerio)
Actinopterygii smc4 35
  • 63.88 (n)
  • 70.19 (a)
smc4l1 35
smc4 36
  • 68 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9052 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007826 35
  • 49.13 (n)
  • 46.05 (a)
fruit fly
(Drosophila melanogaster)
Insecta glu 35
  • 47.17 (n)
  • 40.77 (a)
glu 36
  • 32 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea dpy-27 36
  • 24 (a)
OneToMany
smc-4 36
  • 24 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR089C 35
  • 49.45 (n)
  • 40.98 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F19085g 35
  • 49.27 (n)
  • 38.75 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SMC4 35
  • 49.61 (n)
  • 39.14 (a)
SMC4 36
  • 31 (a)
OneToOne
SMC4 38
thale cress
(Arabidopsis thaliana)
eudicotyledons SMC3 35
  • 51.83 (n)
  • 44.26 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.9522 35
barley
(Hordeum vulgare)
Liliopsida Hv.10104 35
rice
(Oryza sativa)
Liliopsida Os.19862 35
Os05g0497100 35
  • 53.63 (n)
  • 48.12 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.7603 35
corn
(Zea mays)
Liliopsida Zm.16936 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4807 35
bread mold
(Neurospora crassa)
Ascomycetes NCU09063 35
  • 47.89 (n)
  • 42.11 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cut3 35
  • 48.73 (n)
  • 39.34 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2292 36
  • 38 (a)
OneToOne
Species with no ortholog for SMC4:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for SMC4 Gene

ENSEMBL:
Gene Tree for SMC4 (if available)
TreeFam:
Gene Tree for SMC4 (if available)

Paralogs for SMC4 Gene

Pseudogenes.org Pseudogenes for SMC4 Gene

genes like me logo Genes that share paralogs with SMC4: view

No data available for Paralogs for SMC4 Gene

Variants for SMC4 Gene

Sequence variations from dbSNP and Humsavar for SMC4 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
VAR_052439 -
rs33999879 - 160,413,559(-) GTATA(C/T)TGCTC reference, missense
rs2164675 - 160,414,490(-) TGTTT(C/G)TCCAG reference, missense
rs10923 -- 160,434,908(+) TGTAA(A/G)CACAT utr-variant-3-prime
rs13403 -- 160,434,511(+) TTATC(A/C)GGGTA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SMC4 Gene

Variant ID Type Subtype PubMed ID
nsv822305 CNV Gain 20364138

Variation tolerance for SMC4 Gene

Residual Variation Intolerance Score: 3.56% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.35; 63.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SMC4 Gene

HapMap Linkage Disequilibrium report
SMC4
Human Gene Mutation Database (HGMD)
SMC4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SMC4 Gene

Disorders for SMC4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SMC4 Gene - From: DISEASES

Disorder Aliases PubMed IDs
pleural empyema
  • abscess of pleural cavity
- elite association - COSMIC cancer census association via MalaCards
Search SMC4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SMC4

Genetic Association Database (GAD)
SMC4
Human Genome Epidemiology (HuGE) Navigator
SMC4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SMC4
genes like me logo Genes that share disorders with SMC4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SMC4 Gene

Publications for SMC4 Gene

  1. Identification of two distinct human SMC protein complexes involved in mitotic chromosome dynamics. (PMID: 9789013) Schmiesing J.A. … Yokomori K. (Proc. Natl. Acad. Sci. U.S.A. 1998) 2 3 4 23 67
  2. Condensin mutations and abnormal chromosomal structures in pyothorax-associated lymphoma. (PMID: 17488335) Ham M.F. … Aozasa K. (Cancer Sci. 2007) 3 23
  3. A human condensin complex containing hCAP-C-hCAP-E and CNAP1, a homolog of Xenopus XCAP-D2, colocalizes with phosphorylated histone H3 during the early stage of mitotic chromosome condensation. (PMID: 10958694) Schmiesing J.A. … Yokomori K. (Mol. Cell. Biol. 2000) 3 23
  4. Isolation and characterization of a human cDNA homologous to the Xenopus laevis XCAP-C gene belonging to the structural maintenance of chromosomes (SMC) family. (PMID: 10319587) Nishiwaki T. … Nakamura Y. (J. Hum. Genet. 1999) 2 3
  5. ABCE1 is a highly conserved RNA silencing suppressor. (PMID: 25659154) KAorblane K. … Sarmiento C. (PLoS ONE 2015) 3

Products for SMC4 Gene

Sources for SMC4 Gene

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