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Aliases for RANBP9 Gene

Aliases for RANBP9 Gene

  • RAN Binding Protein 9 2 3 5
  • Ran Binding Protein In The Microtubule Organizing Center 2 3
  • Ran-Binding Protein M 3 4
  • RANBP7 3 4
  • RANBPM 3 4
  • BPM-L 3 4
  • BPM90 3 4
  • Novel Centrosomal Protein RanBPM 3
  • Ran Binding Protein, Centrosomal 3
  • Ran-Binding Protein 9 3
  • RanBP9 4

External Ids for RANBP9 Gene

Previous GeneCards Identifiers for RANBP9 Gene

  • GC06M013679
  • GC06M013730
  • GC06M013729
  • GC06M013566

Summaries for RANBP9 Gene

Entrez Gene Summary for RANBP9 Gene

  • This gene encodes a protein that binds RAN, a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The protein encoded by this gene has also been shown to interact with several other proteins, including met proto-oncogene, homeodomain interacting protein kinase 2, androgen receptor, and cyclin-dependent kinase 11. [provided by RefSeq, Jul 2008]

GeneCards Summary for RANBP9 Gene

RANBP9 (RAN Binding Protein 9) is a Protein Coding gene. Among its related pathways are RET signaling and Cytokine Signaling in Immune system. Gene Ontology (GO) annotations related to this gene include enzyme binding and Ran GTPase binding. An important paralog of this gene is RANBP10.

UniProtKB/Swiss-Prot for RANBP9 Gene

  • May act as an adapter protein to couple membrane receptors to intracellular signaling pathways. May be involved in signaling of ITGB2/LFA-1 and other integrins. Enhances HGF-MET signaling by recruiting Sos and activating the Ras pathway. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but not affect estrogen-induced transactivation. Stabilizes TP73 isoform Alpha, probably by inhibiting its ubiquitination, and increases its proapoptotic activity. Inhibits the kinase activity of DYRK1A and DYRK1B. Inhibits FMR1 binding to RNA.

Gene Wiki entry for RANBP9 Gene

Additional gene information for RANBP9 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RANBP9 Gene

Genomics for RANBP9 Gene

GeneHancer (GH) Regulatory Elements for RANBP9 Gene

Promoters and enhancers for RANBP9 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I013708 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 564.4 +0.8 799 5.4 CLOCK YBX1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC ZNF610 GLIS1 RANBP9 SIRT5 MCUR1 CD83 TBC1D7 GC06P013623
GH06I013679 Enhancer 1.2 Ensembl ENCODE dbSUPER 24.1 +30.5 30514 2.3 HDAC1 HDGF FOXA2 ZNF133 CHAMP1 ATF7 RUNX3 CEBPB JUNB ZEB2 RANBP9 SIRT5 GC06P013623
GH06I013666 Enhancer 1 ENCODE dbSUPER 24.2 +44.1 44147 1.9 HDAC1 PKNOX1 ARNT NFRKB FEZF1 ZBTB40 NCOA2 TCF12 ZNF354C ZNF366 RANBP9 SIRT5 GC06P013623
GH06I013810 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 10.4 -101.3 -101346 5.1 PKNOX1 CLOCK SMAD1 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 POLR2B MCUR1 ENSG00000272209 RANBP9 RNF182 GC06M013802 GC06P013802
GH06I013732 Enhancer 1 Ensembl ENCODE 20.2 -22.0 -21974 1.7 HDAC1 CLOCK ZSCAN4 SIN3A ZNF335 ZNF366 ZNF362 USF2 CEBPB TSHZ1 RANBP9 SIRT5 GC06P013771
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RANBP9 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RANBP9 gene promoter:

Genomic Locations for RANBP9 Gene

Genomic Locations for RANBP9 Gene
chr6:13,621,498-13,711,580
(GRCh38/hg38)
Size:
90,083 bases
Orientation:
Minus strand
chr6:13,621,730-13,711,796
(GRCh37/hg19)

Genomic View for RANBP9 Gene

Genes around RANBP9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RANBP9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RANBP9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RANBP9 Gene

Proteins for RANBP9 Gene

  • Protein details for RANBP9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96S59-RANB9_HUMAN
    Recommended name:
    Ran-binding protein 9
    Protein Accession:
    Q96S59
    Secondary Accessions:
    • A0PJA2
    • B2R8E1
    • O94764
    • Q6P3T7
    • Q7LBR2
    • Q7Z7F9

    Protein attributes for RANBP9 Gene

    Size:
    729 amino acids
    Molecular mass:
    77847 Da
    Quaternary structure:
    • Interacts with NGFR and DDX4 (By similarity). Interacts with GTP-bound Ran, AR, CDC2L1/p110C, CALB1, S100A7, USP11, MKLN1, SOS1 or SOS2, GID8, and FMR1. Interacts with the Dyrk kinases HIPK2, DYRK1A, and DYRK1B. Interacts with TP73 isoform Alpha but not with TP53. Interacts with the HGF receptor MET and the integrins ITGB1 and ITGB2, but not with ITGAL. Part of a complex consisting of RANBP9, MKLN1 and GID8. Part of a complex consisting of RANBP9, RAN, DYRK1B and COPS5. Directly interacts with RANBP10. Interacts with TEX19 (By similarity).
    SequenceCaution:
    • Sequence=AAH19886.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH52781.1; Type=Frameshift; Positions=13, 30, 34; Evidence={ECO:0000305}; Sequence=AAK15469.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA23216.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RANBP9 Gene

    Alternative splice isoforms for RANBP9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RANBP9 Gene

Post-translational modifications for RANBP9 Gene

  • Phosphorylated in response to stress. Can be phosphorylated by the cleaved p110 form of CDC2L1 (p110C).
  • Ubiquitinated. Polyubiquitination targets the protein for rapid degradation via the ubiquitin system. Can be deubiquitinated by USP11.
  • Ubiquitination at isoforms=174, Lys405, and Lys445

Other Protein References for RANBP9 Gene

No data available for DME Specific Peptides for RANBP9 Gene

Domains & Families for RANBP9 Gene

Gene Families for RANBP9 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for RANBP9 Gene

Graphical View of Domain Structure for InterPro Entry

Q96S59

UniProtKB/Swiss-Prot:

RANB9_HUMAN :
  • The SPRY domain mediates the interaction with MET, AR, and CDC2L1.
  • Belongs to the RANBP9/10 family.
Domain:
  • The SPRY domain mediates the interaction with MET, AR, and CDC2L1.
Family:
  • Belongs to the RANBP9/10 family.
genes like me logo Genes that share domains with RANBP9: view

Function for RANBP9 Gene

Molecular function for RANBP9 Gene

UniProtKB/Swiss-Prot Function:
May act as an adapter protein to couple membrane receptors to intracellular signaling pathways. May be involved in signaling of ITGB2/LFA-1 and other integrins. Enhances HGF-MET signaling by recruiting Sos and activating the Ras pathway. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but not affect estrogen-induced transactivation. Stabilizes TP73 isoform Alpha, probably by inhibiting its ubiquitination, and increases its proapoptotic activity. Inhibits the kinase activity of DYRK1A and DYRK1B. Inhibits FMR1 binding to RNA.

Phenotypes From GWAS Catalog for RANBP9 Gene

Gene Ontology (GO) - Molecular Function for RANBP9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005088 Ras guanyl-nucleotide exchange factor activity TAS --
GO:0005515 protein binding IPI 12220523
GO:0008536 Ran GTPase binding TAS 9817760
GO:0019899 enzyme binding IPI 17087506
genes like me logo Genes that share ontologies with RANBP9: view
genes like me logo Genes that share phenotypes with RANBP9: view

Animal Model Products

CRISPR Products

miRNA for RANBP9 Gene

miRTarBase miRNAs that target RANBP9

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RANBP9 Gene

Localization for RANBP9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RANBP9 Gene

Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein. Note=The unphosphorylated form is predominantly cytoplasmic. A phosphorylated form is associated with the plasma membrane. {ECO:0000269 PubMed:14722085}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RANBP9 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5
plasma membrane 3
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RANBP9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 12220523
GO:0005737 cytoplasm IDA,IEA 15381419
GO:0005829 cytosol TAS --
GO:0005875 microtubule associated complex TAS 9817760
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with RANBP9: view

Pathways & Interactions for RANBP9 Gene

SuperPathways for RANBP9 Gene

SuperPathway Contained pathways
1 RET signaling
2 Developmental Biology
3 Cytokine Signaling in Immune system
4 Innate Immune System
5 MET promotes cell motility
genes like me logo Genes that share pathways with RANBP9: view

SIGNOR curated interactions for RANBP9 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for RANBP9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0006461 protein complex assembly TAS 9817760
GO:0007020 microtubule nucleation NAS,TAS 12220523
GO:0007411 axon guidance TAS --
GO:0065009 regulation of molecular function IEA --
genes like me logo Genes that share ontologies with RANBP9: view

Drugs & Compounds for RANBP9 Gene

(2) Drugs for RANBP9 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with RANBP9: view

Transcripts for RANBP9 Gene

Unigene Clusters for RANBP9 Gene

RAN binding protein 9:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for RANBP9 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16a · 16b · 16c · 16d ^ 17 ^
SP1: - - - - - - - -
SP2: - -
SP3:
SP4:
SP5: - - -
SP6: - -
SP7:
SP8: - -
SP9: - - - - - -
SP10: - - - - -
SP11: - - - -
SP12: - - -
SP13: -
SP14:

ExUns: 18a · 18b ^ 19a · 19b · 19c ^ 20 ^ 21
SP1:
SP2:
SP3:
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for RANBP9 Gene

GeneLoc Exon Structure for
RANBP9
ECgene alternative splicing isoforms for
RANBP9

Expression for RANBP9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RANBP9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RANBP9 Gene

This gene is overexpressed in Bone (23.5), Liver (9.2), and Peripheral blood mononuclear cells (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RANBP9 Gene



Protein tissue co-expression partners for RANBP9 Gene

NURSA nuclear receptor signaling pathways regulating expression of RANBP9 Gene:

RANBP9

SOURCE GeneReport for Unigene cluster for RANBP9 Gene:

Hs.708182

mRNA Expression by UniProt/SwissProt for RANBP9 Gene:

Q96S59-RANB9_HUMAN
Tissue specificity: Ubiquitously expressed, with highest levels in testes, placenta, heart, and muscle, and lowest levels in lung. Within the brain, expressed predominantly by neurons in the gray matter of cortex, the granular layer of cerebellum and the Purkinje cells.

Evidence on tissue expression from TISSUES for RANBP9 Gene

  • Nervous system(4.9)
  • Lung(3.1)
genes like me logo Genes that share expression patterns with RANBP9: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for RANBP9 Gene

Orthologs for RANBP9 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RANBP9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RANBP9 33 34
  • 99.73 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia RANBP9 34
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RANBP9 33 34
  • 95.07 (n)
mouse
(Mus musculus)
Mammalia Ranbp9 33 16 34
  • 93.73 (n)
rat
(Rattus norvegicus)
Mammalia Ranbp9 33
  • 90.56 (n)
cow
(Bos Taurus)
Mammalia RANBP9 33 34
  • 87.94 (n)
oppossum
(Monodelphis domestica)
Mammalia RANBP9 34
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves RANBP9 33 34
  • 86.39 (n)
lizard
(Anolis carolinensis)
Reptilia RANBP9 34
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ranbp9 33
  • 79.18 (n)
Str.3986 33
African clawed frog
(Xenopus laevis)
Amphibia LOC398677 33
zebrafish
(Danio rerio)
Actinopterygii ranbp9 33 33 34
  • 72.53 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.732 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005063 33
  • 57.79 (n)
fruit fly
(Drosophila melanogaster)
Insecta RanBPM 33 34
  • 54.51 (n)
worm
(Caenorhabditis elegans)
Secernentea Y54E5A.7 35 34
  • 37 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes VID30 34
  • 14 (a)
OneToMany
Species where no ortholog for RANBP9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RANBP9 Gene

ENSEMBL:
Gene Tree for RANBP9 (if available)
TreeFam:
Gene Tree for RANBP9 (if available)

Paralogs for RANBP9 Gene

Paralogs for RANBP9 Gene

(1) SIMAP similar genes for RANBP9 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RANBP9: view

Variants for RANBP9 Gene

Sequence variations from dbSNP and Humsavar for RANBP9 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000006877 -- 13,633,652(-) A/T intron_variant
rs1000007568 -- 13,674,618(-) G/A intron_variant
rs1000025021 -- 13,640,343(-) G/A intron_variant
rs1000121094 -- 13,639,062(-) C/T intron_variant
rs1000144471 -- 13,674,943(-) T/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RANBP9 Gene

Variant ID Type Subtype PubMed ID
esv2299523 CNV deletion 18987734
esv2669023 CNV deletion 23128226
esv2674410 CNV deletion 23128226
esv3608132 CNV loss 21293372
esv3608135 CNV loss 21293372
nsv1016744 CNV loss 25217958
nsv1019422 CNV gain 25217958
nsv1026597 CNV loss 25217958
nsv1145092 CNV deletion 24896259
nsv950771 CNV duplication 24416366

Variation tolerance for RANBP9 Gene

Residual Variation Intolerance Score: 12.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.37; 42.00% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RANBP9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RANBP9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RANBP9 Gene

Disorders for RANBP9 Gene

Additional Disease Information for RANBP9

No disorders were found for RANBP9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RANBP9 Gene

Publications for RANBP9 Gene

  1. When overexpressed, a novel centrosomal protein, RanBPM, causes ectopic microtubule nucleation similar to gamma-tubulin. (PMID: 9817760) Nakamura M … Nishimoto T (The Journal of cell biology 1998) 2 3 4 22 58
  2. RanBPM is a phosphoprotein that associates with the plasma membrane and interacts with the integrin LFA-1. (PMID: 14722085) Denti S … Bianchi E (The Journal of biological chemistry 2004) 3 4 22 58
  3. The C terminus of fragile X mental retardation protein interacts with the multi-domain Ran-binding protein in the microtubule-organising centre. (PMID: 15381419) Menon RP … Pastore A (Journal of molecular biology 2004) 3 4 22 58
  4. The cyclin-dependent kinase 11(p46) isoform interacts with RanBPM. (PMID: 14511641) Mikolajczyk M … Nelson M (Biochemical and biophysical research communications 2003) 3 4 22 58
  5. Structural and functional characterization of the USP11 deubiquitinating enzyme, which interacts with the RanGTP-associated protein RanBPM. (PMID: 12084015) Ideguchi H … Ishigatsubo Y (The Biochemical journal 2002) 3 4 22 58

Products for RANBP9 Gene

Sources for RANBP9 Gene

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