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Aliases for PIGK Gene

Aliases for PIGK Gene

  • Phosphatidylinositol Glycan Anchor Biosynthesis, Class K 2 3
  • GPI8 3 4 6
  • Phosphatidylinositol-Glycan Biosynthesis Class K Protein 3 4
  • Phosphatidylinositol Glycan, Class K 2 3
  • GPI Transamidase Subunit 2 3
  • GPI8 Homolog 3 4
  • PIG-K 3 4
  • GPI-Anchor Transamidase 3
  • GPI Transamidase 4
  • EC 3.-.-.- 4
  • HGPI8 4

External Ids for PIGK Gene

Previous GeneCards Identifiers for PIGK Gene

  • GC01M077684
  • GC01M076501
  • GC01M076962
  • GC01M076979
  • GC01M076977
  • GC01M077269
  • GC01M077554
  • GC01M075685

Summaries for PIGK Gene

Entrez Gene Summary for PIGK Gene

  • This gene encodes a member of the cysteine protease family C13 that is involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This protein is a member of the multisubunit enzyme, GPI transamidase and is thought to be its enzymatic component. GPI transamidase mediates GPI anchoring in the endoplasmic reticulum, by catalyzing the transfer of fully assembled GPI units to proteins. [provided by RefSeq, Jul 2008]

GeneCards Summary for PIGK Gene

PIGK (Phosphatidylinositol Glycan Anchor Biosynthesis, Class K) is a Protein Coding gene. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include cysteine-type endopeptidase activity and GPI anchor binding. An important paralog of this gene is LGMN.

UniProtKB/Swiss-Prot for PIGK Gene

  • Mediates GPI anchoring in the endoplasmic reticulum, by replacing a proteins C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein

Gene Wiki entry for PIGK Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PIGK Gene

Genomics for PIGK Gene

Regulatory Elements for PIGK Gene

Genomic Location for PIGK Gene

Start:
77,088,981 bp from pter
End:
77,219,447 bp from pter
Size:
130,467 bases
Orientation:
Minus strand

Genomic View for PIGK Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PIGK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PIGK Gene

Proteins for PIGK Gene

  • Protein details for PIGK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92643-GPI8_HUMAN
    Recommended name:
    GPI-anchor transamidase
    Protein Accession:
    Q92643
    Secondary Accessions:
    • B2R7K3
    • B4E2M3
    • O14822
    • Q5TG77

    Protein attributes for PIGK Gene

    Size:
    395 amino acids
    Molecular mass:
    45252 Da
    Quaternary structure:
    • Forms a complex with PIGT, PIGS, PIGU and GAA1.

    Alternative splice isoforms for PIGK Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PIGK Gene

Proteomics data for PIGK Gene at MOPED

Post-translational modifications for PIGK Gene

  • The disulfide bond between PIGK/GPI8 and PIGT is important for normal enzyme activity
  • Ubiquitination at Lys296
  • Modification sites at PhosphoSitePlus

Other Protein References for PIGK Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for PIGK Gene

Domains for PIGK Gene

Gene Families for PIGK Gene

HGNC:
  • PIG :Phosphatidylinositol glycan anchor biosynthesis

Protein Domains for PIGK Gene

Graphical View of Domain Structure for InterPro Entry

Q92643

UniProtKB/Swiss-Prot:

GPI8_HUMAN :
  • Q92643
Family:
  • Belongs to the peptidase C13 family.
genes like me logo Genes that share domains with PIGK: view

Function for PIGK Gene

Molecular function for PIGK Gene

GENATLAS Biochemistry: phosphatidylinositol glycan,class K,mutated in K562 cell line,yeast GPI8 homolog,association with GPAA1 for GPI anchor attachment
UniProtKB/Swiss-Prot Function: Mediates GPI anchoring in the endoplasmic reticulum, by replacing a proteins C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein

Enzyme Numbers (IUBMB) for PIGK Gene

Gene Ontology (GO) - Molecular Function for PIGK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003756 protein disulfide isomerase activity TAS 12582175
GO:0003923 GPI-anchor transamidase activity TAS --
GO:0004197 cysteine-type endopeptidase activity IEA --
GO:0005515 protein binding IPI 10793132
GO:0034235 contributes_to GPI anchor binding TAS 10793132
genes like me logo Genes that share ontologies with PIGK: view

Phenotypes for PIGK Gene

GenomeRNAi human phenotypes for PIGK:
genes like me logo Genes that share phenotypes with PIGK: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for PIGK Gene

Localization for PIGK Gene

Subcellular locations from UniProtKB/Swiss-Prot for PIGK Gene

Endoplasmic reticulum membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PIGK Gene COMPARTMENTS Subcellular localization image for PIGK gene
Compartment Confidence
endoplasmic reticulum 5
lysosome 2

Gene Ontology (GO) - Cellular Components for PIGK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane IDA 19946888
GO:0030176 integral component of endoplasmic reticulum membrane NAS 11483512
GO:0042765 GPI-anchor transamidase complex IMP 10793132
genes like me logo Genes that share ontologies with PIGK: view

Pathways for PIGK Gene

genes like me logo Genes that share pathways with PIGK: view

UniProtKB/Swiss-Prot Q92643-GPI8_HUMAN

  • Pathway: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis

Gene Ontology (GO) - Biological Process for PIGK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding TAS 12582175
GO:0006501 C-terminal protein lipidation TAS --
GO:0006508 proteolysis IEA --
GO:0016255 attachment of GPI anchor to protein TAS 11483512
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with PIGK: view

Compounds for PIGK Gene

(519) HMDB Compounds for PIGK Gene

Compound Synonyms Cas Number PubMed IDs
3-Dehydrosphinganine
  • 1-Hydroxy-2-amino-3-oxo-octadecane
16105-69-4
3-O-Sulfogalactosylceramide (d18:1/12:0)
  • Sulfatide (d18:1/12:0)
852100-88-0
3-O-Sulfogalactosylceramide (d18:1/14:0)
  • Sulfatide (d18:1/14:0)
Not Available
3-O-Sulfogalactosylceramide (d18:1/16:0)
  • Sulfatide (d18:1/16:0)
862509-48-6
3-O-Sulfogalactosylceramide (d18:1/18:0)
  • Sulfatide (d18:1/18:0)
244215-65-4

(1) Novoseek inferred chemical compound relationships for PIGK Gene

Compound -log(P) Hits PubMed IDs
lipid 6.54 1
genes like me logo Genes that share compounds with PIGK: view

Transcripts for PIGK Gene

Unigene Clusters for PIGK Gene

Phosphatidylinositol glycan anchor biosynthesis, class K:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PIGK Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b
SP1: -
SP2:
SP3: - - - -

Relevant External Links for PIGK Gene

GeneLoc Exon Structure for
PIGK
ECgene alternative splicing isoforms for
PIGK

Expression for PIGK Gene

mRNA expression in normal human tissues for PIGK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PIGK Gene

SOURCE GeneReport for Unigene cluster for PIGK Gene Hs.178305

genes like me logo Genes that share expressions with PIGK: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PIGK Gene

Orthologs for PIGK Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PIGK Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PIGK 35
  • 99.49 (n)
  • 99.75 (a)
PIGK 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PIGK 35
  • 92.24 (n)
  • 93.92 (a)
PIGK 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PIGK 35
  • 92.16 (n)
  • 94.32 (a)
PIGK 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pigk 35
  • 83.8 (n)
  • 91.39 (a)
Pigk 16
Pigk 36
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PIGK 36
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PIGK 36
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pigk 35
  • 84.11 (n)
  • 94.01 (a)
chicken
(Gallus gallus)
Aves PIGK 35
  • 80.44 (n)
  • 87.24 (a)
PIGK 36
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PIGK 36
  • 70 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.6746 35
tropical clawed frog
(Silurana tropicalis)
Amphibia pigk 35
  • 73.92 (n)
  • 83.42 (a)
zebrafish
(Danio rerio)
Actinopterygii pigk 35
  • 70.91 (n)
  • 81.3 (a)
pigk 36
  • 79 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004301 35
  • 61.13 (n)
  • 67.1 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4406 35
  • 60.15 (n)
  • 62.82 (a)
CG4406 36
  • 55 (a)
OneToOne
EG:133E12.3 37
  • 62 (a)
worm
(Caenorhabditis elegans)
Secernentea hpo-4 35
  • 57.81 (n)
  • 54.1 (a)
hpo-4 36
  • 50 (a)
OneToOne
T05E11.6 37
  • 55 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR299W 35
  • 54.21 (n)
  • 55.36 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GPI8 35
  • 61.25 (n)
  • 60.15 (a)
GPI8 36
  • 42 (a)
OneToMany
GPI8 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E17051g 35
  • 58.76 (n)
  • 56.01 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G08750 35
  • 58.49 (n)
  • 54.4 (a)
corn
(Zea mays)
Liliopsida Zm.15417 35
rice
(Oryza sativa)
Liliopsida Os.24285 35
Os02g0219400 35
  • 59.89 (n)
  • 58.31 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU07259 35
  • 56.82 (n)
  • 60.5 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes gpi8 35
  • 59.47 (n)
  • 57.91 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3540 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1120 36
  • 47 (a)
OneToOne
Species with no ortholog for PIGK:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PIGK Gene

ENSEMBL:
Gene Tree for PIGK (if available)
TreeFam:
Gene Tree for PIGK (if available)

Paralogs for PIGK Gene

Paralogs for PIGK Gene

genes like me logo Genes that share paralogs with PIGK: view

Variants for PIGK Gene

Sequence variations from dbSNP and Humsavar for PIGK Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs169216 -- 77,089,796(+) TCTTT(C/T)GTAAT utr-variant-3-prime
rs199715 -- 77,088,857(+) GGGTC(A/G)TATCA downstream-variant-500B
rs699832 -- 77,182,208(+) GATAA(C/T)AGCTA intron-variant
rs713232 -- 77,170,558(-) ATAGC(C/T)CCTGC intron-variant
rs736453 -- 77,198,568(+) ttgct(A/G)gaaca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PIGK Gene

Variant ID Type Subtype PubMed ID
nsv830292 CNV Loss 17160897
esv2500895 CNV Insertion 19546169
esv272308 CNV Insertion 20981092
esv271361 CNV Insertion 20981092
nsv520629 CNV Loss 19592680
esv271271 CNV Insertion 20981092
esv273566 CNV Insertion 20981092
nsv525188 CNV Loss 19592680

Relevant External Links for PIGK Gene

HapMap Linkage Disequilibrium report
PIGK

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PIGK Gene

Disorders for PIGK Gene

Relevant External Links for PIGK

Genetic Association Database (GAD)
PIGK
Human Genome Epidemiology (HuGE) Navigator
PIGK
genes like me logo Genes that share disorders with PIGK: view

No data available for UniProtKB/Swiss-Prot for PIGK Gene

Publications for PIGK Gene

  1. The affected gene underlying the class K glycosylphosphatidylinositol (GPI) surface protein defect codes for the GPI transamidase. (PMID: 9356492) Yu J. … Medof M.E. (Proc. Natl. Acad. Sci. U.S.A. 1997) 2 3 4 23
  2. Two subunits of glycosylphosphatidylinositol transamidase, GPI8 and PIG-T, form a functionally important intermolecular disulfide bridge. (PMID: 12582175) Ohishi K. … Kinoshita T. (J. Biol. Chem. 2003) 3 4 23
  3. Proprotein interaction with the GPI transamidase. (PMID: 12616539) Chen R. … Medof M.E. (J. Cell. Biochem. 2003) 3 23
  4. Human PIG-U and yeast Cdc91p are the fifth subunit of GPI transamidase that attaches GPI-anchors to proteins. (PMID: 12802054) Hong Y. … Kinoshita T. (Mol. Biol. Cell 2003) 3 23
  5. Yeast Gpi8p is essential for GPI anchor attachment onto proteins. (PMID: 8978684) Benghezal M. … Conzelmann A. (EMBO J. 1996) 3 4

Products for PIGK Gene

Sources for PIGK Gene

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