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Aliases for BCL2L11 Gene

Aliases for BCL2L11 Gene

  • BCL2-Like 11 (Apoptosis Facilitator) 2 3
  • BIM 3 4 6
  • Bcl-2 Interacting Mediator Of Cell Death 3
  • Bcl2-Interacting Mediator Of Cell Death 4
  • Bcl-2-Related Ovarian Death Agonist 3
  • Bcl-2 Interacting Protein Bim 3
  • Bcl-2-Like Protein 11 3
  • Bcl2-L-11 4
  • BAM 3
  • BOD 3

External Ids for BCL2L11 Gene

Previous GeneCards Identifiers for BCL2L11 Gene

  • GC02P109111
  • GC02P109802
  • GC02P111785
  • GC02P111976
  • GC02P111597
  • GC02P111876
  • GC02P104757

Summaries for BCL2L11 Gene

Entrez Gene Summary for BCL2L11 Gene

  • The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq, Jun 2013]

GeneCards Summary for BCL2L11 Gene

BCL2L11 (BCL2-Like 11 (Apoptosis Facilitator)) is a Protein Coding gene. Diseases associated with BCL2L11 include hematologic cancer and burkitt lymphoma. Among its related pathways are PI3K-Akt signaling pathway and Signaling by FGFR. GO annotations related to this gene include protein heterodimerization activity and microtubule binding.

UniProtKB/Swiss-Prot for BCL2L11 Gene

  • Induces apoptosis and anoikis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less potent than isoform BimEL, isoform BimL and isoform BimS. Isoform Bim-gamma induces apoptosis. Isoform Bim-alpha3 induces apoptosis possibly through a caspase-mediated pathway. Isoform BimAC and isoform BimABC lack the ability to induce apoptosis.

Tocris Summary for BCL2L11 Gene

  • Bcl-2 family proteins regulate and contribute to programmed cell death or apoptosis. It is a large protein family and all members contain at least one of four BH (bcl-2 homology) domains. Certain members such as Bcl-2, Bcl-xl and Mcl1 are anti-apoptotic, whilst others are pro-apoptotic. The pro-apoptotic group of Bcl-2 proteins can be further sub-divided into the structurally diverse 'BH3' only proteins (e.g. Bid, Noxa, Puma and Bad) and the multidomain proteins that share BH1 to 3 (e.g. Bax and Bak). Most Bcl-2 family members contain a C-terminal transmembrane domain that functions to target these proteins to the outer mitochondrial and other intracellular membranes.

Gene Wiki entry for BCL2L11 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BCL2L11 Gene

Genomics for BCL2L11 Gene

Regulatory Elements for BCL2L11 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for BCL2L11 Gene

Start:
111,119,378 bp from pter
End:
111,168,447 bp from pter
Size:
49,070 bases
Orientation:
Plus strand

Genomic View for BCL2L11 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BCL2L11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BCL2L11 Gene

Proteins for BCL2L11 Gene

  • Protein details for BCL2L11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43521-B2L11_HUMAN
    Recommended name:
    Bcl-2-like protein 11
    Protein Accession:
    O43521
    Secondary Accessions:
    • A8K2W2
    • O43522
    • Q0MSE7
    • Q0MSE8
    • Q0MSE9
    • Q53R28
    • Q6JTU6
    • Q6T851
    • Q6TE14
    • Q6TE15
    • Q6TE16
    • Q6V402
    • Q8WYL6
    • Q8WYL7
    • Q8WYL8
    • Q8WYL9
    • Q8WYM0
    • Q8WYM1

    Protein attributes for BCL2L11 Gene

    Size:
    198 amino acids
    Molecular mass:
    22171 Da
    Quaternary structure:
    • Forms heterodimers with a number of antiapoptotic Bcl-2 proteins including MCL1, BCL2, BCL2L1 isoform Bcl-X(L), BCL2A1/BFL-1, BHRF1, and BCLW. Isoform BimS and isoform Bim-alpha3 interact with BAX; this interaction induces the conformationally active form of BAX. Does not heterodimerize with proapoptotic proteins such as BAD, BOK or BAK. Interacts with DYNLL1 and YWHAZ. When phosphorylated, interacts with TRIM2; this interaction is associated with ubiquitination and degradation. Interacts with MCL1; may sequester BCL2L11 to prevent its pro-apoptotic activity.

    Three dimensional structures from OCA and Proteopedia for BCL2L11 Gene

neXtProt entry for BCL2L11 Gene

Proteomics data for BCL2L11 Gene at MOPED

Post-translational modifications for BCL2L11 Gene

  • Phosphorylation at Ser-69 by MAPK1/MAPK3 induces interaction with TRIM2, followed by polyubiquitination.
  • Ubiquitinated by TRIM2 following phosphorylation by MAPK1/MAPK3, leading to degradation by the proteasome.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

Protein Products

  • Cloud-Clone Corp. Proteins for BCL2L11

No data available for DME Specific Peptides for BCL2L11 Gene

Domains for BCL2L11 Gene

Protein Domains for BCL2L11 Gene

Suggested Antigen Peptide Sequences for BCL2L11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43521

UniProtKB/Swiss-Prot:

B2L11_HUMAN :
  • O43521
Domain:
  • The BH3 motif is required for Bcl-2 binding and cytotoxicity
Family:
  • Belongs to the Bcl-2 family.
genes like me logo Genes that share domains with BCL2L11: view

No data available for Gene Families for BCL2L11 Gene

Function for BCL2L11 Gene

Molecular function for BCL2L11 Gene

UniProtKB/Swiss-Prot Function: Induces apoptosis and anoikis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less potent than isoform BimEL, isoform BimL and isoform BimS. Isoform Bim-gamma induces apoptosis. Isoform Bim-alpha3 induces apoptosis possibly through a caspase-mediated pathway. Isoform BimAC and isoform BimABC lack the ability to induce apoptosis.
UniProtKB/Swiss-Prot Induction: By ER stress in a DDIT3/CHOP-dependent manner.

Gene Ontology (GO) - Molecular Function for BCL2L11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 14596824
GO:0008017 microtubule binding IEA --
genes like me logo Genes that share ontologies with BCL2L11: view
genes like me logo Genes that share phenotypes with BCL2L11: view

Animal Models for BCL2L11 Gene

MGI Knock Outs for BCL2L11:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BCL2L11

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for BCL2L11 Gene

Localization for BCL2L11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BCL2L11 Gene

Endomembrane system; Peripheral membrane protein. Note=Associated with intracytoplasmic membranes. {ECO:0000250}.
Isoform BimEL: Mitochondrion. Note=Translocates from microtubules to motochondria on loss of cell adherence.
Isoform BimL: Mitochondrion.
Isoform BimS: Mitochondrion.
Isoform Bim-alpha1: Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BCL2L11 Gene COMPARTMENTS Subcellular localization image for BCL2L11 gene
Compartment Confidence
cytosol 5
mitochondrion 5
nucleus 3
cytoskeleton 2
endoplasmic reticulum 2
extracellular 2
plasma membrane 1
vacuole 1

Gene Ontology (GO) - Cellular Components for BCL2L11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0005739 mitochondrion --
GO:0005741 mitochondrial outer membrane TAS --
GO:0005829 cytosol TAS --
GO:0005874 colocalizes_with microtubule IDA 21671007
genes like me logo Genes that share ontologies with BCL2L11: view

Pathways for BCL2L11 Gene

genes like me logo Genes that share pathways with BCL2L11: view

PCR Array Products

Gene Ontology (GO) - Biological Process for BCL2L11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001701 in utero embryonic development IEA --
GO:0001776 leukocyte homeostasis --
GO:0001782 B cell homeostasis IEA --
GO:0001783 B cell apoptotic process IEA --
GO:0001822 kidney development IEA --
genes like me logo Genes that share ontologies with BCL2L11: view

Compounds for BCL2L11 Gene

(5) Tocris Compounds for BCL2L11 Gene

Compound Action Cas Number
AT 101 Downregulates Bcl-2 and Mcl-1; pro-apoptotic [90141-22-3]
BAM 7 Selective Bax activator; induces Bax-mediated apoptosis [331244-89-4]
Bax inhibitor peptide V5 Inhibitor of Bax-mediated apoptosis [579492-81-2]
MIM1 Mcl-1 inhibitor; proapoptotic
TW 37 Bcl-2 inhibitor; induces apoptosis [877877-35-5]

(33) Novoseek inferred chemical compound relationships for BCL2L11 Gene

Compound -log(P) Hits PubMed IDs
noxa 88.3 40
bortezomib 70.6 8
suberoylanilide hydroxamic acid 66.6 5
sp 600125 59.1 1
mg 132 55 4
genes like me logo Genes that share compounds with BCL2L11: view

Transcripts for BCL2L11 Gene

Unigene Clusters for BCL2L11 Gene

BCL2-like 11 (apoptosis facilitator):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BCL2L11

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BCL2L11 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b
SP1: - - -
SP2: - - -
SP3: - -
SP4: - -
SP5: - - - -
SP6:
SP7: - - - - -
SP8: - - - - - -

Relevant External Links for BCL2L11 Gene

GeneLoc Exon Structure for
BCL2L11
ECgene alternative splicing isoforms for
BCL2L11

Expression for BCL2L11 Gene

mRNA expression in normal human tissues for BCL2L11 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for BCL2L11 Gene

SOURCE GeneReport for Unigene cluster for BCL2L11 Gene Hs.469658

mRNA Expression by UniProt/SwissProt for BCL2L11 Gene

O43521-B2L11_HUMAN
Tissue specificity: Isoform BimEL, isoform BimL and isoform BimS are the predominant isoforms and are ubiquitously expressed with a tissue-specific variation. Isoform Bim-gamma is most abundantly expressed in small intestine and colon, and in lower levels in spleen, prostate, testis, heart, liver and kidney.
genes like me logo Genes that share expressions with BCL2L11: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for BCL2L11 Gene

Orthologs for BCL2L11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for BCL2L11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BCL2L11 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia BCL2L11 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BCL2L11 36
  • 92 (a)
OneToOne
LOC612867 35
  • 93.64 (n)
  • 93.3 (a)
mouse
(Mus musculus)
Mammalia Bcl2l11 35
  • 89.35 (n)
  • 89.18 (a)
Bcl2l11 16
Bcl2l11 36
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia BCL2L11 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BCL2L11 36
  • 68 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Bcl2l11 35
  • 88.83 (n)
  • 87.63 (a)
lizard
(Anolis carolinensis)
Reptilia BCL2L11 36
  • 42 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia bcl2l11 35
  • 60.49 (n)
  • 56.61 (a)
Species with no ortholog for BCL2L11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for BCL2L11 Gene

ENSEMBL:
Gene Tree for BCL2L11 (if available)
TreeFam:
Gene Tree for BCL2L11 (if available)

Paralogs for BCL2L11 Gene

No data available for Paralogs for BCL2L11 Gene

Variants for BCL2L11 Gene

Sequence variations from dbSNP and Humsavar for BCL2L11 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs601445 -- 111,156,107(+) AGGCA(A/C)GGACT intron-variant
rs616084 -- 111,155,138(-) CCTTA(C/T)GCTAC intron-variant
rs616130 -- 111,155,104(+) AGTGG(A/C)GAGTA intron-variant
rs616144 -- 111,150,908(+) TTTGT(G/T)TGTGT intron-variant
rs643350 -- 111,158,968(+) TCCTT(G/T)GGCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BCL2L11 Gene

Variant ID Type Subtype PubMed ID
nsv874838 CNV Loss 21882294
nsv521956 CNV Loss 19592680
nsv834331 CNV Loss 17160897
nsv874842 CNV Loss 21882294
nsv829618 CNV Gain 20364138
nsv829619 CNV Loss 20364138
esv2667742 CNV Deletion 23128226
esv2720516 CNV Deletion 23290073
nsv428402 CNV Loss 18775914
dgv1236e1 CNV Complex 17122850

Relevant External Links for BCL2L11 Gene

HapMap Linkage Disequilibrium report
BCL2L11
Human Gene Mutation Database (HGMD)
BCL2L11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BCL2L11 Gene

Disorders for BCL2L11 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for BCL2L11 Gene including...

Search for BCL2L11 Gene in MalaCards »

(2) University of Copenhagen DISEASES for BCL2L11 Gene

(18) Novoseek inferred disease relationships for BCL2L11 Gene

Disease -log(P) Hits PubMed IDs
myeloma 42.5 14
tumors 41 31
cancer 39.8 6
melanoma 32.6 19
leukemia 23.8 9

Relevant External Links for BCL2L11

Genetic Association Database (GAD)
BCL2L11
Human Genome Epidemiology (HuGE) Navigator
BCL2L11
genes like me logo Genes that share disorders with BCL2L11: view

No data available for UniProtKB/Swiss-Prot for BCL2L11 Gene

Publications for BCL2L11 Gene

  1. Identification and characterization of Bimgamma, a novel proapoptotic BH3-only splice variant of Bim. (PMID: 12019181) Liu J.-W. … Tang D.G. (Cancer Res. 2002) 3 4 23
  2. Molecular cloning and characterization of six novel isoforms of human Bim, a member of the proapoptotic Bcl-2 family. (PMID: 11734221) Mami U. … Yamada M. (FEBS Lett. 2001) 3 4 23
  3. Over-expression of Bim alpha3, a novel isoform of human Bim, result in cell apoptosis. (PMID: 15147734) Chen J.Z. … Mao Y.M. (Int. J. Biochem. Cell Biol. 2004) 3 4 23
  4. Bim: a novel member of the Bcl-2 family that promotes apoptosis. (PMID: 9430630) O'Connor L. … Huang D.C.S. (EMBO J. 1998) 2 3 4
  5. The BH3-only protein Bim plays a critical role in leukemia cell death triggered by concomitant inhibition of the PI3K/Akt and MEK/ERK1/2 pathways. (PMID: 19773546) Rahmani M. … Grant S. (Blood 2009) 3 23

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