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Aliases for BCL2L11 Gene

Aliases for BCL2L11 Gene

  • BCL2 Like 11 2 3
  • BCL2-Like 11 (Apoptosis Facilitator) 2 3 5
  • BIM 3 4
  • Bcl-2 Interacting Mediator Of Cell Death 3
  • Bcl2-Interacting Mediator Of Cell Death 4
  • Bcl-2-Related Ovarian Death Agonist 3
  • Bcl-2 Interacting Protein Bim 3
  • Bcl2-L-11 4
  • BAM 3
  • BOD 3

External Ids for BCL2L11 Gene

Previous GeneCards Identifiers for BCL2L11 Gene

  • GC02P109111
  • GC02P109802
  • GC02P111785
  • GC02P111976
  • GC02P111597
  • GC02P111876
  • GC02P104757

Summaries for BCL2L11 Gene

Entrez Gene Summary for BCL2L11 Gene

  • The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq, Jun 2013]

GeneCards Summary for BCL2L11 Gene

BCL2L11 (BCL2 Like 11) is a Protein Coding gene. Diseases associated with BCL2L11 include ocular hyperemia and autoimmune lymphoproliferative syndrome. Among its related pathways are Signaling by GPCR and p75 NTR receptor-mediated signalling. GO annotations related to this gene include microtubule binding.

UniProtKB/Swiss-Prot for BCL2L11 Gene

  • Induces apoptosis and anoikis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less potent than isoform BimEL, isoform BimL and isoform BimS. Isoform Bim-gamma induces apoptosis. Isoform Bim-alpha3 induces apoptosis possibly through a caspase-mediated pathway. Isoform BimAC and isoform BimABC lack the ability to induce apoptosis.

Tocris Summary for BCL2L11 Gene

  • Bcl-2 family proteins contribute to programmed cell death or apoptosis. It is a large protein family and all members contain at least one of four Bcl-2 homology domains. Certain members (Bcl-2, Bcl-XL and Mcl-1) are antiapoptotic, whilst others (Bax, Bak, Bok) are proapoptotic.

Gene Wiki entry for BCL2L11 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BCL2L11 Gene

Genomics for BCL2L11 Gene

Regulatory Elements for BCL2L11 Gene

Genomic Location for BCL2L11 Gene

Chromosome:
2
Start:
111,119,378 bp from pter
End:
111,168,447 bp from pter
Size:
49,070 bases
Orientation:
Plus strand

Genomic View for BCL2L11 Gene

Genes around BCL2L11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BCL2L11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BCL2L11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BCL2L11 Gene

Proteins for BCL2L11 Gene

  • Protein details for BCL2L11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43521-B2L11_HUMAN
    Recommended name:
    Bcl-2-like protein 11
    Protein Accession:
    O43521
    Secondary Accessions:
    • A8K2W2
    • O43522
    • Q0MSE7
    • Q0MSE8
    • Q0MSE9
    • Q53R28
    • Q6JTU6
    • Q6T851
    • Q6TE14
    • Q6TE15
    • Q6TE16
    • Q6V402
    • Q8WYL6
    • Q8WYL7
    • Q8WYL8
    • Q8WYL9
    • Q8WYM0
    • Q8WYM1

    Protein attributes for BCL2L11 Gene

    Size:
    198 amino acids
    Molecular mass:
    22171 Da
    Quaternary structure:
    • Forms heterodimers with a number of antiapoptotic Bcl-2 proteins including MCL1, BCL2, BCL2L1 isoform Bcl-X(L), BCL2A1/BFL-1, BHRF1, and BCLW. Isoform BimS and isoform Bim-alpha3 interact with BAX; this interaction induces the conformationally active form of BAX. Does not heterodimerize with proapoptotic proteins such as BAD, BOK or BAK. Interacts with DYNLL1 and YWHAZ. When phosphorylated, interacts with TRIM2; this interaction is associated with ubiquitination and degradation. Interacts with MCL1; may sequester BCL2L11 to prevent its pro-apoptotic activity.

    Three dimensional structures from OCA and Proteopedia for BCL2L11 Gene

neXtProt entry for BCL2L11 Gene

Proteomics data for BCL2L11 Gene at MOPED

Post-translational modifications for BCL2L11 Gene

  • Phosphorylation at Ser-69 by MAPK1/MAPK3 induces interaction with TRIM2, followed by polyubiquitination.
  • Ubiquitinated by TRIM2 following phosphorylation by MAPK1/MAPK3, leading to degradation by the proteasome.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • R&D Systems Antibodies for BCL2L11 (BIM Long (BIM L))

No data available for DME Specific Peptides for BCL2L11 Gene

Domains & Families for BCL2L11 Gene

Gene Families for BCL2L11 Gene

Protein Domains for BCL2L11 Gene

Suggested Antigen Peptide Sequences for BCL2L11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43521

UniProtKB/Swiss-Prot:

B2L11_HUMAN :
  • The BH3 motif is required for Bcl-2 binding and cytotoxicity.
  • Belongs to the Bcl-2 family.
Domain:
  • The BH3 motif is required for Bcl-2 binding and cytotoxicity.
Family:
  • Belongs to the Bcl-2 family.
genes like me logo Genes that share domains with BCL2L11: view

Function for BCL2L11 Gene

Molecular function for BCL2L11 Gene

UniProtKB/Swiss-Prot Function:
Induces apoptosis and anoikis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less potent than isoform BimEL, isoform BimL and isoform BimS. Isoform Bim-gamma induces apoptosis. Isoform Bim-alpha3 induces apoptosis possibly through a caspase-mediated pathway. Isoform BimAC and isoform BimABC lack the ability to induce apoptosis.
UniProtKB/Swiss-Prot Induction:
By ER stress in a DDIT3/CHOP-dependent manner.
genes like me logo Genes that share phenotypes with BCL2L11: view

Animal Models for BCL2L11 Gene

MGI Knock Outs for BCL2L11:

miRNA for BCL2L11 Gene

miRTarBase miRNAs that target BCL2L11

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BCL2L11 Gene

Localization for BCL2L11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BCL2L11 Gene

Endomembrane system; Peripheral membrane protein. Note=Associated with intracytoplasmic membranes. {ECO:0000250}.
Isoform BimEL: Mitochondrion. Note=Translocates from microtubules to motochondria on loss of cell adherence.
Isoform BimL: Mitochondrion.
Isoform BimS: Mitochondrion.
Isoform Bim-alpha1: Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BCL2L11 Gene COMPARTMENTS Subcellular localization image for BCL2L11 gene
Compartment Confidence
cytosol 5
mitochondrion 5
nucleus 4
cytoskeleton 2
endoplasmic reticulum 2
extracellular 2
plasma membrane 2
lysosome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for BCL2L11 Gene

Pathways & Interactions for BCL2L11 Gene

genes like me logo Genes that share pathways with BCL2L11: view

SIGNOR curated interactions for BCL2L11 Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for BCL2L11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001701 in utero embryonic development IEA --
GO:0001776 leukocyte homeostasis IEA --
GO:0001782 B cell homeostasis IEA --
GO:0002260 lymphocyte homeostasis IEA --
GO:0002262 myeloid cell homeostasis IEA --
genes like me logo Genes that share ontologies with BCL2L11: view

Drugs & Compounds for BCL2L11 Gene

(23) Drugs for BCL2L11 Gene - From: Novoseek, Tocris, and PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
imatinib Approved Pharma Kinase Inhibitors, SRC/BCR-ABL tyrosine kinase inhibitors 0
Bax inhibitor peptide P5 Pharma Bax inhibitor, Inhibitor of Bax-mediated apoptosis 0
Bax inhibitor peptide V5 Pharma Bax inhibitor, Inhibitor of Bax-mediated apoptosis 0
HA14-1 Pharma Bcl-2 inhibitor,potent and cell-permeable, Bcl-2 inhibitor. Induces apoptosis 0

(15) Additional Compounds for BCL2L11 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Bax inhibitor peptide, negative control
1315378-74-5
SMBA 1
906440-37-7

(5) Tocris Compounds for BCL2L11 Gene

Compound Action Cas Number
Bax inhibitor peptide P5 Inhibitor of Bax-mediated apoptosis 579492-83-4
Bax inhibitor peptide V5 Inhibitor of Bax-mediated apoptosis 579492-81-2
Bax inhibitor peptide, negative control Negative control peptide for Bax inhibitor peptides V5 and P5 (Cat. Nos. 1785 and 1786) 1315378-74-5
HA14-1 Bcl-2 inhibitor. Induces apoptosis 65673-63-4
SMBA 1 High affinity and selective activator of Bax 906440-37-7
genes like me logo Genes that share compounds with BCL2L11: view

Transcripts for BCL2L11 Gene

Unigene Clusters for BCL2L11 Gene

BCL2-like 11 (apoptosis facilitator):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BCL2L11 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b
SP1: - - -
SP2: - - -
SP3: - -
SP4: - -
SP5: - - - -
SP6:
SP7: - - - - -
SP8: - - - - - -

Relevant External Links for BCL2L11 Gene

GeneLoc Exon Structure for
BCL2L11
ECgene alternative splicing isoforms for
BCL2L11

Expression for BCL2L11 Gene

mRNA expression in normal human tissues for BCL2L11 Gene

Protein differential expression in normal tissues from HIPED for BCL2L11 Gene

This gene is overexpressed in Blymphocyte (30.1), Placenta (26.3), and Ovary (11.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for BCL2L11 Gene



SOURCE GeneReport for Unigene cluster for BCL2L11 Gene Hs.469658

mRNA Expression by UniProt/SwissProt for BCL2L11 Gene

O43521-B2L11_HUMAN
Tissue specificity: Isoform BimEL, isoform BimL and isoform BimS are the predominant isoforms and are ubiquitously expressed with a tissue-specific variation. Isoform Bim-gamma is most abundantly expressed in small intestine and colon, and in lower levels in spleen, prostate, testis, heart, liver and kidney.
genes like me logo Genes that share expression patterns with BCL2L11: view

Protein tissue co-expression partners for BCL2L11 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for BCL2L11 Gene

Orthologs for BCL2L11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for BCL2L11 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia LOC612867 35
  • 93.64 (n)
  • 93.3 (a)
BCL2L11 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Bcl2l11 35
  • 89.35 (n)
  • 89.18 (a)
Bcl2l11 16
Bcl2l11 36
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Bcl2l11 35
  • 88.83 (n)
  • 87.63 (a)
cow
(Bos Taurus)
Mammalia BCL2L11 36
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia BCL2L11 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BCL2L11 36
  • 68 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia BCL2L11 36
  • 100 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BCL2L11 36
  • 42 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia bcl2l11 35
  • 60.49 (n)
  • 56.61 (a)
Species with no ortholog for BCL2L11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for BCL2L11 Gene

ENSEMBL:
Gene Tree for BCL2L11 (if available)
TreeFam:
Gene Tree for BCL2L11 (if available)

Paralogs for BCL2L11 Gene

No data available for Paralogs for BCL2L11 Gene

Variants for BCL2L11 Gene

Sequence variations from dbSNP and Humsavar for BCL2L11 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs643350 -- 111,158,968(+) TCCTT(G/T)GGCCC intron-variant
rs601445 -- 111,156,107(+) AGGCA(A/C)GGACT intron-variant
rs650094 -- 111,147,348(+) CTCTC(A/T)CACAC intron-variant
rs662267 -- 111,154,338(+) tccca(A/G)caatg intron-variant
rs616084 -- 111,155,138(-) CCTTA(C/T)GCTAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BCL2L11 Gene

Variant ID Type Subtype PubMed ID
nsv874838 CNV Loss 21882294
nsv521956 CNV Loss 19592680
nsv834331 CNV Loss 17160897
nsv874842 CNV Loss 21882294
nsv829618 CNV Gain 20364138
nsv829619 CNV Loss 20364138
esv2667742 CNV Deletion 23128226
esv2720516 CNV Deletion 23290073
nsv428402 CNV Loss 18775914
dgv1236e1 CNV Complex 17122850

Variation tolerance for BCL2L11 Gene

Residual Variation Intolerance Score: 31.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.26; 5.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BCL2L11 Gene

HapMap Linkage Disequilibrium report
BCL2L11
Human Gene Mutation Database (HGMD)
BCL2L11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BCL2L11 Gene

Disorders for BCL2L11 Gene

MalaCards: The human disease database

(3) MalaCards diseases for BCL2L11 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
ocular hyperemia
  • hyperemia eye
autoimmune lymphoproliferative syndrome
  • coffin-siris syndrome
burkitt lymphoma
  • burkitt's lymphoma
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for BCL2L11

Genetic Association Database (GAD)
BCL2L11
Human Genome Epidemiology (HuGE) Navigator
BCL2L11
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BCL2L11
genes like me logo Genes that share disorders with BCL2L11: view

No data available for UniProtKB/Swiss-Prot and Genatlas for BCL2L11 Gene

Publications for BCL2L11 Gene

  1. Bim: a novel member of the Bcl-2 family that promotes apoptosis. (PMID: 9430630) O'Connor L. … Huang D.C.S. (EMBO J. 1998) 2 3 4 67
  2. Bim is the key mediator of glucocorticoid-induced apoptosis and of its potentiation by rapamycin in human myeloma cells. (PMID: 19914305) LA^pez-Royuela N. … Naval J. (Biochim. Biophys. Acta 2010) 3 23
  3. IGF-1 suppresses Bim expression in multiple myeloma via epigenetic and posttranslational mechanisms. (PMID: 20086250) De Bruyne E. … Vanderkerken K. (Blood 2010) 3 23
  4. Role for the proapoptotic factor BIM in mediating imatinib-induced apoptosis in a c-KIT-dependent gastrointestinal stromal tumor cell line. (PMID: 20231287) Gordon P.M. … Fisher D.E. (J. Biol. Chem. 2010) 3 23
  5. Active N-Ras and B-Raf inhibit anoikis by downregulating Bim expression in melanocytic cells. (PMID: 18668139) Goldstein N.B. … Shellman Y.G. (J. Invest. Dermatol. 2009) 3 23

Products for BCL2L11 Gene

Sources for BCL2L11 Gene

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