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Aliases for CD24 Gene

Aliases for CD24 Gene

  • CD24 Molecule 2 3
  • CD24 Antigen (Small Cell Lung Carcinoma Cluster 4 Antigen) 2 3
  • CD24A 3 4
  • Small Cell Lung Carcinoma Cluster 4 Antigen 4
  • Signal Transducer CD24 3
  • CD24 Antigen 4

External Ids for CD24 Gene

Previous GeneCards Identifiers for CD24 Gene

  • GC0YM020359
  • GC06U900001
  • GC0YM020047
  • GC0YM019540
  • GC0YM019611
  • GC0YM021152

Summaries for CD24 Gene

Entrez Gene Summary for CD24 Gene

  • This gene encodes a sialoglycoprotein that is expressed on mature granulocytes and B cells and modulates growth and differentiation signals to these cells. The precursor protein is cleaved to a short 32 amino acid mature peptide which is anchored via a glycosyl phosphatidylinositol (GPI) link to the cell surface. This gene was missing from previous genome assemblies, but is properly located on chromosome 6. Non-transcribed pseudogenes have been designated on chromosomes 1, 15, 20, and Y. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]

GeneCards Summary for CD24 Gene

CD24 (CD24 Molecule) is a Protein Coding gene. Among its related pathways are Hematopoietic cell lineage. GO annotations related to this gene include protein kinase binding and protein tyrosine kinase activator activity.

UniProtKB/Swiss-Prot for CD24 Gene

  • Modulates B-cell activation responses. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Promotes AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells.

Gene Wiki entry for CD24 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD24 Gene

Genomics for CD24 Gene

Regulatory Elements for CD24 Gene

Genomic Location for CD24 Gene

Start:
106,969,831 bp from pter
End:
106,975,627 bp from pter
Size:
5,797 bases
Orientation:
Minus strand

Genomic View for CD24 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CD24 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD24 Gene

Proteins for CD24 Gene

  • Protein details for CD24 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P25063-CD24_HUMAN
    Recommended name:
    Signal transducer CD24
    Protein Accession:
    P25063
    Secondary Accessions:
    • Q16257
    • Q53XS0

    Protein attributes for CD24 Gene

    Size:
    80 amino acids
    Molecular mass:
    8097 Da
    Quaternary structure:
    • Interacts with LYN and FGR in a cell-type specific manner. Binds FRG in a small cell cancer line, LYN in the erythroleukemia cell line K-562 and in Burkitts lymphoma.
    SequenceCaution:
    • Sequence=AAD14170.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for CD24 Gene

Proteomics data for CD24 Gene at MOPED

Post-translational modifications for CD24 Gene

Other Protein References for CD24 Gene

No data available for DME Specific Peptides for CD24 Gene

Domains for CD24 Gene

Gene Families for CD24 Gene

HGNC:
  • CD :CD molecules

Protein Domains for CD24 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CD24 Gene

Graphical View of Domain Structure for InterPro Entry

P25063

UniProtKB/Swiss-Prot:

CD24_HUMAN :
  • P25063
Family:
  • Belongs to the CD24 family.
genes like me logo Genes that share domains with CD24: view

Function for CD24 Gene

Molecular function for CD24 Gene

GENATLAS Biochemistry: cell differentiation antigen CD24,glycosyl phosphatidylinositol (GPI) linked membrane sialoglycoprotein,identified by monoclonal antibodies BA-1,VIB-E3,expressed on granulocyte,B lymphocyte,brain,kidney,regenerating muscle,(? involved in signal transduction),with cell-type specific promoter activity in small cell lung cancer
UniProtKB/Swiss-Prot Function: Modulates B-cell activation responses. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Promotes AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells.
UniProtKB/Swiss-Prot Induction: Expression is lost when primary B-cells are induced to differentiate in antibody-forming cells

Gene Ontology (GO) - Molecular Function for CD24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity NAS 8213086
GO:0005515 protein binding IPI 15633604
GO:0019901 protein kinase binding IPI 8753773
GO:0030246 carbohydrate binding --
GO:0030296 protein tyrosine kinase activator activity IDA 11313396
genes like me logo Genes that share ontologies with CD24: view
genes like me logo Genes that share phenotypes with CD24: view

Animal Models for CD24 Gene

MGI Knock Outs for CD24:

miRNA for CD24 Gene

miRTarBase miRNAs that target CD24

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CD24 Gene

Localization for CD24 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD24 Gene

Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CD24 Gene COMPARTMENTS Subcellular localization image for CD24 gene
Compartment Confidence
plasma membrane 5
extracellular 3
cytoskeleton 2
nucleus 2

Gene Ontology (GO) - Cellular Components for CD24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0009897 external side of plasma membrane --
GO:0009986 cell surface IDA 16532032
GO:0016020 membrane IDA 10037815
GO:0031225 anchored component of membrane IEA --
genes like me logo Genes that share ontologies with CD24: view

Pathways for CD24 Gene

SuperPathways for CD24 Gene

Superpath Contained pathways
1 Hematopoietic cell lineage
genes like me logo Genes that share pathways with CD24: view

Pathways by source for CD24 Gene

1 KEGG pathway for CD24 Gene

Interacting Proteins for CD24 Gene

Gene Ontology (GO) - Biological Process for CD24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001666 response to hypoxia IEP 15174142
GO:0001775 cell activation IDA 8223854
GO:0001959 regulation of cytokine-mediated signaling pathway ISS 16390867
GO:0002237 response to molecule of bacterial origin ISS 15493995
GO:0002329 pre-B cell differentiation --
genes like me logo Genes that share ontologies with CD24: view

Transcripts for CD24 Gene

mRNA/cDNA for CD24 Gene

(5) REFSEQ mRNAs :
(14) Additional mRNA sequences :
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CD24 Gene

CD24 molecule:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CD24 Gene

No ASD Table

Relevant External Links for CD24 Gene

GeneLoc Exon Structure for
CD24
ECgene alternative splicing isoforms for
CD24

Expression for CD24 Gene

mRNA expression in normal human tissues for CD24 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for CD24 Gene Hs.644105

mRNA Expression by UniProt/SwissProt for CD24 Gene

P25063-CD24_HUMAN
Tissue specificity: B-cells. Expressed in a number of B-cell lines including P32/ISH and Namalwa. Expressed in erythroleukemia cell and small cell lung carcinoma cell lines. Also expressed on the surface of T-cells.
genes like me logo Genes that share expressions with CD24: view

No data available for mRNA differential expression in normal tissues and Protein expression for CD24 Gene

Orthologs for CD24 Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for CD24 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Cd24a 16
Species with no ortholog for CD24:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CD24 Gene

ENSEMBL:
Gene Tree for CD24 (if available)
TreeFam:
Gene Tree for CD24 (if available)

Paralogs for CD24 Gene

No data available for Paralogs for CD24 Gene

Variants for CD24 Gene

Sequence variations from dbSNP and Humsavar for CD24 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
VAR_016156 -
VAR_031576 -

Structural Variations from Database of Genomic Variants (DGV) for CD24 Gene

Variant ID Type Subtype PubMed ID
nsv10025 CNV Gain 18304495
esv1565023 CNV Insertion 17803354

Relevant External Links for CD24 Gene

HapMap Linkage Disequilibrium report
CD24
Human Gene Mutation Database (HGMD)
CD24

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD24 Gene

Disorders for CD24 Gene

UniProtKB/Swiss-Prot

CD24_HUMAN
  • Multiple sclerosis (MS) [MIM:126200]: A multifactorial, inflammatory, demyelinating disease of the central nervous system. Sclerotic lesions are characterized by perivascular infiltration of monocytes and lymphocytes and appear as indurated areas in pathologic specimens (sclerosis in plaques). The pathological mechanism is regarded as an autoimmune attack of the myelin sheath, mediated by both cellular and humoral immunity. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia and bladder dysfunction. Genetic and environmental factors influence susceptibility to the disease. {ECO:0000269 PubMed:14657362}. Note=Disease susceptibility may be associated with variations affecting the gene represented in this entry.

(2) University of Copenhagen DISEASES for CD24 Gene

Relevant External Links for CD24

Genetic Association Database (GAD)
CD24
Human Genome Epidemiology (HuGE) Navigator
CD24
genes like me logo Genes that share disorders with CD24: view

Publications for CD24 Gene

  1. Mapping of CD24 and homologous sequences to multiple chromosomal loci. (PMID: 7959762) Hough M.R. … Humphries R.K. (Genomics 1994) 2 3 4
  2. CD24 is a genetic modifier for risk and progression of multiple sclerosis. (PMID: 14657362) Zhou Q. … Liu Y. (Proc. Natl. Acad. Sci. U.S.A. 2003) 3 4 48
  3. CD24 Ala/Val polymorphism and multiple sclerosis. (PMID: 16631259) Goris A. … Sawcer S. (J. Neuroimmunol. 2006) 3 48
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. CD24, a signal-transducing molecule expressed on human B cells, is a major surface antigen on small cell lung carcinomas. (PMID: 1327504) Jackson D. … Stahel R.A. (Cancer Res. 1992) 3 4

Products for CD24 Gene

Sources for CD24 Gene

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