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Aliases for AKT3 Gene

Aliases for AKT3 Gene

  • V-Akt Murine Thymoma Viral Oncogene Homolog 3 2 3
  • PKBG 3 4 6
  • RAC-PK-Gamma 3 4
  • EC 2.7.11.1 4 63
  • PKB Gamma 3 4
  • STK-2 3 4
  • MPPH 3 6
  • V-Akt Murine Thymoma Viral Oncogene Homolog 3 (Protein Kinase B, Gamma) 3
  • RAC-Gamma Serine/Threonine Protein Kinase 3
  • RAC-Gamma Serine/Threonine-Protein Kinase 3
  • Protein Kinase B Gamma 4
  • Protein Kinase Akt-3 4
  • Protein Kinase B 2
  • PKB-GAMMA 3
  • RAC-Gamma 3
  • EC 2.7.11 63
  • Gamma 2
  • MPPH2 3
  • PRKBG 3

External Ids for AKT3 Gene

Previous GeneCards Identifiers for AKT3 Gene

  • GC01M241568
  • GC01M238913
  • GC01M239853
  • GC01M240598
  • GC01M239977
  • GC01M241718
  • GC01M243653
  • GC01M214031

Summaries for AKT3 Gene

Entrez Gene Summary for AKT3 Gene

  • The protein encoded by this gene is a member of the AKT, also called PKB, serine/threonine protein kinase family. AKT kinases are known to be regulators of cell signaling in response to insulin and growth factors. They are involved in a wide variety of biological processes including cell proliferation, differentiation, apoptosis, tumorigenesis, as well as glycogen synthesis and glucose uptake. This kinase has been shown to be stimulated by platelet-derived growth factor (PDGF), insulin, and insulin-like growth factor 1 (IGF1). Alternatively splice transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for AKT3 Gene

AKT3 (V-Akt Murine Thymoma Viral Oncogene Homolog 3) is a Protein Coding gene. Diseases associated with AKT3 include megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2 and hemimegalencephaly. Among its related pathways are PI3K-Akt signaling pathway and PI-3K cascade. GO annotations related to this gene include protein serine/threonine kinase activity and protein kinase activity. An important paralog of this gene is AKT1.

UniProtKB/Swiss-Prot for AKT3 Gene

  • AKT3 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT3 is the least studied AKT isoform. It plays an important role in brain development and is crucial for the viability of malignant glioma cells. AKT3 isoform may also be the key molecule in up-regulation and down-regulation of MMP13 via IL13. Required for the coordination of mitochondrial biogenesis with growth factor-induced increases in cellular energy demands. Down-regulation by RNA interference reduces the expression of the phosphorylated form of BAD, resulting in the induction of caspase-dependent apoptosis.

Tocris Summary for AKT3 Gene

  • Akt (Protein kinase B, PKB) is a serine/threonine kinase that plays a key in regulating cell survival, insulin signaling, angiogenesis and tumor formation. Akt is a downstream mediator of the PI 3-K pathway, resulting in the recruitment of Akt to the plasma membrane via the PH (plexstrin homology domain) of Akt. Akt is fully activated by phosphorylation at two key sites: Ser308 (phosphorylated by PDK1) and Thr478 (phosphorylated by mTOR and DNA-PK). Akt can then phosphorylated a wide range of substrates including transcription factors (e.g. FOXO1), kinases (GSK-3, Raf-1, ASK, Chk1) and other proteins with important signaling roles (e.g. Bad, MDM2). There are three isoforms of Akt; Akt 1, 2 and 3 (also known as PKBalpha, beta and gamma).

Gene Wiki entry for AKT3 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AKT3 Gene

Genomics for AKT3 Gene

Regulatory Elements for AKT3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for AKT3 Gene

Start:
243,488,233 bp from pter
End:
243,851,079 bp from pter
Size:
362,847 bases
Orientation:
Minus strand

Genomic View for AKT3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AKT3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AKT3 Gene

Proteins for AKT3 Gene

  • Protein details for AKT3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y243-AKT3_HUMAN
    Recommended name:
    RAC-gamma serine/threonine-protein kinase
    Protein Accession:
    Q9Y243
    Secondary Accessions:
    • Q0VAA6
    • Q5VTI1
    • Q5VTI2
    • Q96QV3
    • Q9UFP5

    Protein attributes for AKT3 Gene

    Size:
    479 amino acids
    Molecular mass:
    55775 Da
    Quaternary structure:
    • Interacts (via PH domain) with TCL1A; this enhances AKT3 phosphorylation and activation. Interacts with TRAF6. Interacts with KCTD20 (By similarity). Interacts with BTBD10 (By similarity).

    Three dimensional structures from OCA and Proteopedia for AKT3 Gene

    Alternative splice isoforms for AKT3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AKT3 Gene

Proteomics data for AKT3 Gene at MOPED

Post-translational modifications for AKT3 Gene

  • O-GlcNAcylation at Thr-302 and Thr-309 inhibits activating phosphorylation at Thr-305 via disrupting the interaction between AKT and PDK1.
  • Phosphorylation on Thr-305 and Ser-472 is required for full activity.
  • Ubiquitinated. When fully phosphorylated and translocated into the nucleus, undergoes Lys-48-polyubiquitination catalyzed by TTC3, leading to its degradation by the proteasome.
  • Ubiquitination at Lys273
  • Glycosylation at Thr302 and Thr309
  • Modification sites at PhosphoSitePlus

Other Protein References for AKT3 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for AKT3 (Akt3)

Domains for AKT3 Gene

Gene Families for AKT3 Gene

HGNC:
  • PLEKH :Pleckstrin homology (PH) domain containing
IUPHAR :

Suggested Antigen Peptide Sequences for AKT3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y243

UniProtKB/Swiss-Prot:

AKT3_HUMAN :
  • Q9Y243
Domain:
  • Binding of the PH domain to the phosphatidylinositol 3-kinase alpha (PI(3)K) results in its targeting to the plasma membrane
  • Contains 1 AGC-kinase C-terminal domain.
  • Contains 1 PH domain.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily.
genes like me logo Genes that share domains with AKT3: view

Function for AKT3 Gene

Molecular function for AKT3 Gene

GENATLAS Biochemistry: V-akt murine thymoma viral oncogen homolog 3,general mediator of cell survival,induced by insulin growth factor 1,AKT3 and others,widely expressed but not in liver and skeletal muscle
UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=87.9 uM for ATP (for purified and in vitro activated AKT3) {ECO:0000269 PubMed:16540465}; KM=12.4 uM for peptide substrate (for purified and in vitro activated AKT3) {ECO:0000269 PubMed:16540465}; KM=118.7 uM for ATP (for recombinant myristoylated AKT3 expressed and immunoprecipitated from Rat-1 cells) {ECO:0000269 PubMed:16540465}; KM=2.3 uM for peptide substrate (for recombinant myristoylated AKT3 expressed and immunoprecipitated from Rat-1 cells) {ECO:0000269 PubMed:16540465};
UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot EnzymeRegulation: Two specific sites, one in the kinase domain (Thr-305) and the other in the C-terminal regulatory region (Ser-472), need to be phosphorylated for its full activation (By similarity). IGF-1 leads to the activation of AKT3, which may play a role in regulating cell survival.
UniProtKB/Swiss-Prot Function: AKT3 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT3 is the least studied AKT isoform. It plays an important role in brain development and is crucial for the viability of malignant glioma cells. AKT3 isoform may also be the key molecule in up-regulation and down-regulation of MMP13 via IL13. Required for the coordination of mitochondrial biogenesis with growth factor-induced increases in cellular energy demands. Down-regulation by RNA interference reduces the expression of the phosphorylated form of BAD, resulting in the induction of caspase-dependent apoptosis.

Enzyme Numbers (IUBMB) for AKT3 Gene

Gene Ontology (GO) - Molecular Function for AKT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity TAS 10092583
GO:0004674 protein serine/threonine kinase activity IDA 16540465
GO:0004713 protein tyrosine kinase activity --
GO:0005515 protein binding IPI 12176997
GO:0005524 ATP binding IDA 16540465
genes like me logo Genes that share ontologies with AKT3: view
genes like me logo Genes that share phenotypes with AKT3: view

Animal Models for AKT3 Gene

MGI Knock Outs for AKT3:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AKT3

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for AKT3 Gene

Localization for AKT3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AKT3 Gene

Nucleus. Cytoplasm. Membrane; Peripheral membrane protein. Note=Membrane-associated after cell stimulation leading to its translocation.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AKT3 Gene COMPARTMENTS Subcellular localization image for AKT3 gene
Compartment Confidence
nucleus 5
golgi apparatus 4
plasma membrane 4
cytosol 3
extracellular 1
lysosome 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for AKT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005794 Golgi apparatus IDA --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with AKT3: view

Pathways for AKT3 Gene

SuperPathways for AKT3 Gene

Superpath Contained pathways
1 PI-3K cascade
2 Signaling by FGFR
3 Translation Insulin regulation of translation
4 IL-9 Signaling Pathways
5 Development HGF signaling pathway
genes like me logo Genes that share pathways with AKT3: view

Pathways by source for AKT3 Gene

PCR Array Products

Gene Ontology (GO) - Biological Process for AKT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000002 mitochondrial genome maintenance IMP 18524868
GO:0006468 protein phosphorylation IEA --
GO:0007165 signal transduction IMP 18524868
genes like me logo Genes that share ontologies with AKT3: view

Compounds for AKT3 Gene

Compound Products

(12) ApexBio Compounds for AKT3 Gene

Compound Action Cas Number
A-674563 potent selective protein kinase B/Akt inhibitor. [552325-73-2]
AT7867 potent ATP-competitive inhibitor of Akt1, Akt2 and Akt3 [857531-00-1]
AZD5363 Orally bioavailable, selective and potent inhibitor of all PKB/AKT iso-forms [1143532-39-1]
BX795 Cell-permeable, ATP-competitive and reversible PDK1 inhibitor [702675-74-9]
CCT128930 novel potent ATP-competitive AKT inhibitor [885499-61-6]
GDC-0068 (RG7440) Akt inhibitor [1001264-89-6]
GSK690693 Potent, ATP-competitive pan-Akt inhibitor [937174-76-0]
MK-2206 dihydrochloride a highly selective non-ATP competitive allosteric Akt inhibitor [1032350-13-2]
Palomid 529 novel potent antitumour PI3K/Akt/mTOR inhibitor. [914913-88-5]
Perifosine AKT inhibitor [157716-52-4]
PHT-427 pleckstrin homology domain inhibitor with dual Akt and PKB Kinase (PDPK1) inhibitory activity [1191951-57-1]
Triciribine suppresses the phosphorylation level and kinase activity of Akt. [35943-35-2]

(5) Tocris Compounds for AKT3 Gene

Compound Action Cas Number
10-DEBC hydrochloride Selective Akt/PKB inhibitor [925681-41-0]
API-1 Selective Akt/PKB inhibitor. Antitumor [36707-00-3]
API-2 Selective inhibitor of Akt/PKB signaling. Antitumor and antiviral [35943-35-2]
FPA 124 Akt/PKB inhibitor [902779-59-3]
SC 79 Akt activator [305834-79-1]

(2) HMDB Compounds for AKT3 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0

(5) Novoseek inferred chemical compound relationships for AKT3 Gene

Compound -log(P) Hits PubMed IDs
ly294002 68 1
phosphatidylinositol 57.5 1
threonine 51.9 1
serine 44.6 5
lipid 0 1
genes like me logo Genes that share compounds with AKT3: view

Transcripts for AKT3 Gene

Unigene Clusters for AKT3 Gene

V-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AKT3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AKT3 Gene

No ASD Table

Relevant External Links for AKT3 Gene

GeneLoc Exon Structure for
AKT3
ECgene alternative splicing isoforms for
AKT3

Expression for AKT3 Gene

mRNA expression in normal human tissues for AKT3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for AKT3 Gene

SOURCE GeneReport for Unigene cluster for AKT3 Gene Hs.498292

mRNA Expression by UniProt/SwissProt for AKT3 Gene

Q9Y243-AKT3_HUMAN
Tissue specificity: In adult tissues, it is highly expressed in brain, lung and kidney, but weakly in heart, testis and liver. In fetal tissues, it is highly expressed in heart, liver and brain and not at all in kidney
genes like me logo Genes that share expressions with AKT3: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for AKT3 Gene

Orthologs for AKT3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for AKT3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AKT3 35
  • 99.79 (n)
  • 100 (a)
AKT3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia AKT3 35
  • 96.66 (n)
  • 100 (a)
AKT3 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AKT3 35
  • 95.27 (n)
  • 99.58 (a)
AKT3 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Akt3 35
  • 94.08 (n)
  • 99.58 (a)
Akt3 16
Akt3 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia AKT3 36
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AKT3 36
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Akt3 35
  • 94.09 (n)
  • 99.56 (a)
chicken
(Gallus gallus)
Aves AKT3 35
  • 90.05 (n)
  • 99.58 (a)
AKT3 36
  • 100 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia AKT3 36
  • 100 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii AKT3 36
  • 93 (a)
OneToOne
akt3a 35
  • 80.17 (n)
  • 95.82 (a)
fruit fly
(Drosophila melanogaster)
Insecta Akt1 36
  • 51 (a)
OneToMany
Akt1 37
  • 63 (a)
worm
(Caenorhabditis elegans)
Secernentea akt-1 36
  • 50 (a)
ManyToMany
akt-2 36
  • 51 (a)
ManyToMany
F28C10.3 37
  • 35 (a)
akt-1 37
  • 53 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SCH9 36
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9149 36
  • 61 (a)
OneToMany
Species with no ortholog for AKT3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for AKT3 Gene

ENSEMBL:
Gene Tree for AKT3 (if available)
TreeFam:
Gene Tree for AKT3 (if available)

Paralogs for AKT3 Gene

genes like me logo Genes that share paralogs with AKT3: view

Variants for AKT3 Gene

Sequence variations from dbSNP and Humsavar for AKT3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs16356 -- 243,501,623(+) AAGGA(-/ATT)ATTAT intron-variant, utr-variant-3-prime
rs167661 -- 243,665,004(+) TATGG(A/C/T)TCTCC intron-variant
rs172777 -- 243,625,226(+) tcctg(G/T)gttcc intron-variant
rs184395 -- 243,625,202(+) tctca(A/G)atcac intron-variant
rs184396 -- 243,597,424(-) TAAAA(A/C)CCACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AKT3 Gene

Variant ID Type Subtype PubMed ID
nsv833070 CNV Gain 17160897
nsv873389 CNV Gain 21882294
nsv873390 CNV Gain 21882294
esv2677365 CNV Deletion 23128226
esv2575701 CNV Insertion 19546169
nsv833081 CNV Gain 17160897
nsv5121 CNV Loss 18451855
esv274931 CNV Loss 21479260
nsv833093 CNV Loss 17160897
nsv511135 CNV Loss 21212237
esv2606093 CNV Deletion 19546169
nsv511749 CNV Loss 21212237
esv2182482 CNV Deletion 18987734
esv5138 CNV Deletion 18987735
esv2726518 CNV Deletion 23290073
esv2674959 CNV Deletion 23128226
esv7595 CNV Loss 19470904
esv28291 CNV Gain 19812545
esv996767 CNV Loss 20482838
nsv821560 CNV Deletion 20802225
nsv873391 CNV Loss 21882294
nsv522102 CNV Gain 19592680
esv275568 CNV Loss 21479260
nsv873392 CNV Loss 21882294
esv2648270 CNV Deletion 19546169
nsv833104 CNV Gain+Loss 17160897
nsv509724 CNV Insertion 20534489
nsv5132 CNV Insertion 18451855

Relevant External Links for AKT3 Gene

HapMap Linkage Disequilibrium report
AKT3
Human Gene Mutation Database (HGMD)
AKT3

PCR Panel Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AKT3 Gene

Disorders for AKT3 Gene

(1) OMIM Diseases for AKT3 Gene (611223)

UniProtKB/Swiss-Prot

AKT3_HUMAN
  • Note=AKT3 is a key modulator of several tumors like melanoma, glioma and ovarian cancer. Active AKT3 increases progressively during melanoma tumor progression with highest levels present in advanced-stage metastatic melanomas. Promotes melanoma tumorigenesis by decreasing apoptosis. Plays a key role in the genesis of ovarian cancers through modulation of G2/M phase transition. With AKT2, plays a pivotal role in the biology of glioblastoma.
  • Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2 (MPPH2) [MIM:615937]: A syndrome characterized by megalencephaly, hydrocephalus, and polymicrogyria; polydactyly may also be seen. There is considerable phenotypic similarity between this disorder and the megalencephaly-capillary malformation syndrome. {ECO:0000269 PubMed:22500628, ECO:0000269 PubMed:22729223, ECO:0000269 PubMed:22729224}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(8) Novoseek inferred disease relationships for AKT3 Gene

Disease -log(P) Hits PubMed IDs
skin cancer 33.2 1
ovarian cancer 32.7 3
melanoma 32.2 24
tumors 31.5 14
metastatic melanoma 29.1 1

Relevant External Links for AKT3

Genetic Association Database (GAD)
AKT3
Human Genome Epidemiology (HuGE) Navigator
AKT3
genes like me logo Genes that share disorders with AKT3: view

Publications for AKT3 Gene

  1. Identification of a human Akt3 (protein kinase B gamma) which contains the regulatory serine phosphorylation site. (PMID: 10208883) Nakatani K. … Roth R.A. (Biochem. Biophys. Res. Commun. 1999) 2 3 4 23
  2. Molecular cloning, expression and characterization of the human serine/threonine kinase Akt-3. (PMID: 10491192) Masure S. … Richardson A. (Eur. J. Biochem. 1999) 3 4 23
  3. Two splice variants of PKB gamma have different regulatory capacity depending on the presence or absence of the regulatory phosphorylation site Ser-472 in the C-terminal hydrophobic domain. (PMID: 11387345) Brodbeck D. … Hemmings B.A. (J. Biol. Chem. 2001) 3 4 23
  4. Differential regulation of Akt kinase isoforms by the members of the TCL1 oncogene family. (PMID: 11707444) Laine J. … Noguchi M. (J. Biol. Chem. 2002) 3 4 23
  5. Characterization of PDK2 activity against protein kinase B gamma. (PMID: 12162751) Hodgkinson C.P. … Sale G.J. (Biochemistry 2002) 3 4 23

Products for AKT3 Gene

  • Addgene plasmids for AKT3

Sources for AKT3 Gene

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