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Aliases for CDH2 Gene

Aliases for CDH2 Gene

  • Cadherin 2 2 3 5
  • Cadherin 2, Type 1, N-Cadherin (Neuronal) 2 3
  • Neural Cadherin 3 4
  • N-Cadherin 2 4
  • CDw325 3 4
  • NCAD 3 4
  • CDHN 3 4
  • Calcium-Dependent Adhesion Protein, Neuronal 3
  • CD325 Antigen 4
  • N-Cadherin 1 3
  • Cadherin-2 3
  • CD325 3

External Ids for CDH2 Gene

Previous HGNC Symbols for CDH2 Gene

  • NCAD

Previous GeneCards Identifiers for CDH2 Gene

  • GC18M025465
  • GC18M025261
  • GC18M023782
  • GC18M023784
  • GC18M022383
  • GC18M025530

Summaries for CDH2 Gene

Entrez Gene Summary for CDH2 Gene

  • This gene encodes a classical cadherin and member of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein is proteolytically processed to generate a calcium-dependent cell adhesion molecule and glycoprotein. This protein plays a role in the establishment of left-right asymmetry, development of the nervous system and the formation of cartilage and bone. [provided by RefSeq, Nov 2015]

GeneCards Summary for CDH2 Gene

CDH2 (Cadherin 2) is a Protein Coding gene. Diseases associated with CDH2 include Arrhythmogenic Right Ventricular Cardiomyopathy and Malignant Pleural Mesothelioma. Among its related pathways are N-cadherin signaling events and PAK Pathway. Gene Ontology (GO) annotations related to this gene include calcium ion binding and protein phosphatase binding. An important paralog of this gene is CDH4.

UniProtKB/Swiss-Prot for CDH2 Gene

  • Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density (By similarity).

Gene Wiki entry for CDH2 Gene

Additional gene information for CDH2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDH2 Gene

Genomics for CDH2 Gene

GeneHancer (GH) Regulatory Elements for CDH2 Gene

Promoters and enhancers for CDH2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH18I028174 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 555.6 +0.8 786 5 PKNOX1 ARNT ARID4B SIN3A FEZF1 ZNF48 YY1 GLIS2 KLF13 SP3 CDH2 ENSG00000274578
GH18I028108 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 20.7 +64.5 64503 8.7 CTCF SOX13 FOXA2 JUN ZNF384 FEZF1 RAD21 YY1 HIC1 POLR2A CDH2 GC18M028093 GC18M028006 PIR33397
GH18I028083 Enhancer 1.5 VISTA Ensembl ENCODE dbSUPER 15.7 +91.1 91085 5 SOX13 FOXA2 CEBPG FEZF1 RAD21 YY1 ZNF335 POLR2A ZNF600 RXRA CDH2 CHST9 GC18M028093 PIR33397 GC18M028006
GH18I028090 Enhancer 0.8 ENCODE 15 +86.4 86365 1.7 ELF3 FOXA2 MLX ZSCAN9 RAD21 RARA YY1 CREM THAP11 MIXL1 CDH2 GC18M028093 GC18M028006 PIR33397
GH18I028127 Enhancer 0.9 ENCODE 11 +49.1 49095 1.3 ELF3 FOXA2 ARID4B SIN3A RARA ETS1 YY1 TCF12 CREM MIXL1 CDH2 GC18M028093 ENSG00000274578
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CDH2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CDH2 gene promoter:

Genomic Locations for CDH2 Gene

Genomic Locations for CDH2 Gene
chr18:27,932,879-28,177,481
(GRCh38/hg38)
Size:
244,603 bases
Orientation:
Minus strand
chr18:25,530,930-25,757,445
(GRCh37/hg19)

Genomic View for CDH2 Gene

Genes around CDH2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDH2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDH2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDH2 Gene

Proteins for CDH2 Gene

  • Protein details for CDH2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P19022-CADH2_HUMAN
    Recommended name:
    Cadherin-2
    Protein Accession:
    P19022
    Secondary Accessions:
    • A8MWK3
    • B0YIY6
    • Q14923
    • Q8N173

    Protein attributes for CDH2 Gene

    Size:
    906 amino acids
    Molecular mass:
    99809 Da
    Quaternary structure:
    • Interacts with CDCP1 (PubMed:16007225). Interacts with PCDH8; this complex may also include TAOK2. The interaction with PCDH8 may lead to internalization through TAOK2/p38 MAPK pathway (By similarity). Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN (By similarity). May interact with OBSCN (via protein kinase domain 2) (By similarity).

    Alternative splice isoforms for CDH2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDH2 Gene

Post-translational modifications for CDH2 Gene

  • Cleaved by MMP24. Ectodomain cleavage leads to the generation of a soluble 90 kDa amino-terminal soluble fragment and a 45 kDa membrane-bound carboxy-terminal fragment 1 (CTF1), which is further cleaved by gamma-secretase into a 35 kDa. Cleavage in neural stem cells by MMP24 affects CDH2-mediated anchorage of neural stem cells to ependymocytes in the adult subependymal zone, leading to modulate neural stem cell quiescence (By similarity).
  • May be phosphorylated by OBSCN.
  • Ubiquitination at Lys756
  • Glycosylation at Asn190, posLast=273273, posLast=325325, posLast=402402, posLast=572572, posLast=651651, and Asn692

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CDH2 (CDH2)

No data available for DME Specific Peptides for CDH2 Gene

Domains & Families for CDH2 Gene

Gene Families for CDH2 Gene

HGNC:
Human Protein Atlas (HPA):
  • CD markers
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for CDH2 Gene

Graphical View of Domain Structure for InterPro Entry

P19022

UniProtKB/Swiss-Prot:

CADH2_HUMAN :
  • Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain. Calcium-binding sites are occupied sequentially in the order of site 3, then site 2 and site 1 (By similarity).
Domain:
  • Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain. Calcium-binding sites are occupied sequentially in the order of site 3, then site 2 and site 1 (By similarity).
genes like me logo Genes that share domains with CDH2: view

Function for CDH2 Gene

Molecular function for CDH2 Gene

GENATLAS Biochemistry:
cadherin 2,N-cadherin,transmembrane glycoproteincomponent of adherens junction,containing a CCG repeat in 5utr,transmembrane glycoprotein component of adherens junction,expressed in brain,putatively involved in synaptic adhesion,axon outgrowth and guidance,also expressed in muscle
UniProtKB/Swiss-Prot Function:
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density (By similarity).

Phenotypes From GWAS Catalog for CDH2 Gene

Gene Ontology (GO) - Molecular Function for CDH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 7650039
GO:0008013 beta-catenin binding TAS 16344550
GO:0019899 enzyme binding IEA --
GO:0019901 protein kinase binding IEA --
genes like me logo Genes that share ontologies with CDH2: view
genes like me logo Genes that share phenotypes with CDH2: view

Animal Models for CDH2 Gene

MGI Knock Outs for CDH2:

Clone Products

  • Addgene plasmids for CDH2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CDH2 Gene

Localization for CDH2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDH2 Gene

Cell membrane; Single-pass type I membrane protein. Cell membrane, sarcolemma. Cell junction. Cell surface. Note=Colocalizes with TMEM65 at the intercalated disk in cardiomyocytes. Colocalizes with OBSCN at the intercalated disk and at sarcolemma in cardiomyocytes. {ECO:0000250 UniProtKB:P15116}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDH2 gene
Compartment Confidence
plasma membrane 5
extracellular 5
endoplasmic reticulum 5
cytoskeleton 3
peroxisome 2
nucleus 2
mitochondrion 1
cytosol 1
lysosome 1
golgi apparatus 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (3)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CDH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 22467863
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0005886 plasma membrane TAS --
GO:0005911 cell-cell junction IDA 7650039
GO:0005912 adherens junction IEA --
genes like me logo Genes that share ontologies with CDH2: view

Pathways & Interactions for CDH2 Gene

genes like me logo Genes that share pathways with CDH2: view

SIGNOR curated interactions for CDH2 Gene

Activates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for CDH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion TAS,IEA 2384753
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IEA --
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IEA --
GO:0009966 regulation of signal transduction IEA --
GO:0010001 glial cell differentiation ISS --
genes like me logo Genes that share ontologies with CDH2: view

Drugs & Compounds for CDH2 Gene

(22) Drugs for CDH2 Gene - From: ApexBio, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Approved Nutra 0
ADH-1 Investigational Pharma 0
Cadherin Peptide, avian Pharma Role in cell adhesion 0

(20) Additional Compounds for CDH2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for CDH2 Gene

Compound Action Cas Number
Cadherin Peptide, avian Role in cell adhesion 127650-08-2
genes like me logo Genes that share compounds with CDH2: view

Drug Products

Transcripts for CDH2 Gene

Unigene Clusters for CDH2 Gene

Cadherin 2, type 1, N-cadherin (neuronal):
Representative Sequences:

Clone Products

  • Addgene plasmids for CDH2

Alternative Splicing Database (ASD) splice patterns (SP) for CDH2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20
SP1: - - - - -
SP2: - -
SP3: -
SP4:
SP5: - - - -
SP6: - - - - -
SP7: - - -

Relevant External Links for CDH2 Gene

GeneLoc Exon Structure for
CDH2
ECgene alternative splicing isoforms for
CDH2

Expression for CDH2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CDH2 Gene

mRNA differential expression in normal tissues according to GTEx for CDH2 Gene

This gene is overexpressed in Heart - Left Ventricle (x11.4), Heart - Atrial Appendage (x5.3), and Adrenal Gland (x4.4).

Protein differential expression in normal tissues from HIPED for CDH2 Gene

This gene is overexpressed in Amniocyte (33.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CDH2 Gene



NURSA nuclear receptor signaling pathways regulating expression of CDH2 Gene:

CDH2

SOURCE GeneReport for Unigene cluster for CDH2 Gene:

Hs.464829

Evidence on tissue expression from TISSUES for CDH2 Gene

  • Nervous system(4.9)
  • Liver(4.5)
  • Heart(3.4)
  • Muscle(3.4)
  • Eye(2.8)
  • Lung(2.4)
  • Kidney(2.3)
  • Adrenal gland(2.2)
  • Intestine(2)
  • Pancreas(2)
genes like me logo Genes that share expression patterns with CDH2: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CDH2 Gene

Orthologs for CDH2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CDH2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDH2 33 34
  • 99.63 (n)
dog
(Canis familiaris)
Mammalia NCAD 34
  • 98 (a)
OneToOne
CDH2 33
  • 93.05 (n)
oppossum
(Monodelphis domestica)
Mammalia CDH2 34
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CDH2 33 34
  • 91.39 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CDH2 34
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdh2 33 16 34
  • 88.34 (n)
rat
(Rattus norvegicus)
Mammalia Cdh2 33
  • 87.2 (n)
chicken
(Gallus gallus)
Aves CDH2 33 34
  • 79.65 (n)
lizard
(Anolis carolinensis)
Reptilia CDH2 34
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdh2 33
  • 74.12 (n)
Str.2251 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.1873 33
zebrafish
(Danio rerio)
Actinopterygii cdh2 33 34
  • 67.89 (n)
Species where no ortholog for CDH2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CDH2 Gene

ENSEMBL:
Gene Tree for CDH2 (if available)
TreeFam:
Gene Tree for CDH2 (if available)

Paralogs for CDH2 Gene

Paralogs for CDH2 Gene

genes like me logo Genes that share paralogs with CDH2: view

Variants for CDH2 Gene

Sequence variations from dbSNP and Humsavar for CDH2 Gene

SNP ID Clin Chr 18 pos Variation AA Info Type
rs1000019970 -- 28,001,220(-) G/A intron_variant
rs1000026839 -- 28,168,887(-) T/C genic_upstream_transcript_variant, intron_variant
rs1000034174 -- 28,162,418(-) A/T genic_upstream_transcript_variant, intron_variant
rs1000054338 -- 28,168,455(-) G/A genic_upstream_transcript_variant, intron_variant
rs1000065670 -- 28,175,821(-) C/A genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CDH2 Gene

Variant ID Type Subtype PubMed ID
esv2760473 CNV gain 21179565
esv2761996 CNV loss 21179565
esv3573931 CNV gain 25503493
esv3642052 CNV loss 21293372
nsv1059472 CNV gain 25217958
nsv1071839 CNV deletion 25765185
nsv833605 CNV gain 17160897
nsv952695 CNV deletion 24416366
nsv9622 CNV loss 18304495

Variation tolerance for CDH2 Gene

Residual Variation Intolerance Score: 5.28% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.88; 67.50% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CDH2 Gene

Human Gene Mutation Database (HGMD)
CDH2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDH2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDH2 Gene

Disorders for CDH2 Gene

MalaCards: The human disease database

(20) MalaCards diseases for CDH2 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
arrhythmogenic right ventricular cardiomyopathy
  • arrhythmogenic right ventricular dysplasia
malignant pleural mesothelioma
  • malignant mesothelioma of pleura
hypotrichosis, congenital, with juvenile macular dystrophy
  • hjmd
tongue squamous cell carcinoma
  • carcinoma, squamous cell
mesothelioma, malignant
  • mesom
- elite association - COSMIC cancer census association via MalaCards
Search CDH2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CDH2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CDH2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CDH2 Gene

Publications for CDH2 Gene

  1. N-cadherin gene maps to human chromosome 18 and is not linked to the E-cadherin gene. (PMID: 2384753) Walsh FS … Goodfellow PN (Journal of neurochemistry 1990) 2 3 4 22 58
  2. Human N-cadherin: nucleotide and deduced amino acid sequence. (PMID: 2216790) Reid RA … Hemperly JJ (Nucleic acids research 1990) 2 3 4 58
  3. Loss of DLG5 promotes breast cancer malignancy by inhibiting the Hippo signaling pathway. (PMID: 28169360) Liu J … Liu P (Scientific reports 2017) 3 4 58
  4. Combined analysis of three genome-wide association studies on vWF and FVIII plasma levels. (PMID: 21810271) Antoni G … Tregouet DA (BMC medical genetics 2011) 3 44 58
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58

Products for CDH2 Gene

  • Addgene plasmids for CDH2

Sources for CDH2 Gene

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