Aliases for CDH2 Gene
External Ids for CDH2 Gene
Previous Symbols for CDH2 Gene
This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. The protein functions during gastrulation and is required for establishment of left-right asymmetry. At certain central nervous system synapses, presynaptic to postsynaptic adhesion is mediated at least in part by this gene product. [provided by RefSeq, Jul 2008]
GeneCards Summary for CDH2 Gene
CDH2 (Cadherin 2, Type 1, N-Cadherin (Neuronal)) is a Protein Coding gene. Diseases associated with CDH2 include pseudomyxoma peritonei and hypoplastic left heart syndrome. Among its related pathways are L1CAM interactions and ERK Signaling. GO annotations related to this gene include calcium ion binding and protein phosphatase binding. An important paralog of this gene is CDH13.
UniProtKB/Swiss-Prot for CDH2 Gene
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density (By similarity).