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Aliases for NAT2 Gene

Aliases for NAT2 Gene

  • N-Acetyltransferase 2 (Arylamine N-Acetyltransferase) 2 3
  • AAC2 3 4 6
  • N-Acetyltransferase Type 2 3 4
  • Arylamide Acetylase 2 3 4
  • EC 2.3.1.5 4 64
  • NAT-2 3 4
  • PNAT 3 4
  • Polymorphic Arylamine N-Acetyltransferase 4
  • Arylamine N-Acetyltransferase 2 3

External Ids for NAT2 Gene

Previous Symbols for NAT2 Gene

  • AAC2

Summaries for NAT2 Gene

Entrez Gene Summary for NAT2 Gene

  • This gene encodes an enzyme that functions to both activate and deactivate arylamine and hydrazine drugs and carcinogens. Polymorphisms in this gene are responsible for the N-acetylation polymorphism in which human populations segregate into rapid, intermediate, and slow acetylator phenotypes. Polymorphisms in this gene are also associated with higher incidences of cancer and drug toxicity. A second arylamine N-acetyltransferase gene (NAT1) is located near this gene (NAT2). [provided by RefSeq, Jul 2008]

GeneCards Summary for NAT2 Gene

NAT2 (N-Acetyltransferase 2 (Arylamine N-Acetyltransferase)) is a Protein Coding gene. Diseases associated with NAT2 include isoniazid toxicity and multiple chemical sensitivity. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include arylamine N-acetyltransferase activity. An important paralog of this gene is NAT1.

UniProtKB/Swiss-Prot for NAT2 Gene

  • Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine substrates and is able to bioactivate several known carcinogens

Gene Wiki entry for NAT2 Gene

PharmGKB "VIP" Summary for NAT2 Gene

No data available for Tocris Summary , fRNAdb sequence ontologies and piRNA Summary for NAT2 Gene

Genomics for NAT2 Gene

Genomic Location for NAT2 Gene

Start:
18,391,245 bp from pter
End:
18,401,218 bp from pter
Size:
9,974 bases
Orientation:
Plus strand

Genomic View for NAT2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NAT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAT2 Gene

Regulatory Elements for NAT2 Gene

Proteins for NAT2 Gene

  • Protein details for NAT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P11245-ARY2_HUMAN
    Recommended name:
    Arylamine N-acetyltransferase 2
    Protein Accession:
    P11245
    Secondary Accessions:
    • O43637
    • O60654
    • O60655
    • Q13146
    • Q16697
    • Q2MLE4
    • Q2MLF5
    • Q2MLG8
    • Q2MLJ6
    • Q2MLK4
    • Q2MLK6
    • Q2MLN7
    • Q6LET4
    • Q86XS0
    • Q86XS1
    • Q96KY8
    • Q96T64
    • Q96T65
    • Q9H220

    Protein attributes for NAT2 Gene

    Size:
    290 amino acids
    Molecular mass:
    33542 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAK51711.1; Type=Frameshift; Positions=287; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NAT2 Gene

neXtProt entry for NAT2 Gene

Proteomics data for NAT2 Gene at MOPED

Selected DME Specific Peptides for NAT2 Gene

Post-translational modifications for NAT2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NAT2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for NAT2 Gene

Protein Domains for NAT2 Gene

UniProtKB/Swiss-Prot:

ARY2_HUMAN
Family:
  • Belongs to the arylamine N-acetyltransferase family.:
    • P11245
genes like me logo Genes that share domains with NAT2: view

No data available for Gene Families for NAT2 Gene

Function for NAT2 Gene

Molecular function for NAT2 Gene

GENATLAS Biochemistry: arylamine N-acetyltransferase 2,polymorphic,responsible for slow or rapid acetylation of arylamine and hydrazine drugs,putative susceptibility factor in squamous-cell carcinoma of the esophagus,also involved in bladder carcinogenesis and breast cancer
UniProtKB/Swiss-Prot CatalyticActivity: Acetyl-CoA + an arylamine = CoA + an N-acetylarylamine
UniProtKB/Swiss-Prot Function: Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine substrates and is able to bioactivate several known carcinogens

Enzyme Numbers (IUBMB) for NAT2 Gene

Gene Ontology (GO) - Molecular Function for NAT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004060 arylamine N-acetyltransferase activity IEA --
GO:0005515 protein binding IPI 25640309
GO:0016407 acetyltransferase activity --
genes like me logo Genes that share ontologies with NAT2: view

Phenotypes for NAT2 Gene

MGI mutant phenotypes for NAT2:
inferred from 2 alleles
GenomeRNAi human phenotypes for NAT2:
genes like me logo Genes that share phenotypes with NAT2: view

Animal Models for NAT2 Gene

MGI Knock Outs for NAT2:

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for NAT2 Gene

Localization for NAT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NAT2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NAT2 Gene COMPARTMENTS Subcellular localization image for NAT2 gene
Compartment Confidence
cytosol 4
nucleus 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for NAT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with NAT2: view

Pathways for NAT2 Gene

genes like me logo Genes that share pathways with NAT2: view

Interacting Proteins for NAT2 Gene

Gene Ontology (GO) - Biological Process for NAT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006805 xenobiotic metabolic process TAS --
GO:0008152 metabolic process --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with NAT2: view

Compounds for NAT2 Gene

(7) HMDB Compounds for NAT2 Gene

Compound Synonyms Cas Number PubMed IDs
3-Aminosalicylic acid
  • 3-Amino Salicylate
570-23-0
5-Acetylamino-6-formylamino-3-methyluracil
Not Available
Acetyl-CoA
  • S-Acetyl coenzyme A
72-89-9
Aniline
  • Aminobenzene
62-53-3
Coenzyme A
  • Acetoacetyl coenzyme A sodium salt
85-61-0

(6) Drugbank Compounds for NAT2 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Acetaminophen
  • Acetaminofen
103-90-2 enzyme inhibitor
Clonazepam
  • Chlonazepam
1622-61-3 enzyme substrate
Dapsone
  • 1,1'-Sulfonylbis[4-aminobenzene]
80-08-0 enzyme substrate
Ezogabine
  • D-23129
150812-12-7 enzyme substrate
Isoniazid
  • HIA
54-85-3 enzyme substrate

(96) Novoseek inferred chemical compound relationships for NAT2 Gene

Compound -log(P) Hits PubMed IDs
arylamine 96.8 135
afmu 93.2 20
1-methylxanthine 89.6 17
n-acetylsulfapyridine 86.8 4
1,7-dimethyluric acid 85.4 4

(10) PharmGKB related drug/compound annotations for NAT2 Gene

genes like me logo Genes that share compounds with NAT2: view

Transcripts for NAT2 Gene

mRNA/cDNA for NAT2 Gene

Unigene Clusters for NAT2 Gene

N-acetyltransferase 2 (arylamine N-acetyltransferase):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NAT2 Gene

No ASD Table

Relevant External Links for NAT2 Gene

GeneLoc Exon Structure for
NAT2
ECgene alternative splicing isoforms for
NAT2

Expression for NAT2 Gene

mRNA expression in normal human tissues for NAT2 Gene

mRNA differential expression in normal tissues according to GTEx for NAT2 Gene

This gene is overexpressed in Liver (38.0) and Colon - Transverse (6.1).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for NAT2 Gene

SOURCE GeneReport for Unigene cluster for NAT2 Gene Hs.2

genes like me logo Genes that share expressions with NAT2: view

Orthologs for NAT2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NAT2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NAT2 36
  • 98.51 (n)
  • 96.55 (a)
NAT2 37
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NAT1 37
  • 76 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Nat1 36
  • 78.51 (n)
  • 71.72 (a)
Nat1 16
Nat1 37
  • 72 (a)
ManyToMany
Nat2 37
  • 75 (a)
ManyToMany
Nat3 37
  • 66 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 62 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 52 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Nat1 36
  • 79.08 (n)
  • 74.14 (a)
chicken
(Gallus gallus)
Aves NAT 37
  • 44 (a)
ManyToMany
PNAT10 37
  • 56 (a)
ManyToMany
PNAT3 37
  • 51 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 53 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii si:dkey-78a14.4 37
  • 40 (a)
ManyToMany
si:dkey-78a14.5 37
  • 39 (a)
ManyToMany
zgc:101040 37
  • 39 (a)
ManyToMany
zgc:103601 37
  • 39 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 29 (a)
ManyToMany
-- 37
  • 30 (a)
ManyToMany
-- 37
  • 26 (a)
ManyToMany
-- 37
  • 19 (a)
ManyToMany
CSA.3273 37
  • 22 (a)
ManyToMany
Species with no ortholog for NAT2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NAT2 Gene

ENSEMBL:
Gene Tree for NAT2 (if available)
TreeFam:
Gene Tree for NAT2 (if available)

Paralogs for NAT2 Gene

Paralogs for NAT2 Gene

Pseudogenes.org Pseudogenes for NAT2 Gene

genes like me logo Genes that share paralogs with NAT2: view

Variants for NAT2 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for NAT2 Gene

P11245-ARY2_HUMAN
Polymorphisms in NAT2 are the cause of slow and fast acetylation phenotypes [MIM:243400] and influence drug therapy response and susceptibility to chemical toxicity or carcinogenicity

Sequence variations from dbSNP and Humsavar for NAT2 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs1208 drug-response, - 18,400,806(+) GCTGA(A/G)AAATA missense, reference
rs2552 -- 18,401,024(+) GCATT(C/T)ATTAA utr-variant-3-prime
rs923796 -- 18,395,899(+) AAGAC(C/G)TAATA intron-variant
rs971473 -- 18,401,450(+) GGACA(C/T)GGGGT downstream-variant-500B
rs973874 -- 18,399,149(+) ACACT(C/T)GGGAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NAT2 Gene

Variant ID Type Subtype PubMed ID
nsv428196 CNV Gain 18775914
dgv7747n71 CNV Loss 21882294
nsv831252 CNV Gain 17160897
nsv890605 CNV Loss 21882294

Relevant External Links for NAT2 Gene

HapMap Linkage Disequilibrium report
NAT2
Human Gene Mutation Database (HGMD)
NAT2
Locus Specific Mutation Databases (LSDB)
NAT2

Disorders for NAT2 Gene

(1) OMIM Diseases for NAT2 Gene (612182)

(2) University of Copenhagen DISEASES for NAT2 Gene

(93) Novoseek inferred disease relationships for NAT2 Gene

Disease -log(P) Hits PubMed IDs
bladder cancer 74.9 152
genetic susceptibility 63.5 14
colorectal cancer 58.6 82
cancer 56.6 125
hepatitis toxic 55 2

Genatlas disease for NAT2 Gene

isoniazid inactivation

Relevant External Links for NAT2

Genetic Association Database (GAD)
NAT2
Human Genome Epidemiology (HuGE) Navigator
NAT2
genes like me logo Genes that share disorders with NAT2: view

No data available for UniProtKB/Swiss-Prot for NAT2 Gene

Publications for NAT2 Gene

  1. Sequences and expression of alleles of polymorphic arylamine N- acetyltransferase of human liver. (PMID: 1381364) Deguchi T. (J. Biol. Chem. 1992) 3 4 23
  2. Human arylamine N-acetyltransferase genes: isolation, chromosomal localization, and functional expression. (PMID: 2340091) Blum M. … Meyer U.A. (DNA Cell Biol. 1990) 3 4 23
  3. N-Acetyltransferase-2 genetic polymorphism, well-done meat intake, and breast cancer risk among postmenopausal women. (PMID: 11008907) Deitz A.C. … Hein D.W. (Cancer Epidemiol. Biomarkers Prev. 2000) 3 23 49
  4. N-acetyl transferase-2 and bladder cancer risk: a meta-analysis. (PMID: 11044903) Johns L.E. … Houlston R.S. (Environ. Mol. Mutagen. 2000) 3 23 49
  5. N-acetyltransferase 2 (NAT2) genotype and colorectal carcinoma: risk variability according to tumour site? (PMID: 11099063) AgA_ndez JAG . … BenA-tez J. (Scand. J. Gastroenterol. 2000) 3 23 49

Products for NAT2 Gene

  • Addgene plasmids for NAT2

Sources for NAT2 Gene

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