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Aliases for SLCO1B3 Gene

Aliases for SLCO1B3 Gene

  • Solute Carrier Organic Anion Transporter Family Member 1B3 2 3 5
  • Solute Carrier Family 21 (Organic Anion Transporter), Member 8 2 3
  • Solute Carrier Organic Anion Transporter Family, Member 1B3 2 3
  • Liver-Specific Organic Anion Transporter 2 3 4
  • Organic Anion-Transporting Polypeptide 8 3 4
  • Organic Anion Transporter 8 3 4
  • SLC21A8 3 4
  • OATP1B3 3 4
  • OATP-8 3 4
  • LST-2 3 4
  • OATP8 3 4
  • Liver-Specific Organic Anion Transporter 3TM13 3
  • Solute Carrier Family 21 Member 8 4
  • Organic Anion Transporter LST-3c 3
  • LST-3TM13 3
  • HBLRR 3
  • LST3 3
  • LST2 4

External Ids for SLCO1B3 Gene

Previous HGNC Symbols for SLCO1B3 Gene

  • SLC21A8

Previous GeneCards Identifiers for SLCO1B3 Gene

  • GC12P020859
  • GC12P020963

Summaries for SLCO1B3 Gene

Entrez Gene Summary for SLCO1B3 Gene

  • This gene encodes a liver-specific member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of endogenous and xenobiotic compounds and plays a critical role in bile acid and bilirubin transport. Mutations in this gene are a cause of Rotor type hyperbilirubinemia. [provided by RefSeq, Feb 2012]

GeneCards Summary for SLCO1B3 Gene

SLCO1B3 (Solute Carrier Organic Anion Transporter Family Member 1B3) is a Protein Coding gene. Diseases associated with SLCO1B3 include hyperbilirubinemia, rotor type, digenic and ascending colon cancer. Among its related pathways are Bile secretion and Statin Pathway - Generalized, Pharmacokinetics. GO annotations related to this gene include transporter activity and organic anion transmembrane transporter activity. An important paralog of this gene is SLCO1B7.

UniProtKB/Swiss-Prot for SLCO1B3 Gene

  • Mediates the Na(+)-independent uptake of organic anions such as 17-beta-glucuronosyl estradiol, taurocholate, triiodothyronine (T3), leukotriene C4, dehydroepiandrosterone sulfate (DHEAS), methotrexate and sulfobromophthalein (BSP). Involved in the clearance of bile acids and organic anions from the liver.

Gene Wiki entry for SLCO1B3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLCO1B3 Gene

Genomics for SLCO1B3 Gene

Regulatory Elements for SLCO1B3 Gene

Enhancers for SLCO1B3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SLCO1B3 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLCO1B3 Gene

Chromosome:
12
Start:
20,810,702 bp from pter
End:
20,916,911 bp from pter
Size:
106,210 bases
Orientation:
Plus strand

Genomic View for SLCO1B3 Gene

Genes around SLCO1B3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLCO1B3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLCO1B3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLCO1B3 Gene

Proteins for SLCO1B3 Gene

  • Protein details for SLCO1B3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NPD5-SO1B3_HUMAN
    Recommended name:
    Solute carrier organic anion transporter family member 1B3
    Protein Accession:
    Q9NPD5
    Secondary Accessions:
    • E7EMT8
    • Q5JAR4

    Protein attributes for SLCO1B3 Gene

    Size:
    702 amino acids
    Molecular mass:
    77403 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLCO1B3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLCO1B3 Gene

Proteomics data for SLCO1B3 Gene at MOPED

Post-translational modifications for SLCO1B3 Gene

  • N-glycosylated.
  • Glycosylation at Asn 134, Asn 145, Asn 151, Asn 445, Asn 503, and Asn 516
  • Modification sites at PhosphoSitePlus

Other Protein References for SLCO1B3 Gene

Antibody Products

No data available for DME Specific Peptides for SLCO1B3 Gene

Domains & Families for SLCO1B3 Gene

Gene Families for SLCO1B3 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NPD5

UniProtKB/Swiss-Prot:

SO1B3_HUMAN :
  • Contains 1 Kazal-like domain.
  • Belongs to the organo anion transporter (TC 2.A.60) family.
Domain:
  • Contains 1 Kazal-like domain.
Family:
  • Belongs to the organo anion transporter (TC 2.A.60) family.
genes like me logo Genes that share domains with SLCO1B3: view

Function for SLCO1B3 Gene

Molecular function for SLCO1B3 Gene

UniProtKB/Swiss-Prot Function:
Mediates the Na(+)-independent uptake of organic anions such as 17-beta-glucuronosyl estradiol, taurocholate, triiodothyronine (T3), leukotriene C4, dehydroepiandrosterone sulfate (DHEAS), methotrexate and sulfobromophthalein (BSP). Involved in the clearance of bile acids and organic anions from the liver.

Gene Ontology (GO) - Molecular Function for SLCO1B3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008514 organic anion transmembrane transporter activity TAS 10779507
GO:0015125 bile acid transmembrane transporter activity IBA,TAS --
genes like me logo Genes that share ontologies with SLCO1B3: view
genes like me logo Genes that share phenotypes with SLCO1B3: view

Human Phenotype Ontology for SLCO1B3 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for SLCO1B3 Gene

MGI Knock Outs for SLCO1B3:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for SLCO1B3 Gene

Localization for SLCO1B3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLCO1B3 Gene

Basolateral cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLCO1B3 Gene COMPARTMENTS Subcellular localization image for SLCO1B3 gene
Compartment Confidence
plasma membrane 5
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SLCO1B3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with SLCO1B3: view

Pathways & Interactions for SLCO1B3 Gene

genes like me logo Genes that share pathways with SLCO1B3: view

Interacting Proteins for SLCO1B3 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000261196%0d%0a9606.ENSP00000285238%0d%0a9606.ENSP00000377549%0d%0a9606.ENSP00000295897%0d%0a
Selected Interacting proteins: ENSP00000261196 for SLCO1B3 Gene via STRING

Gene Ontology (GO) - Biological Process for SLCO1B3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008206 bile acid metabolic process IBA,TAS --
GO:0055085 transmembrane transport TAS --
genes like me logo Genes that share ontologies with SLCO1B3: view

No data available for SIGNOR curated interactions for SLCO1B3 Gene

Drugs & Compounds for SLCO1B3 Gene

(55) Drugs for SLCO1B3 Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, FDA Approved Drugs, IUPHAR, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Rifampicin Approved Pharma Agonist, binder, Target, Transporter, substrate, inhibitor Pregnane X receptor agonist; antibiotic 324
Docetaxel Approved May 1996, Investigational Pharma Transporter, substrate Microtubulin disassembly inhibitor, Tubulin and VEGF inhibitor, Taxanes 1859
Dabrafenib Approved Pharma Transporter, inhibitor BRAF kinase inhibitor, Kinase Inhibitors, Mutant BRAF Kinase 70
Mycophenolate mofetil Approved, Investigational Pharma Transporter, substrate IMPDH inhibitor 906
Paclitaxel Approved Pharma Transporter, substrate Tubulin and Bcl2 inhibitor, Taxanes 2655

(85) Additional Compounds for SLCO1B3 Gene - From: HMDB, Novoseek, and IUPHAR

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[<sup>3</sup>H]estradiol-17beta-glucuronide
(3a,5b,7a)-23-Carboxy-7-hydroxy-24-norcholan-3-yl-b-D-Glucopyranosiduronic acid
  • Chenodeoxycholic acid 3-glucuronide
  • Chenodeoxycholic acid-3-b-D-glucuronide
  • Chenodeoxycholic acid-3-beta-delta-glucuronide
58814-71-4
1,3,12-Trihydroxycholan-24-oic acid
  • 1,3,12-Trihydroxy-5b-Cholanoate
  • 1,3,12-Trihydroxy-5b-Cholanoic acid
  • 1,3,12-Trihydroxy-Cholan-24-oate
  • 1,3,12-Trihydroxy-Cholan-24-oic acid
  • 1,3,12-Trihydroxycholan-24-oate
63266-91-1
1,3,7,12-Tetrahydroxycholan-24-oic acid
  • 1,3,7,12-Tetrahydroxy-Cholan-24-oate
  • 1,3,7,12-Tetrahydroxy-Cholan-24-oic acid
  • 1,3,7,12-Tetrahydroxycholan-24-oate
  • 1,3,7,12-Tetrahydroxycholan-24-oic acid
  • 1,3,7,12-Tetrahydroxycholanoate
63266-89-7
12a-Hydroxy-3-oxocholadienic acid
  • 12a-Hydroxy-3-oxo-4,6-choladien-24-oate
  • 12a-Hydroxy-3-oxo-4,6-choladien-24-oic acid
  • 12a-Hydroxy-3-oxo-Chola-4,6-dienate
  • 12a-Hydroxy-3-oxo-Chola-4,6-dienic acid
  • 12a-Hydroxy-3-oxochola-4,6-dienate
13535-96-1

(1) ApexBio Compounds for SLCO1B3 Gene

Compound Action Cas Number
Probenecid 57-66-9
genes like me logo Genes that share compounds with SLCO1B3: view

Transcripts for SLCO1B3 Gene

Unigene Clusters for SLCO1B3 Gene

Solute carrier organic anion transporter family, member 1B3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLCO1B3 Gene

No ASD Table

Relevant External Links for SLCO1B3 Gene

GeneLoc Exon Structure for
SLCO1B3
ECgene alternative splicing isoforms for
SLCO1B3

Expression for SLCO1B3 Gene

mRNA expression in normal human tissues for SLCO1B3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLCO1B3 Gene

This gene is overexpressed in Liver (x47.0).

Protein differential expression in normal tissues from HIPED for SLCO1B3 Gene

This gene is overexpressed in Gallbladder (33.5) and Liver (31.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLCO1B3 Gene



SOURCE GeneReport for Unigene cluster for SLCO1B3 Gene Hs.504966

mRNA Expression by UniProt/SwissProt for SLCO1B3 Gene

Q9NPD5-SO1B3_HUMAN
Tissue specificity: Highly expressed in liver, in particular at the basolateral membrane of hepatocytes near the central vein. Not detected in other tissues. Highly expressed in some cancer cell lines derived from colon, pancreas, liver and gall bladder.
genes like me logo Genes that share expression patterns with SLCO1B3: view

Protein tissue co-expression partners for SLCO1B3 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for SLCO1B3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SLCO1B3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLCO1B3 35
  • 80.9 (n)
  • 71.49 (a)
-- 36
  • 70 (a)
OneToMany
dog
(Canis familiaris)
Mammalia SLCO1B3 35
  • 81.88 (n)
  • 71.59 (a)
OATPC 36
  • 71 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Slco1b2 35
  • 75.88 (n)
  • 67.11 (a)
Slco1b2 16
Slco1b2 36
  • 66 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Slco1b2 35
  • 75.46 (n)
  • 65.4 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 51 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 61 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 36
  • 39 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 36 (a)
OneToMany
Species with no ortholog for SLCO1B3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SLCO1B3 Gene

ENSEMBL:
Gene Tree for SLCO1B3 (if available)
TreeFam:
Gene Tree for SLCO1B3 (if available)

Paralogs for SLCO1B3 Gene

genes like me logo Genes that share paralogs with SLCO1B3: view

Variants for SLCO1B3 Gene

Sequence variations from dbSNP and Humsavar for SLCO1B3 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs4149117 - 20,858,546(+) TGACA(G/T)CTTTA reference, missense
VAR_036410 A colorectal cancer sample
VAR_036411 A colorectal cancer sample
rs7311358 - 20,862,826(+) AAAAT(A/G)TACGT reference, missense
rs12299012 - 20,883,599(+) GACTG(C/T)GAAGT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for SLCO1B3 Gene

Variant ID Type Subtype PubMed ID
esv24973 CNV Gain 19812545
dgv481e1 CNV Complex 17122850
nsv428275 CNV Gain 18775914
nsv483093 CNV Loss 15286789
nsv898859 CNV Gain 21882294
nsv898860 CNV Loss 21882294
esv2750761 CNV Loss 17666407
dgv4e24 CNV Loss 17666407
dgv276n67 CNV Gain 20364138
nsv509459 CNV Insertion 20534489
dgv1387n71 CNV Loss 21882294
nsv898865 CNV Loss 21882294
nsv898866 CNV Loss 21882294
nsv898867 CNV Gain+Loss 21882294
nsv898868 CNV Loss 21882294
esv2672824 CNV Deletion 23128226
nsv898869 CNV Loss 21882294
nsv898870 CNV Gain+Loss 21882294
nsv898871 CNV Gain 21882294
nsv898872 CNV Loss 21882294
esv271083 CNV Insertion 20981092
dgv1388n71 CNV Gain+Loss 21882294
nsv898874 CNV Loss 21882294
nsv898875 CNV Loss 21882294
esv2663290 CNV Deletion 23128226
nsv515735 CNV Gain+Loss 19592680
esv2666827 CNV Deletion 23128226
nsv8927 CNV Gain 18304495
nsv8928 CNV Loss 18304495
nsv636 CNV Insertion 18451855
nsv898877 CNV Loss 21882294
nsv438195 CNV Loss 16468122

Variation tolerance for SLCO1B3 Gene

Residual Variation Intolerance Score: 71.4% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLCO1B3 Gene

HapMap Linkage Disequilibrium report
SLCO1B3
Human Gene Mutation Database (HGMD)
SLCO1B3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLCO1B3 Gene

Disorders for SLCO1B3 Gene

MalaCards: The human disease database

(4) MalaCards diseases for SLCO1B3 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
hyperbilirubinemia, rotor type, digenic
  • rotor syndrome
ascending colon cancer
  • ca ascending colon
recessive dystrophic epidermolysis bullosa
  • rdeb
intrahepatic cholestasis
  • intrahepatic cholestasis of pregnancy
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

SO1B3_HUMAN
  • Hyperbilirubinemia, Rotor type (HBLRR) [MIM:237450]: An autosomal recessive form of primary conjugated hyperbilirubinemia. Affected individuals develop mild jaundice not associated with hemolysis shortly after birth or in childhood. They have delayed plasma clearance of the unconjugated anionic dye bromsulphthalein and prominent urinary excretion of coproporphyrin I. Hepatic pigmentation is normal. {ECO:0000269 PubMed:22232210}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for SLCO1B3

Genetic Association Database (GAD)
SLCO1B3
Human Genome Epidemiology (HuGE) Navigator
SLCO1B3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLCO1B3
genes like me logo Genes that share disorders with SLCO1B3: view

No data available for Genatlas for SLCO1B3 Gene

Publications for SLCO1B3 Gene

  1. LST-2, a human liver-specific organic anion transporter, determines methotrexate sensitivity in gastrointestinal cancers. (PMID: 11375950) Abe T. … Matsuno S. (Gastroenterology 2001) 3 4 23 25 26 67
  2. OATP1B1, OATP1B3, and mrp2 are involved in hepatobiliary transport of olmesartan, a novel angiotensin II blocker. (PMID: 16501004) Nakagomi-Hagihara R. … Ikeda T. (Drug Metab. Dispos. 2006) 23 25 26
  3. Contribution of OATP2 (OATP1B1) and OATP8 (OATP1B3) to the hepatic uptake of pitavastatin in humans. (PMID: 15159445) Hirano M. … Sugiyama Y. (J. Pharmacol. Exp. Ther. 2004) 3 23 25
  4. Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver. (PMID: 11159893) Kullak-Ublick G.A. … Hagenbuch B. (Gastroenterology 2001) 3 25 26
  5. Vectorial transport by double-transfected cells expressing the human uptake transporter SLC21A8 and the apical export pump ABCC2. (PMID: 11641421) Cui Y. … Keppler D. (Mol. Pharmacol. 2001) 23 25 26

Products for SLCO1B3 Gene

Sources for SLCO1B3 Gene

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