Aliases for DARS2 Gene
External Ids for DARS2 Gene
The protein encoded by this gene belongs to the class-II aminoacyl-tRNA synthetase family. It is a mitochondrial enzyme that specifically aminoacylates aspartyl-tRNA. Mutations in this gene are associated with leukoencephalopathy with brainstem and spinal cord involvement and lactate elevation (LBSL). [provided by RefSeq, Nov 2009]
GeneCards Summary for DARS2 Gene
DARS2 (Aspartyl-TRNA Synthetase 2, Mitochondrial) is a Protein Coding gene. Diseases associated with DARS2 include leukoencephalopathy with brain stem and spinal cord involvement and lactate elevation and leukoencephalopathy with brain stem and spinal cord involvement - high lactate. Among its related pathways are Gene Expression and tRNA Aminoacylation. GO annotations related to this gene include protein homodimerization activity and aspartate-tRNA ligase activity.