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Aliases for STK11 Gene

Aliases for STK11 Gene

  • Serine/Threonine Kinase 11 2 3
  • LKB1 3 4 6
  • PJS 3 4 6
  • Polarization-Related Protein LKB1 2 3
  • Renal Carcinoma Antigen NY-REN-19 3 4
  • Liver Kinase B1 3 4
  • EC 2.7.11.1 4 63
  • HLKB1 3 4
  • Serine/Threonine Kinase 11 (Peutz-Jeghers Syndrome) 2
  • Serine/Threonine-Protein Kinase STK11 3
  • Serine/Threonine-Protein Kinase LKB1 3
  • Serine/Threonine-Protein Kinase 11 3

External Ids for STK11 Gene

Previous GeneCards Identifiers for STK11 Gene

  • GC19P001264
  • GC19P001117
  • GC19P001157
  • GC19P001156
  • GC19P000982

Summaries for STK11 Gene

Entrez Gene Summary for STK11 Gene

  • This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in this gene have been associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for STK11 Gene

STK11 (Serine/Threonine Kinase 11) is a Protein Coding gene. Diseases associated with STK11 include peutz-jeghers syndrome and intussusception. Among its related pathways are PI3K-Akt signaling pathway and Signaling by GPCR. GO annotations related to this gene include identical protein binding and magnesium ion binding. An important paralog of this gene is CAMKK2.

UniProtKB/Swiss-Prot for STK11 Gene

  • Tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. Acts by phosphorylating the T-loop of AMPK family proteins, thus promoting their activity: phosphorylates PRKAA1, PRKAA2, BRSK1, BRSK2, MARK1, MARK2, MARK3, MARK4, NUAK1, NUAK2, SIK1, SIK2, SIK3 and SNRK but not MELK. Also phosphorylates non-AMPK family proteins such as STRADA, PTEN and possibly p53/TP53. Acts as a key upstream regulator of AMPK by mediating phosphorylation and activation of AMPK catalytic subunits PRKAA1 and PRKAA2 and thereby regulates processes including: inhibition of signaling pathways that promote cell growth and proliferation when energy levels are low, glucose homeostasis in liver, activation of autophagy when cells undergo nutrient deprivation, and B-cell differentiation in the germinal center in response to DNA damage. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton. Required for cortical neuron polarization by mediating phosphorylation and activation of BRSK1 and BRSK2, leading to axon initiation and specification. Involved in DNA damage response: interacts with p53/TP53 and recruited to the CDKN1A/WAF1 promoter to participate in transcription activation. Able to phosphorylate p53/TP53; the relevance of such result in vivo is however unclear and phosphorylation may be indirect and mediated by downstream STK11/LKB1 kinase NUAK1. Also acts as a mediator of p53/TP53-dependent apoptosis via interaction with p53/TP53: translocates to the mitochondrion during apoptosis and regulates p53/TP53-dependent apoptosis pathways. In vein endothelial cells, inhibits PI3K/Akt signaling activity and thus induces apoptosis in response to the oxidant peroxynitrite (in vitro). Regulates UV radiation-induced DNA damage response mediated by CDKN1A. In association with NUAK1, phosphorylates CDKN1A in response to UV radiation and contributes to its degradation which is necessary for optimal DNA repair (PubMed:25329316).

  • Isoform 2: Has a role in spermiogenesis.

Gene Wiki entry for STK11 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STK11 Gene

Genomics for STK11 Gene

Regulatory Elements for STK11 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for STK11 Gene

Start:
1,177,558 bp from pter
End:
1,228,435 bp from pter
Size:
50,878 bases
Orientation:
Plus strand

Genomic View for STK11 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for STK11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STK11 Gene

Proteins for STK11 Gene

  • Protein details for STK11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15831-STK11_HUMAN
    Recommended name:
    Serine/threonine-protein kinase STK11
    Protein Accession:
    Q15831
    Secondary Accessions:
    • B2RBX7
    • E7EW76

    Protein attributes for STK11 Gene

    Size:
    433 amino acids
    Molecular mass:
    48636 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    • Catalytic component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity. Found in a ternary complex composed of SMAD4, STK11/LKB1 and STK11IP. Interacts with p53/TP53, SMAD4, STK11IP and WDR6. Interacts with NR4A1. Interacts with NISCH; this interaction may increase STK11 activity. Interacts with PTEN; leading to PTEN phosphorylation. Interacts with SIRT1; the interaction deacetylates STK11. Interacts with CDKN1A.

    Three dimensional structures from OCA and Proteopedia for STK11 Gene

    Alternative splice isoforms for STK11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STK11 Gene

Proteomics data for STK11 Gene at MOPED

Post-translational modifications for STK11 Gene

  • Acetylated. Deacetylation at Lys-48 enhances cytoplasmic localization and kinase activity in vitro.
  • Phosphorylated by ATM at Thr-363 following ionizing radiation (IR). Phosphorylation at Ser-428 by RPS6KA1 and/or some PKA is required to inhibit cell growth. Phosphorylation at Ser-428 is also required during neuronal polarization to mediate phosphorylation of BRSK1 and BRSK2 (By similarity). Phosphorylation by PKC/PRKCZ at Ser-428 promotes peroxynitrite-induced nuclear export of STK11, leading to PTEN activation and subsequent inhibition of AKT signaling. Phosphorylation by PKC/PRKCZ at Ser-399 in isoform 2 promotes metformin (or peroxynitrite)-induced nuclear export of STK11 and activation of AMPK. UV radiation-induced phosphorylation at Thr-363 mediates CDKN1A degradation (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for STK11 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for STK11 (LKB1)

Domains for STK11 Gene

Gene Families for STK11 Gene

Graphical View of Domain Structure for InterPro Entry

Q15831

UniProtKB/Swiss-Prot:

STK11_HUMAN :
  • Q15831
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. LKB1 subfamily.
genes like me logo Genes that share domains with STK11: view

Function for STK11 Gene

Molecular function for STK11 Gene

GENATLAS Biochemistry: serine/threonine kinase 11,with two alternatively spliced isoforms,expressed in all tissues,strongly homolog of Xenopus early embryonic kinase 1 (XEEK1),tumor suppressor gene in hamartomas syndrome and in left sided colon carcinogenesis,mutated in sporadic testicular cancer,malignant melanomas and laryngeal tumors,playing a minor role in the development of ovarian carcinoma
UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation: Activated by forming a complex with STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): STRADA (or STRADB)-binding promotes a conformational change of STK11/LKB1 in an active conformation, which is stabilized by CAB39/MO25alpha (or CAB39L/MO25beta) interacting with the STK11/LKB1 activation loop. Sequestration in the nucleus by NR4A1 prevents it from phosphorylating and activating cytoplasmic AMPK.
UniProtKB/Swiss-Prot Function: Tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. Acts by phosphorylating the T-loop of AMPK family proteins, thus promoting their activity: phosphorylates PRKAA1, PRKAA2, BRSK1, BRSK2, MARK1, MARK2, MARK3, MARK4, NUAK1, NUAK2, SIK1, SIK2, SIK3 and SNRK but not MELK. Also phosphorylates non-AMPK family proteins such as STRADA, PTEN and possibly p53/TP53. Acts as a key upstream regulator of AMPK by mediating phosphorylation and activation of AMPK catalytic subunits PRKAA1 and PRKAA2 and thereby regulates processes including: inhibition of signaling pathways that promote cell growth and proliferation when energy levels are low, glucose homeostasis in liver, activation of autophagy when cells undergo nutrient deprivation, and B-cell differentiation in the germinal center in response to DNA damage. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton. Required for cortical neuron polarization by mediating phosphorylation and activation of BRSK1 and BRSK2, leading to axon initiation and specification. Involved in DNA damage response: interacts with p53/TP53 and recruited to the CDKN1A/WAF1 promoter to participate in transcription activation. Able to phosphorylate p53/TP53; the relevance of such result in vivo is however unclear and phosphorylation may be indirect and mediated by downstream STK11/LKB1 kinase NUAK1. Also acts as a mediator of p53/TP53-dependent apoptosis via interaction with p53/TP53: translocates to the mitochondrion during apoptosis and regulates p53/TP53-dependent apoptosis pathways. In vein endothelial cells, inhibits PI3K/Akt signaling activity and thus induces apoptosis in response to the oxidant peroxynitrite (in vitro). Regulates UV radiation-induced DNA damage response mediated by CDKN1A. In association with NUAK1, phosphorylates CDKN1A in response to UV radiation and contributes to its degradation which is necessary for optimal DNA repair (PubMed:25329316).
UniProtKB/Swiss-Prot Function: Isoform 2: Has a role in spermiogenesis.

Enzyme Numbers (IUBMB) for STK11 Gene

Gene Ontology (GO) - Molecular Function for STK11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IDA 12805220
GO:0002039 p53 binding IDA 11430832
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity TAS --
GO:0004713 protein tyrosine kinase activity --
genes like me logo Genes that share ontologies with STK11: view
genes like me logo Genes that share phenotypes with STK11: view

Animal Models for STK11 Gene

MGI Knock Outs for STK11:

Animal Model Products

CRISPR Products

miRNA for STK11 Gene

miRTarBase miRNAs that target STK11

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for STK11

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for STK11 Gene

Localization for STK11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STK11 Gene

Nucleus. Cytoplasm. Membrane. Mitochondrion. Note=A small fraction localizes at membranes (By similarity). Relocates to the cytoplasm when bound to STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta). Translocates to the mitochondrion during apoptosis. Translocates to the cytoplasm in response to metformin or peroxynitrite treatment. PTEN promotes cytoplasmic localization. {ECO:0000250}.
Isoform 2: Nucleus. Cytoplasm. Note=Predominantly nuclear, but translocates to the cytoplasm in response to metformin or peroxynitrite treatment.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STK11 Gene COMPARTMENTS Subcellular localization image for STK11 gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 4
cytoskeleton 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for STK11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005737 cytoplasm IDA 11430832
GO:0005739 mitochondrion IDA 11430832
GO:0005829 cytosol TAS --
GO:0016020 membrane ISS --
genes like me logo Genes that share ontologies with STK11: view

Pathways for STK11 Gene

genes like me logo Genes that share pathways with STK11: view

PCR Array Products

Gene Ontology (GO) - Biological Process for STK11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001558 regulation of cell growth ISS --
GO:0001894 tissue homeostasis IEA --
GO:0001944 vasculature development ISS --
GO:0006112 energy reserve metabolic process TAS --
GO:0006468 protein phosphorylation IDA 12805220
genes like me logo Genes that share ontologies with STK11: view

Compounds for STK11 Gene

(5) HMDB Compounds for STK11 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Cyclic AMP
  • Cyclic AMP
60-92-4
Magnesium
  • Magnesium
7439-95-4
Manganese
  • manganese
7439-96-5

(23) Novoseek inferred chemical compound relationships for STK11 Gene

Compound -log(P) Hits PubMed IDs
threonine 77.5 58
phenformin 73.8 2
serine 67.5 56
rapamycin 67.4 8
acadesine 59.2 2
genes like me logo Genes that share compounds with STK11: view

Transcripts for STK11 Gene

Unigene Clusters for STK11 Gene

Serine/threonine kinase 11:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for STK11

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for STK11 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b
SP1: -
SP2: -
SP3:
SP4:
SP5: -
SP6: - - - -

Relevant External Links for STK11 Gene

GeneLoc Exon Structure for
STK11
ECgene alternative splicing isoforms for
STK11

Expression for STK11 Gene

mRNA expression in normal human tissues for STK11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for STK11 Gene

SOURCE GeneReport for Unigene cluster for STK11 Gene Hs.515005

mRNA Expression by UniProt/SwissProt for STK11 Gene

Q15831-STK11_HUMAN
Tissue specificity: Ubiquitously expressed. Strongest expression in testis and fetal liver
genes like me logo Genes that share expressions with STK11: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for STK11 Gene

Orthologs for STK11 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for STK11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STK11 35
  • 99.23 (n)
  • 99.31 (a)
STK11 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia STK11 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia STK11 35
  • 89.61 (n)
  • 93.53 (a)
STK11 36
  • 70 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Stk11 35
  • 85.23 (n)
  • 90.95 (a)
Stk11 16
Stk11 36
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia STK11 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia STK11 36
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Stk11 35
  • 85.54 (n)
  • 91.42 (a)
chicken
(Gallus gallus)
Aves STK11 35
  • 80.22 (n)
  • 90.53 (a)
lizard
(Anolis carolinensis)
Reptilia STK11 36
  • 76 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia XEEK1 35
tropical clawed frog
(Silurana tropicalis)
Amphibia stk11 35
  • 73.89 (n)
  • 83.81 (a)
zebrafish
(Danio rerio)
Actinopterygii stk11 35
  • 77.96 (n)
  • 83.18 (a)
stk11 36
  • 80 (a)
OneToOne
wufj61a05 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003158 35
  • 64.31 (n)
  • 66.47 (a)
fruit fly
(Drosophila melanogaster)
Insecta lkb1 36
  • 38 (a)
OneToOne
lkb1 37
  • 61 (a)
worm
(Caenorhabditis elegans)
Secernentea par-4 35
  • 47.12 (n)
  • 42.9 (a)
par-4 36
  • 25 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SAK1 36
  • 10 (a)
ManyToMany
TOS3 36
  • 19 (a)
ManyToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11343 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 60 (a)
OneToOne
Species with no ortholog for STK11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STK11 Gene

ENSEMBL:
Gene Tree for STK11 (if available)
TreeFam:
Gene Tree for STK11 (if available)

Paralogs for STK11 Gene

Paralogs for STK11 Gene

Selected SIMAP similar genes for STK11 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with STK11: view

Variants for STK11 Gene

Sequence variations from dbSNP and Humsavar for STK11 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs741764 -- 1,221,485(-) CCTGC(A/G)GGGAG intron-variant
rs741765 -- 1,221,546(-) AGTTC(A/G)GAGGG intron-variant
rs1583299 -- 1,213,912(-) GATCA(C/T)ACAGG intron-variant
rs1978727 -- 1,208,400(-) aaccc(A/G)ggagg intron-variant
rs1978728 -- 1,208,290(-) CCCAG(A/G)GCCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STK11 Gene

Variant ID Type Subtype PubMed ID
nsv910292 CNV Loss 21882294
dgv3555n71 CNV Loss 21882294
nsv9662 CNV Gain 18304495
dgv1055e1 CNV Complex 17122850
dgv3575n71 CNV Loss 21882294
dgv3580n71 CNV Loss 21882294
nsv470103 CNV Gain 18288195
nsv910420 CNV Loss 21882294
dgv3583n71 CNV Loss 21882294
dgv3585n71 CNV Loss 21882294
dgv3586n71 CNV Loss 21882294
nsv470104 CNV Loss 18288195
dgv3587n71 CNV Loss 21882294
nsv910442 CNV Gain+Loss 21882294
dgv3588n71 CNV Loss 21882294
dgv3589n71 CNV Loss 21882294
esv2717833 CNV Deletion 23290073
dgv3590n71 CNV Loss 21882294
dgv3591n71 CNV Loss 21882294
esv2717834 CNV Deletion 23290073
dgv3592n71 CNV Loss 21882294
dgv3593n71 CNV Loss 21882294
nsv828368 CNV Gain 20364138
nsv910466 CNV Loss 21882294

Relevant External Links for STK11 Gene

HapMap Linkage Disequilibrium report
STK11
Human Gene Mutation Database (HGMD)
STK11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STK11 Gene

Disorders for STK11 Gene

(3) OMIM Diseases for STK11 Gene (602216)

UniProtKB/Swiss-Prot

STK11_HUMAN
  • Peutz-Jeghers syndrome (PJS) [MIM:175200]: An autosomal dominant disorder characterized by melanocytic macules of the lips, multiple gastrointestinal hamartomatous polyps and an increased risk for various neoplasms, including gastrointestinal cancer. {ECO:0000269 PubMed:10408777, ECO:0000269 PubMed:12372054, ECO:0000269 PubMed:21411391, ECO:0000269 PubMed:9425897, ECO:0000269 PubMed:9428765, ECO:0000269 PubMed:9760200, ECO:0000269 PubMed:9837816}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Testicular germ cell tumor (TGCT) [MIM:273300]: A common malignancy in males representing 95% of all testicular neoplasms. TGCTs have various pathologic subtypes including: unclassified intratubular germ cell neoplasia, seminoma (including cases with syncytiotrophoblastic cells), spermatocytic seminoma, embryonal carcinoma, yolk sac tumor, choriocarcinoma, and teratoma. {ECO:0000269 PubMed:9605748}. Note=The gene represented in this entry may be involved in disease pathogenesis.
  • Note=Defects in STK11 are associated with some sporadic cancers, especially lung cancers. Frequently mutated and inactivated in non-small cell lung cancer (NSCLC). Defects promote lung cancerigenesis process, especially lung cancer progression and metastasis. Confers lung adenocarcinoma the ability to trans-differentiate into squamous cell carcinoma. Also able to promotes lung cancer metastasis, via both cancer-cell autonomous and non-cancer-cell autonomous mechanisms.

(4) University of Copenhagen DISEASES for STK11 Gene

(58) Novoseek inferred disease relationships for STK11 Gene

Disease -log(P) Hits PubMed IDs
peutz-jeghers syndrome 98.3 126
polyposis 85.4 20
germ-line mutation 77.6 20
polyps 77.4 48
hamartoma 74.8 31

Relevant External Links for STK11

GeneTests
STK11
GeneReviews
STK11
Genetic Association Database (GAD)
STK11
Human Genome Epidemiology (HuGE) Navigator
STK11
genes like me logo Genes that share disorders with STK11: view

Publications for STK11 Gene

  1. Prevalence and specificity of LKB1 genetic alterations in lung cancers. (PMID: 17384680) Matsumoto S. … Yokota J. (Oncogene 2007) 3 4 23 48
  2. LKB1 gene mutations in Japanese lung cancer patients. (PMID: 17711506) Onozato R. … Mitsudomi T. (Cancer Sci. 2007) 3 4 23 48
  3. Mutations in the LKB1 tumour suppressor are frequently detected in tumours from Caucasian but not Asian lung cancer patients. (PMID: 18594528) Koivunen J.P. … Janne P.A. (Br. J. Cancer 2008) 3 4 23 48
  4. Is pharmacogenomics our future? Metformin, ovulation and polymorphism of the STK11 gene in polycystic ovary syndrome. (PMID: 18681789) Goldenberg N. … Glueck C.J. (Pharmacogenomics 2008) 3 23 48
  5. Protein kinase Czeta-dependent LKB1 serine 428 phosphorylation increases LKB1 nucleus export and apoptosis in endothelial cells. (PMID: 18321849) Song P. … Zou M.H. (J. Biol. Chem. 2008) 3 4 23

Products for STK11 Gene

  • Addgene plasmids for STK11

Sources for STK11 Gene

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