Free for academic non-profit institutions. Other users need a Commercial license

Aliases for GRIN2B Gene

Aliases for GRIN2B Gene

  • Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2B 2 3
  • NMDAR2B 3 4 6
  • Glutamate [NMDA] Receptor Subunit Epsilon-2 3 4
  • N-Methyl D-Aspartate Receptor Subtype 2B 3 4
  • N-Methyl-D-Aspartate Receptor Subunit 3 3 4
  • GluN2B 3 4
  • MRD6 3 6
  • NR2B 3 4
  • HNR3 3 4
  • NR3 3 4
  • Glutamate Receptor Ionotropic, NMDA 2B 3
  • Glutamate Receptor Subunit Epsilon-2 3
  • EIEE27 3

External Ids for GRIN2B Gene

Previous Symbols for GRIN2B Gene

  • NMDAR2B

Summaries for GRIN2B Gene

Entrez Gene Summary for GRIN2B Gene

  • N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of three different subunits: NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The NR2 subunit acts as the agonist binding site for glutamate. This receptor is the predominant excitatory neurotransmitter receptor in the mammalian brain. [provided by RefSeq, Jul 2008]

GeneCards Summary for GRIN2B Gene

GRIN2B (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2B) is a Protein Coding gene. Diseases associated with GRIN2B include mental retardation, autosomal dominant 6 and epileptic encephalopathy, early infantile, 27. Among its related pathways are Ras signaling pathway and Ras signaling pathway. GO annotations related to this gene include calcium channel activity and glycine binding. An important paralog of this gene is GRIN2A.

UniProtKB/Swiss-Prot for GRIN2B Gene

  • NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death (By similarity).

Tocris Summary for GRIN2B Gene

  • NMDA receptors are members of the ionotropic class of glutamate receptors, which also includes Kainate and AMPA receptors. NMDA receptors consist of NR1 subunits combined with one or more NR2 (A-D) or NR3 (A-B) subunits. The ligand-gated channel is permeable to cations including Ca2+, and at resting membrane potentials NMDA receptors are inactive due to a voltage-dependent blockade of the channel pore by Mg2+. NMDA receptor activation, which requires binding of glutamate and glycine, leads to an influx of Ca2+ into the postsynaptic region where it activates several signaling cascades, including pathways leading to the induction of long-term potentiation (LTP) and depression (LTD). NMDA receptors have a critical role in excitatory synaptic transmission and plasticity in the CNS. They govern a range of physiological conditions including neurological disorders caused by excitotoxic neuronal injury, psychiatric disorders and neuropathic pain syndromes.

Gene Wiki entry for GRIN2B Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GRIN2B Gene

Genomics for GRIN2B Gene

Genomic Location for GRIN2B Gene

Start:
13,537,337 bp from pter
End:
13,980,119 bp from pter
Size:
442,783 bases
Orientation:
Minus strand

Genomic View for GRIN2B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GRIN2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GRIN2B Gene

Proteins for GRIN2B Gene

  • Protein details for GRIN2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13224-NMDE2_HUMAN
    Recommended name:
    Glutamate receptor ionotropic, NMDA 2B
    Protein Accession:
    Q13224
    Secondary Accessions:
    • Q12919
    • Q13220
    • Q13225
    • Q14CU4
    • Q9UM56

    Protein attributes for GRIN2B Gene

    Size:
    1484 amino acids
    Molecular mass:
    166367 Da
    Quaternary structure:
    • Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B). Found in a complex with GRIN1 and GRIN3B. Found in a complex with GRIN1, GRIN3A and PPP2CB. Interacts with PDZ domains of INADL and DLG4. Interacts with HIP1 and NETO1 (By similarity). Interacts with MAGI3. Interacts with DAPK1 (By similarity).

    Three dimensional structures from OCA and Proteopedia for GRIN2B Gene

neXtProt entry for GRIN2B Gene

Proteomics data for GRIN2B Gene at MOPED

Post-translational modifications for GRIN2B Gene

  • Phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity.
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn74, Asn341, Asn348, Asn444, Asn491, Asn542, and Asn688

Other Protein References for GRIN2B Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for GRIN2B Gene

Domains for GRIN2B Gene

Gene Families for GRIN2B Gene

HGNC:
  • GRI :Ligand-gated ion channels / Glutamate receptors, ionotropic
  • GR :Glutamate receptors
IUPHAR :

UniProtKB/Swiss-Prot:

NMDE2_HUMAN
Family:
  • Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR2B/GRIN2B subfamily.:
    • Q13224
genes like me logo Genes that share domains with GRIN2B: view

Function for GRIN2B Gene

Molecular function for GRIN2B Gene

GENATLAS Biochemistry: N-methyl D-aspartate receptor 2,epsilon 2 subunit glutamate receptor,expressed in hippocampal pyramidal cells,neocortex and basal ganglia,involved in excitatory neurotransmission,in neuronal cell death and in the epileptic hyperexcitability of dysplastic cortical regions,playing a central role in verbal memory and cognitive function
UniProtKB/Swiss-Prot Function: NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death (By similarity).

Gene Ontology (GO) - Molecular Function for GRIN2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004970 ionotropic glutamate receptor activity --
GO:0004972 N-methyl-D-aspartate selective glutamate receptor activity IBA --
GO:0005234 extracellular-glutamate-gated ion channel activity IBA --
GO:0005261 cation channel activity --
GO:0005262 calcium channel activity IEA --
genes like me logo Genes that share ontologies with GRIN2B: view
genes like me logo Genes that share phenotypes with GRIN2B: view

Animal Models for GRIN2B Gene

MGI Knock Outs for GRIN2B:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for GRIN2B Gene

Localization for GRIN2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for GRIN2B Gene

Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GRIN2B Gene COMPARTMENTS Subcellular localization image for GRIN2B gene
Compartment Confidence
plasma membrane 5
cytoskeleton 3
extracellular 2
nucleus 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for GRIN2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8768735
GO:0008021 synaptic vesicle IEA --
GO:0009986 cell surface ISS --
GO:0014069 postsynaptic density --
genes like me logo Genes that share ontologies with GRIN2B: view

Pathways for GRIN2B Gene

genes like me logo Genes that share pathways with GRIN2B: view

Gene Ontology (GO) - Biological Process for GRIN2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001662 behavioral fear response IEA --
GO:0001701 in utero embryonic development IEA --
GO:0001964 startle response IEA --
GO:0001967 suckling behavior IEA --
GO:0006810 transport TAS 8768735
genes like me logo Genes that share ontologies with GRIN2B: view

Compounds for GRIN2B Gene

(5) Tocris Compounds for GRIN2B Gene

Compound Action Cas Number
(+)-MK 801 maleate Non-competitive NMDA antagonist, acts at ion channel site [77086-22-7]
D-AP5 Potent, selective NMDA antagonist. More active form of DL-AP5 (Cat. No. 0105) [79055-68-8]
DL-AP5 Potent, selective NMDA antagonist [76326-31-3]
DL-AP5 Sodium salt Sodium salt of DL-AP5 (Cat. No. 0105) [1303993-72-7]
QNZ 46 NR2C/NR2D-selective NMDA receptor non-competitive antagonist [1237744-13-6]

(4) HMDB Compounds for GRIN2B Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
L-Glutamic acid
  • (2S)-2-Aminopentanedioate
56-86-0
Loperamide
  • Apo-Loperamide
53179-11-6
Magnesium
  • Magnesium
7439-95-4

(6) Drugbank Compounds for GRIN2B Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Felbamate
25451-15-4 target antagonist
Haloperidol
52-86-8 target antagonist
L-Glutamic Acid
  • (2S)-2-Aminopentanedioic acid
56-86-0 target
Memantine
  • Memantina [INN-Spanish]
19982-08-2 target antagonist
Meperidine
57-42-1 target antagonist

(35) IUPHAR Ligand for GRIN2B Gene

Ligand Type Action Affinity Pubmed IDs
5,7-dichlorokynurenic acid Antagonist Antagonist 3.7
phencyclidine Channel blocker None
[3H]CGP39653 None None
LY233053 Antagonist Antagonist
D-aspartate Agonist Agonist
L701324 Antagonist Antagonist
glycine Agonist Agonist
Mg2+ Antagonist Antagonist
MK-801 Channel blocker None
CGP37849 Antagonist Antagonist
[3H]glycine None None
d-AP5 Antagonist Antagonist
(RS)-(tetrazol-5-yl)glycine Agonist Full agonist
[3H]CGS19755 None None
[3H]CGP61594 None None
[3H]CPP None None
L-aspartate Agonist Agonist
ketamine Channel blocker None
conantokin-G Antagonist Antagonist
CGS19755 Antagonist Antagonist
NVP-AAM077 Antagonist Antagonist
d-CCPene Antagonist Antagonist
D-serine Agonist Agonist
UBP141 Antagonist Antagonist
[3H]MDL105519 None None
homoquinolinic acid Agonist Full agonist
(+)-HA966 Agonist Partial agonist
L689560 Antagonist Antagonist
memantine Channel blocker None
N1-dansyl-spermine Channel blocker None
amantidine Channel blocker None
NMDA Agonist Full agonist
[3H]L689560 None None
[3H]MK-801 None None
GV196771A Antagonist Antagonist

(17) Novoseek inferred chemical compound relationships for GRIN2B Gene

Compound -log(P) Hits PubMed IDs
nmda 89.8 137
glutamate 72.2 26
ifenprodil 69 4
kainate 56.3 3
tyrosine 37.8 32

(2) PharmGKB related drug/compound annotations for GRIN2B Gene

Drug/compound Annotation
quetiapine CA
risperidone CA
genes like me logo Genes that share compounds with GRIN2B: view

Transcripts for GRIN2B Gene

mRNA/cDNA for GRIN2B Gene

(5) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(14) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GRIN2B Gene

Glutamate receptor, ionotropic, N-methyl D-aspartate 2B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GRIN2B Gene

No ASD Table

Relevant External Links for GRIN2B Gene

GeneLoc Exon Structure for
GRIN2B
ECgene alternative splicing isoforms for
GRIN2B

Expression for GRIN2B Gene

mRNA expression in normal human tissues for GRIN2B Gene

mRNA differential expression in normal tissues according to GTEx for GRIN2B Gene

This gene is overexpressed in Brain - Hippocampus (5.9), Brain - Cortex (5.5), Brain - Anterior cingulate cortex (BA24) (5.4), Testis (5.2), Brain - Nucleus accumbens (basal ganglia) (5.2), Brain - Frontal Cortex (BA9) (5.0), Brain - Putamen (basal ganglia) (4.8), and Brain - Caudate (basal ganglia) (4.2).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for GRIN2B Gene

SOURCE GeneReport for Unigene cluster for GRIN2B Gene Hs.654430

mRNA Expression by UniProt/SwissProt for GRIN2B Gene

Q13224-NMDE2_HUMAN
Tissue specificity: Primarily found in the fronto-parieto-temporal cortex and hippocampus pyramidal cells, lower expression in the basal ganglia.
genes like me logo Genes that share expressions with GRIN2B: view

Orthologs for GRIN2B Gene

This gene was present in the common ancestor of animals.

Orthologs for GRIN2B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GRIN2B 36
  • 99.66 (n)
  • 99.93 (a)
GRIN2B 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GRIN2B 36
  • 90.33 (n)
  • 96.22 (a)
GRIN2B 37
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GRIN2B 36
  • 94.07 (n)
  • 98.38 (a)
GRIN2B 37
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Grin2b 36
  • 91.48 (n)
  • 98.65 (a)
Grin2b 16
Grin2b 37
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 89 (a)
OneToMany
-- 37
  • 96 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia GRIN2B 37
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Grin2b 36
  • 91.36 (n)
  • 98.65 (a)
chicken
(Gallus gallus)
Aves GRIN2B 36
  • 86.1 (n)
  • 94.07 (a)
GRIN2B 37
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GRIN2B 37
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia grin2b 36
  • 75.32 (n)
  • 86.04 (a)
zebrafish
(Danio rerio)
Actinopterygii grin2db 37
  • 27 (a)
ManyToMany
LOC100334883 36
  • 70.32 (n)
  • 74.83 (a)
fruit fly
(Drosophila melanogaster)
Insecta Nmdar2 38
  • 32 (a)
Species with no ortholog for GRIN2B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GRIN2B Gene

ENSEMBL:
Gene Tree for GRIN2B (if available)
TreeFam:
Gene Tree for GRIN2B (if available)

Paralogs for GRIN2B Gene

Paralogs for GRIN2B Gene

Selected SIMAP similar genes for GRIN2B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GRIN2B: view

Variants for GRIN2B Gene

Sequence variations from dbSNP and Humsavar for GRIN2B Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs890 -- 13,562,374(-) CAAAC(G/T)GATCT utr-variant-3-prime
rs25562 -- 13,570,536(-) CCACC(-/CTGCCACC)ACCTC intron-variant
rs52135 -- 13,798,350(-) TCATA(A/C)TTGAA intron-variant
rs124626 -- 13,933,790(+) GGTGT(A/G)GAGCT intron-variant
rs141658 -- 13,805,210(-) TTCTG(C/T)GCTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GRIN2B Gene

Variant ID Type Subtype PubMed ID
esv2668471 CNV Deletion 23128226
nsv826262 CNV Loss 20364138
nsv518482 CNV Loss 19592680
esv2658763 CNV Deletion 23128226
nsv470268 CNV Gain 18288195
esv2745573 CNV Deletion 23290073
esv2745575 CNV Deletion 23290073
esv4674 CNV Deletion 18987735
esv2676271 CNV Deletion 23128226
esv1197500 CNV Deletion 17803354
esv2745576 CNV Deletion 23290073
esv2745577 CNV Deletion 23290073
nsv524950 CNV Loss 19592680
esv2670197 CNV Deletion 23128226
esv992165 CNV Loss 20482838
esv2745578 CNV Deletion 23290073
nsv832334 CNV Gain 17160897
esv2666327 CNV Deletion 23128226
esv275049 CNV Gain+Loss 21479260

Relevant External Links for GRIN2B Gene

HapMap Linkage Disequilibrium report
GRIN2B
Human Gene Mutation Database (HGMD)
GRIN2B

Disorders for GRIN2B Gene

(1) OMIM Diseases for GRIN2B Gene (138252)

UniProtKB/Swiss-Prot

NMDE2_HUMAN
  • Mental retardation, autosomal dominant 6 (MRD6) [MIM:613970]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. {ECO:0000269 PubMed:20890276, ECO:0000269 PubMed:23033978}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Epileptic encephalopathy, early infantile, 27 (EIEE27) [MIM:616139]: A form of epileptic encephalopathy, a heterogeneous group of severe childhood onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Note=A chromosomal aberrations involving GRIN2B has been found in patients with mental retardation. Translocations t(9;12)(p23;p13.1) and t(10;12)(q21.1;p13.1) with a common breakpoint in 12p13.1.

(14) Novoseek inferred disease relationships for GRIN2B Gene

Disease -log(P) Hits PubMed IDs
schizophrenia 51.3 25
epilepsia partialis continua 50.9 1
ischemic brain injury 49.9 2
huntington disease 47.6 3
dysplasia 31.6 2

Relevant External Links for GRIN2B

Genetic Association Database (GAD)
GRIN2B
Human Genome Epidemiology (HuGE) Navigator
GRIN2B
genes like me logo Genes that share disorders with GRIN2B: view

Publications for GRIN2B Gene

  1. mRNA distribution in adult human brain of GRIN2B, a N-methyl-D- aspartate (NMDA) receptor subunit. (PMID: 9547169) Schito A.M. … Mandich P. (Neurosci. Lett. 1997) 3 4 23
  2. Mapping of the human NMDAR2B receptor subunit gene (GRIN2B) to chromosome 12p12. (PMID: 7959773) Mandich P. … Ajmar F. (Genomics 1994) 3 4 23
  3. Human N-methyl-D-aspartate receptor modulatory subunit hNR3: cloning and sequencing of the cDNA and primary structure of the protein. (PMID: 7999784) Adams S.L. … Kamboj R.K. (Biochim. Biophys. Acta 1995) 3 4 23
  4. Mutation analysis of the NMDAR2B (GRIN2B) gene in schizophrenia. (PMID: 11317224) Ohtsuki T. … Arinami T. (Mol. Psychiatry 2001) 3 23 49
  5. Association analysis for the genetic variants of the NMDA receptor subunit 2b and Alzheimer's disease. (PMID: 11844890) Tsai S.J. … Hong C.J. (Dement Geriatr Cogn Disord 2002) 3 23 49

Products for GRIN2B Gene

Sources for GRIN2B Gene

Back to Top

Content