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Aliases for FMO3 Gene

Aliases for FMO3 Gene

  • Flavin Containing Monooxygenase 3 2 3
  • Hepatic Flavin-Containing Monooxygenase 3 3 4
  • Trimethylamine Monooxygenase 3 4
  • Dimethylaniline Oxidase 3 3 4
  • EC 1.14.13.8 4 63
  • FMO Form 2 3 4
  • FMO II 3 4
  • FMO 3 3 4
  • Hepatic Flavin-Containing Monooxygenase-3 3
  • EC 1.14.13.148 4
  • DJ127D3.1 3
  • FMOII 3
  • TMAU 3

External Ids for FMO3 Gene

Previous GeneCards Identifiers for FMO3 Gene

  • GC01P168623
  • GC01P166689
  • GC0XP9N0049
  • GC01P168299
  • GC01P167791
  • GC01P169326
  • GC01P142283

Summaries for FMO3 Gene

Entrez Gene Summary for FMO3 Gene

  • Flavin-containing monooxygenases (FMO) are an important class of drug-metabolizing enzymes that catalyze the NADPH-dependent oxygenation of various nitrogen-,sulfur-, and phosphorous-containing xenobiotics such as therapeutic drugs, dietary compounds, pesticides, and other foreign compounds. The human FMO gene family is composed of 5 genes and multiple pseudogenes. FMO members have distinct developmental- and tissue-specific expression patterns. The expression of this FMO3 gene, the major FMO expressed in adult liver, can vary up to 20-fold between individuals. This inter-individual variation in FMO3 expression levels is likely to have significant effects on the rate at which xenobiotics are metabolised and, therefore, is of considerable interest to the pharmaceutical industry. This transmembrane protein localizes to the endoplasmic reticulum of many tissues. Alternative splicing of this gene results in multiple transcript variants encoding the same protein. Mutations in this gene cause the disorder trimethylaminuria (TMAu) which is characterized by the accumulation and excretion of unmetabolized trimethylamine and a distinctive body odor. In healthy individuals, trimethylamine is primarily converted to the non odorous trimethylamine N-oxide.[provided by RefSeq, Aug 2009]

GeneCards Summary for FMO3 Gene

FMO3 (Flavin Containing Monooxygenase 3) is a Protein Coding gene. Diseases associated with FMO3 include trimethylaminuria and metabolic syndrome x. Among its related pathways are Metabolism and SIDS Susceptibility Pathways. GO annotations related to this gene include oxidoreductase activity and NADP binding. An important paralog of this gene is FMO4.

UniProtKB/Swiss-Prot for FMO3 Gene

  • Involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. It N-oxygenates primary aliphatic alkylamines as well as secondary and tertiary amines. Plays an important role in the metabolism of trimethylamine (TMA), via the production of TMA N-oxide (TMAO). Is also able to perform S-oxidation when acting on sulfide compounds (PubMed:9224773).

Gene Wiki entry for FMO3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FMO3 Gene

Genomics for FMO3 Gene

Regulatory Elements for FMO3 Gene

Genomic Location for FMO3 Gene

Chromosome:
1
Start:
171,090,877 bp from pter
End:
171,117,821 bp from pter
Size:
26,945 bases
Orientation:
Plus strand

Genomic View for FMO3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FMO3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FMO3 Gene

Proteins for FMO3 Gene

  • Protein details for FMO3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P31513-FMO3_HUMAN
    Recommended name:
    Dimethylaniline monooxygenase [N-oxide-forming] 3
    Protein Accession:
    P31513
    Secondary Accessions:
    • B2R816
    • Q14854
    • Q8N5N5

    Protein attributes for FMO3 Gene

    Size:
    532 amino acids
    Molecular mass:
    60033 Da
    Cofactor:
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Quaternary structure:
    No Data Available

neXtProt entry for FMO3 Gene

Proteomics data for FMO3 Gene at MOPED

Post-translational modifications for FMO3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FMO3 Gene

Antibody Products

Domains & Families for FMO3 Gene

Suggested Antigen Peptide Sequences for FMO3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P31513

UniProtKB/Swiss-Prot:

FMO3_HUMAN :
  • Belongs to the FMO family.
Family:
  • Belongs to the FMO family.
genes like me logo Genes that share domains with FMO3: view

No data available for Gene Families for FMO3 Gene

Function for FMO3 Gene

Molecular function for FMO3 Gene

GENATLAS Biochemistry:
flavin containing monooxygenase 3,microsomal,major hepatic form
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=21 uM for trimethylamine (at pH 8.5) {ECO:0000269 PubMed:17050781, ECO:0000269 PubMed:17531949}; KM=31 uM for trimethylamine (at pH 7.4 and 37 degrees Celsius) {ECO:0000269 PubMed:17050781, ECO:0000269 PubMed:17531949}; KM=43 uM for benzydamine (at pH 7.4 and 37 degrees Celsius) {ECO:0000269 PubMed:17050781, ECO:0000269 PubMed:17531949}; KM=55.7 uM for ethylenethiourea (at pH 8.5) {ECO:0000269 PubMed:17050781, ECO:0000269 PubMed:17531949}; KM=71.8 uM for methimazole (at pH 8.5) {ECO:0000269 PubMed:17050781, ECO:0000269 PubMed:17531949}; KM=150.1 uM for sulindac (at pH 8.5) {ECO:0000269 PubMed:17050781, ECO:0000269 PubMed:17531949}; KM=248 uM for methyl p-tolyl sulfide (at pH 7.4 and 37 degrees Celsius) {ECO:0000269 PubMed:17050781, ECO:0000269 PubMed:17531949};
UniProtKB/Swiss-Prot CatalyticActivity:
N,N-dimethylaniline + NADPH + O(2) = N,N-dimethylaniline N-oxide + NADP(+) + H(2)O.
UniProtKB/Swiss-Prot CatalyticActivity:
N,N,N-trimethylamine + NADPH + O(2) = N,N,N-trimethylamine N-oxide + NADP(+) + H(2)O.
UniProtKB/Swiss-Prot Function:
Involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. It N-oxygenates primary aliphatic alkylamines as well as secondary and tertiary amines. Plays an important role in the metabolism of trimethylamine (TMA), via the production of TMA N-oxide (TMAO). Is also able to perform S-oxidation when acting on sulfide compounds (PubMed:9224773).

Enzyme Numbers (IUBMB) for FMO3 Gene

Gene Ontology (GO) - Molecular Function for FMO3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004499 N,N-dimethylaniline monooxygenase activity TAS --
GO:0034899 trimethylamine monooxygenase activity IEA --
GO:0050660 flavin adenine dinucleotide binding IEA --
GO:0050661 NADP binding IEA --
genes like me logo Genes that share ontologies with FMO3: view
genes like me logo Genes that share phenotypes with FMO3: view

Animal Model Products

miRNA for FMO3 Gene

miRTarBase miRNAs that target FMO3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FMO3

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for FMO3 Gene

Localization for FMO3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FMO3 Gene

Microsome membrane. Endoplasmic reticulum membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FMO3 Gene COMPARTMENTS Subcellular localization image for FMO3 gene
Compartment Confidence
endoplasmic reticulum 5
cytoskeleton 2
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for FMO3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016021 integral component of membrane IEA --
GO:0043231 intracellular membrane-bounded organelle TAS 9207220
genes like me logo Genes that share ontologies with FMO3: view

Pathways & Interactions for FMO3 Gene

genes like me logo Genes that share pathways with FMO3: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for FMO3 Gene

Gene Ontology (GO) - Biological Process for FMO3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006805 xenobiotic metabolic process TAS --
GO:0017144 drug metabolic process IBA --
GO:0044281 small molecule metabolic process TAS --
GO:0055114 oxidation-reduction process IBA --
genes like me logo Genes that share ontologies with FMO3: view

No data available for SIGNOR curated interactions for FMO3 Gene

Drugs & Compounds for FMO3 Gene

(33) Drugs for FMO3 Gene - From: NovoSeek, FDA Approved Drugs, PharmGKB, DrugBank, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dasatinib Approved, Investigational Pharma Enzyme, substrate Kinase Inhibitors, SRC/BCR-ABL tyrosine kinase inhibitors 250
Cimetidine Approved Pharma Inhibition, Inhibitor, Enzyme, substrate H2 receptor antagonist, H2 antagonist, I1 agonist 66
Olanzapine Approved, Investigational Pharma Antagonist, Enzyme, substrate 369
Vandetanib Approved April 2011 Pharma Enzyme, substrate VEGFR, EGFR, and RET inhibitor, EGFR Inhibitors, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors 0
Almotriptan Approved, Investigational Pharma Enzyme, substrate 13

(22) Additional Compounds for FMO3 Gene - From: HMDB and NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
nadph
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosyl-3-pyridinecarboxamide
  • b-NADPH
53-57-6
oxygen
  • Dioxygen
  • Molecular oxygen
  • O2
  • Oxygen
  • Oxygen molecule
7782-44-7
Dimethylaniline-N-oxide
  • Dimethyl(phenyl)amine oxide
  • Dimethylaniline N-oxide
  • N,N-Dimethylaniline N-oxide
  • Nn-dimethylaniline-N-oxide
874-52-2
Hydrogen Ion
  • Hydrogen cation
  • Hydron
  • Proton
N,N-Dimethylaniline
  • Dimethylaminobenzene
  • Dimethylaniline
  • Dimethylphenylamine
  • N,N-(Dimethylamino)benzene
  • N,N-Dimethyl-Benzenamine
121-69-7
genes like me logo Genes that share compounds with FMO3: view

Transcripts for FMO3 Gene

Unigene Clusters for FMO3 Gene

Flavin containing monooxygenase 3:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FMO3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FMO3 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11
SP1: - - -
SP2: - - - -
SP3: -
SP4:

Relevant External Links for FMO3 Gene

GeneLoc Exon Structure for
FMO3
ECgene alternative splicing isoforms for
FMO3

Expression for FMO3 Gene

mRNA expression in normal human tissues for FMO3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FMO3 Gene

This gene is overexpressed in Liver (x33.9).

Protein differential expression in normal tissues from HIPED for FMO3 Gene

This gene is overexpressed in Gallbladder (31.6), Nasal epithelium (22.5), and Liver (13.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FMO3 Gene



SOURCE GeneReport for Unigene cluster for FMO3 Gene Hs.445350

mRNA Expression by UniProt/SwissProt for FMO3 Gene

P31513-FMO3_HUMAN
Tissue specificity: Liver
genes like me logo Genes that share expression patterns with FMO3: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for FMO3 Gene

Orthologs for FMO3 Gene

This gene was present in the common ancestor of animals.

Orthologs for FMO3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FMO3 35
  • 84.68 (n)
  • 82.3 (a)
FMO3 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FMO3 35
  • 86.25 (n)
  • 83.43 (a)
FMO3 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fmo3 35
  • 83.11 (n)
  • 79.66 (a)
Fmo3 16
Fmo3 36
  • 79 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FMO3 35
  • 99.62 (n)
  • 99.81 (a)
FMO3 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fmo3 35
  • 82.89 (n)
  • 81.32 (a)
oppossum
(Monodelphis domestica)
Mammalia FMO3 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 74 (a)
OneToMany
chicken
(Gallus gallus)
Aves FMO3 36
  • 61 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 74 (a)
ManyToMany
-- 36
  • 70 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia fmo3 35
  • 63.26 (n)
  • 60.98 (a)
worm
(Caenorhabditis elegans)
Secernentea C01H6.4 37
  • 34 (a)
fmo-11 37
  • 39 (a)
fmo-12 37
  • 40 (a)
fmo-13 37
  • 42 (a)
fmo-14 37
  • 36 (a)
fmo-15 37
  • 42 (a)
Species with no ortholog for FMO3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for FMO3 Gene

ENSEMBL:
Gene Tree for FMO3 (if available)
TreeFam:
Gene Tree for FMO3 (if available)

Paralogs for FMO3 Gene

Paralogs for FMO3 Gene

(6) SIMAP similar genes for FMO3 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with FMO3: view

Variants for FMO3 Gene

Sequence variations from dbSNP and Humsavar for FMO3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1736554 -- 171,089,053(+) TTTAC(A/G)AGATA upstream-variant-2KB
rs1736555 -- 171,089,111(+) CCATC(A/G)TAGCT upstream-variant-2KB
rs1736556 -- 171,109,428(+) TTTCA(C/G)AGATT intron-variant
rs1736557 Pathogenic, - 171,110,939(+) TGTAC(A/G)TGAAG missense, reference
rs1736558 -- 171,089,420(+) CCACT(C/G)CCCCA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for FMO3 Gene

Variant ID Type Subtype PubMed ID
esv28731 CNV Gain+Loss 19812545

Variation tolerance for FMO3 Gene

Residual Variation Intolerance Score: 91.97% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.99; 96.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FMO3 Gene

HapMap Linkage Disequilibrium report
FMO3
Human Gene Mutation Database (HGMD)
FMO3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FMO3 Gene

Disorders for FMO3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for FMO3 Gene - From: OMIM, ClinVar, GeneTests, Swiss-Prot, DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
trimethylaminuria
  • fish odor syndrome
metabolic syndrome x
  • dysmetabolic syndrome x
- elite association
Search FMO3 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

FMO3_HUMAN
  • Trimethylaminuria (TMAU) [MIM:602079]: Inborn error of metabolism associated with an offensive body odor and caused by deficiency of FMO-mediated N-oxidation of amino-trimethylamine (TMA) derived from foodstuffs. Affected individuals excrete relatively large amounts of TMA in their urine, sweat, and breath, and exhibit a fishy body odor characteristic of the malodorous free amine. {ECO:0000269 PubMed:10338091, ECO:0000269 PubMed:10479479, ECO:0000269 PubMed:11191884, ECO:0000269 PubMed:12893987, ECO:0000269 PubMed:9536088}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for FMO3

Genetic Association Database (GAD)
FMO3
Human Genome Epidemiology (HuGE) Navigator
FMO3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FMO3
genes like me logo Genes that share disorders with FMO3: view

No data available for Genatlas for FMO3 Gene

Publications for FMO3 Gene

  1. Human flavin-containing monooxygenase: substrate specificity and role in drug metabolism. (PMID: 11465082) Cashman J.R. (Curr. Drug Metab. 2000) 23 25 26 67
  2. Role of hepatic flavin-containing monooxygenase 3 in drug and chemical metabolism in adult humans. (PMID: 7720103) Cashman J.R. … Cashman L.E. (Chem. Biol. Interact. 1995) 23 25 26 67
  3. Structural organization of the human flavin-containing monooxygenase 3 gene (FMO3), the favored candidate for fish-odor syndrome, determined directly from genomic DNA. (PMID: 9417913) Dolphin C.T. … Phillips I.R. (Genomics 1997) 2 23 67
  4. A physiological role for flavin-containing monooxygenase (FMO3) in humans? (PMID: 20230247) Mitchell S.C. … Smith R.L. (Xenobiotica 2010) 23 67
  5. In vitro hepatic metabolism explains higher clearance of voriconazole in children versus adults: role of CYP2C19 and flavin-containing monooxygenase 3. (PMID: 19841059) Yanni S.B. … Thakker D.R. (Drug Metab. Dispos. 2010) 23 67

Products for FMO3 Gene

Sources for FMO3 Gene

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