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Aliases for ERCC2 Gene

Aliases for ERCC2 Gene

  • Excision Repair Cross-Complementation Group 2 2 3 5
  • Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 2 2 3
  • TFIIH Basal Transcription Factor Complex Helicase XPB Subunit 2 3
  • TFIIH Basal Transcription Factor Complex 80 KDa Subunit 3 4
  • Xeroderma Pigmentosum Group D-Complementing Protein 3 4
  • Xeroderma Pigmentosum Complementary Group D 2 3
  • Basic Transcription Factor 2 80 KDa Subunit 3 4
  • DNA Repair Protein Complementing XP-D Cells 3 4
  • DNA Excision Repair Protein ERCC-2 3 4
  • TFIIH 80 KDa Subunit 3 4
  • TFIIH P80 3 4
  • BTF2 P80 3 4
  • CXPD 3 4
  • XPD 3 4
  • Excision Repair Cross-Complementing Rodent Repair Deficiency 2
  • TFIIH Basal Transcription Factor Complex Helicase Subunit 3
  • Complementation Group 2 Protein 2
  • EC 3.6.4.12 4
  • EC 3.6.1 63
  • COFS2 3
  • TFIIH 3
  • TTD1 3
  • XPDC 4
  • EM9 3
  • TTD 3

External Ids for ERCC2 Gene

Previous HGNC Symbols for ERCC2 Gene

  • XPD

Previous GeneCards Identifiers for ERCC2 Gene

  • GC19M046497
  • GC19M046245
  • GC19M050529
  • GC19M050546
  • GC19M045854
  • GC19M042287

Summaries for ERCC2 Gene

Entrez Gene Summary for ERCC2 Gene

  • The nucleotide excision repair pathway is a mechanism to repair damage to DNA. The protein encoded by this gene is involved in transcription-coupled nucleotide excision repair and is an integral member of the basal transcription factor BTF2/TFIIH complex. The gene product has ATP-dependent DNA helicase activity and belongs to the RAD3/XPD subfamily of helicases. Defects in this gene can result in three different disorders, the cancer-prone syndrome xeroderma pigmentosum complementation group D, trichothiodystrophy, and Cockayne syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

GeneCards Summary for ERCC2 Gene

ERCC2 (Excision Repair Cross-Complementation Group 2) is a Protein Coding gene. Diseases associated with ERCC2 include xeroderma pigmentosum, group d and trichothiodystrophy 1, photosensitive. Among its related pathways are RNA Polymerase II Transcription Initiation And Promoter Clearance and Nucleotide excision repair. GO annotations related to this gene include nucleic acid binding and protein C-terminus binding.

UniProtKB/Swiss-Prot for ERCC2 Gene

  • ATP-dependent 5-3 DNA helicase, component of the core-TFIIH basal transcription factor. Involved in nucleotide excision repair (NER) of DNA by opening DNA around the damage, and in RNA transcription by RNA polymerase II by anchoring the CDK-activating kinase (CAK) complex, composed of CDK7, cyclin H and MAT1, to the core-TFIIH complex. Involved in the regulation of vitamin-D receptor activity. As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation. Might have a role in aging process and could play a causative role in the generation of skin cancers.

Gene Wiki entry for ERCC2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ERCC2 Gene

Genomics for ERCC2 Gene

Regulatory Elements for ERCC2 Gene

Enhancers for ERCC2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ERCC2 on UCSC Golden Path with GeneCards custom track

Promoters for ERCC2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ERCC2 on UCSC Golden Path with GeneCards custom track

Genomic Location for ERCC2 Gene

Chromosome:
19
Start:
45,349,837 bp from pter
End:
45,370,918 bp from pter
Size:
21,082 bases
Orientation:
Minus strand

Genomic View for ERCC2 Gene

Genes around ERCC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ERCC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ERCC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ERCC2 Gene

Proteins for ERCC2 Gene

  • Protein details for ERCC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P18074-ERCC2_HUMAN
    Recommended name:
    TFIIH basal transcription factor complex helicase XPD subunit
    Protein Accession:
    P18074
    Secondary Accessions:
    • Q2TB78
    • Q2YDY2
    • Q7KZU6
    • Q8N721

    Protein attributes for ERCC2 Gene

    Size:
    760 amino acids
    Molecular mass:
    86909 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Cofactor:
    Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
    Quaternary structure:
    • One of the six subunits forming the core-TFIIH basal transcription factor which associates with the CAK complex composed of CDK7, CCNH/cyclin H and MNAT1 to form the TFIIH basal transcription factor. The interaction with GTF2H2 results in the stimulation of the 5-->3 helicase activity. Component of the MMXD complex, which includes CIAO1, ERCC2, FAM96B, MMS19 and SLC25A5. Interacts with FAM196B; the interaction is direct. Interacts with ATF7IP. Interacts with Epstein-Barr virus EBNA2.
    SequenceCaution:
    • Sequence=AAM45142.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for ERCC2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ERCC2 Gene

Proteomics data for ERCC2 Gene at MOPED

Post-translational modifications for ERCC2 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for ERCC2 (ERCC2)

Domains & Families for ERCC2 Gene

Graphical View of Domain Structure for InterPro Entry

P18074

UniProtKB/Swiss-Prot:

ERCC2_HUMAN :
  • Contains 1 helicase ATP-binding domain.
  • Belongs to the helicase family. RAD3/XPD subfamily.
Domain:
  • Contains 1 helicase ATP-binding domain.
Family:
  • Belongs to the helicase family. RAD3/XPD subfamily.
genes like me logo Genes that share domains with ERCC2: view

Function for ERCC2 Gene

Molecular function for ERCC2 Gene

GENATLAS Biochemistry:
excision repair cross-complementing rodent repair defect in CHO cells (includes overlapping antisense sequence),complementation group 2,yeast RAD3 homolog (see XPD) mutations modify GTFIIH stoichiometry in XPD patients
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.
UniProtKB/Swiss-Prot Function:
ATP-dependent 5-3 DNA helicase, component of the core-TFIIH basal transcription factor. Involved in nucleotide excision repair (NER) of DNA by opening DNA around the damage, and in RNA transcription by RNA polymerase II by anchoring the CDK-activating kinase (CAK) complex, composed of CDK7, cyclin H and MAT1, to the core-TFIIH complex. Involved in the regulation of vitamin-D receptor activity. As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation. Might have a role in aging process and could play a causative role in the generation of skin cancers.

Enzyme Numbers (IUBMB) for ERCC2 Gene

Gene Ontology (GO) - Molecular Function for ERCC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 7663514
GO:0008094 DNA-dependent ATPase activity TAS 8663148
GO:0043139 5-3 DNA helicase activity IDA 8663148
genes like me logo Genes that share ontologies with ERCC2: view
genes like me logo Genes that share phenotypes with ERCC2: view

Human Phenotype Ontology for ERCC2 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for ERCC2 Gene

MGI Knock Outs for ERCC2:

Animal Model Products

miRNA for ERCC2 Gene

miRTarBase miRNAs that target ERCC2

No data available for Transcription Factor Targets and HOMER Transcription for ERCC2 Gene

Localization for ERCC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ERCC2 Gene

Nucleus. Cytoplasm, cytoskeleton, spindle.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ERCC2 Gene COMPARTMENTS Subcellular localization image for ERCC2 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 3
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for ERCC2 Gene

Pathways & Interactions for ERCC2 Gene

SuperPathways for ERCC2 Gene

Superpath Contained pathways
1 RNA Polymerase II Transcription Initiation And Promoter Clearance
2 Formation of the HIV-1 Early Elongation Complex
3 Transcription-Coupled Nucleotide Excision Repair (TC-NER)
4 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
5 Infectious disease
.48
genes like me logo Genes that share pathways with ERCC2: view

SIGNOR curated interactions for ERCC2 Gene

Activates:

Gene Ontology (GO) - Biological Process for ERCC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000717 nucleotide-excision repair, DNA duplex unwinding TAS --
GO:0006139 nucleobase-containing compound metabolic process IEA --
GO:0006281 DNA repair TAS --
GO:0006283 transcription-coupled nucleotide-excision repair TAS --
GO:0006293 nucleotide-excision repair, preincision complex stabilization TAS --
genes like me logo Genes that share ontologies with ERCC2: view

Drugs & Compounds for ERCC2 Gene

(19) Drugs for ERCC2 Gene - From: PharmGKB, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cisplatin Approved Pharma Inhibits DNA synthesis,chemotherapy drug, Platinum 2569
Docetaxel Approved May 1996, Investigational Pharma Microtubulin disassembly inhibitor, Tubulin and VEGF inhibitor, Taxanes 1859
Oxaliplatin Approved, Investigational Pharma Antitumor agent, Platinum 1338
Fluorouracil Approved Pharma RNA processing inhibitor and thymidylate synthase inhibitor 1697
leucovorin Approved Pharma 1029

(12) Additional Compounds for ERCC2 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with ERCC2: view

Transcripts for ERCC2 Gene

Unigene Clusters for ERCC2 Gene

Excision repair cross-complementing rodent repair deficiency, complementation group 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ERCC2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^
SP1: - - -
SP2: - -
SP3: - -
SP4:
SP5: - - - -
SP6:
SP7: - - -
SP8: -

ExUns: 22 ^ 23
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for ERCC2 Gene

GeneLoc Exon Structure for
ERCC2
ECgene alternative splicing isoforms for
ERCC2

Expression for ERCC2 Gene

mRNA expression in normal human tissues for ERCC2 Gene

Protein differential expression in normal tissues from HIPED for ERCC2 Gene

This gene is overexpressed in Serum (23.0), Breast (9.1), Liver (7.3), and Monocytes (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ERCC2 Gene



SOURCE GeneReport for Unigene cluster for ERCC2 Gene Hs.487294

genes like me logo Genes that share expression patterns with ERCC2: view

Protein tissue co-expression partners for ERCC2 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ERCC2 Gene

Orthologs for ERCC2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ERCC2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ERCC2 35
  • 91.49 (n)
  • 97.89 (a)
ERCC2 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ERCC2 35
  • 91.36 (n)
  • 98.02 (a)
ERCC2 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ercc2 35
  • 89.21 (n)
  • 97.5 (a)
Ercc2 16
Ercc2 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ERCC2 35
  • 99.3 (n)
  • 99.74 (a)
ERCC2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ercc2 35
  • 88.51 (n)
  • 97.76 (a)
oppossum
(Monodelphis domestica)
Mammalia ERCC2 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 93 (a)
OneToMany
-- 36
  • 89 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia ercc2 35
  • 71.01 (n)
  • 80.39 (a)
zebrafish
(Danio rerio)
Actinopterygii ercc2 35
  • 72.48 (n)
  • 81.58 (a)
zgc56365 35
ercc2 36
  • 83 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Xpd 37
  • 68 (a)
Xpd 35
  • 66.3 (n)
  • 69.26 (a)
Xpd 36
  • 68 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002988 35
  • 67.44 (n)
  • 69.67 (a)
worm
(Caenorhabditis elegans)
Secernentea Y50D7A.2 37
  • 58 (a)
Y50D7A.2 35
  • 58.06 (n)
  • 61.53 (a)
Y50D7A.11 36
  • 51 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR114C 35
  • 56.42 (n)
  • 53.77 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C17776g 35
  • 52.22 (n)
  • 53.09 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RAD3 35
  • 52.03 (n)
  • 53.5 (a)
RAD3 36
  • 51 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons UVH6 35
  • 56.3 (n)
  • 55.62 (a)
rice
(Oryza sativa)
Liliopsida Os05g0144800 35
  • 58.42 (n)
  • 56.46 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU01625 35
  • 59.53 (n)
  • 55.22 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rad15 35
  • 54.4 (n)
  • 56.5 (a)
Species with no ortholog for ERCC2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ERCC2 Gene

ENSEMBL:
Gene Tree for ERCC2 (if available)
TreeFam:
Gene Tree for ERCC2 (if available)

Paralogs for ERCC2 Gene

(1) SIMAP similar genes for ERCC2 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with ERCC2: view

No data available for Paralogs for ERCC2 Gene

Variants for ERCC2 Gene

Sequence variations from dbSNP and Humsavar for ERCC2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_003622 Trichothiodystrophy 1, photosensitive (TTD1)
VAR_003622 Xeroderma pigmentosum complementation group D (XP-D)
VAR_003623 Trichothiodystrophy 1, photosensitive (TTD1)
VAR_003623 Xeroderma pigmentosum complementation group D (XP-D)
rs121913019 Xeroderma pigmentosum complementation group D (XP-D) 45,354,774(-) TCACC(A/C)GCTAC nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ERCC2 Gene

Variant ID Type Subtype PubMed ID
nsv833844 CNV Loss 17160897
nsv912146 CNV Loss 21882294
nsv833845 CNV Loss 17160897
nsv470146 CNV Loss 18288195
nsv458711 CNV Gain 19166990
dgv29n64 CNV Gain 17921354
nsv442466 CNV CNV 18776908
nsv515681 CNV Loss 19592680
nsv428365 CNV Gain+Loss 18775914

Variation tolerance for ERCC2 Gene

Residual Variation Intolerance Score: 13.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.97; 93.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ERCC2 Gene

HapMap Linkage Disequilibrium report
ERCC2
Human Gene Mutation Database (HGMD)
ERCC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ERCC2 Gene

Disorders for ERCC2 Gene

MalaCards: The human disease database

(24) MalaCards diseases for ERCC2 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
xeroderma pigmentosum, group d
  • xeroderma pigmentosum, complementation group d
trichothiodystrophy 1, photosensitive
  • amish brittle hair brain syndrome
cerebrooculofacioskeletal syndrome 2
  • cofs syndrome
cerebrooculofacioskeletal syndrome 1
  • cerebro-oculo-facio-skeletal syndrome
ercc2-related xeroderma pigmentosum
- elite association - COSMIC cancer census association via MalaCards
Search ERCC2 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

ERCC2_HUMAN
  • Cerebro-oculo-facio-skeletal syndrome 2 (COFS2) [MIM:610756]: A disorder of prenatal onset characterized by microcephaly, congenital cataracts, facial dysmorphism, neurogenic arthrogryposis, growth failure and severe psychomotor retardation. COFS is considered to be part of the nucleotide-excision repair disorders spectrum that include also xeroderma pigmentosum, trichothiodystrophy and Cockayne syndrome. {ECO:0000269 PubMed:11443545}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Trichothiodystrophy 1, photosensitive (TTD1) [MIM:601675]: A form of trichothiodystrophy, an autosomal recessive disease characterized by sulfur-deficient brittle hair and multisystem variable abnormalities. The spectrum of clinical features varies from mild disease with only hair involvement to severe disease with cutaneous, neurologic and profound developmental defects. Ichthyosis, intellectual and developmental disabilities, decreased fertility, abnormal characteristics at birth, ocular abnormalities, short stature, and infections are common manifestations. There are both photosensitive and non-photosensitive forms of the disorder. TTD1 patients manifest cutaneous photosensitivity. {ECO:0000269 PubMed:11242112, ECO:0000269 PubMed:7920640, ECO:0000269 PubMed:8571952, ECO:0000269 PubMed:9195225, ECO:0000269 PubMed:9238033, ECO:0000269 PubMed:9758621}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Xeroderma pigmentosum complementation group D (XP-D) [MIM:278730]: An autosomal recessive pigmentary skin disorder characterized by solar hypersensitivity of the skin, high predisposition for developing cancers on areas exposed to sunlight and, in some cases, neurological abnormalities. The skin develops marked freckling and other pigmentation abnormalities. Some XP-D patients present features of Cockayne syndrome, including cachectic dwarfism, pigmentary retinopathy, ataxia, decreased nerve conduction velocities. The phenotype combining xeroderma pigmentosum and Cockayne syndrome traits is referred to as XP-CS complex. {ECO:0000269 PubMed:11709541, ECO:0000269 PubMed:7585650, ECO:0000269 PubMed:7825573, ECO:0000269 PubMed:7849702, ECO:0000269 PubMed:9101292}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for ERCC2

Genetic Association Database (GAD)
ERCC2
Human Genome Epidemiology (HuGE) Navigator
ERCC2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ERCC2
genes like me logo Genes that share disorders with ERCC2: view

No data available for Genatlas for ERCC2 Gene

Publications for ERCC2 Gene

  1. Associations between ercc2 polymorphisms and gliomas. (PMID: 11319176) Caggana M. … Wrensch M.R. (Cancer Epidemiol. Biomarkers Prev. 2001) 3 4 23 48 67
  2. Human Xeroderma pigmentosum group D gene encodes a DNA helicase. (PMID: 8413672) Sung P. … Prakash S. (Nature 1993) 2 3 23
  3. ERCC2: cDNA cloning and molecular characterization of a human nucleotide excision repair gene with high homology to yeast RAD3. (PMID: 2184031) Weber C.A. … Thompson L.H. (EMBO J. 1990) 2 3 23
  4. Decreased expression and the Lys751Gln polymorphism of the XPD gene are associated with extreme longevity. (PMID: 19707883) Polosak J. … Puzianowska-Kuznicka M. (Biogerontology 2010) 3 23
  5. DNA repair gene X-ray repair cross-complementing group 1 and xeroderma pigmentosum group D polymorphisms and risk of prostate cancer: a study from North India. (PMID: 20070155) Mandal R.K. … Mittal R.D. (DNA Cell Biol. 2010) 3 23

Products for ERCC2 Gene

Sources for ERCC2 Gene

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